{"id":"https://openalex.org/W4409824596","doi":"https://doi.org/10.1038/s41598-026-46173-x","title":"Effects of NAD\u207a repletion with Nicotinamide riboside on obesity-induced chronic kidney disease and renal cell lipotoxicity","display_name":"Effects of NAD\u207a repletion with Nicotinamide riboside on obesity-induced chronic kidney disease and renal cell lipotoxicity","publication_year":2026,"publication_date":"2026-04-09","ids":{"openalex":"https://openalex.org/W4409824596","doi":"https://doi.org/10.1038/s41598-026-46173-x","pmid":"https://pubmed.ncbi.nlm.nih.gov/41957052","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13222884"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-026-46173-x","doi":"https://doi.org/10.1038/s41598-026-46173-x","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-46173-x","pdf_url":"https://www.nature.com/articles/s41598-026-46173-x_reference.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-026-46173-x_reference.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088186930","display_name":"Morgane Decarnoncle","orcid":"https://orcid.org/0000-0003-3259-4109","observed_orcids":["https://orcid.org/0000-0003-3259-4109"]},"institutions":[{"id":"https://openalex.org/I130929987","display_name":"University of Mons","ror":"https://ror.org/02qnnz951","country_code":"BE","type":"education","lineage":["https://openalex.org/I130929987"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Morgane Decarnoncle","raw_affiliation_strings":["Laboratory of Metabolic and Molecular Biochemistry, Faculty of Medicine, Pharmacy and Biomedical Sciences (FMPB), Research Institute for Health Sciences and Technology, University of Mons (UMONS), Avenue du Champ de Mars, 6, 7000, Mons, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Metabolic and Molecular Biochemistry, Faculty of Medicine, Pharmacy and Biomedical Sciences (FMPB), Research Institute for Health Sciences and Technology, University of Mons (UMONS), Avenue du Champ de Mars, 6, 7000, Mons, Belgium","institution_ids":["https://openalex.org/I130929987"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054053861","display_name":"Louise Pierre","orcid":"https://orcid.org/0009-0007-3332-1432","observed_orcids":["https://orcid.org/0009-0007-3332-1432"]},"institutions":[{"id":"https://openalex.org/I130929987","display_name":"University of Mons","ror":"https://ror.org/02qnnz951","country_code":"BE","type":"education","lineage":["https://openalex.org/I130929987"]},{"id":"https://openalex.org/I149768937","display_name":"University of Namur","ror":"https://ror.org/03d1maw17","country_code":"BE","type":"education","lineage":["https://openalex.org/I149768937"]},{"id":"https://openalex.org/I4391767857","display_name":"Namur Research Institute for Life Sciences","ror":"https://ror.org/038bmak92","country_code":"BE","type":"facility","lineage":["https://openalex.org/I149768937","https://openalex.org/I4391767857"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Louise Pierre","raw_affiliation_strings":["Biochemistry and Cellular Biology Research Unit (URBC), Namur Research Institute for Life Sciences (NARILIS), University of Namur (UNamur), 5000, Namur, Belgium","Laboratory of Metabolic and Molecular Biochemistry, Faculty of Medicine, Pharmacy and Biomedical Sciences (FMPB), Research Institute for Health Sciences and Technology, University of Mons (UMONS), Avenue du Champ de Mars, 6, 7000, Mons, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry and Cellular Biology Research Unit (URBC), Namur Research Institute for Life Sciences (NARILIS), University of Namur (UNamur), 5000, Namur, Belgium","institution_ids":["https://openalex.org/I149768937","https://openalex.org/I4391767857"]},{"raw_affiliation_string":"Laboratory of Metabolic and Molecular Biochemistry, Faculty of Medicine, Pharmacy and Biomedical Sciences (FMPB), Research Institute for Health Sciences and Technology, University of Mons (UMONS), Avenue du Champ de Mars, 6, 7000, Mons, Belgium","institution_ids":["https://openalex.org/I130929987"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Marine Thirion","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130929987","display_name":"University of Mons","ror":"https://ror.org/02qnnz951","country_code":"BE","type":"education","lineage":["https://openalex.org/I130929987"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Marine Thirion","raw_affiliation_strings":["Laboratory of Metabolic and Molecular Biochemistry, Faculty of Medicine, Pharmacy and Biomedical Sciences (FMPB), Research Institute for Health Sciences and Technology, University of Mons (UMONS), Avenue du Champ de Mars, 6, 7000, Mons, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Metabolic and Molecular Biochemistry, Faculty of Medicine, Pharmacy and Biomedical Sciences (FMPB), Research Institute for Health Sciences and Technology, University of Mons (UMONS), Avenue du Champ de Mars, 6, 7000, Mons, Belgium","institution_ids":["https://openalex.org/I130929987"]}]},{"author_position":"middle","author":{"id":null,"display_name":"H\u00e9l\u00e8ne Marlier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130929987","display_name":"University of Mons","ror":"https://ror.org/02qnnz951","country_code":"BE","type":"education","lineage":["https://openalex.org/I130929987"]},{"id":"https://openalex.org/I149768937","display_name":"University of Namur","ror":"https://ror.org/03d1maw17","country_code":"BE","type":"education","lineage":["https://openalex.org/I149768937"]},{"id":"https://openalex.org/I4391767857","display_name":"Namur Research Institute for Life Sciences","ror":"https://ror.org/038bmak92","country_code":"BE","type":"facility","lineage":["https://openalex.org/I149768937","https://openalex.org/I4391767857"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"H\u00e9l\u00e8ne Marlier","raw_affiliation_strings":["Biochemistry and Cellular Biology Research Unit (URBC), Namur Research Institute for Life Sciences (NARILIS), University of Namur (UNamur), 5000, Namur, Belgium","Laboratory of Metabolic and Molecular Biochemistry, Faculty of Medicine, Pharmacy and Biomedical Sciences (FMPB), Research Institute for Health Sciences and Technology, University of Mons (UMONS), Avenue du Champ de Mars, 6, 7000, Mons, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry and Cellular Biology Research Unit (URBC), Namur Research Institute for Life Sciences (NARILIS), University of Namur (UNamur), 5000, Namur, Belgium","institution_ids":["https://openalex.org/I149768937","https://openalex.org/I4391767857"]},{"raw_affiliation_string":"Laboratory of Metabolic and Molecular Biochemistry, Faculty of Medicine, Pharmacy and Biomedical Sciences (FMPB), Research Institute for Health Sciences and Technology, University of Mons (UMONS), Avenue du Champ de Mars, 6, 7000, Mons, Belgium","institution_ids":["https://openalex.org/I130929987"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Louis Mar\u00e9chal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130929987","display_name":"University of Mons","ror":"https://ror.org/02qnnz951","country_code":"BE","type":"education","lineage":["https://openalex.org/I130929987"]},{"id":"https://openalex.org/I149768937","display_name":"University of Namur","ror":"https://ror.org/03d1maw17","country_code":"BE","type":"education","lineage":["https://openalex.org/I149768937"]},{"id":"https://openalex.org/I4391767857","display_name":"Namur Research Institute for Life Sciences","ror":"https://ror.org/038bmak92","country_code":"BE","type":"facility","lineage":["https://openalex.org/I149768937","https://openalex.org/I4391767857"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Louis Mar\u00e9chal","raw_affiliation_strings":["Biochemistry and Cellular Biology Research Unit (URBC), Namur Research Institute for Life Sciences (NARILIS), University of Namur (UNamur), 5000, Namur, Belgium","Laboratory of Metabolic and Molecular Biochemistry, Faculty of Medicine, Pharmacy and Biomedical Sciences (FMPB), Research Institute for Health Sciences and Technology, University of Mons (UMONS), Avenue du Champ de Mars, 6, 7000, Mons, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry and Cellular Biology Research Unit (URBC), Namur Research Institute for Life Sciences (NARILIS), University of Namur (UNamur), 5000, Namur, Belgium","institution_ids":["https://openalex.org/I149768937","https://openalex.org/I4391767857"]},{"raw_affiliation_string":"Laboratory of Metabolic and Molecular Biochemistry, Faculty of Medicine, Pharmacy and Biomedical Sciences (FMPB), Research Institute for Health Sciences and Technology, University of Mons (UMONS), Avenue du Champ de Mars, 6, 7000, Mons, Belgium","institution_ids":["https://openalex.org/I130929987"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Pauline Rouz\u00e9","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130929987","display_name":"University of Mons","ror":"https://ror.org/02qnnz951","country_code":"BE","type":"education","lineage":["https://openalex.org/I130929987"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Pauline Rouz\u00e9","raw_affiliation_strings":["Laboratory of Metabolic and Molecular Biochemistry, Faculty of Medicine, Pharmacy and Biomedical Sciences (FMPB), Research Institute for Health Sciences and Technology, University of Mons (UMONS), Avenue du Champ de Mars, 6, 7000, Mons, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Metabolic and Molecular Biochemistry, Faculty of Medicine, Pharmacy and Biomedical Sciences (FMPB), Research Institute for Health Sciences and Technology, University of Mons (UMONS), Avenue du Champ de Mars, 6, 7000, Mons, Belgium","institution_ids":["https://openalex.org/I130929987"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059623910","display_name":"In\u00e8s Jadot","orcid":"https://orcid.org/0000-0002-4090-8385","observed_orcids":["https://orcid.org/0000-0002-4090-8385"]},"institutions":[{"id":"https://openalex.org/I149768937","display_name":"University of Namur","ror":"https://ror.org/03d1maw17","country_code":"BE","type":"education","lineage":["https://openalex.org/I149768937"]},{"id":"https://openalex.org/I4391767857","display_name":"Namur Research Institute for Life Sciences","ror":"https://ror.org/038bmak92","country_code":"BE","type":"facility","lineage":["https://openalex.org/I149768937","https://openalex.org/I4391767857"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"In\u00e8s Jadot","raw_affiliation_strings":["Molecular Physiology Research Unit (URPhyM), Namur Research Institute for Life Sciences (NARILIS), University of Namur (UNamur), 5000, Namur, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Physiology Research Unit (URPhyM), Namur Research Institute for Life Sciences (NARILIS), University of Namur (UNamur), 5000, Namur, Belgium","institution_ids":["https://openalex.org/I149768937","https://openalex.org/I4391767857"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Thierry Arnould","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149768937","display_name":"University of Namur","ror":"https://ror.org/03d1maw17","country_code":"BE","type":"education","lineage":["https://openalex.org/I149768937"]},{"id":"https://openalex.org/I4391767857","display_name":"Namur Research Institute for Life Sciences","ror":"https://ror.org/038bmak92","country_code":"BE","type":"facility","lineage":["https://openalex.org/I149768937","https://openalex.org/I4391767857"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Thierry Arnould","raw_affiliation_strings":["Biochemistry and Cellular Biology Research Unit (URBC), Namur Research Institute for Life Sciences (NARILIS), University of Namur (UNamur), 5000, Namur, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry and Cellular Biology Research Unit (URBC), Namur Research Institute for Life Sciences (NARILIS), University of Namur (UNamur), 5000, Namur, Belgium","institution_ids":["https://openalex.org/I149768937","https://openalex.org/I4391767857"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037941279","display_name":"Anne\u2010\u00c9milie Decl\u00e8ves","orcid":"https://orcid.org/0000-0002-0838-2432","observed_orcids":["https://orcid.org/0000-0002-0838-2432"]},"institutions":[{"id":"https://openalex.org/I130929987","display_name":"University of Mons","ror":"https://ror.org/02qnnz951","country_code":"BE","type":"education","lineage":["https://openalex.org/I130929987"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Anne-Emilie Decl\u00e8ves","raw_affiliation_strings":["Laboratory of Metabolic and Molecular Biochemistry, Faculty of Medicine, Pharmacy and Biomedical Sciences (FMPB), Research Institute for Health Sciences and Technology, University of Mons (UMONS), Avenue du Champ de Mars, 6, 7000, Mons, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Metabolic and Molecular Biochemistry, Faculty of Medicine, Pharmacy and Biomedical Sciences (FMPB), Research Institute for Health Sciences and Technology, University of Mons (UMONS), Avenue du Champ de Mars, 6, 7000, Mons, Belgium","institution_ids":["https://openalex.org/I130929987"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040274263","display_name":"Florian Juszczak","orcid":"https://orcid.org/0000-0001-8526-0204","observed_orcids":["https://orcid.org/0000-0001-8526-0204"]},"institutions":[{"id":"https://openalex.org/I130929987","display_name":"University of Mons","ror":"https://ror.org/02qnnz951","country_code":"BE","type":"education","lineage":["https://openalex.org/I130929987"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"Florian Juszczak","raw_affiliation_strings":["Laboratory of Metabolic and Molecular Biochemistry, Faculty of Medicine, Pharmacy and Biomedical Sciences (FMPB), Research Institute for Health Sciences and Technology, University of Mons (UMONS), Avenue du Champ de Mars, 6, 7000, Mons, Belgium. Florian.juszczak@umons.ac.be"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Metabolic and Molecular Biochemistry, Faculty of Medicine, Pharmacy and Biomedical Sciences (FMPB), Research Institute for Health Sciences and Technology, University of Mons (UMONS), Avenue du Champ de Mars, 6, 7000, Mons, Belgium. Florian.juszczak@umons.ac.be","institution_ids":["https://openalex.org/I130929987"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5040274263"],"corresponding_institution_ids":["https://openalex.org/I130929987"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":3.4231,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.84003434,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":92,"max":95},"biblio":{"volume":"16","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nicotinamide-riboside","display_name":"nicotinamide riboside","score":1.0},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.7540000081062317},{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.9760000109672546},{"id":"https://openalex.org/keywords/palmitic-acid","display_name":"palmitic acid","score":0.890999972820282},{"id":"https://openalex.org/keywords/sirt3","display_name":"SIRT3","score":0.8270000219345093},{"id":"https://openalex.org/keywords/mitochondrial-function","display_name":"mitochondrial function","score":0.5690000057220459},{"id":"https://openalex.org/keywords/mitophagy","display_name":"mitophagy","score":0.9639999866485596},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9190000295639038},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.9599999785423279},{"id":"https://openalex.org/keywords/proximal-tubular-epithelial-cells","display_name":"proximal tubular epithelial cells","score":0.9269999861717224},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.7379999756813049},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.8429999947547913}],"concepts":[{"id":"https://openalex.org/C44353895","wikidata":"https://www.wikidata.org/wiki/Q6556772","display_name":"Lipotoxicity","level":4,"score":0.8963403701782227},{"id":"https://openalex.org/C75520062","wikidata":"https://www.wikidata.org/wiki/Q15321392","display_name":"NAD+ kinase","level":3,"score":0.7700320482254028},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.5809476375579834},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.535876989364624},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4816776216030121},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.47607937455177307},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.44485539197921753},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.44135767221450806},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.380222350358963},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37978827953338623},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3246089220046997},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20426872372627258},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.1530686914920807},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.07515013217926025}],"mesh":[{"descriptor_ui":"D000099156","descriptor_name":"Superoxide Dismutase 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009243","descriptor_name":"NAD","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009536","descriptor_name":"Niacinamide","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D009536","descriptor_name":"Niacinamide","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D009536","descriptor_name":"Niacinamide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011726","descriptor_name":"Pyridinium Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013482","descriptor_name":"Superoxide Dismutase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019308","descriptor_name":"Palmitic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051436","descriptor_name":"Renal Insufficiency, Chronic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D051436","descriptor_name":"Renal Insufficiency, Chronic","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D051436","descriptor_name":"Renal Insufficiency, Chronic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051436","descriptor_name":"Renal Insufficiency, Chronic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D056566","descriptor_name":"Sirtuin 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D059305","descriptor_name":"Diet, High-Fat","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1038/s41598-026-46173-x","doi":"https://doi.org/10.1038/s41598-026-46173-x","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-46173-x","pdf_url":"https://www.nature.com/articles/s41598-026-46173-x_reference.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"doi:10.1101/2025.04.22.649334","doi":"https://doi.org/10.1101/2025.04.22.649334","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.04.22.649334","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2025/04/24/2025.04.22.649334.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:41957052","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41957052","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13222884","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13222884/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmh:oai:orbi.umons.ac.be:20.500.12907/56255","doi":null,"is_oa":true,"landing_page_url":"https://orbi.umons.ac.be/handle/20.500.12907/56255","pdf_url":null,"source":{"id":"https://openalex.org/S7407055454","display_name":"ORBi UMONS","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Scientific Reports, 16 (1) (2026-04-09)","raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"pmh:oai:orbi.umons.ac.be:20.500.12907/55848","doi":null,"is_oa":true,"landing_page_url":"https://orbi.umons.ac.be/handle/20.500.12907/55848","pdf_url":"https://orbi.umons.ac.be/bitstream/20.500.12907/55848/1/2025.04.22.649334v1.full.pdf","source":{"id":"https://openalex.org/S7407055454","display_name":"ORBi UMONS","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports (in press)","raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"pmh:oai:doaj.org/article:fc95bf2c94e14475a85e408773f1bf78","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/fc95bf2c94e14475a85e408773f1bf78","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 16, Iss 1 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41598-026-46173-x","doi":"https://doi.org/10.1038/s41598-026-46173-x","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-46173-x","pdf_url":"https://www.nature.com/articles/s41598-026-46173-x_reference.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321390","display_name":"Fonds De La Recherche Scientifique - FNRS","ror":"https://ror.org/03q83t159"},{"id":"https://openalex.org/F4320325519","display_name":"Soci\u00e9t\u00e9 Francophone du Diab\u00e8te","ror":"https://ror.org/05gdhxj91"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4409824596.pdf","grobid_xml":"https://content.openalex.org/works/W4409824596.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W2007923680","https://openalex.org/W2035075611","https://openalex.org/W2069798035","https://openalex.org/W2082393205","https://openalex.org/W2130492862","https://openalex.org/W2135985828","https://openalex.org/W2153459372","https://openalex.org/W2157296254","https://openalex.org/W2168486424","https://openalex.org/W2298455799","https://openalex.org/W2311898277","https://openalex.org/W2323596853","https://openalex.org/W2341462106","https://openalex.org/W2415080161","https://openalex.org/W2512845699","https://openalex.org/W2530388030","https://openalex.org/W2530753724","https://openalex.org/W2560569403","https://openalex.org/W2587125180","https://openalex.org/W2588342194","https://openalex.org/W2592892973","https://openalex.org/W2750514629","https://openalex.org/W2775008495","https://openalex.org/W2788432017","https://openalex.org/W2788894248","https://openalex.org/W2805234895","https://openalex.org/W2887579551","https://openalex.org/W2922171607","https://openalex.org/W2949358699","https://openalex.org/W2979702122","https://openalex.org/W2980676121","https://openalex.org/W2990517669","https://openalex.org/W2998881619","https://openalex.org/W3022457072","https://openalex.org/W3034018227","https://openalex.org/W3038492183","https://openalex.org/W3116978215","https://openalex.org/W3137082340","https://openalex.org/W3187627352","https://openalex.org/W3212857357","https://openalex.org/W4200597370","https://openalex.org/W4211047194","https://openalex.org/W4281732677","https://openalex.org/W4312043163","https://openalex.org/W4313505504","https://openalex.org/W4319341071","https://openalex.org/W4324129407","https://openalex.org/W4385336685","https://openalex.org/W4387140147","https://openalex.org/W4398174531","https://openalex.org/W4400093043","https://openalex.org/W4403500405","https://openalex.org/W4405409171"],"related_works":["https://openalex.org/W4408264243","https://openalex.org/W4411880480","https://openalex.org/W4281732677","https://openalex.org/W4283452908","https://openalex.org/W4383619109","https://openalex.org/W3118270778","https://openalex.org/W4282841227","https://openalex.org/W3165730824","https://openalex.org/W3028716101","https://openalex.org/W3016629372"],"abstract_inverted_index":{"Nicotinamide":[0],"riboside":[1],"(NR),":[2],"a":[3,148],"natural":[4],"precursor":[5],"of":[6,31,42,47,56,114,120,145,180,187],"NAD\u207a,":[7],"has":[8],"been":[9],"suggested":[10],"to":[11,161],"confer":[12],"protection":[13],"against":[14],"metabolic":[15,52,233],"and":[16,53,59,92,102,128,195,217,235],"age-related":[17],"disorders.":[18],"However,":[19,198],"its":[20,153],"effect":[21],"on":[22,155],"chronic":[23],"kidney":[24],"disease":[25],"(CKD),":[26],"particularly":[27],"in":[28,45,65,116,147,170,221,224],"the":[29,39,117,138,142,178,185],"context":[30],"obesity,":[32],"remains":[33],"poorly":[34],"understood.":[35],"Here,":[36],"we":[37,151],"evaluated":[38],"potential":[40],"effects":[41,55,144,216],"NR":[43,61,79,106,146,165,191,199,213],"supplementation":[44,62,107],"models":[46],"obesity-induced":[48],"renal":[49,54,103,118,126,143,156,222],"injury.":[50],"The":[51],"both":[57],"preventive":[58,82],"interventional":[60],"were":[63],"assessed":[64],"mice":[66,231],"fed":[67],"high-fat":[68],"or":[69,83,89,100],"low-fat":[70],"diets.":[71],"Our":[72],"data":[73],"showed":[74],"that":[75,212],"NAD\u207a":[76],"repletion":[77],"by":[78,177],"supplementation,":[80],"whether":[81],"interventional,":[84],"did":[85,93,200],"not":[86,94,201,228],"affect":[87],"body":[88],"organ":[90],"weights,":[91],"ameliorate":[95],"glucose":[96],"metabolism,":[97],"insulin":[98],"resistance,":[99],"hepatic":[101],"lipid":[104,188,204],"accumulation.":[105,205],"was":[108,129],"however":[109],"associated":[110,130,236],"with":[111,131],"SIRT3-mediated":[112],"deacetylation":[113],"SOD2":[115,181],"tissue":[119],"obese":[121,230],"mice.":[122],"It":[123],"moderately":[124],"reduced":[125],"dysfunction":[127],"increased":[132],"mitochondrial":[133,193,219],"content.":[134],"To":[135],"further":[136],"explore":[137],"cellular":[139],"mechanisms":[140],"underlying":[141],"lipotoxic":[149],"context,":[150],"investigated":[152],"impact":[154],"proximal":[157,171],"tubular":[158,172],"cells":[159,223],"exposed":[160],"palmitic":[162],"acid":[163],"(PA).":[164],"significantly":[166],"prevented":[167],"oxidative":[168],"stress":[169],"epithelial":[173],"cells,":[174],"as":[175,182,184],"evidenced":[176],"activation":[179],"well":[183],"reduction":[186],"peroxidation.":[189],"Moreover,":[190],"improved":[192],"damage":[194],"promoted":[196],"mitophagy.":[197],"reduce":[202],"PA-induced":[203],"In":[206],"conclusion,":[207],"this":[208],"study":[209],"provides":[210],"evidence":[211],"exerts":[214],"antioxidant":[215],"enhances":[218],"function":[220],"vitro":[225],"but":[226],"does":[227],"protect":[229],"from":[232],"disorders":[234],"CKD.":[237]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-04-26T00:00:00"}
