{"id":"https://openalex.org/W4409841968","doi":"https://doi.org/10.5114/aoms/202218","title":"Metabolic Mediators Linking Type 1 Diabetes Mellitus to Osteoporosis","display_name":"Metabolic Mediators Linking Type 1 Diabetes Mellitus to Osteoporosis","publication_year":2025,"publication_date":"2025-04-26","ids":{"openalex":"https://openalex.org/W4409841968","doi":"https://doi.org/10.5114/aoms/202218","pmid":"https://pubmed.ncbi.nlm.nih.gov/42110599","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13154756"},"language":"en","primary_location":{"id":"doi:10.5114/aoms/202218","doi":"https://doi.org/10.5114/aoms/202218","is_oa":true,"landing_page_url":"https://doi.org/10.5114/aoms/202218","pdf_url":"https://www.archivesofmedicalscience.com/pdf-202218-124754?filename=Metabolic Mediators.pdf","source":{"id":"https://openalex.org/S30890154","display_name":"Archives of Medical Science","issn_l":"1734-1922","issn":["1734-1922","1896-9151"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320332","host_organization_name":"Termedia Publishing House","host_organization_lineage":["https://openalex.org/P4310320332"],"host_organization_lineage_names":["Termedia Publishing House"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Medical Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.archivesofmedicalscience.com/pdf-202218-124754?filename=Metabolic Mediators.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042526258","display_name":"Yuxin Chu","orcid":"https://orcid.org/0000-0001-5526-997X","observed_orcids":["https://orcid.org/0000-0001-5526-997X"]},"institutions":[{"id":"https://openalex.org/I4210140357","display_name":"Renmin Hospital of Wuhan University","ror":"https://ror.org/03ekhbz91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140357"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuxin Chu","raw_affiliation_strings":["Wuhan Renmin Hospital, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wuhan Renmin Hospital, China","institution_ids":["https://openalex.org/I4210140357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051576855","display_name":"Jinjin Zhu","orcid":"https://orcid.org/0000-0002-1546-652X","observed_orcids":["https://orcid.org/0000-0002-1546-652X"]},"institutions":[{"id":"https://openalex.org/I4210129222","display_name":"Wuhan Union Hospital","ror":"https://ror.org/0371fqr87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129222"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinjin Zhu","raw_affiliation_strings":["Wuhan Union Hospital, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wuhan Union Hospital, China","institution_ids":["https://openalex.org/I4210129222"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077108182","display_name":"Zheming Liu","orcid":"https://orcid.org/0000-0001-5610-6558","observed_orcids":["https://orcid.org/0000-0001-5610-6558"]},"institutions":[{"id":"https://openalex.org/I4210140357","display_name":"Renmin Hospital of Wuhan University","ror":"https://ror.org/03ekhbz91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140357"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zheming Liu","raw_affiliation_strings":["Wuhan Renmin Hospital, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wuhan Renmin Hospital, China","institution_ids":["https://openalex.org/I4210140357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027533301","display_name":"Fuben Liao","orcid":"https://orcid.org/0009-0001-5329-1628","observed_orcids":["https://orcid.org/0009-0001-5329-1628"]},"institutions":[{"id":"https://openalex.org/I4210140357","display_name":"Renmin Hospital of Wuhan University","ror":"https://ror.org/03ekhbz91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140357"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fuben Liao","raw_affiliation_strings":["Wuhan Renmin Hospital, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wuhan Renmin Hospital, China","institution_ids":["https://openalex.org/I4210140357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111184337","display_name":"Yi Yao","orcid":"https://orcid.org/0009-0006-5491-4096","observed_orcids":["https://orcid.org/0009-0006-5491-4096","https://orcid.org/0000-0003-3110-1720"]},"institutions":[{"id":"https://openalex.org/I4210140357","display_name":"Renmin Hospital of Wuhan University","ror":"https://ror.org/03ekhbz91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140357"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi Yao","raw_affiliation_strings":["Wuhan Renmin Hospital, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wuhan Renmin Hospital, China","institution_ids":["https://openalex.org/I4210140357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065433678","display_name":"Wei Wu","orcid":"https://orcid.org/0000-0002-1592-4332","observed_orcids":["https://orcid.org/0000-0002-1592-4332"]},"institutions":[{"id":"https://openalex.org/I4210160344","display_name":"Tongji Hospital","ror":"https://ror.org/04xy45965","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160344"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Wu","raw_affiliation_strings":["Tongji Hospital, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tongji Hospital, China","institution_ids":["https://openalex.org/I4210160344"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101622819","display_name":"Kehan Song","orcid":"https://orcid.org/0000-0003-3587-1511","observed_orcids":["https://orcid.org/0000-0003-3587-1511"]},"institutions":[{"id":"https://openalex.org/I4210160344","display_name":"Tongji Hospital","ror":"https://ror.org/04xy45965","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160344"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Kehan Song","raw_affiliation_strings":["Tongji Hospital, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tongji Hospital, China","institution_ids":["https://openalex.org/I4210160344"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5101622819"],"corresponding_institution_ids":["https://openalex.org/I4210160344"],"apc_list":{"value":1000,"currency":"EUR","value_usd":1078},"apc_paid":{"value":1000,"currency":"EUR","value_usd":1078},"fwci":0.7371,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.62322977,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"22","issue":"1","first_page":"316","last_page":"324"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":1.0},{"id":"https://openalex.org/keywords/osteoporosis","display_name":"osteoporosis","score":1.0},{"id":"https://openalex.org/keywords/causal-mediation-analysis","display_name":"causal mediation analysis","score":0.718999981880188},{"id":"https://openalex.org/keywords/sex-hormone-binding-globulin","display_name":"sex hormone-binding globulin","score":0.9850000143051147},{"id":"https://openalex.org/keywords/saturated-fatty-acids","display_name":"saturated fatty acids","score":0.996999979019165},{"id":"https://openalex.org/keywords/body-mass-index","display_name":"body mass index","score":0.8930000066757202},{"id":"https://openalex.org/keywords/hba1c","display_name":"HbA1c","score":0.996999979019165},{"id":"https://openalex.org/keywords/bone-health","display_name":"bone health","score":0.8690000176429749},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.5529999732971191}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9819837212562561},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.6575748920440674},{"id":"https://openalex.org/C2910068830","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 Diabetes Mellitus","level":3,"score":0.611829400062561},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.6011170744895935},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.45334339141845703},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.43976661562919617},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3659270107746124},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.33081692457199097},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.5114/aoms/202218","doi":"https://doi.org/10.5114/aoms/202218","is_oa":true,"landing_page_url":"https://doi.org/10.5114/aoms/202218","pdf_url":"https://www.archivesofmedicalscience.com/pdf-202218-124754?filename=Metabolic Mediators.pdf","source":{"id":"https://openalex.org/S30890154","display_name":"Archives of Medical Science","issn_l":"1734-1922","issn":["1734-1922","1896-9151"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320332","host_organization_name":"Termedia Publishing House","host_organization_lineage":["https://openalex.org/P4310320332"],"host_organization_lineage_names":["Termedia Publishing House"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Medical Science","raw_type":"journal-article"},{"id":"pmid:42110599","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42110599","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of medical science : AMS","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13154756","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13154756/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arch Med Sci","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:9ef9e6d4749e497ea3304b4833ed79f6","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/9ef9e6d4749e497ea3304b4833ed79f6","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Archives of Medical Science, Vol 22, Iss 1, Pp 316-324 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.5114/aoms/202218","doi":"https://doi.org/10.5114/aoms/202218","is_oa":true,"landing_page_url":"https://doi.org/10.5114/aoms/202218","pdf_url":"https://www.archivesofmedicalscience.com/pdf-202218-124754?filename=Metabolic Mediators.pdf","source":{"id":"https://openalex.org/S30890154","display_name":"Archives of Medical Science","issn_l":"1734-1922","issn":["1734-1922","1896-9151"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320332","host_organization_name":"Termedia Publishing House","host_organization_lineage":["https://openalex.org/P4310320332"],"host_organization_lineage_names":["Termedia Publishing House"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Medical Science","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G425649609","display_name":null,"funder_award_id":"2021KFY064","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4409841968.pdf","grobid_xml":"https://content.openalex.org/works/W4409841968.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4396724728","https://openalex.org/W4394962600","https://openalex.org/W4362523648","https://openalex.org/W4401001190","https://openalex.org/W4395041906","https://openalex.org/W4379197678","https://openalex.org/W4408834868","https://openalex.org/W2072223506","https://openalex.org/W4409512519","https://openalex.org/W2588939544"],"abstract_inverted_index":{"Introduction:":[0],"The":[1,219],"causal":[2,27,44,65],"relationship":[3,45],"between":[4,29,46],"type":[5],"1":[6],"diabetes":[7],"mellitus":[8],"(T1DM)":[9],"and":[10,31,33,39,48,81,104,109,122,149,151,170,189,213,230],"osteoporosis":[11,49,125,209,233],"has":[12],"not":[13,176],"been":[14],"clarified":[15],"in":[16,79,93,126,217,234],"large":[17],"prospective":[18,131],"cohort":[19,132,199],"studies.":[20],"This":[21],"study":[22],"aimed":[23],"to":[24,76],"assess":[25],"the":[26,43,118,197],"association":[28],"T1DM":[30,47,80,121,140,206,235],"osteoporosis,":[32],"further":[34],"identify":[35],"eligible":[36,111,194],"mediators.":[37,195],"Material":[38],"methods:":[40],"We":[41,67,116],"explored":[42],"by":[50,113,210],"two-sample":[51],"Mendelian":[52],"randomization":[53],"(MR),":[54],"a":[55,127],"method":[56],"that":[57],"uses":[58],"genetic":[59],"variants":[60],"as":[61,193,224],"instrumental":[62],"variables":[63],"for":[64,227],"inference.":[66],"selected":[68],"five":[69],"candidate":[70],"mediators":[71,112,123,221],"based":[72],"on":[73,161],"their":[74],"relevance":[75],"metabolic":[77],"processes":[78],"bone":[82],"health,":[83],"including":[84],"body":[85],"mass":[86],"index":[87],"(BMI),":[88],"glycated":[89],"hemoglobin":[90],"(HbA1c),":[91],"cholesterol":[92],"medium":[94],"very":[95],"low-density":[96],"lipoprotein":[97],"particles":[98],"(M-VLDL-C),":[99],"saturated":[100],"fatty":[101],"acids":[102],"(SFA),":[103],"sex":[105],"hormone-binding":[106],"globulin":[107],"(SHBG),":[108],"identified":[110,192,220],"two-step":[114,138],"MR.":[115],"validated":[117],"correlation":[119],"of":[120,147,154,168,173,185,232],"with":[124,144,181],"UK":[128],"Biobank":[129],"(UKB)":[130],"study.":[133],"Results:":[134],"=":[135],"0.004).":[136],"In":[137,196],"MR,":[139],"was":[141],"significantly":[142,179],"associated":[143,180],"decreased":[145],"levels":[146,153,167,172,216],"M-VLDL-C":[148,169,188,212],"SFA":[150],"increased":[152],"SHBG,":[155,174],"but":[156,175],"showed":[157],"no":[158],"significant":[159],"effect":[160],"BMI":[162],"or":[163],"HbA1c.":[164],"Furthermore,":[165],"lower":[166],"higher":[171],"SFA,":[177],"were":[178,191,203],"an":[182],"elevated":[183],"risk":[184],"osteoporosis.":[186],"Hence":[187],"SHBG":[190,215],"UKB":[198],"study,":[200],"consistent":[201],"results":[202],"found.":[204],"Conclusions:":[205],"may":[207,222],"cause":[208],"reducing":[211],"increasing":[214],"plasma.":[218],"serve":[223],"important":[225],"biomarkers":[226],"early":[228],"detection":[229],"treatment":[231],"patients.":[236]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2025-04-27T00:00:00"}
