{"id":"https://openalex.org/W4409735289","doi":"https://doi.org/10.7324/japs.2025.200685","title":"Anti-gastric ulcer activity of chromatography-separated fractions from the rhizome of Zingiber simaoense Y. Y. Qian","display_name":"Anti-gastric ulcer activity of chromatography-separated fractions from the rhizome of Zingiber simaoense Y. Y. Qian","publication_year":2025,"publication_date":"2025-04-24","ids":{"openalex":"https://openalex.org/W4409735289","doi":"https://doi.org/10.7324/japs.2025.200685"},"language":"en","primary_location":{"id":"doi:10.7324/japs.2025.200685","doi":"https://doi.org/10.7324/japs.2025.200685","is_oa":true,"landing_page_url":"https://doi.org/10.7324/japs.2025.200685","pdf_url":"https://japsonline.com/admin/php/uploads/4557_pdf.pdf","source":{"id":"https://openalex.org/S2764844132","display_name":"Journal of Applied Pharmaceutical Science","issn_l":"2231-3354","issn":["2231-3354"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4327876862","host_organization_name":"Open Science Publishers LLP","host_organization_lineage":["https://openalex.org/P4327876862"],"host_organization_lineage_names":["Open Science Publishers LLP"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Pharmaceutical Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://japsonline.com/admin/php/uploads/4557_pdf.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062297617","display_name":"Puongtip Kunanusorn","orcid":"https://orcid.org/0000-0003-3669-6145","observed_orcids":["https://orcid.org/0000-0003-3669-6145"]},"institutions":[{"id":"https://openalex.org/I48076826","display_name":"Chiang Mai University","ror":"https://ror.org/05m2fqn25","country_code":"TH","type":"education","lineage":["https://openalex.org/I48076826"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Puongtip Kunanusorn","raw_affiliation_strings":["Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand","institution_ids":["https://openalex.org/I48076826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081379711","display_name":"Shisanupong Anukanon","orcid":"https://orcid.org/0000-0002-8259-2120","observed_orcids":["https://orcid.org/0000-0002-8259-2120"]},"institutions":[{"id":"https://openalex.org/I34002243","display_name":"Mae Fah Luang University","ror":"https://ror.org/00mwhaw71","country_code":"TH","type":"education","lineage":["https://openalex.org/I34002243"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Shisanupong Anukanon","raw_affiliation_strings":["School of Medicine, Mae Fah Luang University, Chiang Rai, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Mae Fah Luang University, Chiang Rai, Thailand","institution_ids":["https://openalex.org/I34002243"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016587096","display_name":"Parirat Khonsung","orcid":"https://orcid.org/0000-0003-1516-0106","observed_orcids":["https://orcid.org/0000-0003-1516-0106"]},"institutions":[{"id":"https://openalex.org/I48076826","display_name":"Chiang Mai University","ror":"https://ror.org/05m2fqn25","country_code":"TH","type":"education","lineage":["https://openalex.org/I48076826"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Parirat Khonsung","raw_affiliation_strings":["Corresponding Author Parirat Khonsung, Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand","Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Corresponding Author Parirat Khonsung, Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand","institution_ids":["https://openalex.org/I48076826"]},{"raw_affiliation_string":"Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand","institution_ids":["https://openalex.org/I48076826"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"15","issue":"7","first_page":"147","last_page":"155"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12347","display_name":"Ginger and Zingiberaceae research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12347","display_name":"Ginger and Zingiberaceae research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12215","display_name":"Phytochemical Studies and Bioactivities","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rhizome","display_name":"rhizome","score":0.9279999732971191},{"id":"https://openalex.org/keywords/gastric-ulcer","display_name":"gastric ulcer","score":0.5979999899864197},{"id":"https://openalex.org/keywords/ethanol-extract","display_name":"ethanol extract","score":0.4350000023841858},{"id":"https://openalex.org/keywords/solvent-partitioning","display_name":"solvent partitioning","score":0.7279999852180481},{"id":"https://openalex.org/keywords/column-chromatography","display_name":"column chromatography","score":0.8899999856948853},{"id":"https://openalex.org/keywords/alpha-eudesmol","display_name":"\u03b1-eudesmol","score":0.8659999966621399},{"id":"https://openalex.org/keywords/elemol","display_name":"elemol","score":1.0},{"id":"https://openalex.org/keywords/gastric-mucus-production","display_name":"gastric mucus production","score":0.6359999775886536},{"id":"https://openalex.org/keywords/herbal-medicine","display_name":"herbal medicine","score":0.7020000219345093},{"id":"https://openalex.org/keywords/thai-traditional-medicine","display_name":"Thai traditional medicine","score":0.699999988079071},{"id":"https://openalex.org/keywords/oral-ld50","display_name":"oral LD50","score":0.7279999852180481}],"concepts":[{"id":"https://openalex.org/C134550120","wikidata":"https://www.wikidata.org/wiki/Q184208","display_name":"Rhizome","level":2,"score":0.9400516748428345},{"id":"https://openalex.org/C2994357274","wikidata":"https://www.wikidata.org/wiki/Q35625","display_name":"Zingiber officinale","level":2,"score":0.6638841032981873},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.5645219087600708},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.5531210899353027},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5285410284996033},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.25830864906311035}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.7324/japs.2025.200685","doi":"https://doi.org/10.7324/japs.2025.200685","is_oa":true,"landing_page_url":"https://doi.org/10.7324/japs.2025.200685","pdf_url":"https://japsonline.com/admin/php/uploads/4557_pdf.pdf","source":{"id":"https://openalex.org/S2764844132","display_name":"Journal of Applied Pharmaceutical Science","issn_l":"2231-3354","issn":["2231-3354"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4327876862","host_organization_name":"Open Science Publishers LLP","host_organization_lineage":["https://openalex.org/P4327876862"],"host_organization_lineage_names":["Open Science Publishers LLP"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Pharmaceutical Science","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.7324/japs.2025.200685","doi":"https://doi.org/10.7324/japs.2025.200685","is_oa":true,"landing_page_url":"https://doi.org/10.7324/japs.2025.200685","pdf_url":"https://japsonline.com/admin/php/uploads/4557_pdf.pdf","source":{"id":"https://openalex.org/S2764844132","display_name":"Journal of Applied Pharmaceutical Science","issn_l":"2231-3354","issn":["2231-3354"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4327876862","host_organization_name":"Open Science Publishers LLP","host_organization_lineage":["https://openalex.org/P4327876862"],"host_organization_lineage_names":["Open Science Publishers LLP"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Pharmaceutical Science","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320335535","display_name":"Faculty of Medicine, Chiang Mai University","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4409735289.pdf","grobid_xml":"https://content.openalex.org/works/W4409735289.grobid-xml"},"referenced_works_count":23,"referenced_works":["https://openalex.org/W1965164780","https://openalex.org/W1976480513","https://openalex.org/W1980946958","https://openalex.org/W2000313790","https://openalex.org/W2004438580","https://openalex.org/W2017412276","https://openalex.org/W2020371828","https://openalex.org/W2027834869","https://openalex.org/W2028534110","https://openalex.org/W2028686794","https://openalex.org/W2047698724","https://openalex.org/W2063012247","https://openalex.org/W2079409197","https://openalex.org/W2088361302","https://openalex.org/W2088779093","https://openalex.org/W2091031702","https://openalex.org/W2094848304","https://openalex.org/W2105180276","https://openalex.org/W2113212777","https://openalex.org/W2134525915","https://openalex.org/W2163949090","https://openalex.org/W2538828574","https://openalex.org/W3015024081"],"related_works":["https://openalex.org/W2582167236","https://openalex.org/W3015024081","https://openalex.org/W2746681317","https://openalex.org/W2028686794","https://openalex.org/W1485449238","https://openalex.org/W2392017880","https://openalex.org/W2176892998","https://openalex.org/W3013550742","https://openalex.org/W6969064618","https://openalex.org/W2995180003"],"abstract_inverted_index":{"Zingiber":[0],"simaoense":[1,45,177],"Y.":[2,3],"Qian":[4],"(family":[5],"Zingiberaceae)":[6],"has":[7,21],"a":[8,180],"long":[9],"history":[10],"of":[11,18,39,43,51,92,157,168,175],"use":[12],"in":[13,31,106,133,160,191],"traditional":[14],"Thai":[15],"medicine.The":[16],"rhizome":[17,46],"this":[19,134,141],"plant":[20],"been":[22],"traditionally":[23],"employed":[24],"to":[25,54,73,148],"treat":[26],"gastric":[27,56,103],"disorders.Notably,":[28],"scientific":[29],"studies":[30,145],"rats":[32,161],"have":[33],"documented":[34],"the":[35,40,64,115,122,129,153,173,192],"anti-gastric":[36,67,89,124,188],"ulcer":[37,68,90,104,125,189],"activity":[38,91,190],"ethanol":[41,101],"extract":[42],"Z.":[44,176],"(ZSE),":[47],"with":[48,63,187],"its":[49,169],"mechanism":[50],"action":[52],"attributed":[53],"increased":[55],"wall":[57],"mucus":[58],"production.To":[59],"identify":[60],"ZSE":[61,70],"sub-fractions":[62,94],"most":[65,130],"potent":[66],"activity,":[69,142],"was":[71,95],"subjected":[72],"sequential":[74],"solvent":[75],"partitioning":[76],"using":[77,98],"n-hexane,":[78],"dichloromethane,":[79],"ethyl":[80],"acetate,":[81],"n-butanol,":[82],"and":[83,118,127],"water,":[84],"followed":[85],"by":[86],"column":[87],"chromatography.The":[88],"these":[93],"then":[96],"evaluated":[97],"an":[99],"acidified":[100],"(EtOH/HCl)-induced":[102],"model":[105],"rats.The":[107],"results":[108],"showed":[109],"that":[110],"sub-fraction":[111,135,158],"1,":[112,136],"eluted":[113],"from":[114],"combined":[116],"n-hexane":[117],"dichloromethane":[119],"fractions,":[120],"exhibited":[121],"highest":[123],"activity.\u03b1-Eudesmol":[126],"elemol,":[128],"abundant":[131],"compounds":[132],"may":[137],"be":[138],"responsible":[139],"for":[140,182],"though":[143],"further":[144],"are":[146],"required":[147],"confirm":[149],"their":[150],"specific":[151],"roles.Notably,":[152],"oral":[154],"LD":[155],"50":[156],"1":[159],"exceeded":[162],"2,000":[163],"mg/kg,":[164],"providing":[165],"preliminary":[166],"evidence":[167],"safety.These":[170],"findings":[171],"highlight":[172],"potential":[174],"rhizomes":[178],"as":[179],"source":[181],"developing":[183],"herbal":[184],"health":[185],"products":[186],"future.":[193]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2025-04-24T00:00:00"}