{"id":"https://openalex.org/W4409689484","doi":"https://doi.org/10.1158/1538-7445.am2025-2038","title":"Abstract 2038: Antibody Drug Conjugates Treatment Response Score (ADC TRS) for predicting ADC treatment response","display_name":"Abstract 2038: Antibody Drug Conjugates Treatment Response Score (ADC TRS) for predicting ADC treatment response","publication_year":2025,"publication_date":"2025-04-21","ids":{"openalex":"https://openalex.org/W4409689484","doi":"https://doi.org/10.1158/1538-7445.am2025-2038"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2025-2038","doi":"https://doi.org/10.1158/1538-7445.am2025-2038","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2025-2038","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043991433","display_name":"Sachdev P. Thomas","orcid":"https://orcid.org/0000-0003-3867-2454","observed_orcids":["https://orcid.org/0000-0003-3867-2454","https://orcid.org/0000-0002-5841-9213"]},"institutions":[{"id":"https://openalex.org/I1343052199","display_name":"Kaiser Permanente","ror":"https://ror.org/00t60zh31","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1343052199"]},{"id":"https://openalex.org/I4210122253","display_name":"Kaiser Permanente Vallejo Medical Center","ror":"https://ror.org/02r3xg590","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343052199","https://openalex.org/I4210122253"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sachdev P. Thomas","raw_affiliation_strings":["1Kaiser Permanente, Vallejo, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Kaiser Permanente, Vallejo, CA;","institution_ids":["https://openalex.org/I1343052199","https://openalex.org/I4210122253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029294320","display_name":"Laurel A. Habel","orcid":"https://orcid.org/0000-0002-7230-587X","observed_orcids":["https://orcid.org/0000-0002-7230-587X"]},"institutions":[{"id":"https://openalex.org/I1343052199","display_name":"Kaiser Permanente","ror":"https://ror.org/00t60zh31","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1343052199"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laurel A. Habel","raw_affiliation_strings":["2Kaiser Permanente Division of Research, Pleasanton, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Kaiser Permanente Division of Research, Pleasanton, CA;","institution_ids":["https://openalex.org/I1343052199"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024459006","display_name":"Jennifer Marie Suga","orcid":"https://orcid.org/0009-0005-9560-7511","observed_orcids":["https://orcid.org/0009-0005-9560-7511"]},"institutions":[{"id":"https://openalex.org/I1343052199","display_name":"Kaiser Permanente","ror":"https://ror.org/00t60zh31","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1343052199"]},{"id":"https://openalex.org/I4210122253","display_name":"Kaiser Permanente Vallejo Medical Center","ror":"https://ror.org/02r3xg590","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343052199","https://openalex.org/I4210122253"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer M. Suga","raw_affiliation_strings":["1Kaiser Permanente, Vallejo, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Kaiser Permanente, Vallejo, CA;","institution_ids":["https://openalex.org/I1343052199","https://openalex.org/I4210122253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052022673","display_name":"Ninah S. Achacoso","orcid":"https://orcid.org/0000-0002-9713-5942","observed_orcids":["https://orcid.org/0000-0002-9713-5942"]},"institutions":[{"id":"https://openalex.org/I1343052199","display_name":"Kaiser Permanente","ror":"https://ror.org/00t60zh31","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1343052199"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ninah Achacoso","raw_affiliation_strings":["2Kaiser Permanente Division of Research, Pleasanton, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Kaiser Permanente Division of Research, Pleasanton, CA;","institution_ids":["https://openalex.org/I1343052199"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031204545","display_name":"Joshua R. Nugent","orcid":"https://orcid.org/0000-0002-4479-9673","observed_orcids":["https://orcid.org/0000-0002-4479-9673"]},"institutions":[{"id":"https://openalex.org/I1343052199","display_name":"Kaiser Permanente","ror":"https://ror.org/00t60zh31","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1343052199"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua R. Nugent","raw_affiliation_strings":["2Kaiser Permanente Division of Research, Pleasanton, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Kaiser Permanente Division of Research, Pleasanton, CA;","institution_ids":["https://openalex.org/I1343052199"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101819927","display_name":"Chen Jiang","orcid":"https://orcid.org/0000-0003-4672-3549","observed_orcids":["https://orcid.org/0000-0003-4672-3549"]},"institutions":[{"id":"https://openalex.org/I1343052199","display_name":"Kaiser Permanente","ror":"https://ror.org/00t60zh31","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1343052199"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chen Jiang","raw_affiliation_strings":["2Kaiser Permanente Division of Research, Pleasanton, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Kaiser Permanente Division of Research, Pleasanton, CA;","institution_ids":["https://openalex.org/I1343052199"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075021917","display_name":"Elaine H. Chung","orcid":"https://orcid.org/0009-0003-7267-9235","observed_orcids":["https://orcid.org/0009-0003-7267-9235"]},"institutions":[{"id":"https://openalex.org/I1343052199","display_name":"Kaiser Permanente","ror":"https://ror.org/00t60zh31","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1343052199"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elaine Chung","raw_affiliation_strings":["2Kaiser Permanente Division of Research, Pleasanton, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Kaiser Permanente Division of Research, Pleasanton, CA;","institution_ids":["https://openalex.org/I1343052199"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Stephanie Bush","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405264897","display_name":"Strata Oncology (United States)","ror":"https://ror.org/039tnn984","country_code":"US","type":"company","lineage":["https://openalex.org/I4405264897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephanie Bush","raw_affiliation_strings":["3Strata Oncology, Ann Arbor, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Strata Oncology, Ann Arbor, MI","institution_ids":["https://openalex.org/I4405264897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5117257806","display_name":"Michael D. Nitchie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405264897","display_name":"Strata Oncology (United States)","ror":"https://ror.org/039tnn984","country_code":"US","type":"company","lineage":["https://openalex.org/I4405264897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael D. Nitchie","raw_affiliation_strings":["3Strata Oncology, Ann Arbor, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Strata Oncology, Ann Arbor, MI","institution_ids":["https://openalex.org/I4405264897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114178350","display_name":"Katarina M. Robinson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405264897","display_name":"Strata Oncology (United States)","ror":"https://ror.org/039tnn984","country_code":"US","type":"company","lineage":["https://openalex.org/I4405264897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katarina M. Robinson","raw_affiliation_strings":["3Strata Oncology, Ann Arbor, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Strata Oncology, Ann Arbor, MI","institution_ids":["https://openalex.org/I4405264897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113254805","display_name":"Jasie Inman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405264897","display_name":"Strata Oncology (United States)","ror":"https://ror.org/039tnn984","country_code":"US","type":"company","lineage":["https://openalex.org/I4405264897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jasie Inman","raw_affiliation_strings":["3Strata Oncology, Ann Arbor, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Strata Oncology, Ann Arbor, MI","institution_ids":["https://openalex.org/I4405264897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112965973","display_name":"Ryan White","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405264897","display_name":"Strata Oncology (United States)","ror":"https://ror.org/039tnn984","country_code":"US","type":"company","lineage":["https://openalex.org/I4405264897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryan White","raw_affiliation_strings":["3Strata Oncology, Ann Arbor, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Strata Oncology, Ann Arbor, MI","institution_ids":["https://openalex.org/I4405264897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069304786","display_name":"Komal R. Plouffe","orcid":"https://orcid.org/0009-0005-7674-3681","observed_orcids":["https://orcid.org/0009-0005-7674-3681"]},"institutions":[{"id":"https://openalex.org/I4405264897","display_name":"Strata Oncology (United States)","ror":"https://ror.org/039tnn984","country_code":"US","type":"company","lineage":["https://openalex.org/I4405264897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Komal Plouffe","raw_affiliation_strings":["3Strata Oncology, Ann Arbor, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Strata Oncology, Ann Arbor, MI","institution_ids":["https://openalex.org/I4405264897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011310452","display_name":"Daniel R. Rhodes","orcid":"https://orcid.org/0009-0004-6336-9849","observed_orcids":["https://orcid.org/0009-0004-6336-9849"]},"institutions":[{"id":"https://openalex.org/I4405264897","display_name":"Strata Oncology (United States)","ror":"https://ror.org/039tnn984","country_code":"US","type":"company","lineage":["https://openalex.org/I4405264897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel R. Rhodes","raw_affiliation_strings":["3Strata Oncology, Ann Arbor, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Strata Oncology, Ann Arbor, MI","institution_ids":["https://openalex.org/I4405264897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068238406","display_name":"Scott A. Tomlins","orcid":"https://orcid.org/0000-0001-8661-9821","observed_orcids":["https://orcid.org/0000-0001-8661-9821"]},"institutions":[{"id":"https://openalex.org/I4405264897","display_name":"Strata Oncology (United States)","ror":"https://ror.org/039tnn984","country_code":"US","type":"company","lineage":["https://openalex.org/I4405264897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott A. Tomlins","raw_affiliation_strings":["3Strata Oncology, Ann Arbor, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Strata Oncology, Ann Arbor, MI","institution_ids":["https://openalex.org/I4405264897"]}]},{"author_position":"last","author":{"id":null,"display_name":"Bryan Johnson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405264897","display_name":"Strata Oncology (United States)","ror":"https://ror.org/039tnn984","country_code":"US","type":"company","lineage":["https://openalex.org/I4405264897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bryan Johnson","raw_affiliation_strings":["3Strata Oncology, Ann Arbor, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Strata Oncology, Ann Arbor, MI","institution_ids":["https://openalex.org/I4405264897"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"85","issue":"8_Supplement_1","first_page":"2038","last_page":"2038"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.513700008392334,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.513700008392334,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.09000000357627869,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.0738999992609024,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antibody-drug-conjugates","display_name":"antibody-drug conjugates","score":0.8790000081062317},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.9860000014305115},{"id":"https://openalex.org/keywords/enfortumab-vedotin","display_name":"enfortumab vedotin","score":0.8960000276565552},{"id":"https://openalex.org/keywords/sacituzumab-govitecan","display_name":"sacituzumab govitecan","score":0.9980000257492065},{"id":"https://openalex.org/keywords/trastuzumab-deruxtecan","display_name":"trastuzumab deruxtecan","score":0.9980000257492065},{"id":"https://openalex.org/keywords/advanced-bladder-cancer","display_name":"advanced bladder cancer","score":0.9089999794960022},{"id":"https://openalex.org/keywords/advanced-breast-cancer","display_name":"advanced breast cancer","score":0.9359999895095825},{"id":"https://openalex.org/keywords/qrt-pcr-assay","display_name":"qRT-PCR assay","score":0.7080000042915344},{"id":"https://openalex.org/keywords/treatment-response-prediction","display_name":"treatment response prediction","score":0.5740000009536743},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.8730000257492065},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.996999979019165},{"id":"https://openalex.org/keywords/kaiser-permanente","display_name":"Kaiser Permanente","score":0.7820000052452087}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6729547381401062},{"id":"https://openalex.org/C2777325958","wikidata":"https://www.wikidata.org/wiki/Q1069596","display_name":"Antibody-drug conjugate","level":4,"score":0.6160092949867249},{"id":"https://openalex.org/C2994119904","wikidata":"https://www.wikidata.org/wiki/Q1251001","display_name":"Drug response","level":3,"score":0.5011501312255859},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4323676526546478},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4255558252334595},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41338858008384705},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.37957870960235596},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.2588309943675995},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1649121642112732},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.12744522094726562}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2025-2038","doi":"https://doi.org/10.1158/1538-7445.am2025-2038","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2025-2038","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4399737228","https://openalex.org/W4396597926","https://openalex.org/W4410803684","https://openalex.org/W4402561467","https://openalex.org/W7165042248","https://openalex.org/W4399323703","https://openalex.org/W4394989609","https://openalex.org/W7148813501","https://openalex.org/W7130720695","https://openalex.org/W151654754"],"abstract_inverted_index":{"Abstract":[0],"Background:":[1],"Predictive":[2],"biomarkers":[3],"for":[4,74,226,248,277,294,351,363],"multiple":[5],"ADCs/tumor":[6],"types":[7],"(beyond":[8],"3+":[9],"HER2":[10],"IHC)":[11],"are":[12],"lacking.":[13],"We":[14],"previously":[15],"reported":[16],"the":[17,54,82,180,233,360],"discovery":[18],"of":[19,192,284,359],"ADC":[20,25,35,45,56,76,106,135,148,157,168,210,250,353],"TRS\u2014an":[21],"algorithm":[22],"combining":[23],"individual":[24],"target":[26],"expression,":[27],"proliferation,":[28],"and":[29,183,216,221,228,243,246,258,275],"adhesion":[30],"by":[31,66,119,179],"RNAseq":[32],"to":[33,133,156,163],"predict":[34],"clinical":[36,70,77],"benefit":[37],"across":[38,256],"tumor":[39,63,259],"types/targets\u2014and":[40],"association":[41],"with":[42,89,103,123,140,196,207,239,271,286],"OS":[43,247,276],"after":[44],"treatment":[46,150,354],"(Abstract":[47],"3140,":[48],"ASCO":[49],"2024).":[50],"Here":[51],"we":[52],"evaluated":[53],"final":[55],"TRS":[57,126,158,169,227],"biomarker":[58],"(ADC-specific;":[59],"tuned":[60],"on":[61],">100":[62],"type/ADC":[64],"RRs)":[65],"a":[67,186,263],"qRT-PCR":[68,264],"based":[69,265],"trial":[71,98],"assay":[72],"(CTA)":[73],"predicting":[75,352],"benefit.":[78],"Methods:":[79],"Adults":[80],"in":[81,95,232,280],"Kaiser":[83],"Permanente":[84],"Northern":[85],"California":[86],"(KPNC)":[87],"system":[88],"advanced":[90,197,287],"bladder":[91,198,288],"or":[92,113,143,201,289],"breast":[93,202,290],"cancer":[94,205],"an":[96,104,208,281],"observational":[97,282],"(NCT03061305)":[99],"who":[100],"were":[101,137,151,177,224,253],"treated":[102,206],"approved":[105,209,249,278,295],"(enfortumab":[107],"vedotin":[108],"[EV],":[109],"sacituzumab":[110],"govitecan":[111],"[SG]":[112],"trastuzumab":[114,142],"deruxtecan":[115],"[T-DXd];":[116],"first":[117],"dose":[118],"Apr.":[120],"21,":[121],"2023)":[122],"valid":[124],"CTA":[125],"results":[127,252],"from":[128,165],"FFPE":[129],"tissue":[130,146],"(collected":[131],"prior":[132,141],"1st":[134],"treatment)":[136],"eligible;":[138],"patients":[139,195,285],"hormonal":[144],"(between":[145],"collection/":[147],"start)":[149],"excluded.":[152],"KPNC":[153,181,194],"oncologists":[154],"(blinded":[155],"status)":[159],"determined":[160],"best":[161],"response":[162,175,355],"therapy":[164],"chart":[166],"review.":[167],"status":[170,236,268],"(+":[171],"vs.":[172],"-)":[173],"/":[174],"data":[176],"merged":[178],"statistician":[182],"analyzed":[184],"per":[185],"prespecified":[187],"plan.":[188],"Results:":[189],"A":[190],"total":[191],"117":[193],"(n=58":[199],"[50%])":[200,204],"(n=59":[203],"(n=":[211],"56":[212],"[48%],":[213],"47":[214],"[40%],":[215],"14":[217],"[12%]":[218],"EV,":[219],"SG,":[220],"T-DXd,":[222],"respectively)":[223],"evaluable":[225],"RR.":[229],"As":[230],"shown":[231],"Table,":[234],"TRS+":[235,267],"was":[237,269],"associated":[238,270],"significantly":[240],"higher":[241],"RR":[242],"longer":[244],"PFS":[245,274],"treatment;":[251],"generally":[254],"similar":[255],"ADCs":[257,279,298],"type.":[260],"Conclusions:":[261],"By":[262],"CTA,":[266],"improved":[272],"RR,":[273],"cohort":[283],"cancer.":[291],"Prospective":[292],"validation":[293],"and/or":[296],"investigational":[297],"is":[299],"warranted.":[300],"Citation":[301],"Format:":[302],"Sachdev":[303],"P.":[304],"Thomas,":[305],"Laurel":[306],"A.":[307,339],"Habel,":[308],"Jennifer":[309],"M.":[310,327],"Suga,":[311],"Ninah":[312],"Achacoso,":[313],"Joshua":[314],"R.":[315,336],"Nugent,":[316],"Chen":[317],"Jiang,":[318],"Elaine":[319],"Chung,":[320],"Stephanie":[321],"Bush,":[322],"Michael":[323],"D.":[324],"Nitchie,":[325],"Katarina":[326],"Robinson,":[328],"Jasie":[329],"Inman,":[330],"Ryan":[331],"White,":[332],"Komal":[333],"Plouffe,":[334],"Daniel":[335],"Rhodes,":[337],"Scott":[338],"Tomlins,":[340],"Bryan":[341],"Johnson.":[342],"Antibody":[343],"Drug":[344],"Conjugates":[345],"Treatment":[346],"Response":[347],"Score":[348],"(ADC":[349],"TRS)":[350],"[abstract].":[356],"In:":[357],"Proceedings":[358],"American":[361],"Association":[362],"Cancer":[364,381],"Research":[365],"Annual":[366],"Meeting":[367],"2025;":[368],"Part":[369],"1":[370],"(Regular":[371],"Abstracts);":[372],"2025":[373],"Apr":[374],"25-30;":[375],"Chicago,":[376],"IL.":[377],"Philadelphia":[378],"(PA):":[379],"AACR;":[380],"Res":[382],"2025;85(8_Suppl_1):Abstract":[383],"nr":[384],"2038.":[385]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-04-23T00:00:00"}