{"id":"https://openalex.org/W4409689683","doi":"https://doi.org/10.1158/1538-7445.am2025-2853","title":"Abstract 2853: Engineered extrachromosomal oncogene amplifications promote tumorigenesis","display_name":"Abstract 2853: Engineered extrachromosomal oncogene amplifications promote tumorigenesis","publication_year":2025,"publication_date":"2025-04-21","ids":{"openalex":"https://openalex.org/W4409689683","doi":"https://doi.org/10.1158/1538-7445.am2025-2853"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2025-2853","doi":"https://doi.org/10.1158/1538-7445.am2025-2853","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2025-2853","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069561354","display_name":"Melissa A. Yao","orcid":"https://orcid.org/0000-0002-2274-6925","observed_orcids":["https://orcid.org/0000-0002-2274-6925"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melissa A. Yao","raw_affiliation_strings":["1Memorial Sloan Kettering Cancer Center, New York, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Memorial Sloan Kettering Cancer Center, New York, NY;","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071838619","display_name":"Davide Pradella","orcid":"https://orcid.org/0000-0002-8649-7817","observed_orcids":["https://orcid.org/0000-0002-8649-7817"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Davide Pradella","raw_affiliation_strings":["1Memorial Sloan Kettering Cancer Center, New York, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Memorial Sloan Kettering Cancer Center, New York, NY;","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018879462","display_name":"Minsi Zhang","orcid":"https://orcid.org/0009-0003-6182-1195","observed_orcids":["https://orcid.org/0009-0003-6182-1195"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Minsi Zhang","raw_affiliation_strings":["1Memorial Sloan Kettering Cancer Center, New York, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Memorial Sloan Kettering Cancer Center, New York, NY;","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Rui Gao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rui Gao","raw_affiliation_strings":["1Memorial Sloan Kettering Cancer Center, New York, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Memorial Sloan Kettering Cancer Center, New York, NY;","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046766810","display_name":"Katarzyna G\u0142uchowska","orcid":"https://orcid.org/0009-0002-8686-774X","observed_orcids":["https://orcid.org/0009-0002-8686-774X"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katarzyna M. Gluchowska","raw_affiliation_strings":["1Memorial Sloan Kettering Cancer Center, New York, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Memorial Sloan Kettering Cancer Center, New York, NY;","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074668396","display_name":"Ylenia Cendon Florez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ylenia Cendon Florez","raw_affiliation_strings":["1Memorial Sloan Kettering Cancer Center, New York, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Memorial Sloan Kettering Cancer Center, New York, NY;","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072388826","display_name":"Tanmay Mishra","orcid":"https://orcid.org/0009-0009-9658-1535","observed_orcids":["https://orcid.org/0009-0009-9658-1535"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tanmay Mishra","raw_affiliation_strings":["1Memorial Sloan Kettering Cancer Center, New York, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Memorial Sloan Kettering Cancer Center, New York, NY;","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076543673","display_name":"Gaspare La Rocca","orcid":"https://orcid.org/0000-0003-1277-0566","observed_orcids":["https://orcid.org/0000-0003-1277-0566"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gaspare La Rocca","raw_affiliation_strings":["1Memorial Sloan Kettering Cancer Center, New York, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Memorial Sloan Kettering Cancer Center, New York, NY;","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078607845","display_name":"Moritz Weigl","orcid":"https://orcid.org/0000-0002-3941-5671","observed_orcids":["https://orcid.org/0000-0002-3941-5671"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Moritz Weigl","raw_affiliation_strings":["1Memorial Sloan Kettering Cancer Center, New York, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Memorial Sloan Kettering Cancer Center, New York, NY;","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112945787","display_name":"Ziqi Jiao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ziqi Jiao","raw_affiliation_strings":["1Memorial Sloan Kettering Cancer Center, New York, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Memorial Sloan Kettering Cancer Center, New York, NY;","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008924087","display_name":"Hieu Nguyen","orcid":"https://orcid.org/0000-0002-1877-6689","observed_orcids":["https://orcid.org/0000-0002-1877-6689"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hieu H. Nguyen","raw_affiliation_strings":["1Memorial Sloan Kettering Cancer Center, New York, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Memorial Sloan Kettering Cancer Center, New York, NY;","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089244652","display_name":"Marta Lisi","orcid":"https://orcid.org/0009-0004-3386-5163","observed_orcids":["https://orcid.org/0009-0004-3386-5163"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marta Lisi","raw_affiliation_strings":["1Memorial Sloan Kettering Cancer Center, New York, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Memorial Sloan Kettering Cancer Center, New York, NY;","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115522237","display_name":"Mateusz M. Ozimek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mateusz M. Ozimek","raw_affiliation_strings":["1Memorial Sloan Kettering Cancer Center, New York, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Memorial Sloan Kettering Cancer Center, New York, NY;","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053060247","display_name":"Chiara Mastroleo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chiara Mastroleo","raw_affiliation_strings":["1Memorial Sloan Kettering Cancer Center, New York, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Memorial Sloan Kettering Cancer Center, New York, NY;","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100350891","display_name":"Kevin Chen","orcid":"https://orcid.org/0000-0002-0674-1411","observed_orcids":["https://orcid.org/0000-0002-0674-1411","https://orcid.org/0009-0001-1863-3047"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin Chen","raw_affiliation_strings":["1Memorial Sloan Kettering Cancer Center, New York, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Memorial Sloan Kettering Cancer Center, New York, NY;","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Felix Grimm","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Felix Grimm","raw_affiliation_strings":["1Memorial Sloan Kettering Cancer Center, New York, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Memorial Sloan Kettering Cancer Center, New York, NY;","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061386740","display_name":"Jens Luebeck","orcid":"https://orcid.org/0000-0003-4391-979X","observed_orcids":["https://orcid.org/0000-0003-4391-979X"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jens Luebeck","raw_affiliation_strings":["2UC San Diego, La Jolla, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2UC San Diego, La Jolla, CA;","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100452868","display_name":"Shu Zhang","orcid":"https://orcid.org/0000-0003-2543-5943","observed_orcids":["https://orcid.org/0000-0003-2543-5943"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shu Zhang","raw_affiliation_strings":["3Stanford University, Stanford, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Stanford University, Stanford, CA;","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115522238","display_name":"Andrea Alice Zolli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrea Alice Zolli","raw_affiliation_strings":["1Memorial Sloan Kettering Cancer Center, New York, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Memorial Sloan Kettering Cancer Center, New York, NY;","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069418648","display_name":"Eric G. Sun","orcid":"https://orcid.org/0000-0002-9109-1969","observed_orcids":["https://orcid.org/0000-0002-9109-1969"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric G. Sun","raw_affiliation_strings":["1Memorial Sloan Kettering Cancer Center, New York, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Memorial Sloan Kettering Cancer Center, New York, NY;","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003876312","display_name":"Bhargavi Dameracharla","orcid":"https://orcid.org/0000-0001-5001-5057","observed_orcids":["https://orcid.org/0000-0001-5001-5057"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bhargavi Dameracharla","raw_affiliation_strings":["2UC San Diego, La Jolla, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2UC San Diego, La Jolla, CA;","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021677656","display_name":"Zhengqiao Zhao","orcid":"https://orcid.org/0000-0001-6873-6098","observed_orcids":["https://orcid.org/0000-0001-6873-6098"]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhengqiao Zhao","raw_affiliation_strings":["4Princeton University, Princeton, NJ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Princeton University, Princeton, NJ","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065602641","display_name":"Yuri Pritykin","orcid":"https://orcid.org/0000-0001-6589-981X","observed_orcids":["https://orcid.org/0000-0001-6589-981X"]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuri Pritykin","raw_affiliation_strings":["4Princeton University, Princeton, NJ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Princeton University, Princeton, NJ","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Carlie Siegel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carlie Siegel","raw_affiliation_strings":["1Memorial Sloan Kettering Cancer Center, New York, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Memorial Sloan Kettering Cancer Center, New York, NY;","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040230088","display_name":"Howard Y. Chang","orcid":"https://orcid.org/0000-0002-9459-4393","observed_orcids":["https://orcid.org/0000-0002-9459-4393"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Howard Y. Chang","raw_affiliation_strings":["3Stanford University, Stanford, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Stanford University, Stanford, CA;","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042065032","display_name":"Paul S. Mischel","orcid":"https://orcid.org/0000-0002-4560-2211","observed_orcids":["https://orcid.org/0000-0002-4560-2211"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul S. Mischel","raw_affiliation_strings":["3Stanford University, Stanford, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Stanford University, Stanford, CA;","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028801735","display_name":"Vineet Bafna","orcid":"https://orcid.org/0000-0002-5810-6241","observed_orcids":["https://orcid.org/0000-0002-5810-6241"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vineet Bafna","raw_affiliation_strings":["2UC San Diego, La Jolla, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2UC San Diego, La Jolla, CA;","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086786876","display_name":"Cristina R. Antonescu","orcid":"https://orcid.org/0000-0002-9717-8205","observed_orcids":["https://orcid.org/0000-0002-9717-8205"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cristina R. Antonescu","raw_affiliation_strings":["1Memorial Sloan Kettering Cancer Center, New York, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Memorial Sloan Kettering Cancer Center, New York, NY;","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033666678","display_name":"Andrea Ventura","orcid":"https://orcid.org/0000-0003-4320-9907","observed_orcids":["https://orcid.org/0000-0003-4320-9907"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrea Ventura","raw_affiliation_strings":["1Memorial Sloan Kettering Cancer Center, New York, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Memorial Sloan Kettering Cancer Center, New York, NY;","institution_ids":["https://openalex.org/I1334819555"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"85","issue":"8_Supplement_1","first_page":"2853","last_page":"2853"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.447299987077713,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.447299987077713,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.13109999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.09229999780654907,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/extrachromosomal-dna","display_name":"extrachromosomal DNA","score":0.9660000205039978},{"id":"https://openalex.org/keywords/oncogene-amplification","display_name":"oncogene amplification","score":0.8889999985694885},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.9330000281333923},{"id":"https://openalex.org/keywords/c-myc","display_name":"c-Myc","score":0.6470000147819519},{"id":"https://openalex.org/keywords/mdm2","display_name":"MDM2","score":1.0},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9150000214576721},{"id":"https://openalex.org/keywords/cell-transformation","display_name":"cell transformation","score":0.5379999876022339},{"id":"https://openalex.org/keywords/cell-immortalization","display_name":"cell immortalization","score":0.8029999732971191},{"id":"https://openalex.org/keywords/autochthonous-mouse-model","display_name":"autochthonous mouse model","score":0.6570000052452087}],"concepts":[{"id":"https://openalex.org/C89684784","wikidata":"https://www.wikidata.org/wiki/Q5422184","display_name":"Extrachromosomal DNA","level":4,"score":0.7769110202789307},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.6173610091209412},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5859627723693848},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.5557444095611572},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3897937536239624},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34406283497810364},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.31594598293304443},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3069458305835724},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.12389501929283142},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.10462498664855957},{"id":"https://openalex.org/C22744801","wikidata":"https://www.wikidata.org/wiki/Q172778","display_name":"Plasmid","level":3,"score":0.07752406597137451}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2025-2853","doi":"https://doi.org/10.1158/1538-7445.am2025-2853","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2025-2853","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4405515088","https://openalex.org/W4382047065","https://openalex.org/W4406241696","https://openalex.org/W7014700394","https://openalex.org/W2922323966","https://openalex.org/W4213306296","https://openalex.org/W3117782711","https://openalex.org/W7128376195","https://openalex.org/W3092390840","https://openalex.org/W4292790981"],"abstract_inverted_index":{"Abstract":[0],"Focal":[1],"gene":[2,150,184],"amplifications":[3,37,151,260],"are":[4],"among":[5],"the":[6,64,74,104,125,146,267],"most":[7],"common":[8],"cancer-associated":[9],"mutations":[10],"but":[11],"have":[12],"proven":[13],"challenging":[14],"to":[15,29,85,95,130],"engineer":[16,30],"in":[17,43,48,51,73,98,109,134,152],"primary":[18,110],"cells":[19,49,68,111],"and":[20,50,72,91,120,170],"model":[21,138],"organisms.":[22],"Here":[23],"we":[24,62,123],"describe":[25],"a":[26,44],"general":[27],"strategy":[28],"large":[31],"(more":[32],"than":[33],"1":[34,277],"Mbp)":[35],"focal":[36,183],"mediated":[38],"by":[39],"extrachromosomal":[40,258],"DNAs":[41],"(ecDNAs)":[42],"spatiotemporally":[45],"controlled":[46],"manner":[47],"mice.":[52],"By":[53],"coupling":[54],"ecDNA":[55,168],"formation":[56,133],"with":[57],"expression":[58],"of":[59,66,76,127,139,148,167,178,266],"selectable":[60],"markers,":[61],"track":[63],"dynamics":[65],"ecDNA-containing":[67],"under":[69],"physiological":[70],"conditions":[71],"presence":[75],"specific":[77,182],"selective":[78],"pressures.":[79],"We":[80,101,154],"also":[81],"apply":[82],"this":[83,157],"approach":[84,158],"generate":[86],"mice":[87],"harbouring":[88,181],"Cre-inducible":[89],"Myc-":[90],"Mdm2-containing":[92,128],"ecDNAs":[93,106,129],"analogous":[94],"those":[96],"occurring":[97],"human":[99,179],"cancers.":[100],"show":[102],"that":[103,156],"engineered":[105],"spontaneously":[107],"accumulate":[108],"derived":[112],"from":[113],"these":[114],"animals,":[115],"promoting":[116],"their":[117],"proliferation,":[118],"immortalization":[119],"transformation.":[121],"Finally,":[122],"demonstrate":[124],"ability":[126],"promote":[131,261],"tumour":[132],"an":[135],"autochthonous":[136],"mouse":[137,176],"hepatocellular":[140],"carcinoma.These":[141],"findings":[142],"offer":[143],"insights":[144],"into":[145],"role":[147],"ecDNA-mediated":[149],"tumorigenesis.":[153],"anticipate":[155],"will":[159],"be":[160],"valuable":[161],"for":[162,171,270],"investigating":[163],"further":[164],"unresolved":[165],"aspects":[166],"biology":[169],"developing":[172],"new":[173],"preclinical":[174],"immunocompetent":[175],"models":[177],"cancers":[180],"amplifications.":[185],"Citation":[186],"Format:":[187],"Melissa":[188],"A.":[189],"Yao,":[190],"Davide":[191],"Pradella,":[192],"Minsi":[193],"Zhang,":[194,229],"Rui":[195],"Gao,":[196],"Katarzyna":[197],"M.":[198,218],"Gluchowska,":[199],"Ylenia":[200],"Cendon":[201],"Florez,":[202],"Tanmay":[203],"Mishra,":[204],"Gaspare":[205],"La":[206],"Rocca,":[207],"Moritz":[208],"Weigl,":[209],"Ziqi":[210],"Jiao,":[211],"Hieu":[212],"H.":[213],"Nguyen,":[214],"Marta":[215],"Lisi,":[216],"Mateusz":[217],"Ozimek,":[219],"Chiara":[220],"Mastroleo,":[221],"Kevin":[222],"Chen,":[223],"Felix":[224],"Grimm,":[225],"Jens":[226],"Luebeck,":[227],"Shu":[228],"Andrea":[230,255],"Alice":[231],"Zolli,":[232],"Eric":[233],"G.":[234],"Sun,":[235],"Bhargavi":[236],"Dameracharla,":[237],"Zhengqiao":[238],"Zhao,":[239],"Yuri":[240],"Pritykin,":[241],"Carlie":[242],"Siegel,":[243],"Howard":[244],"Y.":[245],"Chang,":[246],"Paul":[247],"S.":[248],"Mischel,":[249],"Vineet":[250],"Bafna,":[251],"Cristina":[252],"R.":[253],"Antonescu,":[254],"Ventura.":[256],"Engineered":[257],"oncogene":[259],"tumorigenesis":[262],"[abstract].":[263],"In:":[264],"Proceedings":[265],"American":[268],"Association":[269],"Cancer":[271,288],"Research":[272],"Annual":[273],"Meeting":[274],"2025;":[275],"Part":[276],"(Regular":[278],"Abstracts);":[279],"2025":[280],"Apr":[281],"25-30;":[282],"Chicago,":[283],"IL.":[284],"Philadelphia":[285],"(PA):":[286],"AACR;":[287],"Res":[289],"2025;85(8_Suppl_1):Abstract":[290],"nr":[291],"2853.":[292]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2025-04-23T00:00:00"}
