{"id":"https://openalex.org/W4409702091","doi":"https://doi.org/10.1093/ehjacc/zuaf044.078","title":"Negative impact of low IGF-1 levels and hypovitaminosis D on coronary artery disease severity and prognosis in patients with AMI","display_name":"Negative impact of low IGF-1 levels and hypovitaminosis D on coronary artery disease severity and prognosis in patients with AMI","publication_year":2025,"publication_date":"2025-04-01","ids":{"openalex":"https://openalex.org/W4409702091","doi":"https://doi.org/10.1093/ehjacc/zuaf044.078"},"language":"en","primary_location":{"id":"doi:10.1093/ehjacc/zuaf044.078","doi":"https://doi.org/10.1093/ehjacc/zuaf044.078","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ehjacc/zuaf044.078","pdf_url":"https://academic.oup.com/ehjacc/article-pdf/14/Supplement_1/zuaf044.078/62991283/zuaf044.078.pdf","source":{"id":"https://openalex.org/S2764501950","display_name":"European Heart Journal Acute Cardiovascular Care","issn_l":"2048-8726","issn":["2048-8726","2048-8734"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Heart Journal: Acute Cardiovascular Care","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/ehjacc/article-pdf/14/Supplement_1/zuaf044.078/62991283/zuaf044.078.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031097183","display_name":"Aneta Aleksova","orcid":"https://orcid.org/0000-0001-7711-9905","observed_orcids":["https://orcid.org/0000-0001-7711-9905"]},"institutions":[{"id":"https://openalex.org/I142444530","display_name":"University of Trieste","ror":"https://ror.org/02n742c10","country_code":"IT","type":"education","lineage":["https://openalex.org/I142444530"]},{"id":"https://openalex.org/I4210164020","display_name":"Azienda Sanitaria Universitaria Integrata di Trieste","ror":"https://ror.org/05g7qp006","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210164020","https://openalex.org/I4405278440"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"A Aleksova","raw_affiliation_strings":["Azienda Sanitaria Universitaria di Trieste and University of Trieste, Department of Medical Surgical and Health Sciences, Cardiovascular Department , Trieste ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Azienda Sanitaria Universitaria di Trieste and University of Trieste, Department of Medical Surgical and Health Sciences, Cardiovascular Department , Trieste ,","institution_ids":["https://openalex.org/I142444530","https://openalex.org/I4210164020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002464650","display_name":"Alessandra Lucia Fluca","orcid":"https://orcid.org/0000-0001-6427-8093","observed_orcids":["https://orcid.org/0000-0001-6427-8093"]},"institutions":[{"id":"https://openalex.org/I142444530","display_name":"University of Trieste","ror":"https://ror.org/02n742c10","country_code":"IT","type":"education","lineage":["https://openalex.org/I142444530"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"A L Fluca","raw_affiliation_strings":["University of Trieste , Trieste ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Trieste , Trieste ,","institution_ids":["https://openalex.org/I142444530"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063828064","display_name":"Agnese Derin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142444530","display_name":"University of Trieste","ror":"https://ror.org/02n742c10","country_code":"IT","type":"education","lineage":["https://openalex.org/I142444530"]},{"id":"https://openalex.org/I4210164020","display_name":"Azienda Sanitaria Universitaria Integrata di Trieste","ror":"https://ror.org/05g7qp006","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210164020","https://openalex.org/I4405278440"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"A Derin","raw_affiliation_strings":["Azienda Sanitaria Universitaria di Trieste and University of Trieste, Department of Medical Surgical and Health Sciences, Cardiovascular Department , Trieste ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Azienda Sanitaria Universitaria di Trieste and University of Trieste, Department of Medical Surgical and Health Sciences, Cardiovascular Department , Trieste ,","institution_ids":["https://openalex.org/I142444530","https://openalex.org/I4210164020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112464049","display_name":"Lorenzo Zandon\u00e0","orcid":"https://orcid.org/0009-0003-0776-9592","observed_orcids":["https://orcid.org/0009-0003-0776-9592"]},"institutions":[{"id":"https://openalex.org/I142444530","display_name":"University of Trieste","ror":"https://ror.org/02n742c10","country_code":"IT","type":"education","lineage":["https://openalex.org/I142444530"]},{"id":"https://openalex.org/I4210164020","display_name":"Azienda Sanitaria Universitaria Integrata di Trieste","ror":"https://ror.org/05g7qp006","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210164020","https://openalex.org/I4405278440"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"L Zandona'","raw_affiliation_strings":["Azienda Sanitaria Universitaria di Trieste and University of Trieste, Department of Medical Surgical and Health Sciences, Cardiovascular Department , Trieste ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Azienda Sanitaria Universitaria di Trieste and University of Trieste, Department of Medical Surgical and Health Sciences, Cardiovascular Department , Trieste ,","institution_ids":["https://openalex.org/I142444530","https://openalex.org/I4210164020"]}]},{"author_position":"middle","author":{"id":null,"display_name":"A Chicco","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142444530","display_name":"University of Trieste","ror":"https://ror.org/02n742c10","country_code":"IT","type":"education","lineage":["https://openalex.org/I142444530"]},{"id":"https://openalex.org/I4210164020","display_name":"Azienda Sanitaria Universitaria Integrata di Trieste","ror":"https://ror.org/05g7qp006","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210164020","https://openalex.org/I4405278440"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"A Chicco","raw_affiliation_strings":["Azienda Sanitaria Universitaria di Trieste and University of Trieste, Department of Medical Surgical and Health Sciences, Cardiovascular Department , Trieste ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Azienda Sanitaria Universitaria di Trieste and University of Trieste, Department of Medical Surgical and Health Sciences, Cardiovascular Department , Trieste ,","institution_ids":["https://openalex.org/I142444530","https://openalex.org/I4210164020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073346307","display_name":"Elisabetta Stenner","orcid":"https://orcid.org/0000-0001-9330-1117","observed_orcids":["https://orcid.org/0000-0001-9330-1117"]},"institutions":[{"id":"https://openalex.org/I4210149390","display_name":"Ospedale di Livorno","ror":"https://ror.org/04yrw5x43","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210149390"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"E Stenner","raw_affiliation_strings":["Livorno Hospital, Department of Diagnostics , Livorno ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Livorno Hospital, Department of Diagnostics , Livorno ,","institution_ids":["https://openalex.org/I4210149390"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076248582","display_name":"Stefano D\u2019Errico","orcid":"https://orcid.org/0000-0003-3689-0001","observed_orcids":["https://orcid.org/0000-0003-3689-0001"]},"institutions":[{"id":"https://openalex.org/I142444530","display_name":"University of Trieste","ror":"https://ror.org/02n742c10","country_code":"IT","type":"education","lineage":["https://openalex.org/I142444530"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"S D'errico","raw_affiliation_strings":["University of Trieste , Trieste ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Trieste , Trieste ,","institution_ids":["https://openalex.org/I142444530"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024753725","display_name":"Gianfranco Sinagra","orcid":"https://orcid.org/0000-0003-2700-8478","observed_orcids":["https://orcid.org/0000-0003-2700-8478"]},"institutions":[{"id":"https://openalex.org/I142444530","display_name":"University of Trieste","ror":"https://ror.org/02n742c10","country_code":"IT","type":"education","lineage":["https://openalex.org/I142444530"]},{"id":"https://openalex.org/I4210164020","display_name":"Azienda Sanitaria Universitaria Integrata di Trieste","ror":"https://ror.org/05g7qp006","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210164020","https://openalex.org/I4405278440"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"G Sinagra","raw_affiliation_strings":["Azienda Sanitaria Universitaria di Trieste and University of Trieste, Department of Medical Surgical and Health Sciences, Cardiovascular Department , Trieste ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Azienda Sanitaria Universitaria di Trieste and University of Trieste, Department of Medical Surgical and Health Sciences, Cardiovascular Department , Trieste ,","institution_ids":["https://openalex.org/I142444530","https://openalex.org/I4210164020"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009051993","display_name":"Milijana Janjusevic","orcid":"https://orcid.org/0000-0001-9579-1439","observed_orcids":["https://orcid.org/0000-0001-9579-1439"]},"institutions":[{"id":"https://openalex.org/I142444530","display_name":"University of Trieste","ror":"https://ror.org/02n742c10","country_code":"IT","type":"education","lineage":["https://openalex.org/I142444530"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M Janjusevic","raw_affiliation_strings":["University of Trieste , Trieste ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Trieste , Trieste ,","institution_ids":["https://openalex.org/I142444530"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3355,"currency":"EUR","value_usd":3792},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"14","issue":"Supplement_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.8695999979972839,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.8695999979972839,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10292","display_name":"Acute Myocardial Infarction Research","score":0.05730000138282776,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.02710000053048134,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/insulin-like-growth-factor-i","display_name":"insulin-like growth factor I","score":0.902999997138977},{"id":"https://openalex.org/keywords/vitamin-d-deficiency","display_name":"vitamin D deficiency","score":0.8849999904632568},{"id":"https://openalex.org/keywords/vitamin-d","display_name":"vitamin D","score":0.7990000247955322},{"id":"https://openalex.org/keywords/acute-myocardial-infarction","display_name":"acute myocardial infarction","score":0.9769999980926514},{"id":"https://openalex.org/keywords/coronary-artery-disease-severity","display_name":"coronary artery disease severity","score":0.9240000247955322},{"id":"https://openalex.org/keywords/chronic-low-grade-inflammation","display_name":"low-grade inflammation","score":0.6520000100135803},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.9779999852180481},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.9169999957084656},{"id":"https://openalex.org/keywords/all-cause-mortality","display_name":"all-cause mortality","score":0.7639999985694885},{"id":"https://openalex.org/keywords/recurrent-myocardial-infarction","display_name":"reinfarction","score":0.7639999985694885},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.9860000014305115},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7609999775886536},{"id":"https://openalex.org/keywords/left-main-coronary-artery-disease","display_name":"left main coronary artery disease","score":0.4749999940395355},{"id":"https://openalex.org/keywords/multivessel-coronary-disease","display_name":"multivessel coronary artery disease","score":0.7670000195503235},{"id":"https://openalex.org/keywords/st-elevation-myocardial-infarction","display_name":"ST-elevation myocardial infarction","score":0.45399999618530273},{"id":"https://openalex.org/keywords/non-st-elevation-myocardial-infarction","display_name":"non-ST-elevation myocardial infarction","score":0.574999988079071}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9654493927955627},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7773013114929199},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.7243581414222717},{"id":"https://openalex.org/C2778213512","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Coronary artery disease","level":2,"score":0.7101426720619202},{"id":"https://openalex.org/C2778277197","wikidata":"https://www.wikidata.org/wiki/Q194435","display_name":"Hypovitaminosis","level":4,"score":0.5143962502479553},{"id":"https://openalex.org/C124490489","wikidata":"https://www.wikidata.org/wiki/Q7936963","display_name":"Vitamin D and neurology","level":2,"score":0.34292471408843994},{"id":"https://openalex.org/C2779740938","wikidata":"https://www.wikidata.org/wiki/Q4138762","display_name":"vitamin D deficiency","level":3,"score":0.1970902979373932}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1093/ehjacc/zuaf044.078","doi":"https://doi.org/10.1093/ehjacc/zuaf044.078","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ehjacc/zuaf044.078","pdf_url":"https://academic.oup.com/ehjacc/article-pdf/14/Supplement_1/zuaf044.078/62991283/zuaf044.078.pdf","source":{"id":"https://openalex.org/S2764501950","display_name":"European Heart Journal Acute Cardiovascular Care","issn_l":"2048-8726","issn":["2048-8726","2048-8734"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Heart Journal: Acute Cardiovascular Care","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1093/ehjacc/zuaf044.078","doi":"https://doi.org/10.1093/ehjacc/zuaf044.078","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ehjacc/zuaf044.078","pdf_url":"https://academic.oup.com/ehjacc/article-pdf/14/Supplement_1/zuaf044.078/62991283/zuaf044.078.pdf","source":{"id":"https://openalex.org/S2764501950","display_name":"European Heart Journal Acute Cardiovascular Care","issn_l":"2048-8726","issn":["2048-8726","2048-8734"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Heart Journal: Acute Cardiovascular Care","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4409702091.pdf"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7151471503","https://openalex.org/W4367055497","https://openalex.org/W3128261868","https://openalex.org/W7160250018","https://openalex.org/W2541546700","https://openalex.org/W2737638234","https://openalex.org/W4403046841","https://openalex.org/W4377988613","https://openalex.org/W7217699816","https://openalex.org/W2789447337"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Low":[2,231],"IGF-1":[3,42,52,65,159,210,232,290,314,330,355,382,424,445],"levels,":[4],"low-grade":[5,26],"inflammation":[6,27,88],"and":[7,25,34,53,66,90,127,140,150,160,167,197,208,247,260,289,315,338,363,384,413,430,447],"Vitamin":[8],"D":[9,23],"(VitD)":[10],"are":[11,28,38,425],"implicated":[12],"in":[13,43,176,307],"the":[14,49,54,61,80,264,274,283,287,293,311,323,333,339,352,358,366,378,436,441],"pathogenesis":[15],"of":[16,32,56,64,70,82,87,135,158,178,184,236,268,285,313,319,341,350,380,392,423,433,443],"coronary":[17],"heart":[18,128],"disease":[19,116],"(CHD).":[20],"While":[21],"hypovitaminosis":[22],"(HypoD)":[24],"associated":[29,387,426,450],"with":[30,72,227,242,354,388,399,407,427,451],"presence":[31],"CHD":[33,149,238,428],"its":[35],"severity,":[36],"there":[37],"limited":[39],"data":[40],"on":[41,68,84,317],"this":[44],"setting.":[45],"Purpose":[46],"To":[47],"investigate":[48],"association":[50,281],"between":[51,282],"severity":[55,429],"CHD,":[57],"as":[58,60],"well":[59],"combined":[62,121],"effects":[63],"VitD":[67,107,161,228,316],"outcome":[69,318,394],"patients":[71,146,272,398],"acute":[73],"myocardial":[74],"infarction":[75],"(AMI).":[76],"Also,":[77],"to":[78,225,309,329,397],"analyze":[79,310],"impact":[81,312],"HypoD":[83,173,364,385,401,448],"systemic":[85],"markers":[86],"(CRP":[89,187],"IL-1\u03b2).":[91],"Methods":[92],"Blood":[93],"samples":[94],"were":[95,142,162,234],"collected":[96],"at":[97],"fasting":[98],"state":[99],"from":[100],"685":[101],"AMI":[102,419],"patients.":[103],"Definitions:":[104],"1)":[105],"HypoD:":[106],"levels":[108,183,211,291,331,356,383,422,446],"\u226420":[109],"ng/ml;":[110],"2)":[111],"severe":[112,148,237],"CHD:":[113],"left":[114],"main":[115],"and/or":[117],"three-vessel":[118],"disease.":[119],"The":[120,132,155,372],"endpoint":[122,288],"comprised":[123],"all-cause":[124],"mortality,":[125],"re-infarction,":[126],"failure":[129],"development.":[130],"Results":[131],"mean":[133],"age":[134],"cohort":[136,324],"was":[137,174,278,386],"66(11)":[138],"years":[139],"73.1%":[141],"male.":[143],"Overall,":[144],"28%":[145],"had":[147,152,181,365],"72%":[151],"STEMI":[153],"presentation.":[154],"median":[156,265],"concentration":[157],"539":[163,296,336,361],"[290":[164],"\u2013":[165,170,194,203,214,219],"824]pg/ml":[166],"18.7":[168],"[11.8":[169],"25.9]ng/ml,":[171],"respectively.":[172],"present":[175],"56.1%":[177],"patients,":[179,320,351,420],"who":[180],"higher":[182,431],"inflammatory":[185],"makers":[186],"6":[188],"[2.1\u2013":[189],"15.8]":[190],"vs":[191,201,216],"3.4":[192],"[1.3":[193],"9.3]":[195],"mg/l,":[196],"IL-1\u03b2":[198],"0.46":[199],"[0.19-0.71]":[200],"0.35[0.14":[202],"0.61]":[204],"pg/ml,":[205,221],"both":[206],"p<0.01)":[207],"lower":[209,411],"(500.8":[212],"[261.2":[213],"793.5]":[215],"577":[217],"[342.5":[218],"867]":[220],"p<0.01,":[222],"respectively)":[223],"compared":[224,396],"those":[226],">20":[229],"ng/ml.":[230],"values":[233],"predictive":[235],"(OR":[239],"1.80,p<0.01),":[240],"along":[241,406],"older":[243,408],"age,":[244,409],"male":[245],"gender":[246],"GFR":[248],"<60":[249],"mL/min/1.73m2,":[250],"after":[251],"correction":[252],"for":[253],"VitD,":[254],"CRP,":[255,410],"IL-1\u03b2,":[256],"diabetes":[257],"mellitus,":[258],"smoking":[259],"LDL":[261],"levels.":[262],"During":[263],"follow-up":[266],"time":[267],"45-months,":[269],"249":[270],"(36%)":[271],"reached":[273],"composite":[275],"endpoint.":[276],"There":[277],"a":[279],"linear":[280],"risk":[284,391,432],"reaching":[286],"below":[292,357],"cut-off":[294,334,359],"level":[295,360],"pg/ml":[297,337,362],"(identified":[298],"by":[299],"continuous":[300],"hazard":[301],"ratio":[302],"analysis,":[303,346],"Fig.":[304,370],"1a).":[305],"Subsequently,":[306],"order":[308],"we":[321],"divided":[322],"into":[325],"4":[326,348],"groups":[327,349],"according":[328],"under/over":[332],"value":[335],"presence/absence":[340],"HypoD,":[342],"Fig.1b.":[343],"At":[344],"Kaplan-Meier":[345],"among":[347],"group":[353],"worse":[367,414,454],"prognosis":[368],"(p<0.01;":[369],"1c).":[371],"multivariable":[373],"Cox":[374],"regression":[375],"confirmed":[376],"that":[377],"co-existence":[379],"low":[381,421,444],"an":[389,452],"increased":[390],"adverse":[393],"when":[395],"only":[400],"(HR":[402],"1.52":[403],"[1.04-2.2],":[404],"p=0.03),":[405],"LVEF":[412],"renal":[415],"function.":[416],"Conclusions":[417],"In":[418,439],"events":[434],"during":[435],"long-term":[437],"follow-up.":[438],"addition,":[440],"co-presence":[442],"is":[449],"even":[453],"prognosis.":[455]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2025-04-24T00:00:00"}