{"id":"https://openalex.org/W4409708317","doi":"https://doi.org/10.2174/0125899775365699250408091801","title":"Repositioning Drugs: A Computational Approach","display_name":"Repositioning Drugs: A Computational Approach","publication_year":2025,"publication_date":"2025-04-23","ids":{"openalex":"https://openalex.org/W4409708317","doi":"https://doi.org/10.2174/0125899775365699250408091801","pmid":"https://pubmed.ncbi.nlm.nih.gov/40264316"},"language":"en","primary_location":{"id":"doi:10.2174/0125899775365699250408091801","doi":"https://doi.org/10.2174/0125899775365699250408091801","is_oa":false,"landing_page_url":"https://doi.org/10.2174/0125899775365699250408091801","pdf_url":null,"source":{"id":"https://openalex.org/S4210180567","display_name":"Current Drug Research Reviews","issn_l":"2589-9775","issn":["2589-9775","2589-9783"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","medline"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Drug Research Reviews","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101596158","display_name":"Bhawna Sharma","orcid":"https://orcid.org/0000-0002-3132-2964","observed_orcids":["https://orcid.org/0000-0002-3132-2964"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Bhawna Sharma","raw_affiliation_strings":["Department of Pharmaceutics, Dr. K.N. Modi Institute of Pharmaceutical Education and Research, Modinagar, Ghaziabad,\nUP, India","Department of Pharmaceutics, Dr. K. N. MODI Institute of Pharmaceutical Education and Research, Modinagar, Ghaziabad,\nUP, India"],"raw_orcid":"https://orcid.org/0000-0002-3132-2964","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, Dr. K.N. Modi Institute of Pharmaceutical Education and Research, Modinagar, Ghaziabad,\nUP, India","institution_ids":[]},{"raw_affiliation_string":"Department of Pharmaceutics, Dr. K. N. MODI Institute of Pharmaceutical Education and Research, Modinagar, Ghaziabad,\nUP, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004517166","display_name":"Iti Chauhan","orcid":"https://orcid.org/0000-0002-4440-9903","observed_orcids":["https://orcid.org/0000-0002-4440-9903"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Iti Chauhan","raw_affiliation_strings":["Department of Pharmaceutics, I.T.S College of Pharmacy, Muradnagar, Ghaziabad, UP, India"],"raw_orcid":"https://orcid.org/0000-0002-4440-9903","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, I.T.S College of Pharmacy, Muradnagar, Ghaziabad, UP, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051140868","display_name":"Rohit Pandey","orcid":"https://orcid.org/0000-0002-3565-6734","observed_orcids":["https://orcid.org/0000-0002-3565-6734"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rohit Pandey","raw_affiliation_strings":["Department of Pharmaceutical Chemistry, Dr. K.N. Modi Institute of Pharmaceutical Education and Research,\nModinagar, Ghaziabad, UP, India","Department of Pharmaceutical Chemistry, Dr. K. N. MODI Institute of Pharmaceutical Education and Research, Modinagar, Ghaziabad, UP, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Chemistry, Dr. K.N. Modi Institute of Pharmaceutical Education and Research,\nModinagar, Ghaziabad, UP, India","institution_ids":[]},{"raw_affiliation_string":"Department of Pharmaceutical Chemistry, Dr. K. N. MODI Institute of Pharmaceutical Education and Research, Modinagar, Ghaziabad, UP, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006905292","display_name":"Raj Kumar Tiwari","orcid":"https://orcid.org/0000-0001-7373-4679","observed_orcids":["https://orcid.org/0000-0001-7373-4679"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Raj Kumar Tiwari","raw_affiliation_strings":["Department of Pharmacology, Dr. K.N. Modi Institute of Pharmaceutical Education\nand Research, Modinagar, Ghaziabad, UP, India","Department of Pharmacology, Dr. K. N. MODI Institute of Pharmaceutical Education and Research, Modinagar, Ghaziabad, UP, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Dr. K.N. Modi Institute of Pharmaceutical Education\nand Research, Modinagar, Ghaziabad, UP, India","institution_ids":[]},{"raw_affiliation_string":"Department of Pharmacology, Dr. K. N. MODI Institute of Pharmaceutical Education and Research, Modinagar, Ghaziabad, UP, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101605758","display_name":"Gaurav Kumar","orcid":"https://orcid.org/0000-0001-7675-7710","observed_orcids":["https://orcid.org/0000-0001-7675-7710"]},"institutions":[{"id":"https://openalex.org/I145286018","display_name":"SRM Institute of Science and Technology","ror":"https://ror.org/050113w36","country_code":"IN","type":"education","lineage":["https://openalex.org/I145286018"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Gaurav Kumar","raw_affiliation_strings":["SRM Modinagar College of Pharmacy, SRMIST, Delhi-NCR campus, Modinagar, Ghaziabad, UP, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SRM Modinagar College of Pharmacy, SRMIST, Delhi-NCR campus, Modinagar, Ghaziabad, UP, India","institution_ids":["https://openalex.org/I145286018"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102830356","display_name":"Gaurav Pratap Singh","orcid":"https://orcid.org/0009-0002-2078-9523","observed_orcids":["https://orcid.org/0009-0002-2078-9523"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gaurav Pratap Singh","raw_affiliation_strings":["Department of Pharmaceutics, Dr. K.N. Modi Institute of Pharmaceutical Education and Research, Modinagar, Ghaziabad,\nUP, India","Department of Pharmaceutics, Dr. K. N. MODI Institute of Pharmaceutical Education and Research, Modinagar, Ghaziabad,\nUP, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, Dr. K.N. Modi Institute of Pharmaceutical Education and Research, Modinagar, Ghaziabad,\nUP, India","institution_ids":[]},{"raw_affiliation_string":"Department of Pharmaceutics, Dr. K. N. MODI Institute of Pharmaceutical Education and Research, Modinagar, Ghaziabad,\nUP, India","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5101596158"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.985,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.86486574,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":97},"biblio":{"volume":"18","issue":"1","first_page":"62","last_page":"76"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11710","display_name":"Biomedical Text Mining and Ontologies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug-repurposing","display_name":"drug repurposing","score":0.734000027179718},{"id":"https://openalex.org/keywords/new-drug-indications","display_name":"new drug indications","score":0.7129999995231628},{"id":"https://openalex.org/keywords/multi-omics","display_name":"multi-omics","score":0.8550000190734863},{"id":"https://openalex.org/keywords/drug-structure","display_name":"drug structure","score":0.4690000116825104},{"id":"https://openalex.org/keywords/biomedical-databases","display_name":"biomedical databases","score":0.7710000276565552},{"id":"https://openalex.org/keywords/negative-sample-selection","display_name":"negative sample selection","score":0.8600000143051147},{"id":"https://openalex.org/keywords/data-sparsity","display_name":"data sparsity","score":0.8790000081062317}],"concepts":[{"id":"https://openalex.org/C7952369","wikidata":"https://www.wikidata.org/wiki/Q844116","display_name":"Phenome","level":4,"score":0.7539170384407043},{"id":"https://openalex.org/C153083717","wikidata":"https://www.wikidata.org/wiki/Q6535263","display_name":"Leverage (statistics)","level":2,"score":0.6693713665008545},{"id":"https://openalex.org/C103637391","wikidata":"https://www.wikidata.org/wiki/Q5308921","display_name":"Drug repositioning","level":3,"score":0.6615962982177734},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5911090970039368},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.5725722312927246},{"id":"https://openalex.org/C75684735","wikidata":"https://www.wikidata.org/wiki/Q858810","display_name":"Big data","level":2,"score":0.5146001577377319},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.4593975245952606},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.40057119727134705},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3898754119873047},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.37640440464019775},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3402976393699646},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2386399507522583},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18486765027046204},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.115457683801651},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.07472318410873413},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.2174/0125899775365699250408091801","doi":"https://doi.org/10.2174/0125899775365699250408091801","is_oa":false,"landing_page_url":"https://doi.org/10.2174/0125899775365699250408091801","pdf_url":null,"source":{"id":"https://openalex.org/S4210180567","display_name":"Current Drug Research Reviews","issn_l":"2589-9775","issn":["2589-9775","2589-9783"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","medline"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Drug Research Reviews","raw_type":"journal-article"},{"id":"pmid:40264316","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40264316","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current drug research reviews","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2086237400","https://openalex.org/W2274048411","https://openalex.org/W4282960395","https://openalex.org/W2304386326","https://openalex.org/W2171789864","https://openalex.org/W3010058077","https://openalex.org/W2920569584","https://openalex.org/W2951512731","https://openalex.org/W4400243266","https://openalex.org/W2046431380"],"abstract_inverted_index":{"Computational":[0],"drug":[1,24,56,68,89,98],"repositioning":[2,90],"has":[3],"emerged":[4],"as":[5,47],"an":[6],"efficient":[7],"approach":[8],"to":[9,22,92],"discovering":[10],"new":[11,67],"indications":[12],"for":[13],"existing":[14],"drugs,":[15],"offering":[16],"lower":[17],"risk":[18],"and":[19,37,50,58,84,100],"cost":[20],"compared":[21],"traditional":[23],"discovery":[25,99],"methods.":[26,39],"Various":[27],"computational":[28,88],"approaches":[29],"have":[30,61],"been":[31],"developed,":[32],"including":[33,75],"targetbased,":[34],"gene-expression-based,":[35],"phenome-based,":[36],"multi-omics-based":[38],"Recent":[40],"advancements":[41],"leverage":[42],"diverse":[43],"data":[44,76,85],"sources,":[45],"such":[46],"biomedical":[48],"databases":[49],"online":[51],"healthrelated":[52],"information.":[53],"Techniques":[54],"incorporating":[55],"structure":[57],"target":[59],"information":[60],"shown":[62],"promising":[63],"results":[64],"in":[65,97],"predicting":[66],"indications.":[69],"Despite":[70],"significant":[71],"progress,":[72],"challenges":[73],"remain,":[74],"noise":[77],"reduction,":[78],"method":[79],"ensemble,":[80],"negative":[81],"sample":[82],"selection,":[83],"sparseness.":[86],"Overall,":[87],"continues":[91],"be":[93],"a":[94],"valuable":[95],"tool":[96],"development.":[101]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2025-10-10T00:00:00"}
