{"id":"https://openalex.org/W4409688959","doi":"https://doi.org/10.1158/1538-7445.am2025-3178","title":"Abstract 3178: Discovery and characterization of small molecules to enhance NK cell cytotoxicity against solid tumors","display_name":"Abstract 3178: Discovery and characterization of small molecules to enhance NK cell cytotoxicity against solid tumors","publication_year":2025,"publication_date":"2025-04-21","ids":{"openalex":"https://openalex.org/W4409688959","doi":"https://doi.org/10.1158/1538-7445.am2025-3178"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2025-3178","doi":"https://doi.org/10.1158/1538-7445.am2025-3178","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2025-3178","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Indrani Das","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Indrani Das","raw_affiliation_strings":["Case Western Reserve University School of Medicine, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Case Western Reserve University School of Medicine, Cleveland, OH","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065620648","display_name":"Olubukola M. Abiona","orcid":"https://orcid.org/0000-0002-2745-1691","observed_orcids":["https://orcid.org/0000-0002-2745-1691"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Olubukola Abiona","raw_affiliation_strings":["Case Western Reserve University School of Medicine, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Case Western Reserve University School of Medicine, Cleveland, OH","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002070042","display_name":"Riufu Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Riufu Liu","raw_affiliation_strings":["Case Western Reserve University School of Medicine, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Case Western Reserve University School of Medicine, Cleveland, OH","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005791561","display_name":"David N. Wald","orcid":"https://orcid.org/0000-0002-8695-1178","observed_orcids":["https://orcid.org/0000-0002-8695-1178"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David N. Wald","raw_affiliation_strings":["Case Western Reserve University School of Medicine, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Case Western Reserve University School of Medicine, Cleveland, OH","institution_ids":["https://openalex.org/I58956616"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I58956616"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"85","issue":"8_Supplement_1","first_page":"3178","last_page":"3178"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nk-cell-cytotoxicity","display_name":"NK cell cytotoxicity","score":0.9070000052452087},{"id":"https://openalex.org/keywords/nk-cell-therapy","display_name":"NK cell therapy","score":0.859000027179718},{"id":"https://openalex.org/keywords/small-molecule-enhancers","display_name":"small molecule enhancers","score":0.7580000162124634},{"id":"https://openalex.org/keywords/solid-tumors","display_name":"solid tumors","score":0.7559999823570251},{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.9729999899864197},{"id":"https://openalex.org/keywords/ovcar-3-cells","display_name":"OVCAR-3 cells","score":0.890999972820282},{"id":"https://openalex.org/keywords/high-throughput-phenotypic-screening","display_name":"high-throughput phenotypic screening","score":0.8880000114440918},{"id":"https://openalex.org/keywords/adoptive-immunotherapy","display_name":"adoptive immunotherapy","score":0.921999990940094},{"id":"https://openalex.org/keywords/lead-identification","display_name":"lead compound identification","score":0.5400000214576721},{"id":"https://openalex.org/keywords/medicinal-chemistry","display_name":"medicinal chemistry","score":0.609000027179718}],"concepts":[{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.7771719098091125},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5065802335739136},{"id":"https://openalex.org/C2780841128","wikidata":"https://www.wikidata.org/wiki/Q5073781","display_name":"Characterization (materials science)","level":2,"score":0.4782071113586426},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.45893192291259766},{"id":"https://openalex.org/C2993640289","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Solid tumor","level":3,"score":0.4355373978614807},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4263918101787567},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3722281754016876},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.34786373376846313},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3230592608451843},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.28630566596984863},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.25429660081863403},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.213943749666214},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.18332144618034363},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12504488229751587}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2025-3178","doi":"https://doi.org/10.1158/1538-7445.am2025-3178","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2025-3178","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2366562690","https://openalex.org/W2796949944","https://openalex.org/W2395219877","https://openalex.org/W3092521730","https://openalex.org/W2045299745","https://openalex.org/W3152230514","https://openalex.org/W3147138563","https://openalex.org/W891673278","https://openalex.org/W2409963492","https://openalex.org/W2095277644"],"abstract_inverted_index":{"Abstract":[0],"Adoptive":[1],"cell":[2,24,73,109,218,249],"therapies":[3,25],"(ACT),":[4],"such":[5],"as":[6],"CAR-T":[7],"and":[8,47,98,168,176,241],"NK":[9,23,72,88,108,141,206,217,248],"therapy,":[10],"have":[11,28],"transformed":[12],"hematologic":[13],"cancer":[14,40,92],"treatment":[15],"but":[16,42],"show":[17],"limited":[18],"efficacy":[19,225],"against":[20,75,90,143,226,251],"solid":[21,227,252],"tumors.":[22],"in":[26,51],"particular":[27],"an":[29],"excellent":[30],"safety":[31],"profile":[32,178],"due":[33],"to":[34,44,65,86,134,171,189,212,222,246],"their":[35,84],"specific,":[36],"innate":[37],"recognition":[38],"of":[39,111,130,150,166,179,192,243,257],"cells,":[41],"fail":[43],"elicit":[45],"adequate":[46],"sustained":[48],"tumor":[49,76],"clearance":[50],"vivo.":[52],"To":[53],"address":[54],"this":[55],"hurdle,":[56],"we":[57,155,210],"developed":[58],"a":[59,124,164],"high-throughput":[60],"phenotypic":[61],"small":[62,244],"molecule":[63],"screen":[64,97],"identify":[66,157],"novel":[67],"compounds":[68,82,105,133],"that":[69,106,137],"can":[70],"enhance":[71,87,140,247],"cytotoxicity":[74,89,142,250],"cells.":[77],"We":[78,119,182],"screened":[79],"300,":[80],"000":[81],"for":[83,201,261],"ability":[85],"ovarian":[91],"cells":[93,113],"(OVCAR-3).":[94],"Our":[95],"primary":[96],"subsequent":[99],"hit":[100],"validation":[101],"identified":[102],"11":[103,132],"lead":[104,161,195],"increase":[107,115,190],"killing":[110],"OVCAR-3":[112],"(>10%":[114],"over":[116],"vehicle-treated":[117],"control).":[118],"performed":[120],"secondary":[121,148,167],"screening":[122,149],"using":[123],"flow":[125],"cytometry-based":[126],"assay":[127],"on":[128],"5":[129],"these":[131],"date,":[135],"confirming":[136],"3":[138],"significantly":[139],"OVCAR-3.":[144],"After":[145],"completing":[146],"the":[147,151,158,173,203,258],"remaining":[152],"6":[153],"compounds,":[154],"will":[156,183],"most":[159],"promising":[160],"compound(s)":[162],"through":[163],"series":[165],"orthogonal":[169],"assays":[170],"characterize":[172],"biological":[174],"activity":[175],"toxicity":[177],"validated":[180],"hits.":[181],"then":[184],"pursue":[185],"medicinal":[186],"chemistry":[187],"efforts":[188],"potency":[191],"our":[193,214],"best":[194],"compound,":[196],"coupled":[197],"with":[198],"mechanistic":[199],"studies":[200],"how":[202],"compound":[204],"promotes":[205],"cytotoxic":[207],"activity.":[208],"Ultimately,":[209],"hope":[211],"translate":[213],"findings":[215],"into":[216],"therapy":[219],"clinical":[220],"trials":[221],"achieve":[223],"greater":[224],"cancers.":[228],"Citation":[229],"Format:":[230],"Indrani":[231],"Das,":[232],"Olubukola":[233],"Abiona,":[234],"Riufu":[235],"Liu,":[236],"David":[237],"N.":[238],"Wald.":[239],"Discovery":[240],"characterization":[242],"molecules":[245],"tumors":[253],"[abstract].":[254],"In:":[255],"Proceedings":[256],"American":[259],"Association":[260],"Cancer":[262,279],"Research":[263],"Annual":[264],"Meeting":[265],"2025;":[266],"Part":[267],"1":[268],"(Regular":[269],"Abstracts);":[270],"2025":[271],"Apr":[272],"25-30;":[273],"Chicago,":[274],"IL.":[275],"Philadelphia":[276],"(PA):":[277],"AACR;":[278],"Res":[280],"2025;85(8_Suppl_1):Abstract":[281],"nr":[282],"3178.":[283]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2025-10-10T00:00:00"}