{"id":"https://openalex.org/W4409727550","doi":"https://doi.org/10.1016/j.bone.2025.117494","title":"Oral versus intravenous antibiotics for bone and joint infections: Systematic review and meta-analysis of randomized controlled trials","display_name":"Oral versus intravenous antibiotics for bone and joint infections: Systematic review and meta-analysis of randomized controlled trials","publication_year":2025,"publication_date":"2025-04-23","ids":{"openalex":"https://openalex.org/W4409727550","doi":"https://doi.org/10.1016/j.bone.2025.117494","pmid":"https://pubmed.ncbi.nlm.nih.gov/40280255"},"language":"en","primary_location":{"id":"doi:10.1016/j.bone.2025.117494","doi":"https://doi.org/10.1016/j.bone.2025.117494","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bone.2025.117494","pdf_url":null,"source":{"id":"https://openalex.org/S121725775","display_name":"Bone","issn_l":"1873-2763","issn":["1873-2763","8756-3282"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bone","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Jo\u00e3o P.C. Lima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210111429","display_name":"Hospital S\u00e3o Vicente de Paulo","ror":"https://ror.org/01pmf1z12","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210111429"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Jo\u00e3o P.C. Lima","raw_affiliation_strings":["Department of Medicine, UniREDENTOR/Afya, Itaperuna, Brazil; Department of Research, Hospital S\u00e3o Vicente de Paulo, Bom Jesus do Itabapoana, Brazil. Electronic address: itsjoaopedrocampos@gmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, UniREDENTOR/Afya, Itaperuna, Brazil; Department of Research, Hospital S\u00e3o Vicente de Paulo, Bom Jesus do Itabapoana, Brazil. Electronic address: itsjoaopedrocampos@gmail.com","institution_ids":["https://openalex.org/I4210111429"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047731831","display_name":"Kau\u00ea Abreu Chagas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088694","display_name":"Faculdade Redentor","ror":"https://ror.org/00720xw25","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210088694"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Kau\u00ea A. Chagas","raw_affiliation_strings":["Department of Medicine, UniREDENTOR/Afya, Itaperuna, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, UniREDENTOR/Afya, Itaperuna, Brazil","institution_ids":["https://openalex.org/I4210088694"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Lucas B.P. Oliveira","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088694","display_name":"Faculdade Redentor","ror":"https://ror.org/00720xw25","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210088694"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Lucas B.P. Oliveira","raw_affiliation_strings":["Department of Medicine, UniREDENTOR/Afya, Itaperuna, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, UniREDENTOR/Afya, Itaperuna, Brazil","institution_ids":["https://openalex.org/I4210088694"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5117275412","display_name":"Bruno S B Filho","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088694","display_name":"Faculdade Redentor","ror":"https://ror.org/00720xw25","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210088694"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Bruno S.B. Filho","raw_affiliation_strings":["Department of Medicine, UniREDENTOR/Afya, Itaperuna, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, UniREDENTOR/Afya, Itaperuna, Brazil","institution_ids":["https://openalex.org/I4210088694"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038149494","display_name":"Fl\u00e1via MR Vital","orcid":"https://orcid.org/0000-0003-3269-0088","observed_orcids":["https://orcid.org/0000-0003-3269-0088"]},"institutions":[{"id":"https://openalex.org/I4210088694","display_name":"Faculdade Redentor","ror":"https://ror.org/00720xw25","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210088694"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Fl\u00e1via M.R. Vital","raw_affiliation_strings":["Department of Medicine, UniREDENTOR/Afya, Itaperuna, Brazil; Department of Research, Funda\u00e7\u00e3o Cristiano Varella, Muria\u00e9, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, UniREDENTOR/Afya, Itaperuna, Brazil; Department of Research, Funda\u00e7\u00e3o Cristiano Varella, Muria\u00e9, Brazil","institution_ids":["https://openalex.org/I4210088694"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210111429"],"apc_list":{"value":3960,"currency":"USD","value_usd":3960},"apc_paid":null,"fwci":1.5675,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.80548254,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"196","issue":null,"first_page":"117494","last_page":"117494"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11293","display_name":"Orthopedic Infections and Treatments","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11293","display_name":"Orthopedic Infections and Treatments","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10897","display_name":"Antibiotic Use and Resistance","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bone-and-joint-infections","display_name":"bone and joint infections","score":0.8259999752044678},{"id":"https://openalex.org/keywords/osteomyelitis","display_name":"osteomyelitis","score":0.9020000100135803},{"id":"https://openalex.org/keywords/oral-antibiotics","display_name":"oral antibiotics","score":0.8149999976158142},{"id":"https://openalex.org/keywords/intravenous-antibiotics","display_name":"intravenous antibiotics","score":0.9980000257492065},{"id":"https://openalex.org/keywords/antibiotic-therapy","display_name":"antibiotic therapy","score":0.414000004529953},{"id":"https://openalex.org/keywords/treatment-failure","display_name":"treatment failure","score":0.8550000190734863},{"id":"https://openalex.org/keywords/recurrent-infections","display_name":"recurrent infections","score":0.7250000238418579},{"id":"https://openalex.org/keywords/superinfection","display_name":"superinfection","score":0.9150000214576721},{"id":"https://openalex.org/keywords/length-of-hospital-stay","display_name":"length of hospital stay","score":0.843999981880188},{"id":"https://openalex.org/keywords/fracture-related-infection","display_name":"fracture-related infection","score":0.703000009059906}],"concepts":[{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.8235980272293091},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7584099769592285},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.7329528331756592},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.5638282895088196},{"id":"https://openalex.org/C3020230634","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Intravenous antibiotics","level":3,"score":0.485578715801239},{"id":"https://openalex.org/C3020326648","wikidata":"https://www.wikidata.org/wiki/Q924421","display_name":"Joint infections","level":4,"score":0.4729727804660797},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37940624356269836},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.33950698375701904},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.21133270859718323},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.11720612645149231},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.06971988081932068},{"id":"https://openalex.org/C2778336525","wikidata":"https://www.wikidata.org/wiki/Q708178","display_name":"Arthroplasty","level":2,"score":0.0},{"id":"https://openalex.org/C2778120723","wikidata":"https://www.wikidata.org/wiki/Q16872681","display_name":"Periprosthetic","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001850","descriptor_name":"Bone Diseases, Infectious","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061605","descriptor_name":"Administration, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.bone.2025.117494","doi":"https://doi.org/10.1016/j.bone.2025.117494","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bone.2025.117494","pdf_url":null,"source":{"id":"https://openalex.org/S121725775","display_name":"Bone","issn_l":"1873-2763","issn":["1873-2763","8756-3282"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bone","raw_type":"journal-article"},{"id":"pmid:40280255","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40280255","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bone","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"},{"display_name":"Meta-Analysis","id":"https://openalex.org/study-designs/meta-analysis"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W1984254945","https://openalex.org/W2020611199","https://openalex.org/W2025130596","https://openalex.org/W2038571788","https://openalex.org/W2041395411","https://openalex.org/W2068494910","https://openalex.org/W2074508865","https://openalex.org/W2101137840","https://openalex.org/W2111956140","https://openalex.org/W2120535511","https://openalex.org/W2124042548","https://openalex.org/W2131704332","https://openalex.org/W2217768243","https://openalex.org/W2287532490","https://openalex.org/W2330042664","https://openalex.org/W2332243705","https://openalex.org/W2409461703","https://openalex.org/W2612480126","https://openalex.org/W2743552350","https://openalex.org/W2796711734","https://openalex.org/W2804207600","https://openalex.org/W2914477527","https://openalex.org/W2914625246","https://openalex.org/W2941848295","https://openalex.org/W2956366322","https://openalex.org/W2970684805","https://openalex.org/W2984662682","https://openalex.org/W3005817986","https://openalex.org/W3008206894","https://openalex.org/W3011293552","https://openalex.org/W3113066677","https://openalex.org/W3118615836","https://openalex.org/W3175160140","https://openalex.org/W3209878046","https://openalex.org/W4241464497","https://openalex.org/W4282011463","https://openalex.org/W4291283185","https://openalex.org/W4362507146","https://openalex.org/W4367678806","https://openalex.org/W4376256622","https://openalex.org/W4400641236","https://openalex.org/W4406693340","https://openalex.org/W6798096552"],"related_works":["https://openalex.org/W7167912213","https://openalex.org/W2966083096","https://openalex.org/W6921670399","https://openalex.org/W2794784072","https://openalex.org/W2994879298","https://openalex.org/W3086784454","https://openalex.org/W4200227347","https://openalex.org/W6995554237","https://openalex.org/W2215744541","https://openalex.org/W7143323959"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":2}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2025-04-24T00:00:00"}
