{"id":"https://openalex.org/W4409769843","doi":"https://doi.org/10.1039/d5bm00357a","title":"Osteoimmunomodulation by bone implant materials: harnessing physicochemical properties and chemical composition","display_name":"Osteoimmunomodulation by bone implant materials: harnessing physicochemical properties and chemical composition","publication_year":2025,"publication_date":"2025-01-01","ids":{"openalex":"https://openalex.org/W4409769843","doi":"https://doi.org/10.1039/d5bm00357a","pmid":"https://pubmed.ncbi.nlm.nih.gov/40289736"},"language":"en","primary_location":{"id":"doi:10.1039/d5bm00357a","doi":"https://doi.org/10.1039/d5bm00357a","is_oa":true,"landing_page_url":"https://doi.org/10.1039/d5bm00357a","pdf_url":"https://pubs.rsc.org/en/content/articlepdf/2025/bm/d5bm00357a","source":{"id":"https://openalex.org/S2494179437","display_name":"Biomaterials Science","issn_l":"2047-4830","issn":["2047-4830","2047-4849"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomaterials Science","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://pubs.rsc.org/en/content/articlepdf/2025/bm/d5bm00357a","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052424595","display_name":"Mehdi Sanati","orcid":"https://orcid.org/0000-0003-3864-0620","observed_orcids":["https://orcid.org/0000-0003-3864-0620"]},"institutions":[{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Mehdi Sanati","raw_affiliation_strings":["Department of Orthopedics, University Medical Center Utrecht, Utrecht, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0003-3864-0620","affiliations":[{"raw_affiliation_string":"Department of Orthopedics, University Medical Center Utrecht, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I3018483916"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007610031","display_name":"Ines Pieterman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Ines Pieterman","raw_affiliation_strings":["Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I193662353"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Natacha Levy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]},{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Natacha Levy","raw_affiliation_strings":["Metabolic Diseases Pediatrics Division, University Medical Centre Utrecht, Utrecht, The Netherlands","Regenerative Medicine Centre Utrecht, Utrecht University, Utrecht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Metabolic Diseases Pediatrics Division, University Medical Centre Utrecht, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I3018483916"]},{"raw_affiliation_string":"Regenerative Medicine Centre Utrecht, Utrecht University, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I193662353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012206338","display_name":"Tayebeh Akbari","orcid":"https://orcid.org/0000-0001-9338-1049","observed_orcids":["https://orcid.org/0000-0001-9338-1049"]},"institutions":[{"id":"https://openalex.org/I183067279","display_name":"Islamic Azad University North Tehran Branch","ror":"https://ror.org/00sb1nr29","country_code":"IR","type":"education","lineage":["https://openalex.org/I110525433","https://openalex.org/I183067279"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Tayebeh Akbari","raw_affiliation_strings":["Department of Microbiology, Islamic Azad University, North Tehran Branch, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Islamic Azad University, North Tehran Branch, Tehran, Iran","institution_ids":["https://openalex.org/I183067279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030843287","display_name":"Mohamadreza Tavakoli","orcid":"https://orcid.org/0000-0002-5739-1909","observed_orcids":["https://orcid.org/0000-0002-5739-1909"]},"institutions":[{"id":"https://openalex.org/I70640408","display_name":"Tehran University of Medical Sciences","ror":"https://ror.org/01c4pz451","country_code":"IR","type":"education","lineage":["https://openalex.org/I70640408"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Mohamadreza Tavakoli","raw_affiliation_strings":["Department of Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I70640408"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007244623","display_name":"Alireza Hassani Najafabadi","orcid":"https://orcid.org/0000-0002-8215-4374","observed_orcids":["https://orcid.org/0000-0002-8215-4374"]},"institutions":[{"id":"https://openalex.org/I4210097936","display_name":"Terasaki Foundation","ror":"https://ror.org/012381002","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210097936"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alireza Hassani Najafabadi","raw_affiliation_strings":["Terasaki Institute for Biomedical Innovation, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Terasaki Institute for Biomedical Innovation, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I4210097936"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027118553","display_name":"Saber Amin Yavari","orcid":"https://orcid.org/0000-0003-1677-5751","observed_orcids":["https://orcid.org/0000-0003-1677-5751"]},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]},{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Saber Amin Yavari","raw_affiliation_strings":["Department of Orthopedics, University Medical Center Utrecht, Utrecht, The Netherlands","Regenerative Medicine Centre Utrecht, Utrecht University, Utrecht, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0003-1677-5751","affiliations":[{"raw_affiliation_string":"Department of Orthopedics, University Medical Center Utrecht, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I3018483916"]},{"raw_affiliation_string":"Regenerative Medicine Centre Utrecht, Utrecht University, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I193662353"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.0897,"has_fulltext":true,"cited_by_count":32,"citation_normalized_percentile":{"value":0.88324446,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"13","issue":"11","first_page":"2836","last_page":"2870"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10512","display_name":"Orthopaedic implants and arthroplasty","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteoimmunomodulation","display_name":"osteoimmunomodulation","score":0.9950000047683716},{"id":"https://openalex.org/keywords/bone-implants","display_name":"bone implants","score":0.9399999976158142},{"id":"https://openalex.org/keywords/macrophage-polarization","display_name":"macrophage polarization","score":0.871999979019165},{"id":"https://openalex.org/keywords/chronic-inflammation","display_name":"chronic inflammation","score":0.7110000252723694},{"id":"https://openalex.org/keywords/bone-regeneration","display_name":"bone regeneration","score":0.9279999732971191},{"id":"https://openalex.org/keywords/implant-integration","display_name":"implant integration","score":0.6420000195503235},{"id":"https://openalex.org/keywords/aseptic-loosening","display_name":"aseptic loosening","score":0.8569999933242798},{"id":"https://openalex.org/keywords/fibrous-encapsulation","display_name":"fibrous encapsulation","score":0.9440000057220459},{"id":"https://openalex.org/keywords/bone-defects","display_name":"bone defects","score":0.37299999594688416}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5854705572128296},{"id":"https://openalex.org/C40231798","wikidata":"https://www.wikidata.org/wiki/Q1333743","display_name":"Composition (language)","level":2,"score":0.5417066812515259},{"id":"https://openalex.org/C149849071","wikidata":"https://www.wikidata.org/wiki/Q1263816","display_name":"Chemical composition","level":2,"score":0.5218590497970581},{"id":"https://openalex.org/C2781411149","wikidata":"https://www.wikidata.org/wiki/Q486975","display_name":"Implant","level":2,"score":0.5007729530334473},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.3441435694694519},{"id":"https://openalex.org/C107872376","wikidata":"https://www.wikidata.org/wiki/Q321355","display_name":"Environmental chemistry","level":1,"score":0.32855722308158875},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.11147153377532959},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.07624799013137817},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.0650978684425354},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.05900353193283081},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001672","descriptor_name":"Biocompatible Materials","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001861","descriptor_name":"Bone Regeneration","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D019736","descriptor_name":"Prostheses and Implants","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056747","descriptor_name":"Immunomodulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1039/d5bm00357a","doi":"https://doi.org/10.1039/d5bm00357a","is_oa":true,"landing_page_url":"https://doi.org/10.1039/d5bm00357a","pdf_url":"https://pubs.rsc.org/en/content/articlepdf/2025/bm/d5bm00357a","source":{"id":"https://openalex.org/S2494179437","display_name":"Biomaterials Science","issn_l":"2047-4830","issn":["2047-4830","2047-4849"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomaterials Science","raw_type":"journal-article"},{"id":"pmid:40289736","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40289736","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomaterials science","raw_type":"Journal Article"},{"id":"pmh:oai:dspace.library.uu.nl:1874/465945","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/465945","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:dspace.library.uu.nl:1874/476869","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/476869","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1039/d5bm00357a","doi":"https://doi.org/10.1039/d5bm00357a","is_oa":true,"landing_page_url":"https://doi.org/10.1039/d5bm00357a","pdf_url":"https://pubs.rsc.org/en/content/articlepdf/2025/bm/d5bm00357a","source":{"id":"https://openalex.org/S2494179437","display_name":"Biomaterials Science","issn_l":"2047-4830","issn":["2047-4830","2047-4849"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomaterials Science","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4409769843.pdf","grobid_xml":"https://content.openalex.org/works/W4409769843.grobid-xml"},"referenced_works_count":348,"referenced_works":["https://openalex.org/W58836509","https://openalex.org/W329955381","https://openalex.org/W1149703769","https://openalex.org/W1224709979","https://openalex.org/W1489759013","https://openalex.org/W1509156154","https://openalex.org/W1512684673","https://openalex.org/W1535838746","https://openalex.org/W1550446004","https://openalex.org/W1579631502","https://openalex.org/W1626331993","https://openalex.org/W1683802707","https://openalex.org/W1718090003","https://openalex.org/W1782883292","https://openalex.org/W1896571263","https://openalex.org/W1913879859","https://openalex.org/W1956258286","https://openalex.org/W1963611198","https://openalex.org/W1965153231","https://openalex.org/W1970352308","https://openalex.org/W1972885332","https://openalex.org/W1981617621","https://openalex.org/W1985656444","https://openalex.org/W1990428395","https://openalex.org/W1994073967","https://openalex.org/W1994929166","https://openalex.org/W1999382841","https://openalex.org/W2000311116","https://openalex.org/W2002306991","https://openalex.org/W2002361100","https://openalex.org/W2011360473","https://openalex.org/W2013761623","https://openalex.org/W2014770545","https://openalex.org/W2014931694","https://openalex.org/W2016639612","https://openalex.org/W2016704225","https://openalex.org/W2021703335","https://openalex.org/W2024900877","https://openalex.org/W2024971445","https://openalex.org/W2031041031","https://openalex.org/W2033423153","https://openalex.org/W2033792417","https://openalex.org/W2041912408","https://openalex.org/W2042617428","https://openalex.org/W2042965746","https://openalex.org/W2043044540","https://openalex.org/W2044964332","https://openalex.org/W2045982747","https://openalex.org/W2046935888","https://openalex.org/W2049828715","https://openalex.org/W2049963741","https://openalex.org/W2053058794","https://openalex.org/W2053451322","https://openalex.org/W2055248506","https://openalex.org/W2056116287","https://openalex.org/W2056336363","https://openalex.org/W2058864165","https://openalex.org/W2059532851","https://openalex.org/W2060119002","https://openalex.org/W2060766214","https://openalex.org/W2062192568","https://openalex.org/W2062393603","https://openalex.org/W2069453298","https://openalex.org/W2074967291","https://openalex.org/W2076075717","https://openalex.org/W2080408646","https://openalex.org/W2083080528","https://openalex.org/W2084587462","https://openalex.org/W2084610464","https://openalex.org/W2086618483","https://openalex.org/W2089158871","https://openalex.org/W2092881555","https://openalex.org/W2094704598","https://openalex.org/W2100474263","https://openalex.org/W2105838733","https://openalex.org/W2107658520","https://openalex.org/W2115147216","https://openalex.org/W2123270129","https://openalex.org/W2124392720","https://openalex.org/W2126675210","https://openalex.org/W2127533496","https://openalex.org/W2127999139","https://openalex.org/W2131395371","https://openalex.org/W2131720028","https://openalex.org/W2132430482","https://openalex.org/W2132551021","https://openalex.org/W2144390061","https://openalex.org/W2145063094","https://openalex.org/W2146065571","https://openalex.org/W2150457539","https://openalex.org/W2150692938","https://openalex.org/W2155024437","https://openalex.org/W2155493718","https://openalex.org/W2157331367","https://openalex.org/W2157366956","https://openalex.org/W2157788478","https://openalex.org/W2163105501","https://openalex.org/W2165804863","https://openalex.org/W2166732256","https://openalex.org/W2170512777","https://openalex.org/W2170595515","https://openalex.org/W2171264448","https://openalex.org/W2173457865","https://openalex.org/W2182798903","https://openalex.org/W2191654227","https://openalex.org/W2193505608","https://openalex.org/W2195285929","https://openalex.org/W2235654207","https://openalex.org/W2281571103","https://openalex.org/W2291522985","https://openalex.org/W2293669149","https://openalex.org/W2338968478","https://openalex.org/W2405505865","https://openalex.org/W2501376457","https://openalex.org/W2516344353","https://openalex.org/W2531586085","https://openalex.org/W2533102687","https://openalex.org/W2543546237","https://openalex.org/W2559590402","https://openalex.org/W2570636362","https://openalex.org/W2580042282","https://openalex.org/W2580188336","https://openalex.org/W2580555388","https://openalex.org/W2596662882","https://openalex.org/W2596733592","https://openalex.org/W2606199910","https://openalex.org/W2621377986","https://openalex.org/W2622883680","https://openalex.org/W2737576005","https://openalex.org/W2744021789","https://openalex.org/W2754665588","https://openalex.org/W2762816177","https://openalex.org/W2789462186","https://openalex.org/W2790865466","https://openalex.org/W2795901967","https://openalex.org/W2799518769","https://openalex.org/W2802328524","https://openalex.org/W2805461865","https://openalex.org/W2807902435","https://openalex.org/W2883537915","https://openalex.org/W2884099436","https://openalex.org/W2884686305","https://openalex.org/W2885305610","https://openalex.org/W2885316173","https://openalex.org/W2886159181","https://openalex.org/W2888165459","https://openalex.org/W2888573347","https://openalex.org/W2889795645","https://openalex.org/W2891591061","https://openalex.org/W2897714759","https://openalex.org/W2901401086","https://openalex.org/W2902649319","https://openalex.org/W2910159428","https://openalex.org/W2911746990","https://openalex.org/W2911834174","https://openalex.org/W2912502989","https://openalex.org/W2913840193","https://openalex.org/W2921824125","https://openalex.org/W2921851255","https://openalex.org/W2923149190","https://openalex.org/W2930974050","https://openalex.org/W2944419520","https://openalex.org/W2945703177","https://openalex.org/W2952835325","https://openalex.org/W2955200445","https://openalex.org/W2955366557","https://openalex.org/W2966275957","https://openalex.org/W2968137280","https://openalex.org/W2973794719","https://openalex.org/W2982493204","https://openalex.org/W2982895754","https://openalex.org/W2983099613","https://openalex.org/W2985281929","https://openalex.org/W2988109514","https://openalex.org/W2990298304","https://openalex.org/W2991937030","https://openalex.org/W2995083410","https://openalex.org/W2998609342","https://openalex.org/W2999381997","https://openalex.org/W3000288759","https://openalex.org/W3000530413","https://openalex.org/W3003780370","https://openalex.org/W3003900143","https://openalex.org/W3003916947","https://openalex.org/W3004238134","https://openalex.org/W3007896308","https://openalex.org/W3011483961","https://openalex.org/W3013067729","https://openalex.org/W3014808794","https://openalex.org/W3020529057","https://openalex.org/W3022257635","https://openalex.org/W3025445372","https://openalex.org/W3027578465","https://openalex.org/W3033093244","https://openalex.org/W3033845885","https://openalex.org/W3034287631","https://openalex.org/W3036120527","https://openalex.org/W3039394007","https://openalex.org/W3039655065","https://openalex.org/W3039933878","https://openalex.org/W3044931624","https://openalex.org/W3048545591","https://openalex.org/W3087417812","https://openalex.org/W3090030517","https://openalex.org/W3092629596","https://openalex.org/W3092783063","https://openalex.org/W3095357109","https://openalex.org/W3107085554","https://openalex.org/W3108342272","https://openalex.org/W3110371626","https://openalex.org/W3110868528","https://openalex.org/W3119625604","https://openalex.org/W3124680705","https://openalex.org/W3125645105","https://openalex.org/W3125781270","https://openalex.org/W3126687945","https://openalex.org/W3128298548","https://openalex.org/W3128592268","https://openalex.org/W3128979454","https://openalex.org/W3129982058","https://openalex.org/W3139308280","https://openalex.org/W3141681677","https://openalex.org/W3156569796","https://openalex.org/W3161474660","https://openalex.org/W3161978623","https://openalex.org/W3163218484","https://openalex.org/W3164964550","https://openalex.org/W3168981793","https://openalex.org/W3172850887","https://openalex.org/W3173707161","https://openalex.org/W3186380954","https://openalex.org/W3191142761","https://openalex.org/W3193975704","https://openalex.org/W3196103724","https://openalex.org/W3197482769","https://openalex.org/W3198086737","https://openalex.org/W3198340505","https://openalex.org/W3199606452","https://openalex.org/W3199896451","https://openalex.org/W3201279682","https://openalex.org/W3209526386","https://openalex.org/W3209601733","https://openalex.org/W3217170430","https://openalex.org/W3217318668","https://openalex.org/W4200096980","https://openalex.org/W4200289342","https://openalex.org/W4205274827","https://openalex.org/W4205428329","https://openalex.org/W4205517163","https://openalex.org/W4210556775","https://openalex.org/W4210719922","https://openalex.org/W4212788184","https://openalex.org/W4213261780","https://openalex.org/W4213446257","https://openalex.org/W4220731763","https://openalex.org/W4220927121","https://openalex.org/W4224230549","https://openalex.org/W4224994189","https://openalex.org/W4225272163","https://openalex.org/W4281809489","https://openalex.org/W4282918318","https://openalex.org/W4283641637","https://openalex.org/W4283740149","https://openalex.org/W4292567122","https://openalex.org/W4295737138","https://openalex.org/W4296031307","https://openalex.org/W4297270933","https://openalex.org/W4298393502","https://openalex.org/W4303043637","https://openalex.org/W4303857931","https://openalex.org/W4306968472","https://openalex.org/W4307717484","https://openalex.org/W4308031356","https://openalex.org/W4308156319","https://openalex.org/W4308566924","https://openalex.org/W4308685953","https://openalex.org/W4310021006","https://openalex.org/W4310131926","https://openalex.org/W4310290437","https://openalex.org/W4311836740","https://openalex.org/W4313479473","https://openalex.org/W4313839410","https://openalex.org/W4316035350","https://openalex.org/W4316194097","https://openalex.org/W4318473831","https://openalex.org/W4318611978","https://openalex.org/W4318762041","https://openalex.org/W4319733385","https://openalex.org/W4321378938","https://openalex.org/W4321483436","https://openalex.org/W4323317758","https://openalex.org/W4323667314","https://openalex.org/W4327699819","https://openalex.org/W4360982612","https://openalex.org/W4367669219","https://openalex.org/W4372258191","https://openalex.org/W4376105294","https://openalex.org/W4377563825","https://openalex.org/W4377940143","https://openalex.org/W4378376618","https://openalex.org/W4380086399","https://openalex.org/W4384564465","https://openalex.org/W4384829540","https://openalex.org/W4385294172","https://openalex.org/W4385296371","https://openalex.org/W4385383217","https://openalex.org/W4385407670","https://openalex.org/W4385454004","https://openalex.org/W4385469368","https://openalex.org/W4385857906","https://openalex.org/W4386067550","https://openalex.org/W4386071006","https://openalex.org/W4386357382","https://openalex.org/W4387661098","https://openalex.org/W4387662603","https://openalex.org/W4387931224","https://openalex.org/W4387966147","https://openalex.org/W4388178867","https://openalex.org/W4389236023","https://openalex.org/W4389453021","https://openalex.org/W4389890770","https://openalex.org/W4391108292","https://openalex.org/W4391221059","https://openalex.org/W4391387683","https://openalex.org/W4391439210","https://openalex.org/W4391541671","https://openalex.org/W4392059587","https://openalex.org/W4392241576","https://openalex.org/W4392507607","https://openalex.org/W4392545705","https://openalex.org/W4393315169","https://openalex.org/W4393390344","https://openalex.org/W4393948361","https://openalex.org/W4394594488","https://openalex.org/W4394718054","https://openalex.org/W4394931563","https://openalex.org/W4395085476","https://openalex.org/W4395662841","https://openalex.org/W4396622636","https://openalex.org/W4396796818","https://openalex.org/W4398197718","https://openalex.org/W4399258773","https://openalex.org/W4399303307","https://openalex.org/W4399753743","https://openalex.org/W4400036919","https://openalex.org/W4400070344","https://openalex.org/W4400302731","https://openalex.org/W4403041143"],"related_works":["https://openalex.org/W4413113407","https://openalex.org/W4409906807","https://openalex.org/W4407725263","https://openalex.org/W7172314884","https://openalex.org/W4393188325","https://openalex.org/W7158317170","https://openalex.org/W7165058089","https://openalex.org/W4405438834","https://openalex.org/W2897714759","https://openalex.org/W4303857931"],"abstract_inverted_index":{"Chronic":[0],"inflammation":[1,58,83],"at":[2],"bone":[3,34,38,45,62,91,113],"defect":[4],"sites":[5],"can":[6,14],"impede":[7],"regenerative":[8],"processes,":[9,86],"but":[10],"local":[11],"immune":[12,53],"responses":[13],"be":[15],"adjusted":[16],"to":[17,61,80],"promote":[18],"healing.":[19],"Regulating":[20],"the":[21,52,100],"osteoimmune":[22],"microenvironment,":[23],"particularly":[24],"through":[25],"macrophage":[26],"polarization,":[27],"has":[28],"become":[29],"a":[30,77],"key":[31],"focus":[32],"in":[33,108],"regeneration":[35],"research.":[36],"While":[37],"implants":[39,75],"are":[40,48],"crucial":[41],"for":[42],"addressing":[43],"significant":[44],"defects,":[46],"they":[47],"often":[49],"recognized":[50],"by":[51],"system":[54],"as":[55],"foreign,":[56],"triggering":[57],"that":[59],"leads":[60],"resorption":[63],"and":[64,70,90,103,111],"implant":[65,88],"issues":[66],"like":[67],"fibrous":[68],"encapsulation":[69],"aseptic":[71],"loosening.":[72],"Developing":[73],"osteoimmunomodulatory":[74,110],"offers":[76],"promising":[78],"approach":[79],"transforming":[81],"destructive":[82],"into":[84],"healing":[85],"enhancing":[87],"integration":[89],"regeneration.":[92],"This":[93],"review":[94],"explores":[95],"strategies":[96],"based":[97],"on":[98],"tuning":[99],"physicochemical":[101],"attributes":[102],"chemical":[104],"composition":[105],"of":[106],"materials":[107],"engineering":[109],"pro-regenerative":[112],"implants.":[114]},"counts_by_year":[{"year":2026,"cited_by_count":26},{"year":2025,"cited_by_count":6}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2025-04-25T00:00:00"}