{"id":"https://openalex.org/W4409766819","doi":"https://doi.org/10.1101/2025.04.21.25326138","title":"Age-specific trends in colorectal, appendiceal, and anal tumour incidence by histological subtype in Australia from 1990 to 2020: a population-based time-series analysis","display_name":"Age-specific trends in colorectal, appendiceal, and anal tumour incidence by histological subtype in Australia from 1990 to 2020: a population-based time-series analysis","publication_year":2025,"publication_date":"2025-04-24","ids":{"openalex":"https://openalex.org/W4409766819","doi":"https://doi.org/10.1101/2025.04.21.25326138","pmid":"https://pubmed.ncbi.nlm.nih.gov/40313308","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12045447"},"language":"en","primary_location":{"id":"doi:10.1101/2025.04.21.25326138","doi":"https://doi.org/10.1101/2025.04.21.25326138","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.04.21.25326138","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2025/04/24/2025.04.21.25326138.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.medrxiv.org/content/medrxiv/early/2025/04/24/2025.04.21.25326138.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000978510","display_name":"Aaron L. Meyers","orcid":"https://orcid.org/0009-0008-6440-5396","observed_orcids":["https://orcid.org/0009-0008-6440-5396"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I4210103203","display_name":"Victorian Comprehensive Cancer Centre","ror":"https://ror.org/00st91468","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210103203"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Aaron L. Meyers","raw_affiliation_strings":["Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Parkville, Victoria, Australia","Collaborative Centre for Genomic Cancer Medicine, Victorian Comprehensive Cancer Centre, Melbourne, Victoria, Australia","Colorectal Oncogenomics Group, Department of Clinical Pathology, Melbourne Medical School, University of Melbourne, Parkville, Victoria, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Parkville, Victoria, Australia","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"Collaborative Centre for Genomic Cancer Medicine, Victorian Comprehensive Cancer Centre, Melbourne, Victoria, Australia","institution_ids":["https://openalex.org/I4210103203"]},{"raw_affiliation_string":"Colorectal Oncogenomics Group, Department of Clinical Pathology, Melbourne Medical School, University of Melbourne, Parkville, Victoria, Australia","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114374591","display_name":"James G. Dowty","orcid":"https://orcid.org/0000-0003-2383-0886","observed_orcids":["https://orcid.org/0000-0003-2383-0886"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"James G. Dowty","raw_affiliation_strings":["Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Parkville, Victoria, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Parkville, Victoria, Australia","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073553657","display_name":"Khalid Mahmood","orcid":"https://orcid.org/0000-0003-0980-3646","observed_orcids":["https://orcid.org/0000-0003-0980-3646"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I347366330","display_name":"Melbourne Bioinformatics","ror":"https://ror.org/05gkzhv48","country_code":"AU","type":"education","lineage":["https://openalex.org/I347366330"]},{"id":"https://openalex.org/I4210103203","display_name":"Victorian Comprehensive Cancer Centre","ror":"https://ror.org/00st91468","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210103203"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Khalid Mahmood","raw_affiliation_strings":["Collaborative Centre for Genomic Cancer Medicine, Victorian Comprehensive Cancer Centre, Melbourne, Victoria, Australia","Colorectal Oncogenomics Group, Department of Clinical Pathology, Melbourne Medical School, University of Melbourne, Parkville, Victoria, Australia","Melbourne Bioinformatics, University of Melbourne, Parkville, Victoria, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Collaborative Centre for Genomic Cancer Medicine, Victorian Comprehensive Cancer Centre, Melbourne, Victoria, Australia","institution_ids":["https://openalex.org/I4210103203"]},{"raw_affiliation_string":"Colorectal Oncogenomics Group, Department of Clinical Pathology, Melbourne Medical School, University of Melbourne, Parkville, Victoria, Australia","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"Melbourne Bioinformatics, University of Melbourne, Parkville, Victoria, Australia","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I347366330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066787545","display_name":"Finlay Macrae","orcid":"https://orcid.org/0000-0003-4035-9678","observed_orcids":["https://orcid.org/0000-0003-4035-9678"]},"institutions":[{"id":"https://openalex.org/I1320473756","display_name":"The Royal Melbourne Hospital","ror":"https://ror.org/005bvs909","country_code":"AU","type":"funder","lineage":["https://openalex.org/I1320473756","https://openalex.org/I4210158168"]},{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Finlay A. Macrae","raw_affiliation_strings":["Colorectal Medicine and Genetics, Royal Melbourne Hospital, Parkville, Victoria, Australia","Department of Medicine, University of Melbourne, Parkville, Victoria, Australia","Genomic Medicine and Family Cancer Clinic, Royal Melbourne Hospital, Parkville, Victoria, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Colorectal Medicine and Genetics, Royal Melbourne Hospital, Parkville, Victoria, Australia","institution_ids":["https://openalex.org/I1320473756"]},{"raw_affiliation_string":"Department of Medicine, University of Melbourne, Parkville, Victoria, Australia","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"Genomic Medicine and Family Cancer Clinic, Royal Melbourne Hospital, Parkville, Victoria, Australia","institution_ids":["https://openalex.org/I1320473756"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053217861","display_name":"Christophe Rosty","orcid":"https://orcid.org/0000-0001-7671-2651","observed_orcids":["https://orcid.org/0000-0001-7671-2651"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]},{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I4210089472","display_name":"Envoi Specialist Pathologists","ror":"https://ror.org/00687yy04","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210089472"]},{"id":"https://openalex.org/I4210103203","display_name":"Victorian Comprehensive Cancer Centre","ror":"https://ror.org/00st91468","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210103203"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Christophe Rosty","raw_affiliation_strings":["Collaborative Centre for Genomic Cancer Medicine, Victorian Comprehensive Cancer Centre, Melbourne, Victoria, Australia","Colorectal Oncogenomics Group, Department of Clinical Pathology, Melbourne Medical School, University of Melbourne, Parkville, Victoria, Australia","Envoi Specialist Pathologists, Brisbane, Queensland, Australia","University of Queensland, Brisbane, Queensland, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Collaborative Centre for Genomic Cancer Medicine, Victorian Comprehensive Cancer Centre, Melbourne, Victoria, Australia","institution_ids":["https://openalex.org/I4210103203"]},{"raw_affiliation_string":"Colorectal Oncogenomics Group, Department of Clinical Pathology, Melbourne Medical School, University of Melbourne, Parkville, Victoria, Australia","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"Envoi Specialist Pathologists, Brisbane, Queensland, Australia","institution_ids":["https://openalex.org/I4210089472"]},{"raw_affiliation_string":"University of Queensland, Brisbane, Queensland, Australia","institution_ids":["https://openalex.org/I165143802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061298063","display_name":"Daniel D. Buchanan","orcid":"https://orcid.org/0000-0003-2225-6675","observed_orcids":["https://orcid.org/0000-0003-2225-6675"]},"institutions":[{"id":"https://openalex.org/I1320473756","display_name":"The Royal Melbourne Hospital","ror":"https://ror.org/005bvs909","country_code":"AU","type":"funder","lineage":["https://openalex.org/I1320473756","https://openalex.org/I4210158168"]},{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I4210103203","display_name":"Victorian Comprehensive Cancer Centre","ror":"https://ror.org/00st91468","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210103203"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Daniel D. Buchanan","raw_affiliation_strings":["Collaborative Centre for Genomic Cancer Medicine, Victorian Comprehensive Cancer Centre, Melbourne, Victoria, Australia","Colorectal Oncogenomics Group, Department of Clinical Pathology, Melbourne Medical School, University of Melbourne, Parkville, Victoria, Australia","Genomic Medicine and Family Cancer Clinic, Royal Melbourne Hospital, Parkville, Victoria, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Collaborative Centre for Genomic Cancer Medicine, Victorian Comprehensive Cancer Centre, Melbourne, Victoria, Australia","institution_ids":["https://openalex.org/I4210103203"]},{"raw_affiliation_string":"Colorectal Oncogenomics Group, Department of Clinical Pathology, Melbourne Medical School, University of Melbourne, Parkville, Victoria, Australia","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"Genomic Medicine and Family Cancer Clinic, Royal Melbourne Hospital, Parkville, Victoria, Australia","institution_ids":["https://openalex.org/I1320473756"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090508414","display_name":"Mark A. Jenkins","orcid":"https://orcid.org/0000-0002-8964-6160","observed_orcids":["https://orcid.org/0000-0002-8964-6160"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I4210103203","display_name":"Victorian Comprehensive Cancer Centre","ror":"https://ror.org/00st91468","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210103203"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Mark A. Jenkins","raw_affiliation_strings":["Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Parkville, Victoria, Australia","Collaborative Centre for Genomic Cancer Medicine, Victorian Comprehensive Cancer Centre, Melbourne, Victoria, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Parkville, Victoria, Australia","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"Collaborative Centre for Genomic Cancer Medicine, Victorian Comprehensive Cancer Centre, Melbourne, Victoria, Australia","institution_ids":["https://openalex.org/I4210103203"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5000978510"],"corresponding_institution_ids":["https://openalex.org/I165779595","https://openalex.org/I4210103203"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10552","display_name":"Colorectal Cancer Screening and Detection","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10552","display_name":"Colorectal Cancer Screening and Detection","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10556","display_name":"Global Cancer Incidence and Screening","score":0.019200000911951065,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13110","display_name":"Colorectal and Anal Carcinomas","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.7289999723434448},{"id":"https://openalex.org/keywords/appendiceal-neoplasms","display_name":"appendiceal neoplasms","score":0.9660000205039978},{"id":"https://openalex.org/keywords/anal-cancer","display_name":"anal cancer","score":0.9919999837875366},{"id":"https://openalex.org/keywords/rectal-cancer","display_name":"rectal cancer","score":0.824999988079071},{"id":"https://openalex.org/keywords/early-onset-cancer","display_name":"early-onset cancer","score":0.7440000176429749},{"id":"https://openalex.org/keywords/cancer-incidence-trends","display_name":"cancer incidence trends","score":0.8090000152587891},{"id":"https://openalex.org/keywords/histological-subtypes","display_name":"histological subtypes","score":0.9229999780654907},{"id":"https://openalex.org/keywords/appendiceal-mucinous-adenocarcinoma","display_name":"appendiceal mucinous adenocarcinoma","score":0.9020000100135803},{"id":"https://openalex.org/keywords/anal-squamous-cell-carcinoma","display_name":"anal squamous cell carcinoma","score":0.9129999876022339},{"id":"https://openalex.org/keywords/colorectal-adenocarcinoma","display_name":"colorectal adenocarcinoma","score":0.8669999837875366},{"id":"https://openalex.org/keywords/birth-cohort-effects","display_name":"birth cohort effects","score":0.5920000076293945},{"id":"https://openalex.org/keywords/australia","display_name":"Australia","score":0.503000020980835},{"id":"https://openalex.org/keywords/signet-ring-cell-carcinoma","display_name":"signet ring cell carcinoma","score":0.9350000023841858},{"id":"https://openalex.org/keywords/neuroendocrine-neoplasms","display_name":"neuroendocrine neoplasms","score":0.9470000267028809}],"concepts":[{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.729520320892334},{"id":"https://openalex.org/C143724316","wikidata":"https://www.wikidata.org/wiki/Q312468","display_name":"Series (stratigraphy)","level":2,"score":0.526628315448761},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5138909816741943},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.47279876470565796},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.43724286556243896},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.342447429895401},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13141405582427979},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0742470920085907},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.05305933952331543},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1101/2025.04.21.25326138","doi":"https://doi.org/10.1101/2025.04.21.25326138","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.04.21.25326138","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2025/04/24/2025.04.21.25326138.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},{"id":"pmid:40313308","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40313308","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"medRxiv : the preprint server for health sciences","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12045447","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12045447","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1101/2025.04.21.25326138","doi":"https://doi.org/10.1101/2025.04.21.25326138","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.04.21.25326138","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2025/04/24/2025.04.21.25326138.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G4593767870","display_name":"Tackling Australia\u2019s low screening participation to prevent bowel cancer deaths","funder_award_id":"1195099","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"},{"id":"https://openalex.org/G6409046104","display_name":"Precision Prevention of Colorectal Cancer: understanding tumourigenesis in high risk people to optimise prevention","funder_award_id":"1194896","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"},{"id":"https://openalex.org/G804866679","display_name":null,"funder_award_id":"CA167551","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000874947","display_name":"Colon Cancer Family Registry Cohort","funder_award_id":"U01CA167551","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320315488","display_name":"ACT Government","ror":"https://ror.org/03fy7b149"},{"id":"https://openalex.org/F4320315885","display_name":"Australian Government","ror":"https://ror.org/0314h5y94"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334705","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4409766819.pdf","grobid_xml":"https://content.openalex.org/works/W4409766819.grobid-xml"},"referenced_works_count":69,"referenced_works":["https://openalex.org/W1581665297","https://openalex.org/W1970101878","https://openalex.org/W1989035497","https://openalex.org/W1991503334","https://openalex.org/W2011371737","https://openalex.org/W2013974060","https://openalex.org/W2037445783","https://openalex.org/W2053182010","https://openalex.org/W2066932778","https://openalex.org/W2077618811","https://openalex.org/W2089668061","https://openalex.org/W2113029107","https://openalex.org/W2149214723","https://openalex.org/W2151827737","https://openalex.org/W2158684959","https://openalex.org/W2161602896","https://openalex.org/W2266999193","https://openalex.org/W2378783258","https://openalex.org/W2490521015","https://openalex.org/W2573079308","https://openalex.org/W2582743722","https://openalex.org/W2622531725","https://openalex.org/W2738316236","https://openalex.org/W2808908968","https://openalex.org/W2893700051","https://openalex.org/W2905521034","https://openalex.org/W2946385297","https://openalex.org/W2963880203","https://openalex.org/W2972102107","https://openalex.org/W2981768636","https://openalex.org/W2982686054","https://openalex.org/W2994034599","https://openalex.org/W3008636084","https://openalex.org/W3009963727","https://openalex.org/W3026748200","https://openalex.org/W3082066016","https://openalex.org/W3083028620","https://openalex.org/W3112517629","https://openalex.org/W3126443376","https://openalex.org/W3134497723","https://openalex.org/W3166629602","https://openalex.org/W3176964769","https://openalex.org/W3180899706","https://openalex.org/W3185513176","https://openalex.org/W3193975526","https://openalex.org/W3201449765","https://openalex.org/W3213664942","https://openalex.org/W4210327840","https://openalex.org/W4224117459","https://openalex.org/W4224217056","https://openalex.org/W4224221983","https://openalex.org/W4225670412","https://openalex.org/W4235739337","https://openalex.org/W4254110675","https://openalex.org/W4283267578","https://openalex.org/W4293777772","https://openalex.org/W4296742977","https://openalex.org/W4311472757","https://openalex.org/W4385649165","https://openalex.org/W4389306137","https://openalex.org/W4392304105","https://openalex.org/W4392984046","https://openalex.org/W4393935425","https://openalex.org/W4394997392","https://openalex.org/W4401255794","https://openalex.org/W4401982664","https://openalex.org/W4404311881","https://openalex.org/W4405267343","https://openalex.org/W4407823342"],"related_works":["https://openalex.org/W7113896951","https://openalex.org/W4296742977","https://openalex.org/W2946385297","https://openalex.org/W4413453410","https://openalex.org/W7222120057","https://openalex.org/W2905521034","https://openalex.org/W3092512609","https://openalex.org/W4393094075","https://openalex.org/W3112517629","https://openalex.org/W4405267343"],"abstract_inverted_index":{"Background:":[0],"Early-onset":[1],"bowel":[2],"cancer":[3,39,58,88,120,140,229],"incidence":[4,40,50,64,89,159,230],"(age":[5,194],"<50":[6],"years)":[7],"has":[8],"increased":[9,150],"worldwide":[10],"and":[11,22,37,44,68,79,117,134,171,187,197,212,221,227,239,265,276,294,337],"is":[12,231,252,270,321],"highest":[13],"in":[14,46,72,124,132,137,144,160,233],"Australia,":[15],"but":[16],"how":[17],"this":[18],"varies":[19],"across":[20,219,237],"histology":[21,45],"anatomical":[23],"site":[24],"remains":[25],"unclear.":[26],"We":[27],"aimed":[28],"to":[29,244,298,341],"investigate":[30],"appendiceal,":[31],"proximal":[32],"colon,":[33,35,104],"distal":[34],"rectal,":[36],"anal":[38,139,188,198,228],"trends":[41],"by":[42,114,254,272,295,323,338],"age":[43,238],"Australia.":[47],"Methods:":[48],"Cancer":[49,301,309],"rate":[51,65],"data":[52],"were":[53,74],"obtained":[54],"from":[55,122,129,135,142,306,344],"all":[56,147],"Australian":[57,256],"registries":[59],"(1990-2020":[60],"period).":[61],"Birth":[62],"cohort-specific":[63],"ratios":[66],"(IRRs)":[67],"annual":[69],"percentage":[70],"change":[71],"rates":[73,200],"estimated":[75],"using":[76],"age-period-cohort":[77],"modelling":[78],"joinpoint":[80],"regression.":[81],"Findings:":[82],"After":[83],"excluding":[84],"neuroendocrine":[85,204],"neoplasms,":[86],"early-onset":[87,220],"rose":[90,121,128,141,218],"5-9%":[91],"annually,":[92],"yielding":[93],"5,341":[94],"excess":[95],"cases":[96],"(2":[97],"per":[98],"100,000":[99],"person-years;":[100],"12%":[101],"appendix,":[102],"45%":[103],"36%":[105],"rectum,":[106],"7%":[107],"anus;":[108],"20-214%":[109],"relative":[110],"increase).":[111],"Trends":[112],"varied":[113],"site,":[115],"period,":[116],"age:":[118],"appendiceal":[119,181],"1990-2020":[123],"30-49-year-olds;":[125],"colorectal":[126,184,196],"cancers":[127],"around":[130],"1990-2010":[131],"20-29-year-olds":[133],"2010-2020":[136],"30-39-year-olds;":[138],"1990-2009":[143],"40-49-year-olds.":[145],"Across":[146],"sites,":[148],"IRRs":[149],"with":[151,235],"successive":[152],"birth":[153,165],"cohorts":[154],"since":[155],"1960.":[156],"Notably,":[157],"adenocarcinoma":[158,199],"the":[161,242,307,342],"1990s":[162],"versus":[163],"1950s":[164],"cohort":[166],"was":[167],"2-3-fold":[168],"for":[169,173,180],"colorectum":[170],"7-fold":[172],"appendix.":[174],"The":[175,299],"greatest":[176],"subtype-specific":[177],"increases":[178],"occurred":[179],"mucinous":[182],"adenocarcinoma,":[183,186],"non-mucinous":[185],"squamous":[189,209],"cell":[190,210,216],"carcinoma.":[191],"Only":[192],"later-onset":[193,222],"\u226550)":[195],"declined.":[201],"Appendiceal":[202],"tumours,":[203],"neoplasms":[205],"(all":[206],"sites),":[207],"anorectal":[208],"carcinomas,":[211],"colon":[213],"signet":[214],"ring":[215],"carcinomas":[217],"strata.":[223],"Interpretation:":[224],"Appendiceal,":[225],"colorectal,":[226],"rising":[232],"Australia":[234,281],"variation":[236],"histology,":[240],"underscoring":[241],"need":[243],"identify":[245],"factors":[246],"driving":[247],"these":[248],"trends.":[249],"Funding:":[250],"ALM":[251],"supported":[253,271,322],"an":[255,324],"Government":[257],"Research":[258,278],"Training":[259],"Program":[260],"Scholarship,":[261,264],"Rowden":[262],"White":[263],"WP":[266],"Greene":[267],"Scholarship.":[268],"DDB":[269],"a":[273,286,329],"National":[274,308,312],"Health":[275,315],"Medical":[277],"Council":[279],"of":[280,288,314,331],"(NHMRC)":[282],"Investigator":[283,326],"grant":[284,327],"(GNT1194896),":[285],"University":[287,330],"Melbourne":[289,332],"Dame":[290,333],"Kate":[291,334],"Campbell":[292,335],"Fellowship,":[293,336],"funding":[296,339],"awarded":[297,340],"Colon":[300],"Family":[302],"Registry":[303],"(CCFR,":[304],"www.coloncfr.org)":[305],"Institute":[310],"(NCI),":[311],"Institutes":[313],"(NIH)":[316],"[award":[317,347],"U01":[318,348],"CA167551].":[319,349],"MAJ":[320],"NHMRC":[325],"(GNT1195099),":[328],"CCFR":[343],"NCI,":[345],"NIH":[346]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-04-25T00:00:00"}