{"id":"https://openalex.org/W4409727196","doi":"https://doi.org/10.1101/2025.04.14.647515","title":"Plasmodium Repetome: A mysterious space with a wealth of information","display_name":"Plasmodium Repetome: A mysterious space with a wealth of information","publication_year":2025,"publication_date":"2025-04-19","ids":{"openalex":"https://openalex.org/W4409727196","doi":"https://doi.org/10.1101/2025.04.14.647515"},"language":"en","primary_location":{"id":"doi:10.1101/2025.04.14.647515","doi":"https://doi.org/10.1101/2025.04.14.647515","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.04.14.647515","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2025/04/19/2025.04.14.647515.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2025/04/19/2025.04.14.647515.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Satinder Kaur","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165682329","display_name":"Guru Nanak Dev University","ror":"https://ror.org/05ghzpa93","country_code":"IN","type":"education","lineage":["https://openalex.org/I165682329"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Satinder Kaur","raw_affiliation_strings":["Department of Molecular Biology and Biochemistry, GNDU, Amritsar"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Biochemistry, GNDU, Amritsar","institution_ids":["https://openalex.org/I165682329"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Vikash Kumar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165682329","display_name":"Guru Nanak Dev University","ror":"https://ror.org/05ghzpa93","country_code":"IN","type":"education","lineage":["https://openalex.org/I165682329"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Vikash Kumar","raw_affiliation_strings":["Department of Molecular Biology and Biochemistry, GNDU, Amritsar"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Biochemistry, GNDU, Amritsar","institution_ids":["https://openalex.org/I165682329"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065407436","display_name":"Karanbir Singh","orcid":"https://orcid.org/0000-0002-4595-5586","observed_orcids":["https://orcid.org/0000-0002-4595-5586"]},"institutions":[{"id":"https://openalex.org/I165682329","display_name":"Guru Nanak Dev University","ror":"https://ror.org/05ghzpa93","country_code":"IN","type":"education","lineage":["https://openalex.org/I165682329"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Karanbir Singh","raw_affiliation_strings":["Department of Molecular Biology and Biochemistry, GNDU, Amritsar"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Biochemistry, GNDU, Amritsar","institution_ids":["https://openalex.org/I165682329"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084550328","display_name":"Ankita Behl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165682329","display_name":"Guru Nanak Dev University","ror":"https://ror.org/05ghzpa93","country_code":"IN","type":"education","lineage":["https://openalex.org/I165682329"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Ankita Behl","raw_affiliation_strings":["Department of Biotechnology, GNDU, Amritsar"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, GNDU, Amritsar","institution_ids":["https://openalex.org/I165682329"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093351356","display_name":"Arpna","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165682329","display_name":"Guru Nanak Dev University","ror":"https://ror.org/05ghzpa93","country_code":"IN","type":"education","lineage":["https://openalex.org/I165682329"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Arpna","raw_affiliation_strings":["Department of Molecular Biology and Biochemistry, GNDU, Amritsar"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Biochemistry, GNDU, Amritsar","institution_ids":["https://openalex.org/I165682329"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001968958","display_name":"Prakash Chandra Mishra","orcid":"https://orcid.org/0000-0002-6059-7174","observed_orcids":["https://orcid.org/0000-0002-6059-7174"]},"institutions":[{"id":"https://openalex.org/I165682329","display_name":"Guru Nanak Dev University","ror":"https://ror.org/05ghzpa93","country_code":"IN","type":"education","lineage":["https://openalex.org/I165682329"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Prakash Chandra Mishra","raw_affiliation_strings":["Department of Biotechnology, GNDU, Amritsar"],"raw_orcid":"https://orcid.org/0000-0002-6059-7174","affiliations":[{"raw_affiliation_string":"Department of Biotechnology, GNDU, Amritsar","institution_ids":["https://openalex.org/I165682329"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053537530","display_name":"Rachna Hora","orcid":"https://orcid.org/0000-0002-6085-8389","observed_orcids":["https://orcid.org/0000-0002-6085-8389"]},"institutions":[{"id":"https://openalex.org/I165682329","display_name":"Guru Nanak Dev University","ror":"https://ror.org/05ghzpa93","country_code":"IN","type":"education","lineage":["https://openalex.org/I165682329"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Rachna Hora","raw_affiliation_strings":["Department of Molecular Biology and Biochemistry, GNDU, Amritsar"],"raw_orcid":"https://orcid.org/0000-0002-6085-8389","affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Biochemistry, GNDU, Amritsar","institution_ids":["https://openalex.org/I165682329"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5001968958","https://openalex.org/A5053537530"],"corresponding_institution_ids":["https://openalex.org/I165682329"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plasmodium","display_name":"Plasmodium","score":0.8309999704360962},{"id":"https://openalex.org/keywords/tandem-repeats","display_name":"tandem repeats","score":0.902999997138977},{"id":"https://openalex.org/keywords/repetitive-amino-acid-sequences","display_name":"repetitive amino acid sequences","score":0.5830000042915344},{"id":"https://openalex.org/keywords/plasmodium-falciparum","display_name":"Plasmodium falciparum","score":0.9639999866485596},{"id":"https://openalex.org/keywords/plasmodium-vivax","display_name":"Plasmodium vivax","score":1.0},{"id":"https://openalex.org/keywords/protein-export","display_name":"protein export","score":0.47099998593330383},{"id":"https://openalex.org/keywords/immune-evasion","display_name":"immune evasion","score":0.9769999980926514},{"id":"https://openalex.org/keywords/variable-surface-antigens","display_name":"variable surface antigens","score":0.746999979019165},{"id":"https://openalex.org/keywords/replication-slippage","display_name":"replication slippage","score":0.8040000200271606},{"id":"https://openalex.org/keywords/positive-selection","display_name":"positive selection","score":0.8980000019073486},{"id":"https://openalex.org/keywords/asparagine","display_name":"asparagine","score":0.6510000228881836},{"id":"https://openalex.org/keywords/supersecondary-structure","display_name":"supersecondary structure","score":0.6449999809265137},{"id":"https://openalex.org/keywords/protein-localization","display_name":"protein localization","score":0.5339999794960022},{"id":"https://openalex.org/keywords/gene-ontology","display_name":"Gene Ontology","score":0.5899999737739563}],"concepts":[{"id":"https://openalex.org/C2778572836","wikidata":"https://www.wikidata.org/wiki/Q380933","display_name":"Space (punctuation)","level":2,"score":0.6049711108207703},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.36124682426452637},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1101/2025.04.14.647515","doi":"https://doi.org/10.1101/2025.04.14.647515","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.04.14.647515","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2025/04/19/2025.04.14.647515.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1101/2025.04.14.647515","doi":"https://doi.org/10.1101/2025.04.14.647515","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.04.14.647515","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2025/04/19/2025.04.14.647515.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4409727196.pdf","grobid_xml":"https://content.openalex.org/works/W4409727196.grobid-xml"},"referenced_works_count":112,"referenced_works":["https://openalex.org/W133512539","https://openalex.org/W1499198785","https://openalex.org/W1963964944","https://openalex.org/W1965910641","https://openalex.org/W1968967605","https://openalex.org/W1970280049","https://openalex.org/W1971071440","https://openalex.org/W1977677374","https://openalex.org/W1986676184","https://openalex.org/W1986769472","https://openalex.org/W1988972558","https://openalex.org/W1991342096","https://openalex.org/W1991731239","https://openalex.org/W1993166171","https://openalex.org/W1996333777","https://openalex.org/W2004384173","https://openalex.org/W2004435774","https://openalex.org/W2005685893","https://openalex.org/W2012128918","https://openalex.org/W2015082048","https://openalex.org/W2018731733","https://openalex.org/W2023114159","https://openalex.org/W2027171056","https://openalex.org/W2029372771","https://openalex.org/W2039994188","https://openalex.org/W2046320595","https://openalex.org/W2049402769","https://openalex.org/W2049700891","https://openalex.org/W2049797818","https://openalex.org/W2051569783","https://openalex.org/W2052523483","https://openalex.org/W2053948426","https://openalex.org/W2054681398","https://openalex.org/W2056828940","https://openalex.org/W2060809301","https://openalex.org/W2066688961","https://openalex.org/W2068495725","https://openalex.org/W2069764731","https://openalex.org/W2072300667","https://openalex.org/W2073268533","https://openalex.org/W2075700927","https://openalex.org/W2076384712","https://openalex.org/W2076387494","https://openalex.org/W2076615456","https://openalex.org/W2077013312","https://openalex.org/W2079165897","https://openalex.org/W2080585834","https://openalex.org/W2083280521","https://openalex.org/W2084881478","https://openalex.org/W2087449281","https://openalex.org/W2095369948","https://openalex.org/W2096425463","https://openalex.org/W2102549002","https://openalex.org/W2110434201","https://openalex.org/W2113174682","https://openalex.org/W2116423958","https://openalex.org/W2118557791","https://openalex.org/W2126876237","https://openalex.org/W2129117190","https://openalex.org/W2129328366","https://openalex.org/W2130479394","https://openalex.org/W2132179389","https://openalex.org/W2132773532","https://openalex.org/W2132781864","https://openalex.org/W2135409136","https://openalex.org/W2136522326","https://openalex.org/W2138751727","https://openalex.org/W2143370123","https://openalex.org/W2143399071","https://openalex.org/W2145617194","https://openalex.org/W2146472503","https://openalex.org/W2148621849","https://openalex.org/W2149459456","https://openalex.org/W2153893707","https://openalex.org/W2155827721","https://openalex.org/W2156012420","https://openalex.org/W2156022009","https://openalex.org/W2157282532","https://openalex.org/W2158875508","https://openalex.org/W2161162374","https://openalex.org/W2169185843","https://openalex.org/W2169300762","https://openalex.org/W2170142510","https://openalex.org/W2170535845","https://openalex.org/W2172154503","https://openalex.org/W2228248433","https://openalex.org/W2238875425","https://openalex.org/W2400954299","https://openalex.org/W2765886061","https://openalex.org/W2768477255","https://openalex.org/W2904765466","https://openalex.org/W2942212856","https://openalex.org/W2980016529","https://openalex.org/W3010878318","https://openalex.org/W3017136048","https://openalex.org/W3036319615","https://openalex.org/W3080829022","https://openalex.org/W3095528982","https://openalex.org/W3119569277","https://openalex.org/W3125860677","https://openalex.org/W3177828909","https://openalex.org/W4210833982","https://openalex.org/W4244736178","https://openalex.org/W4254848468","https://openalex.org/W4308616064","https://openalex.org/W4320856678","https://openalex.org/W4328142518","https://openalex.org/W4367052125","https://openalex.org/W4376598486","https://openalex.org/W4388464011","https://openalex.org/W4390086319","https://openalex.org/W4399980909"],"related_works":["https://openalex.org/W7124740765","https://openalex.org/W2765886061","https://openalex.org/W2402225322","https://openalex.org/W2056299698","https://openalex.org/W1977009223","https://openalex.org/W7166335066","https://openalex.org/W1973507234","https://openalex.org/W2083766157","https://openalex.org/W2055276101","https://openalex.org/W1977677374"],"abstract_inverted_index":{"ABSTRACT":[0],"Eukaryotic":[1],"proteomes":[2],"harbour":[3],"repetitive":[4],"stretches":[5],"of":[6,17,39,53,82,94,111,146,197,228,246],"amino":[7,117],"acids":[8,118],"that":[9,18,208],"may":[10],"play":[11],"critical":[12],"roles":[13,176],"in":[14,73,98,115,127,177,230],"the":[15,36,50,59,160,226,244],"biology":[16,233],"organism.":[19],"While":[20],"several":[21,93,201],"tandem":[22],"repeats":[23,202],"(TR)":[24],"are":[25,166,209],"known":[26,210],"to":[27,29,69,89,153,203,211,222,239],"contribute":[28],"protein":[30,241],"structure":[31,195],"and":[32,57,66,105,119,129,140,162,234],"function,":[33],"information":[34],"about":[35],"vast":[37],"majority":[38],"repeat":[40,51,109,188,247],"regions":[41,75,110,199],"remains":[42],"obscure.":[43],"In":[44],"this":[45,86,216],"article,":[46],"we":[47],"have":[48],"analysed":[49],"content":[52,189],"different":[54],"Plasmodium":[55],"species":[56],"found":[58],"leading":[60],"human":[61],"malaria-causing":[62],"P.":[63,67],"falciparum":[64],"(Pf)":[65],"vivax":[68],"be":[70],"exceptionally":[71],"rich":[72],"TR":[74,77,147,198],"(>40%":[76],"containing":[78,148],"proteins).":[79],"Detailed":[80],"analysis":[81,145],"Pf":[83,112,149,170],"\u2018repetome\u2019":[84],"showed":[85],"intracellular":[87],"parasite":[88,103,232],"carry":[90],"longer":[91],"TRs,":[92,131],"which":[95],"were":[96,113],"present":[97,190],"exported":[99],"proteins":[100,150],"important":[101,178],"for":[102],"survival":[104],"immune":[106,183],"evasion.":[107],"The":[108,169],"enriched":[114],"acidic":[116],"asparagine":[120],"(Asn),":[121],"where":[122],"Asn":[123],"was":[124],"more":[125],"abundant":[126],"short":[128],"intermediate":[130],"suggesting":[132],"an":[133],"evolutionary":[134],"bias":[135],"influenced":[136],"by":[137],"replication":[138],"slippage":[139],"positive":[141],"selection.":[142],"Gene":[143],"ontology":[144],"helped":[151],"us":[152],"understand":[154],"their":[155],"cellular":[156],"localization":[157],"along":[158],"with":[159,175],"molecular":[161],"biological":[163],"processes":[164,180],"they":[165],"involved":[167],"in.":[168],"variable":[171],"surface":[172],"antigen":[173],"families":[174],"pathogenic":[179],"like":[181],"cytoadherence,":[182],"evasion":[184],"etc.":[185],"had":[186],"low":[187],"within":[191],"seroreactive":[192],"peptides.":[193],"Three-dimensional":[194],"predictions":[196],"revealed":[200],"adopt":[204],"ordered":[205],"super-secondary":[206],"conformations":[207],"facilitate":[212],"intermolecular":[213],"interactions.":[214],"Overall,":[215],"is":[217],"a":[218,236],"comprehensive":[219],"study":[220],"attempting":[221],"gain":[223],"insights":[224],"on":[225],"importance":[227],"TRs":[229],"malaria":[231],"suggests":[235],"novel":[237],"route":[238],"understanding":[240],"function":[242],"through":[243],"characterization":[245],"content.":[248]},"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2025-04-24T00:00:00"}