{"id":"https://openalex.org/W4409727646","doi":"https://doi.org/10.1097/bot.0000000000002997","title":"The Impact of Time to Surgical Debridement on Infection Rates in Open Tibial Shaft Fractures Treated With Immediate Medullary Nailing","display_name":"The Impact of Time to Surgical Debridement on Infection Rates in Open Tibial Shaft Fractures Treated With Immediate Medullary Nailing","publication_year":2025,"publication_date":"2025-04-23","ids":{"openalex":"https://openalex.org/W4409727646","doi":"https://doi.org/10.1097/bot.0000000000002997","pmid":"https://pubmed.ncbi.nlm.nih.gov/40266571"},"language":"en","primary_location":{"id":"doi:10.1097/bot.0000000000002997","doi":"https://doi.org/10.1097/bot.0000000000002997","is_oa":false,"landing_page_url":"https://doi.org/10.1097/bot.0000000000002997","pdf_url":null,"source":{"id":"https://openalex.org/S65618785","display_name":"Journal of Orthopaedic Trauma","issn_l":"0890-5339","issn":["0890-5339","1531-2291"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Orthopaedic Trauma","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088280917","display_name":"Mohamed Kareem Shaath","orcid":"https://orcid.org/0000-0002-4171-0434","observed_orcids":["https://orcid.org/0000-0002-4171-0434"]},"institutions":[{"id":"https://openalex.org/I103163165","display_name":"Florida State University","ror":"https://ror.org/05g3dte14","country_code":"US","type":"education","lineage":["https://openalex.org/I103163165"]},{"id":"https://openalex.org/I106165777","display_name":"University of Central Florida","ror":"https://ror.org/036nfer12","country_code":"US","type":"education","lineage":["https://openalex.org/I106165777"]},{"id":"https://openalex.org/I147878501","display_name":"Orlando Health","ror":"https://ror.org/0488cct49","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I147878501"]},{"id":"https://openalex.org/I4210122672","display_name":"Jewett Orthopaedic Clinic","ror":"https://ror.org/023jg3g40","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210122672"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mohamed Kareem Shaath","raw_affiliation_strings":["Florida State College of Medicine, Orlando, FL; and","Orlando Health Jewett Orthopedic Institute, Orlando, FL;","University of Central Florida College of Medicine, Orlando, FL","Florida State College of Medicine","Orlando Health Jewett Orthopedic Institute","University of Central Florida College of Medicine"],"raw_orcid":"https://orcid.org/0000-0002-4171-0434","affiliations":[{"raw_affiliation_string":"Florida State College of Medicine, Orlando, FL; and","institution_ids":["https://openalex.org/I103163165"]},{"raw_affiliation_string":"Orlando Health Jewett Orthopedic Institute, Orlando, FL;","institution_ids":["https://openalex.org/I147878501","https://openalex.org/I4210122672"]},{"raw_affiliation_string":"University of Central Florida College of Medicine, Orlando, FL","institution_ids":["https://openalex.org/I106165777"]},{"raw_affiliation_string":"Florida State College of Medicine","institution_ids":[]},{"raw_affiliation_string":"Orlando Health Jewett Orthopedic Institute","institution_ids":["https://openalex.org/I147878501","https://openalex.org/I4210122672"]},{"raw_affiliation_string":"University of Central Florida College of Medicine","institution_ids":["https://openalex.org/I106165777"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Rogerio Ferreira","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I147878501","display_name":"Orlando Health","ror":"https://ror.org/0488cct49","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I147878501"]},{"id":"https://openalex.org/I4210122672","display_name":"Jewett Orthopaedic Clinic","ror":"https://ror.org/023jg3g40","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210122672"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rogerio Ferreira","raw_affiliation_strings":["Orlando Health Jewett Orthopedic Institute, Orlando, FL;","Orlando Health Jewett Orthopedic Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Orlando Health Jewett Orthopedic Institute, Orlando, FL;","institution_ids":["https://openalex.org/I147878501","https://openalex.org/I4210122672"]},{"raw_affiliation_string":"Orlando Health Jewett Orthopedic Institute","institution_ids":["https://openalex.org/I147878501","https://openalex.org/I4210122672"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087018273","display_name":"Brendan Page","orcid":"https://orcid.org/0000-0002-3128-6721","observed_orcids":["https://orcid.org/0000-0002-3128-6721"]},"institutions":[{"id":"https://openalex.org/I147878501","display_name":"Orlando Health","ror":"https://ror.org/0488cct49","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I147878501"]},{"id":"https://openalex.org/I4210122672","display_name":"Jewett Orthopaedic Clinic","ror":"https://ror.org/023jg3g40","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210122672"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brendan Page","raw_affiliation_strings":["Orlando Health Jewett Orthopedic Institute, Orlando, FL;","Orlando Health Jewett Orthopedic Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Orlando Health Jewett Orthopedic Institute, Orlando, FL;","institution_ids":["https://openalex.org/I147878501","https://openalex.org/I4210122672"]},{"raw_affiliation_string":"Orlando Health Jewett Orthopedic Institute","institution_ids":["https://openalex.org/I147878501","https://openalex.org/I4210122672"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032606175","display_name":"Griffin R. Rechter","orcid":"https://orcid.org/0000-0002-0218-5024","observed_orcids":["https://orcid.org/0000-0002-0218-5024"]},"institutions":[{"id":"https://openalex.org/I147878501","display_name":"Orlando Health","ror":"https://ror.org/0488cct49","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I147878501"]},{"id":"https://openalex.org/I4210122672","display_name":"Jewett Orthopaedic Clinic","ror":"https://ror.org/023jg3g40","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210122672"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Griffin R. Rechter","raw_affiliation_strings":["Orlando Health Jewett Orthopedic Institute, Orlando, FL;","Orlando Health Jewett Orthopedic Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Orlando Health Jewett Orthopedic Institute, Orlando, FL;","institution_ids":["https://openalex.org/I147878501","https://openalex.org/I4210122672"]},{"raw_affiliation_string":"Orlando Health Jewett Orthopedic Institute","institution_ids":["https://openalex.org/I147878501","https://openalex.org/I4210122672"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Bader A. Nasir","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I147878501","display_name":"Orlando Health","ror":"https://ror.org/0488cct49","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I147878501"]},{"id":"https://openalex.org/I4210122672","display_name":"Jewett Orthopaedic Clinic","ror":"https://ror.org/023jg3g40","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210122672"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bader A. Nasir","raw_affiliation_strings":["Orlando Health Jewett Orthopedic Institute, Orlando, FL;","Orlando Health Jewett Orthopedic Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Orlando Health Jewett Orthopedic Institute, Orlando, FL;","institution_ids":["https://openalex.org/I147878501","https://openalex.org/I4210122672"]},{"raw_affiliation_string":"Orlando Health Jewett Orthopedic Institute","institution_ids":["https://openalex.org/I147878501","https://openalex.org/I4210122672"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070438706","display_name":"George John Haidukewych","orcid":"https://orcid.org/0000-0002-0193-0969","observed_orcids":["https://orcid.org/0000-0002-0193-0969"]},"institutions":[{"id":"https://openalex.org/I103163165","display_name":"Florida State University","ror":"https://ror.org/05g3dte14","country_code":"US","type":"education","lineage":["https://openalex.org/I103163165"]},{"id":"https://openalex.org/I106165777","display_name":"University of Central Florida","ror":"https://ror.org/036nfer12","country_code":"US","type":"education","lineage":["https://openalex.org/I106165777"]},{"id":"https://openalex.org/I147878501","display_name":"Orlando Health","ror":"https://ror.org/0488cct49","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I147878501"]},{"id":"https://openalex.org/I4210122672","display_name":"Jewett Orthopaedic Clinic","ror":"https://ror.org/023jg3g40","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210122672"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George J. Haidukewych","raw_affiliation_strings":["Florida State College of Medicine, Orlando, FL; and","Orlando Health Jewett Orthopedic Institute, Orlando, FL;","University of Central Florida College of Medicine, Orlando, FL","Florida State College of Medicine","Orlando Health Jewett Orthopedic Institute","University of Central Florida College of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Florida State College of Medicine, Orlando, FL; and","institution_ids":["https://openalex.org/I103163165"]},{"raw_affiliation_string":"Orlando Health Jewett Orthopedic Institute, Orlando, FL;","institution_ids":["https://openalex.org/I147878501","https://openalex.org/I4210122672"]},{"raw_affiliation_string":"University of Central Florida College of Medicine, Orlando, FL","institution_ids":["https://openalex.org/I106165777"]},{"raw_affiliation_string":"Florida State College of Medicine","institution_ids":[]},{"raw_affiliation_string":"Orlando Health Jewett Orthopedic Institute","institution_ids":["https://openalex.org/I147878501","https://openalex.org/I4210122672"]},{"raw_affiliation_string":"University of Central Florida College of Medicine","institution_ids":["https://openalex.org/I106165777"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2089,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.77797497,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":97},"biblio":{"volume":"39","issue":"8","first_page":"409","last_page":"413"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10658","display_name":"Bone fractures and treatments","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10658","display_name":"Bone fractures and treatments","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11293","display_name":"Orthopedic Infections and Treatments","score":0.014499999582767487,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11080","display_name":"Surgical site infection prevention","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/open-tibial-shaft-fractures","display_name":"open tibial shaft fractures","score":0.9660000205039978},{"id":"https://openalex.org/keywords/intramedullary-nailing","display_name":"intramedullary nailing","score":0.8349999785423279},{"id":"https://openalex.org/keywords/deep-infection","display_name":"deep infection","score":0.5899999737739563},{"id":"https://openalex.org/keywords/postoperative-infection","display_name":"postoperative infection","score":0.5649999976158142},{"id":"https://openalex.org/keywords/irrigation-and-debridement","display_name":"irrigation and debridement","score":0.8349999785423279},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.3109999895095825},{"id":"https://openalex.org/keywords/smoking","display_name":"smoking","score":0.9819999933242798},{"id":"https://openalex.org/keywords/risk-factors-for-infection","display_name":"infection risk factors","score":0.6290000081062317},{"id":"https://openalex.org/keywords/soft-tissue-coverage","display_name":"soft tissue coverage","score":0.6740000247955322},{"id":"https://openalex.org/keywords/timing-of-surgery","display_name":"timing of surgery","score":0.32600000500679016},{"id":"https://openalex.org/keywords/limb-salvage","display_name":"limb salvage","score":0.34200000762939453},{"id":"https://openalex.org/keywords/nonunion","display_name":"nonunion","score":0.38100001215934753},{"id":"https://openalex.org/keywords/reoperation","display_name":"reoperation","score":0.37599998712539673},{"id":"https://openalex.org/keywords/length-of-hospital-stay","display_name":"length of hospital stay","score":0.5009999871253967}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9825723171234131},{"id":"https://openalex.org/C195121873","wikidata":"https://www.wikidata.org/wiki/Q1131385","display_name":"Medullary cavity","level":2,"score":0.8323595523834229},{"id":"https://openalex.org/C2777438270","wikidata":"https://www.wikidata.org/wiki/Q5248564","display_name":"Debridement (dental)","level":2,"score":0.7038892507553101},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.6331090331077576},{"id":"https://openalex.org/C3018971929","wikidata":"https://www.wikidata.org/wiki/Q3080304","display_name":"Open fracture","level":3,"score":0.6129503846168518},{"id":"https://openalex.org/C68312169","wikidata":"https://www.wikidata.org/wiki/Q216685","display_name":"Orthopedic surgery","level":2,"score":0.4246594309806824},{"id":"https://openalex.org/C2777236700","wikidata":"https://www.wikidata.org/wiki/Q178366","display_name":"Tibia","level":2,"score":0.4152575135231018},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.10916537046432495}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1097/bot.0000000000002997","doi":"https://doi.org/10.1097/bot.0000000000002997","is_oa":false,"landing_page_url":"https://doi.org/10.1097/bot.0000000000002997","pdf_url":null,"source":{"id":"https://openalex.org/S65618785","display_name":"Journal of Orthopaedic Trauma","issn_l":"0890-5339","issn":["0890-5339","1531-2291"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Orthopaedic Trauma","raw_type":"journal-article"},{"id":"pmid:40266571","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40266571","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of orthopaedic trauma","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8600000143051147}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W170802749","https://openalex.org/W1931183062","https://openalex.org/W1996583804","https://openalex.org/W2012099970","https://openalex.org/W2019856358","https://openalex.org/W2020341428","https://openalex.org/W2026849248","https://openalex.org/W2026917545","https://openalex.org/W2044278667","https://openalex.org/W2054429969","https://openalex.org/W2056845345","https://openalex.org/W2089560383","https://openalex.org/W2144087471","https://openalex.org/W2150127991","https://openalex.org/W2153413762","https://openalex.org/W2188067640","https://openalex.org/W2299342878","https://openalex.org/W2333766890","https://openalex.org/W2777366205","https://openalex.org/W2908482416","https://openalex.org/W2947147947","https://openalex.org/W3012825094","https://openalex.org/W3113094569","https://openalex.org/W3135059867"],"related_works":["https://openalex.org/W2388016463","https://openalex.org/W2093260177","https://openalex.org/W2153413762","https://openalex.org/W2328115840","https://openalex.org/W2047007034","https://openalex.org/W1980041032","https://openalex.org/W2549666337","https://openalex.org/W2267325649","https://openalex.org/W4236269522","https://openalex.org/W2032349877"],"abstract_inverted_index":{"OBJECTIVES:":[0],"To":[1],"evaluate":[2],"whether":[3,180],"time":[4,192,199,415,421,463,469],"to":[5,48,128,133,143,155,159,163,178,193,352,376,381,401,416,464,474],"surgical":[6,144],"debridement":[7,145,194,417],"and":[8,55,73,166,191,232,250,288,296,304,307,343,424,437,442],"medullary":[9,455],"nailing":[10,79,456],"of":[11,18,61,71,99,122,203,208,217,274,316,357,451,457],"open":[12,39,458],"tibial":[13,40,459],"shaft":[14,41,460],"fractures":[15,42,88,108,445],"was":[16,119,135,354,471],"predictive":[17,202,356],"infection.":[19,204],"METHODS:":[20],"Design:":[21],"Retrospective":[22],"chart":[23],"review.":[24],"SETTING:":[25],"Single,":[26],"academic,":[27],"level-1":[28,50],"trauma":[29,51],"center.":[30],"PATIENT":[31],"SELECTION":[32],"CRITERIA:":[33],"All":[34,65],"skeletally":[35],"mature":[36],"patients":[37,66,210,228,234,276,284,292,300,309,365],"with":[38,57,85,105,213,366],"(AO/OTA":[43],"type":[44,86,106,242,247,253,258,264,270,326,333,340,348,368,443],"42)":[45],"who":[46,89],"presented":[47],"a":[49,58,126,138,214,367,476],"center":[52],"between":[53,286,294,302],"2012":[54],"2024":[56],"minimum":[59],"follow-up":[60],"3-months":[62],"were":[63,109,146,176,201,223,236,239,263,269,278,320,371,396,446],"included.":[64,224],"underwent":[67],"definitive":[68],"treatment":[69],"consisting":[70],"irrigation":[72],"debridement,":[74,465],"followed":[75],"by":[76],"immediate":[77,454],"intramedullary":[78],"during":[80],"the":[81,120,129,196,257,419,467],"same":[82],"anesthetic.":[83],"Patients":[84],"IIIB":[87,349,369,444],"did":[90,427],"not":[91,355,428,472],"receive":[92],"soft":[93],"tissue":[94],"coverage":[95],"within":[96,280,466],"7":[97],"days":[98],"presentation,":[100],"as":[101,103,137,148,448],"well":[102],"those":[104],"IIIC":[107],"excluded.":[110],"OUTCOME":[111],"MEASURES":[112],"AND":[113],"COMPARISONS:":[114],"The":[115],"primary":[116],"outcome":[117],"measure":[118],"incidence":[121],"deep":[123],"infection":[124,358,379,404,431,452],"necessitating":[125],"return":[127],"operating":[130],"room.":[131],"Time":[132,141,351],"surgery":[134,353],"evaluated":[136],"secondary":[139],"outcome.":[140],"intervals":[142],"categorized":[147,198,468],"follows:":[149],"less":[150],"than":[151,168],"6":[152,154,281,287,322],"hours,":[153,157,161,165,282,290,298,306],"12":[156,158,289,295],"18":[160,162,297,303],"24":[164,169,227,305,312],"greater":[167],"hours.":[170,313],"Multivariate":[171],"binary":[172],"logistic":[173],"regression":[174,361],"analyses":[175],"performed":[177],"determine":[179],"key":[181],"factors,":[182],"including":[183],"age,":[184],"diabetes,":[185,423],"fracture":[186,370,383],"type,":[187],"smoking,":[188],"ASA":[189,425],"classification,":[190],"at":[195,418],"previously":[197],"points":[200],"RESULTS:":[205],"A":[206,272,314],"total":[207,273,315],"393":[209],"(306":[211],"males)":[212],"mean":[215],"age":[216],"38":[218],"years":[219],"(range":[220],"15-87":[221],"years)":[222],"Of":[225,256],"these,":[226],"(6%)":[229],"had":[230],"diabetes":[231],"126":[233],"(32%)":[235,268],"smokers.":[237],"There":[238],"78":[240],"(20%)":[241,331],"I":[243,327],"fractures,":[244,249,260,328,335,342,461],"170":[245],"(43%)":[246],"II":[248,334],"144":[251],"(37%)":[252],"III":[254,259],"fractures.":[255,350],"99":[261],"(68%)":[262],"IIIA":[265,341],"while":[266],"45":[267],"IIIB.":[271],"32":[275],"(8%)":[277],"treated":[279],"111":[283],"(28%)":[285],"131":[291],"(33%)":[293],"69":[299],"(18%)":[301],"50":[308],"(13%)":[310,324],"after":[311],"46":[317],"infections":[318,323,330,337,345],"(12.5%)":[319],"observed:":[321],"in":[325,332,339,347],"14":[329],"10":[336],"(22%)":[338],"16":[344],"(35%)":[346],"(p=0.31).":[359],"Logistic":[360],"analysis":[362],"showed":[363],"that":[364],"6.1":[372],"times":[373,398],"more":[374,399],"likely":[375,400],"develop":[377,402],"an":[378,403],"compared":[380],"other":[382],"types":[384],"(OR":[385,405],"=":[386,393,406,412,433],"6.147,":[387],"95%":[388,408],"CI:":[389,409],"1.975-":[390],"19.129,":[391],"p":[392],"0.002).":[394],"Smokers":[395],"2.8":[397],"2.779,":[407],"1.357-5.691,":[410],"P":[411],"0.005).":[413],"Age,":[414],"specified":[420],"points,":[422,470],"classification":[426],"significantly":[429],"predict":[430],"(p":[432],"0.32,":[434],"0.31,":[435],"0.27,":[436],"0.50,":[438],"respectively).":[439],"CONCLUSIONS:":[440],"Smoking":[441],"identified":[447],"significant":[449,477],"predictors":[450],"following":[453],"whereas":[462],"found":[473],"be":[475],"factor.":[478]},"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}
