{"id":"https://openalex.org/W4409730500","doi":"https://doi.org/10.7554/elife.105876.1","title":"IL-27 limits HSPC differentiation during infection and protects from stem cell exhaustion","display_name":"IL-27 limits HSPC differentiation during infection and protects from stem cell exhaustion","publication_year":2025,"publication_date":"2025-04-23","ids":{"openalex":"https://openalex.org/W4409730500","doi":"https://doi.org/10.7554/elife.105876.1"},"language":"en","primary_location":{"id":"doi:10.7554/elife.105876.1","doi":"https://doi.org/10.7554/elife.105876.1","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.105876.1","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"eLife","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.7554/elife.105876.1","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071023180","display_name":"Daniel L. Aldridge","orcid":"https://orcid.org/0000-0003-2224-5159","observed_orcids":["https://orcid.org/0000-0003-2224-5159"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel L Aldridge","raw_affiliation_strings":["University of Pennsylvania School of Veterinary Medicine"],"raw_orcid":"https://orcid.org/0000-0003-2224-5159","affiliations":[{"raw_affiliation_string":"University of Pennsylvania School of Veterinary Medicine","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030817440","display_name":"Zachary R. Lanzar","orcid":"https://orcid.org/0000-0001-7229-0973","observed_orcids":["https://orcid.org/0000-0001-7229-0973"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zachary Lanzar","raw_affiliation_strings":["University of Pennsylvania School of Veterinary Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pennsylvania School of Veterinary Medicine","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071427508","display_name":"Anthony T. Phan","orcid":"https://orcid.org/0000-0003-2935-6070","observed_orcids":["https://orcid.org/0000-0003-2935-6070"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anthony T Phan","raw_affiliation_strings":["University of Pennsylvania School of Veterinary Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pennsylvania School of Veterinary Medicine","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061442255","display_name":"David A. Christian","orcid":"https://orcid.org/0000-0002-7160-9900","observed_orcids":["https://orcid.org/0000-0002-7160-9900"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David A Christian","raw_affiliation_strings":["University of Pennsylvania School of Veterinary Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pennsylvania School of Veterinary Medicine","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073136952","display_name":"Ryan D. Pardy","orcid":"https://orcid.org/0000-0002-0024-8888","observed_orcids":["https://orcid.org/0000-0002-0024-8888"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryan Pardy","raw_affiliation_strings":["University of Pennsylvania School of Veterinary Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pennsylvania School of Veterinary Medicine","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020575520","display_name":"Booki Min","orcid":"https://orcid.org/0000-0002-2151-9413","observed_orcids":["https://orcid.org/0000-0002-2151-9413"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Booki Min","raw_affiliation_strings":["Department of Microbiology and Immunology, Feinber School of Medicine, Northwestern University,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Feinber School of Medicine, Northwestern University,","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066347052","display_name":"Ross M. Kedl","orcid":"https://orcid.org/0000-0002-9065-7895","observed_orcids":["https://orcid.org/0000-0002-9065-7895"]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ross M Kedl","raw_affiliation_strings":["University of Colorado, Anschuitz Medical Campus"],"raw_orcid":"https://orcid.org/0000-0002-9065-7895","affiliations":[{"raw_affiliation_string":"University of Colorado, Anschuitz Medical Campus","institution_ids":["https://openalex.org/I51713134"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003951398","display_name":"Christopher A. Hunter","orcid":"https://orcid.org/0000-0003-3092-1428","observed_orcids":["https://orcid.org/0000-0003-3092-1428"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher A Hunter","raw_affiliation_strings":["University of Pennsylvania School of Veterinary Medicine"],"raw_orcid":"https://orcid.org/0000-0003-3092-1428","affiliations":[{"raw_affiliation_string":"University of Pennsylvania School of Veterinary Medicine","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3000,"currency":"USD","value_usd":2500},"apc_paid":{"value":3000,"currency":"USD","value_usd":2500},"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12528","display_name":"IL-33, ST2, and ILC Pathways","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/il-27","display_name":"IL-27","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hematopoietic-stem-and-progenitor-cells","display_name":"hematopoietic stem and progenitor cells","score":0.9929999709129333},{"id":"https://openalex.org/keywords/emergency-myelopoiesis","display_name":"emergency myelopoiesis","score":0.9290000200271606},{"id":"https://openalex.org/keywords/toxoplasmosis","display_name":"toxoplasmosis","score":0.9229999780654907},{"id":"https://openalex.org/keywords/monocyte-differentiation","display_name":"monocyte differentiation","score":0.7319999933242798},{"id":"https://openalex.org/keywords/inflammatory-monocytes","display_name":"inflammatory monocytes","score":0.8140000104904175},{"id":"https://openalex.org/keywords/il-27-receptor","display_name":"IL-27 receptor","score":0.8759999871253967},{"id":"https://openalex.org/keywords/stem-cell-exhaustion","display_name":"stem cell exhaustion","score":0.6919999718666077},{"id":"https://openalex.org/keywords/trained-immunity","display_name":"trained immunity","score":0.6690000295639038},{"id":"https://openalex.org/keywords/cytokine-receptor-expression","display_name":"cytokine receptor expression","score":0.6349999904632568},{"id":"https://openalex.org/keywords/hematopoietic-recovery","display_name":"hematopoietic recovery","score":0.8740000128746033}],"concepts":[{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.6586651802062988},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.42853114008903503},{"id":"https://openalex.org/C144133560","wikidata":"https://www.wikidata.org/wiki/Q4830453","display_name":"Business","level":0,"score":0.3460959196090698},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3397091031074524}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.7554/elife.105876.1","doi":"https://doi.org/10.7554/elife.105876.1","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.105876.1","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"eLife","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.7554/elife.105876.1","doi":"https://doi.org/10.7554/elife.105876.1","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.105876.1","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"eLife","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9907000064849854,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1192527373","display_name":null,"funder_award_id":"R01-AI125247","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G4888193509","display_name":"Impact of IL-27 on monocyte responses to Toxoplasma gondii infection","funder_award_id":"F31AI161962","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G7842280888","display_name":"Neuronal Latency and Toxoplasma","funder_award_id":"R01AI157247","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000887570","display_name":"Mechanisms of combined CD40/TLR adjuvant-elicited cellular immunity","funder_award_id":"U01AI160664","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000910693","display_name":"Impact of Toxoplasma gondii on Treg homeostasis","funder_award_id":"F31AI179240","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":74,"referenced_works":["https://openalex.org/W126539919","https://openalex.org/W1483521748","https://openalex.org/W1552070280","https://openalex.org/W1869510227","https://openalex.org/W1912951449","https://openalex.org/W1972403272","https://openalex.org/W1973099013","https://openalex.org/W1974815398","https://openalex.org/W1975502601","https://openalex.org/W1984097606","https://openalex.org/W1989157069","https://openalex.org/W2003182569","https://openalex.org/W2016825113","https://openalex.org/W2016956768","https://openalex.org/W2017965105","https://openalex.org/W2025535815","https://openalex.org/W2027581425","https://openalex.org/W2032618329","https://openalex.org/W2045000380","https://openalex.org/W2045308986","https://openalex.org/W2055438217","https://openalex.org/W2063921781","https://openalex.org/W2072411272","https://openalex.org/W2073242835","https://openalex.org/W2087990669","https://openalex.org/W2111253543","https://openalex.org/W2119986617","https://openalex.org/W2123777859","https://openalex.org/W2124890828","https://openalex.org/W2144544139","https://openalex.org/W2149011343","https://openalex.org/W2155338282","https://openalex.org/W2155853417","https://openalex.org/W2158049453","https://openalex.org/W2169841221","https://openalex.org/W2293267472","https://openalex.org/W2299632915","https://openalex.org/W2342126943","https://openalex.org/W2358421111","https://openalex.org/W2743779992","https://openalex.org/W2753100644","https://openalex.org/W2781832654","https://openalex.org/W2783711120","https://openalex.org/W2807354979","https://openalex.org/W2810071777","https://openalex.org/W2899605467","https://openalex.org/W2904542956","https://openalex.org/W2904698165","https://openalex.org/W2984350404","https://openalex.org/W2994710719","https://openalex.org/W2994912991","https://openalex.org/W3007217411","https://openalex.org/W3010252522","https://openalex.org/W3016850173","https://openalex.org/W3024959805","https://openalex.org/W3044618203","https://openalex.org/W3095443433","https://openalex.org/W3097788036","https://openalex.org/W3132096414","https://openalex.org/W3167469263","https://openalex.org/W3168900950","https://openalex.org/W4205851972","https://openalex.org/W4220657575","https://openalex.org/W4306408058","https://openalex.org/W4313384954","https://openalex.org/W4353044653","https://openalex.org/W4384561176","https://openalex.org/W4385977967","https://openalex.org/W4388425059","https://openalex.org/W4391955636","https://openalex.org/W4392283079","https://openalex.org/W4392302320","https://openalex.org/W4393234811","https://openalex.org/W4396748069"],"related_works":["https://openalex.org/W2774415968","https://openalex.org/W2299632915","https://openalex.org/W7135286272","https://openalex.org/W1989157069","https://openalex.org/W7162138489","https://openalex.org/W2978000970","https://openalex.org/W2891658737","https://openalex.org/W3213435600","https://openalex.org/W2776365853","https://openalex.org/W4417008466"],"abstract_inverted_index":{"Abstract":[0],"Many":[1],"inflammatory":[2,92],"stimuli":[3],"can":[4,35,48],"induce":[5],"progenitor":[6,43],"cells":[7,18],"in":[8,132,165],"the":[9,22,63,73,95,129,151,162,181,185],"bone":[10,96,138],"marrow":[11,97,139],"to":[12,124,126,179,189,199],"produce":[13],"increased":[14,89,103],"numbers":[15,90],"of":[16,21,24,85,91,98,105,114,131,161,187],"myeloid":[17],"as":[19,171],"part":[20],"process":[23],"emergency":[25,57],"myelopoiesis.":[26],"These":[27],"events":[28],"are":[29,148],"associated":[30],"with":[31,78,109],"innate":[32],"training":[33],"and":[34,42,88,111,136,175,203],"have":[36],"long-term":[37],"impacts":[38],"on":[39,191,197],"hematopoietic":[40,182],"stem":[41],"cell":[44],"(HSPC)":[45],"development":[46],"but":[47],"also":[49],"compromise":[50],"their":[51],"function.":[52],"While":[53],"many":[54],"cytokines":[55],"support":[56],"myelopoiesis,":[58],"less":[59],"is":[60],"known":[61],"about":[62],"mechanisms":[64],"that":[65,71,107,119,142,157,169],"temper":[66],"these":[67],"events.":[68],"When":[69],"mice":[70,100,147],"lack":[72],"cytokine":[74,115],"IL-27":[75,106,145,188],"were":[76,121],"infected":[77,99],"Toxoplasma":[79],"gondii,":[80],"there":[81,101],"was":[82,102],"enhanced":[83],"generation":[84],"monocyte":[86,152,201],"progenitors":[87],"monocytes.":[93],"In":[94],"production":[104],"localized":[108],"HSPCs":[110,120,143],"a":[112,176,194],"survey":[113],"receptor":[116],"expression":[117],"highlighted":[118,156],"uniquely":[122],"poised":[123],"respond":[125],"IL-27.":[127],"Furthermore,":[128],"use":[130],"vitro":[133],"differentiation":[134,198],"assays":[135],"mixed":[137],"chimeras":[140],"revealed":[141],"from":[144],"deficient":[146],"pre-disposed":[149],"towards":[150],"lineage.":[153],"Additional":[154],"studies":[155],"after":[158],"infection":[159],"loss":[160],"IL-27R":[163],"resulted":[164],"reduced":[166,172],"HSPC":[167,192,205],"fitness":[168],"manifested":[170],"proliferative":[173],"responses":[174],"decreased":[177],"ability":[178,186],"reconstitute":[180],"system.":[183],"Thus,":[184],"act":[190],"provides":[193],"regulatory":[195],"brake":[196],"limit":[200],"induction":[202],"preserve":[204],"stemness.":[206]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2025-04-24T00:00:00"}
