{"id":"https://openalex.org/W4409870517","doi":"https://doi.org/10.1021/acsabm.5c00116","title":"Tailoring Alkyl Side Chains of Ionizable Amino-Polyesters for Enhanced In Vivo mRNA Delivery","display_name":"Tailoring Alkyl Side Chains of Ionizable Amino-Polyesters for Enhanced In Vivo mRNA Delivery","publication_year":2025,"publication_date":"2025-04-28","ids":{"openalex":"https://openalex.org/W4409870517","doi":"https://doi.org/10.1021/acsabm.5c00116","pmid":"https://pubmed.ncbi.nlm.nih.gov/40293247"},"language":"en","primary_location":{"id":"doi:10.1021/acsabm.5c00116","doi":"https://doi.org/10.1021/acsabm.5c00116","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acsabm.5c00116","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acsabm.5c00116?ref=article_openPDF","source":{"id":"https://openalex.org/S4210214000","display_name":"ACS Applied Bio Materials","issn_l":"2576-6422","issn":["2576-6422"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Applied Bio Materials","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://pubs.acs.org/doi/pdf/10.1021/acsabm.5c00116?ref=article_openPDF","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040564810","display_name":"Aida L\u00f3pez Espinar","orcid":"https://orcid.org/0000-0002-3934-1764","observed_orcids":["https://orcid.org/0000-0002-3934-1764"]},"institutions":[{"id":"https://openalex.org/I27577105","display_name":"University College Cork","ror":"https://ror.org/03265fv13","country_code":"IE","type":"education","lineage":["https://openalex.org/I27577105"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Aida L\u00f3pez Espinar","raw_affiliation_strings":["School of Pharmacy","University College Cork"],"raw_orcid":"https://orcid.org/0000-0002-3934-1764","affiliations":[{"raw_affiliation_string":"School of Pharmacy","institution_ids":[]},{"raw_affiliation_string":"University College Cork","institution_ids":["https://openalex.org/I27577105"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085830645","display_name":"Lianne M. Mulder","orcid":"https://orcid.org/0000-0002-3617-7188","observed_orcids":["https://orcid.org/0000-0002-3617-7188"]},"institutions":[{"id":"https://openalex.org/I27577105","display_name":"University College Cork","ror":"https://ror.org/03265fv13","country_code":"IE","type":"education","lineage":["https://openalex.org/I27577105"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Lianne M. Mulder","raw_affiliation_strings":["School of Pharmacy","University College Cork"],"raw_orcid":"https://orcid.org/0000-0002-3617-7188","affiliations":[{"raw_affiliation_string":"School of Pharmacy","institution_ids":[]},{"raw_affiliation_string":"University College Cork","institution_ids":["https://openalex.org/I27577105"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Mohamed Elkhashab","orcid":"https://orcid.org/0000-0002-9760-2272","observed_orcids":["https://orcid.org/0000-0002-9760-2272"]},"institutions":[{"id":"https://openalex.org/I27577105","display_name":"University College Cork","ror":"https://ror.org/03265fv13","country_code":"IE","type":"education","lineage":["https://openalex.org/I27577105"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Mohamed Elkhashab","raw_affiliation_strings":["School of Pharmacy","University College Cork"],"raw_orcid":"https://orcid.org/0000-0002-9760-2272","affiliations":[{"raw_affiliation_string":"School of Pharmacy","institution_ids":[]},{"raw_affiliation_string":"University College Cork","institution_ids":["https://openalex.org/I27577105"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Zahra Khan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27577105","display_name":"University College Cork","ror":"https://ror.org/03265fv13","country_code":"IE","type":"education","lineage":["https://openalex.org/I27577105"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Zahra Khan","raw_affiliation_strings":["School of Pharmacy","University College Cork"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy","institution_ids":[]},{"raw_affiliation_string":"University College Cork","institution_ids":["https://openalex.org/I27577105"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052605246","display_name":"Mariusz Czarnocki\u2010Cieciura","orcid":"https://orcid.org/0000-0001-5582-2851","observed_orcids":["https://orcid.org/0000-0001-5582-2851"]},"institutions":[{"id":"https://openalex.org/I4210120699","display_name":"International Institute of Molecular and Cell Biology","ror":"https://ror.org/01y3dkx74","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210120699"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Mariusz Czarnocki-Cieciura","raw_affiliation_strings":["International Institute of Molecular and Cell Biology","Laboratory of Protein Structure"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"International Institute of Molecular and Cell Biology","institution_ids":["https://openalex.org/I4210120699"]},{"raw_affiliation_string":"Laboratory of Protein Structure","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005264057","display_name":"Mar\u00eda R. Aburto","orcid":"https://orcid.org/0000-0001-5806-251X","observed_orcids":["https://orcid.org/0000-0001-5806-251X"]},"institutions":[{"id":"https://openalex.org/I27577105","display_name":"University College Cork","ror":"https://ror.org/03265fv13","country_code":"IE","type":"education","lineage":["https://openalex.org/I27577105"]},{"id":"https://openalex.org/I4210141138","display_name":"APC Microbiome Institute","ror":"https://ror.org/03f2ct267","country_code":"IE","type":"facility","lineage":["https://openalex.org/I4210141138"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Maria R. Aburto","raw_affiliation_strings":["APC Microbiome Ireland","Department of Anatomy and Neuroscience","University College Cork"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"APC Microbiome Ireland","institution_ids":["https://openalex.org/I4210141138"]},{"raw_affiliation_string":"Department of Anatomy and Neuroscience","institution_ids":[]},{"raw_affiliation_string":"University College Cork","institution_ids":["https://openalex.org/I27577105"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075694007","display_name":"Sonja R. Vu\u010den","orcid":"https://orcid.org/0000-0003-0140-0121","observed_orcids":["https://orcid.org/0000-0003-0140-0121"]},"institutions":[{"id":"https://openalex.org/I27577105","display_name":"University College Cork","ror":"https://ror.org/03265fv13","country_code":"IE","type":"education","lineage":["https://openalex.org/I27577105"]},{"id":"https://openalex.org/I4404532877","display_name":"Taighde \u00c9ireann - Research Ireland","ror":"https://ror.org/010t7sr36","country_code":"IE","type":"government","lineage":["https://openalex.org/I4404532877"]},{"id":"https://openalex.org/I4405269133","display_name":"Synthesis and Solid State Pharmaceutical Centre","ror":"https://ror.org/036q2ga39","country_code":"IE","type":"facility","lineage":["https://openalex.org/I4405269133"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Sonja Vucen","raw_affiliation_strings":["SSPC, Research Ireland Centre for Pharmaceuticals, School of Pharmacy","University College Cork"],"raw_orcid":"https://orcid.org/0000-0003-0140-0121","affiliations":[{"raw_affiliation_string":"SSPC, Research Ireland Centre for Pharmaceuticals, School of Pharmacy","institution_ids":["https://openalex.org/I4404532877","https://openalex.org/I4405269133"]},{"raw_affiliation_string":"University College Cork","institution_ids":["https://openalex.org/I27577105"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086704505","display_name":"Piotr S. Kowalski","orcid":"https://orcid.org/0000-0001-8607-0189","observed_orcids":["https://orcid.org/0000-0001-8607-0189"]},"institutions":[{"id":"https://openalex.org/I27577105","display_name":"University College Cork","ror":"https://ror.org/03265fv13","country_code":"IE","type":"education","lineage":["https://openalex.org/I27577105"]},{"id":"https://openalex.org/I4210141138","display_name":"APC Microbiome Institute","ror":"https://ror.org/03f2ct267","country_code":"IE","type":"facility","lineage":["https://openalex.org/I4210141138"]}],"countries":["IE"],"is_corresponding":true,"raw_author_name":"Piotr S. Kowalski","raw_affiliation_strings":["APC Microbiome Ireland","School of Pharmacy","University College Cork"],"raw_orcid":"https://orcid.org/0000-0001-8607-0189","affiliations":[{"raw_affiliation_string":"APC Microbiome Ireland","institution_ids":["https://openalex.org/I4210141138"]},{"raw_affiliation_string":"School of Pharmacy","institution_ids":[]},{"raw_affiliation_string":"University College Cork","institution_ids":["https://openalex.org/I27577105"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5086704505"],"corresponding_institution_ids":["https://openalex.org/I27577105","https://openalex.org/I4210141138"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":{"value":4500,"currency":"USD","value_usd":4500},"fwci":2.0299,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.86701621,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"8","issue":"5","first_page":"3958","last_page":"3971"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alkyl-side-chain-length","display_name":"alkyl side chain length","score":0.8790000081062317},{"id":"https://openalex.org/keywords/mrna-delivery","display_name":"mRNA delivery","score":0.6259999871253967},{"id":"https://openalex.org/keywords/lipid-nanoparticles","display_name":"lipid nanoparticles","score":0.9229999780654907},{"id":"https://openalex.org/keywords/lipid-polymer-hybrid-nanoparticles","display_name":"lipid-polymer hybrid nanoparticles","score":0.9229999780654907},{"id":"https://openalex.org/keywords/ionizable-lipids","display_name":"ionizable lipids","score":0.718999981880188},{"id":"https://openalex.org/keywords/tissue-targeting","display_name":"tissue targeting","score":0.4659999907016754},{"id":"https://openalex.org/keywords/unsaturated-phospholipids","display_name":"unsaturated phospholipids","score":0.8479999899864197},{"id":"https://openalex.org/keywords/cholesterol","display_name":"cholesterol","score":0.8949999809265137},{"id":"https://openalex.org/keywords/ring-opening-polymerization","display_name":"ring-opening polymerization","score":0.8830000162124634}],"concepts":[{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7928339838981628},{"id":"https://openalex.org/C204921945","wikidata":"https://www.wikidata.org/wiki/Q899689","display_name":"Side chain","level":3,"score":0.7846126556396484},{"id":"https://openalex.org/C2780263894","wikidata":"https://www.wikidata.org/wiki/Q335268","display_name":"Alkyl","level":2,"score":0.7812796235084534},{"id":"https://openalex.org/C119394753","wikidata":"https://www.wikidata.org/wiki/Q188245","display_name":"Polyester","level":2,"score":0.7749336957931519},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6017115116119385},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.5305650234222412},{"id":"https://openalex.org/C188027245","wikidata":"https://www.wikidata.org/wiki/Q750446","display_name":"Polymer chemistry","level":1,"score":0.37327638268470764},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.35836756229400635},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.35026249289512634},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.34320348501205444},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.3100312352180481},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1310538947582245},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07098057866096497},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.07019582390785217}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001672","descriptor_name":"Biocompatible Materials","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D001672","descriptor_name":"Biocompatible Materials","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D001672","descriptor_name":"Biocompatible Materials","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D001672","descriptor_name":"Biocompatible Materials","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D001672","descriptor_name":"Biocompatible Materials","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D001672","descriptor_name":"Biocompatible Materials","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D001672","descriptor_name":"Biocompatible Materials","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D001672","descriptor_name":"Biocompatible Materials","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008422","descriptor_name":"Materials Testing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008422","descriptor_name":"Materials Testing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008422","descriptor_name":"Materials Testing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008422","descriptor_name":"Materials Testing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010316","descriptor_name":"Particle Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010316","descriptor_name":"Particle Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010316","descriptor_name":"Particle Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010316","descriptor_name":"Particle Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011108","descriptor_name":"Polymers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011108","descriptor_name":"Polymers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011108","descriptor_name":"Polymers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011108","descriptor_name":"Polymers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018014","descriptor_name":"Gene Transfer Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018014","descriptor_name":"Gene Transfer Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018014","descriptor_name":"Gene Transfer Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018014","descriptor_name":"Gene Transfer Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1021/acsabm.5c00116","doi":"https://doi.org/10.1021/acsabm.5c00116","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acsabm.5c00116","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acsabm.5c00116?ref=article_openPDF","source":{"id":"https://openalex.org/S4210214000","display_name":"ACS Applied Bio Materials","issn_l":"2576-6422","issn":["2576-6422"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Applied Bio Materials","raw_type":"journal-article"},{"id":"pmid:40293247","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40293247","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS applied bio materials","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12093369","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12093369","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ACS Appl Bio Mater","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1021/acsabm.5c00116","doi":"https://doi.org/10.1021/acsabm.5c00116","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acsabm.5c00116","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acsabm.5c00116?ref=article_openPDF","source":{"id":"https://openalex.org/S4210214000","display_name":"ACS Applied Bio Materials","issn_l":"2576-6422","issn":["2576-6422"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Applied Bio Materials","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.766700029373169,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3276408083","display_name":"Oral delivery of encapsulated RNA nanotherapeutics for targeted treatment of ileal Crohn's disease","funder_award_id":"101057491","funder_id":"https://openalex.org/F4320338440","funder_display_name":"HORIZON EUROPE Health"},{"id":"https://openalex.org/G5403633375","display_name":null,"funder_award_id":"EIA-2019-006","funder_id":"https://openalex.org/F4320312041","funder_display_name":"Health Research Board"},{"id":"https://openalex.org/G7365700441","display_name":"Synthetic Circular RNA therapeutics for prevention of sepsis-associated organ failure","funder_award_id":"101041424","funder_id":"https://openalex.org/F4320338453","funder_display_name":"HORIZON EUROPE European Research Council"},{"id":"https://openalex.org/G7444230431","display_name":null,"funder_award_id":"GOIPG/2021/1649","funder_id":"https://openalex.org/F4320321056","funder_display_name":"Irish Research Council"}],"funders":[{"id":"https://openalex.org/F4320312041","display_name":"Health Research Board","ror":"https://ror.org/003hb2249"},{"id":"https://openalex.org/F4320321056","display_name":"Irish Research Council","ror":"https://ror.org/051xex213"},{"id":"https://openalex.org/F4320323873","display_name":"Uniwersytet Warszawski","ror":"https://ror.org/039bjqg32"},{"id":"https://openalex.org/F4320334322","display_name":"HORIZON EUROPE Framework Programme","ror":null},{"id":"https://openalex.org/F4320338440","display_name":"HORIZON EUROPE Health","ror":null},{"id":"https://openalex.org/F4320338453","display_name":"HORIZON EUROPE European Research Council","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4409870517.pdf","grobid_xml":"https://content.openalex.org/works/W4409870517.grobid-xml"},"referenced_works_count":57,"referenced_works":["https://openalex.org/W2281696593","https://openalex.org/W2344598639","https://openalex.org/W2401221324","https://openalex.org/W2525553968","https://openalex.org/W2626326218","https://openalex.org/W2790364541","https://openalex.org/W2830843390","https://openalex.org/W2836673225","https://openalex.org/W2883278308","https://openalex.org/W2908627286","https://openalex.org/W2915308412","https://openalex.org/W2922097899","https://openalex.org/W2945045272","https://openalex.org/W3001950911","https://openalex.org/W3004417314","https://openalex.org/W3015140168","https://openalex.org/W3037243268","https://openalex.org/W3040633579","https://openalex.org/W3042594979","https://openalex.org/W3111255098","https://openalex.org/W3112340407","https://openalex.org/W3113734454","https://openalex.org/W3127944141","https://openalex.org/W3170484712","https://openalex.org/W3172739738","https://openalex.org/W3188661591","https://openalex.org/W3188940990","https://openalex.org/W3212316750","https://openalex.org/W3215276910","https://openalex.org/W3217272213","https://openalex.org/W4200561001","https://openalex.org/W4210268003","https://openalex.org/W4212774448","https://openalex.org/W4214731502","https://openalex.org/W4220740991","https://openalex.org/W4241986789","https://openalex.org/W4281628101","https://openalex.org/W4283803576","https://openalex.org/W4285087306","https://openalex.org/W4309565456","https://openalex.org/W4315436084","https://openalex.org/W4317436849","https://openalex.org/W4318014975","https://openalex.org/W4320709457","https://openalex.org/W4388979260","https://openalex.org/W4389429870","https://openalex.org/W4391434671","https://openalex.org/W4391991048","https://openalex.org/W4391997052","https://openalex.org/W4392092523","https://openalex.org/W4392383230","https://openalex.org/W4392462199","https://openalex.org/W4392564463","https://openalex.org/W4392851800","https://openalex.org/W4394960825","https://openalex.org/W4400356321","https://openalex.org/W4400886839"],"related_works":["https://openalex.org/W2151247174","https://openalex.org/W2626433236","https://openalex.org/W2348803601","https://openalex.org/W2358630745","https://openalex.org/W2976637636","https://openalex.org/W2042120492","https://openalex.org/W4281555835","https://openalex.org/W4378175347","https://openalex.org/W4210998540","https://openalex.org/W1971352671"],"abstract_inverted_index":{"High":[0],"Resolution":[1],"Image":[2],"Download":[3],"MS":[4],"PowerPoint":[5],"Slide":[6],"Lipid":[7],"nanoparticles":[8,32,129,180],"(LNPs)":[9],"containing":[10],"ionizable":[11,62,93,210,298],"lipids":[12,299],"are":[13],"the":[14,26,38,47,53,64,67,116,124,175,217,230,246,254,268,279,286,292,302],"most":[15],"clinically":[16],"advanced":[17],"platform":[18],"for":[19,61,100,131,174,283],"mRNA":[20,77,132,179,183,265,305],"delivery,":[21,266],"but":[22],"their":[23],"application":[24],"beyond":[25],"liver":[27,241],"remains":[28,83],"challenging.":[29],"Polymer\u2013lipid":[30],"hybrid":[31],"offer":[33],"a":[34,90,110],"promising":[35],"alternative,":[36],"combining":[37],"synthetic":[39],"versatility":[40],"and":[41,80,109,114,149,162,181,188,200,232,264,267,300],"unique":[42],"properties":[43],"of":[44,49,55,66,92,118,126,136,144,177,220,248,257,271,281,294,304],"polymers":[45,282],"with":[46,74,152,222],"biocompatibility":[48],"lipid":[50,75,128,249],"excipients.":[51],"While":[52],"significance":[54],"alkyl":[56,154,168],"tail":[57],"design":[58,280],"is":[59,172],"well-recognized":[60],"lipids,":[63],"impact":[65],"polymer":[68,119,213],"side":[69,120,155,169,224],"chain":[70,121,156,170,214],"composition":[71,122,215],"on":[72,89,123],"interactions":[73],"excipients,":[76],"delivery":[78,184,196],"efficacy,":[79],"tissue":[81,218],"specificity":[82],"poorly":[84],"understood.":[85],"Here,":[86],"we":[87],"focus":[88],"class":[91],"amino-polyesters":[94],"(APEs)":[95],"that":[96,166],"exhibit":[97],"features":[98],"desired":[99],"potential":[101],"clinical":[102],"applications,":[103],"including":[104,158,208],"narrow":[105],"molecular":[106],"weight":[107],"distribution":[108],"good":[111],"safety":[112],"profile,":[113],"investigate":[115],"effect":[117],"formulation":[125],"APE":[127],"(APE-LNPs)":[130],"delivery.":[133,242],"A":[134],"library":[135],"36":[137],"APEs":[138],"was":[139],"synthesized":[140],"via":[141],"ring-opening":[142],"polymerization":[143],"chemically":[145],"diverse":[146],"tertiary":[147],"amino-alcohols":[148],"lactone":[150],"monomers":[151],"distinct":[153],"compositions,":[157],"variations":[159],"in":[160,186,189,198,201,251,260,285],"length":[161,171],"unsaturation.":[163],"We":[164,243],"show":[165,239],"optimal":[167],"critical":[173],"assembly":[176],"stable":[178],"efficient":[182],"both":[185],"vitro":[187,199],"vivo":[190],".":[191],"Top-performing":[192],"APE-LNPs":[193],"display":[194],"superior":[195],"efficacy":[197],"extrahepatic":[202],"tissues":[203],"compared":[204],"to":[205,297,308],"benchmark":[206],"LNPs,":[207],"DLin-MC3-DMA":[209],"lipid.":[211],"The":[212],"affects":[216],"selectivity":[219],"APE-LNPs,":[221,252],"shorter":[223],"chains":[225,236],"(4\u20135":[226],"carbons)":[227,238],"effectively":[228],"targeting":[229],"spleen":[231],"lungs,":[233],"while":[234],"longer":[235],"(7\u20139":[237],"enhanced":[240],"also":[244],"explored":[245],"relevance":[247,270],"excipients":[250],"demonstrating":[253],"essential":[255],"role":[256],"unsaturated":[258],"phospholipids":[259],"enhancing":[261],"cellular":[262],"uptake":[263],"limited":[269],"cholesterol.":[272],"These":[273],"findings":[274],"provide":[275],"valuable":[276],"insights":[277],"into":[278],"use":[284],"LNP":[287,306],"context,":[288],"which":[289],"could":[290],"aid":[291],"development":[293],"polymeric":[295],"alternatives":[296],"expand":[301],"utility":[303],"technology":[307],"nonliver":[309],"tissues.":[310]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":3}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-04-28T00:00:00"}