{"id":"https://openalex.org/W4409709643","doi":"https://doi.org/10.1007/s00210-025-04169-w","title":"Polymeric and lipidic nanoparticles in transforming anti-HIV combinational therapy: can they turn the tide?","display_name":"Polymeric and lipidic nanoparticles in transforming anti-HIV combinational therapy: can they turn the tide?","publication_year":2025,"publication_date":"2025-04-23","ids":{"openalex":"https://openalex.org/W4409709643","doi":"https://doi.org/10.1007/s00210-025-04169-w","pmid":"https://pubmed.ncbi.nlm.nih.gov/40266304"},"language":"en","primary_location":{"id":"doi:10.1007/s00210-025-04169-w","doi":"https://doi.org/10.1007/s00210-025-04169-w","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00210-025-04169-w","pdf_url":null,"source":{"id":"https://openalex.org/S159534381","display_name":"Naunyn-Schmiedeberg s Archives of Pharmacology","issn_l":"0028-1298","issn":["0028-1298","0340-5249","1432-1912"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Naunyn-Schmiedeberg's Archives of Pharmacology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102745506","display_name":"Pankaj Popli","orcid":"https://orcid.org/0009-0004-8636-1700","observed_orcids":["https://orcid.org/0009-0004-8636-1700"]},"institutions":[{"id":"https://openalex.org/I74319210","display_name":"Chitkara University","ror":"https://ror.org/057d6z539","country_code":"IN","type":"education","lineage":["https://openalex.org/I74319210"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Pankaj Popli","raw_affiliation_strings":["Chitkara College of Pharmacy, Chitkara University, Punjab, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chitkara College of Pharmacy, Chitkara University, Punjab, India","institution_ids":["https://openalex.org/I74319210"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046574006","display_name":"Ravi Teja Meduri","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ravi Teja Meduri","raw_affiliation_strings":["Medpharm, Durham, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medpharm, Durham, NC, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019418897","display_name":"Teenu Sharma","orcid":"https://orcid.org/0000-0002-4704-6925","observed_orcids":["https://orcid.org/0000-0002-4704-6925"]},"institutions":[{"id":"https://openalex.org/I74319210","display_name":"Chitkara University","ror":"https://ror.org/057d6z539","country_code":"IN","type":"education","lineage":["https://openalex.org/I74319210"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Teenu Sharma","raw_affiliation_strings":["Chitkara College of Pharmacy, Chitkara University, Punjab, India. teenu.2129@chitkara.edu.in"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chitkara College of Pharmacy, Chitkara University, Punjab, India. teenu.2129@chitkara.edu.in","institution_ids":["https://openalex.org/I74319210"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013029485","display_name":"Ranadheer Reddy Challa","orcid":"https://orcid.org/0009-0001-8855-1047","observed_orcids":["https://orcid.org/0009-0001-8855-1047"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ranadheer Reddy Challa","raw_affiliation_strings":["Quotient Sciences, 3080 McCann Farm Dr, Garnet Valley, PA, 19060, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Quotient Sciences, 3080 McCann Farm Dr, Garnet Valley, PA, 19060, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Bhaskar Vallamkonda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149313025","display_name":"Vignan's Foundation for Science, Technology & Research","ror":"https://ror.org/03bzf1g85","country_code":"IN","type":"education","lineage":["https://openalex.org/I149313025"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Bhaskar Vallamkonda","raw_affiliation_strings":["Department of Pharmaceutical Science, School of Applied Sciences and Humanities, VIGNAN'S Foundation for Science, Technology & Research, Guntur, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Science, School of Applied Sciences and Humanities, VIGNAN'S Foundation for Science, Technology & Research, Guntur, India","institution_ids":["https://openalex.org/I149313025"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104678557","display_name":"PhanikumarReddy Satti","orcid":"https://orcid.org/0009-0006-2020-3691","observed_orcids":["https://orcid.org/0009-0006-2020-3691"]},"institutions":[{"id":"https://openalex.org/I177001074","display_name":"Acharya Nagarjuna University","ror":"https://ror.org/02mfapa96","country_code":"IN","type":"education","lineage":["https://openalex.org/I177001074"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Phanikumar Reddy Satti","raw_affiliation_strings":["Acharya Nagarjuna University, Guntur, Andhra Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Acharya Nagarjuna University, Guntur, Andhra Pradesh, India","institution_ids":["https://openalex.org/I177001074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016919399","display_name":"Thakur Gurjeet Singh","orcid":"https://orcid.org/0000-0003-2979-1590","observed_orcids":["https://orcid.org/0000-0003-2979-1590"]},"institutions":[{"id":"https://openalex.org/I74319210","display_name":"Chitkara University","ror":"https://ror.org/057d6z539","country_code":"IN","type":"education","lineage":["https://openalex.org/I74319210"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Thakur Gurjeet Singh","raw_affiliation_strings":["Chitkara College of Pharmacy, Chitkara University, Punjab, India. gurjeet.singh@chitkara.edu.in"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chitkara College of Pharmacy, Chitkara University, Punjab, India. gurjeet.singh@chitkara.edu.in","institution_ids":["https://openalex.org/I74319210"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003770829","display_name":"Rajan Swami","orcid":"https://orcid.org/0000-0001-6291-3807","observed_orcids":["https://orcid.org/0000-0001-6291-3807"]},"institutions":[{"id":"https://openalex.org/I74319210","display_name":"Chitkara University","ror":"https://ror.org/057d6z539","country_code":"IN","type":"education","lineage":["https://openalex.org/I74319210"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Rajan Swami","raw_affiliation_strings":["Chitkara College of Pharmacy, Chitkara University, Punjab, India. drrjnswami@gmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chitkara College of Pharmacy, Chitkara University, Punjab, India. drrjnswami@gmail.com","institution_ids":["https://openalex.org/I74319210"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5003770829","https://openalex.org/A5016919399","https://openalex.org/A5019418897"],"corresponding_institution_ids":["https://openalex.org/I74319210"],"apc_list":{"value":4790,"currency":"USD","value_usd":4790},"apc_paid":null,"fwci":0.0954,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.06450463,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":95},"biblio":{"volume":"398","issue":"10","first_page":"13153","last_page":"13172"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.007799999788403511,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1","display_name":"HIV-1","score":0.9670000076293945},{"id":"https://openalex.org/keywords/polymeric-nanoparticles","display_name":"polymeric nanoparticles","score":0.7549999952316284},{"id":"https://openalex.org/keywords/nanocarriers","display_name":"nanocarriers","score":0.8569999933242798},{"id":"https://openalex.org/keywords/highly-active-antiretroviral-therapy","display_name":"highly active antiretroviral therapy","score":0.9279999732971191},{"id":"https://openalex.org/keywords/targeted-drug-delivery","display_name":"targeted drug delivery","score":0.8169999718666077},{"id":"https://openalex.org/keywords/controlled-release","display_name":"controlled release","score":0.7950000166893005},{"id":"https://openalex.org/keywords/co-delivery","display_name":"co-delivery","score":0.8130000233650208},{"id":"https://openalex.org/keywords/encapsulation-efficiency","display_name":"encapsulation efficiency","score":0.8769999742507935},{"id":"https://openalex.org/keywords/nanocarrier-stability","display_name":"nanocarrier stability","score":0.8960000276565552},{"id":"https://openalex.org/keywords/nanomedicine-translation","display_name":"nanomedicine translation","score":0.6119999885559082},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.597000002861023},{"id":"https://openalex.org/keywords/patient-adherence","display_name":"patient adherence","score":0.6100000143051147}],"concepts":[{"id":"https://openalex.org/C85641259","wikidata":"https://www.wikidata.org/wiki/Q290042","display_name":"Turn (biochemistry)","level":2,"score":0.6620534658432007},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.5819818377494812},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.5670623183250427},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36832916736602783},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.32465243339538574},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.28805816173553467},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.2810754179954529},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.27430564165115356},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.2738352417945862},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0875789225101471}],"mesh":[{"descriptor_ui":"D000090783","descriptor_name":"Nanoparticle Drug Delivery System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011108","descriptor_name":"Polymers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D023241","descriptor_name":"Antiretroviral Therapy, Highly Active","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D050997","descriptor_name":"Nanomedicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1007/s00210-025-04169-w","doi":"https://doi.org/10.1007/s00210-025-04169-w","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00210-025-04169-w","pdf_url":null,"source":{"id":"https://openalex.org/S159534381","display_name":"Naunyn-Schmiedeberg s Archives of Pharmacology","issn_l":"0028-1298","issn":["0028-1298","0340-5249","1432-1912"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Naunyn-Schmiedeberg's Archives of Pharmacology","raw_type":"journal-article"},{"id":"pmid:40266304","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40266304","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Naunyn-Schmiedeberg's archives of pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":122,"referenced_works":["https://openalex.org/W46230828","https://openalex.org/W1544659534","https://openalex.org/W1966962897","https://openalex.org/W1968811693","https://openalex.org/W1969018013","https://openalex.org/W1981729500","https://openalex.org/W1999787793","https://openalex.org/W2006516628","https://openalex.org/W2006682004","https://openalex.org/W2014453984","https://openalex.org/W2036995059","https://openalex.org/W2037373236","https://openalex.org/W2039759758","https://openalex.org/W2042249858","https://openalex.org/W2048538876","https://openalex.org/W2054454823","https://openalex.org/W2056646254","https://openalex.org/W2059525783","https://openalex.org/W2069618188","https://openalex.org/W2071692849","https://openalex.org/W2073439757","https://openalex.org/W2077453101","https://openalex.org/W2078937040","https://openalex.org/W2082281440","https://openalex.org/W2084169152","https://openalex.org/W2087786156","https://openalex.org/W2089155556","https://openalex.org/W2094146325","https://openalex.org/W2100225360","https://openalex.org/W2107070235","https://openalex.org/W2112299847","https://openalex.org/W2128995317","https://openalex.org/W2130739913","https://openalex.org/W2143311761","https://openalex.org/W2153848350","https://openalex.org/W2155493645","https://openalex.org/W2159042112","https://openalex.org/W2163695841","https://openalex.org/W2179769347","https://openalex.org/W2273558707","https://openalex.org/W2315025523","https://openalex.org/W2329021144","https://openalex.org/W2340140899","https://openalex.org/W2418354878","https://openalex.org/W2514202594","https://openalex.org/W2557382181","https://openalex.org/W2595228741","https://openalex.org/W2610639910","https://openalex.org/W2611505834","https://openalex.org/W2741610949","https://openalex.org/W2752989011","https://openalex.org/W2767118718","https://openalex.org/W2792328576","https://openalex.org/W2794962979","https://openalex.org/W2801338974","https://openalex.org/W2801576905","https://openalex.org/W2803207333","https://openalex.org/W2806385366","https://openalex.org/W2886420031","https://openalex.org/W2888712616","https://openalex.org/W2896248144","https://openalex.org/W2900449011","https://openalex.org/W2938453597","https://openalex.org/W2953372741","https://openalex.org/W2959154646","https://openalex.org/W2970489783","https://openalex.org/W2980598648","https://openalex.org/W2992566954","https://openalex.org/W2998984898","https://openalex.org/W3021977647","https://openalex.org/W3022238111","https://openalex.org/W3037313455","https://openalex.org/W3042076644","https://openalex.org/W3073760749","https://openalex.org/W3074051289","https://openalex.org/W3091816257","https://openalex.org/W3092325190","https://openalex.org/W3113340367","https://openalex.org/W3120640948","https://openalex.org/W3125448277","https://openalex.org/W3126239898","https://openalex.org/W3131290635","https://openalex.org/W3131758069","https://openalex.org/W3157207945","https://openalex.org/W3157916043","https://openalex.org/W3159665217","https://openalex.org/W3163929392","https://openalex.org/W3165838867","https://openalex.org/W3168073011","https://openalex.org/W3175685856","https://openalex.org/W3177391675","https://openalex.org/W3181591840","https://openalex.org/W3189229536","https://openalex.org/W3207603856","https://openalex.org/W3207923413","https://openalex.org/W4205583506","https://openalex.org/W4205729477","https://openalex.org/W4210422553","https://openalex.org/W4211183388","https://openalex.org/W4211187545","https://openalex.org/W4225291894","https://openalex.org/W4309237050","https://openalex.org/W4321371922","https://openalex.org/W4322489597","https://openalex.org/W4323317169","https://openalex.org/W4323352171","https://openalex.org/W4362468012","https://openalex.org/W4367052719","https://openalex.org/W4378082491","https://openalex.org/W4390795639","https://openalex.org/W4391310669","https://openalex.org/W4392342977","https://openalex.org/W4392385932","https://openalex.org/W4396695828","https://openalex.org/W4399390073","https://openalex.org/W4400570824","https://openalex.org/W4400945396","https://openalex.org/W4401101274","https://openalex.org/W4404515475","https://openalex.org/W4405951182","https://openalex.org/W4406062469","https://openalex.org/W4408405102"],"related_works":["https://openalex.org/W4403907580","https://openalex.org/W7119010931","https://openalex.org/W4408161864","https://openalex.org/W3176933813","https://openalex.org/W3164611479","https://openalex.org/W2327200082","https://openalex.org/W2800208837","https://openalex.org/W2109792045","https://openalex.org/W2973049998","https://openalex.org/W4415378489"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":2}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2025-04-24T00:00:00"}
