{"id":"https://openalex.org/W4409688955","doi":"https://doi.org/10.1158/1538-7445.am2025-2843","title":"Abstract 2843: Neoantigen evaluation in viably cryopreserved dissociated tissue via large scale proteomic profiling","display_name":"Abstract 2843: Neoantigen evaluation in viably cryopreserved dissociated tissue via large scale proteomic profiling","publication_year":2025,"publication_date":"2025-04-21","ids":{"openalex":"https://openalex.org/W4409688955","doi":"https://doi.org/10.1158/1538-7445.am2025-2843"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2025-2843","doi":"https://doi.org/10.1158/1538-7445.am2025-2843","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2025-2843","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078677394","display_name":"Shawn P. Fahl","orcid":"https://orcid.org/0000-0002-0489-2048","observed_orcids":["https://orcid.org/0000-0002-0489-2048"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shawn P. Fahl","raw_affiliation_strings":["Discovery Life Sciences, Huntsville, AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Life Sciences, Huntsville, AL","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Casey Smith","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Casey Smith","raw_affiliation_strings":["Discovery Life Sciences, Huntsville, AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Life Sciences, Huntsville, AL","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013682490","display_name":"Kerri Colwell","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kerri Colwell","raw_affiliation_strings":["Discovery Life Sciences, Huntsville, AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Life Sciences, Huntsville, AL","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000780531","display_name":"Jessica L. Moore","orcid":"https://orcid.org/0000-0003-2519-6209","observed_orcids":["https://orcid.org/0000-0003-2519-6209","https://orcid.org/0000-0001-8273-198X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jessica Moore","raw_affiliation_strings":["Discovery Life Sciences, Huntsville, AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Life Sciences, Huntsville, AL","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061030639","display_name":"Jaison Arivalagan","orcid":"https://orcid.org/0000-0001-8426-5273","observed_orcids":["https://orcid.org/0000-0001-8426-5273"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jaison Arivalagan","raw_affiliation_strings":["Discovery Life Sciences, Huntsville, AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Life Sciences, Huntsville, AL","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082734868","display_name":"Danielle B. Gutierrez","orcid":"https://orcid.org/0000-0001-6355-2134","observed_orcids":["https://orcid.org/0000-0001-6355-2134"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Danielle Gutierrez","raw_affiliation_strings":["Discovery Life Sciences, Huntsville, AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Life Sciences, Huntsville, AL","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"85","issue":"8_Supplement_1","first_page":"2843","last_page":"2843"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9585000276565552,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9585000276565552,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.03269999846816063,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neoantigens","display_name":"neoantigens","score":0.8529999852180481},{"id":"https://openalex.org/keywords/proteomic-profiling","display_name":"proteomic profiling","score":0.8529999852180481},{"id":"https://openalex.org/keywords/microsatellite-instability","display_name":"microsatellite instability","score":0.953000009059906},{"id":"https://openalex.org/keywords/genomic-instability","display_name":"genomic instability","score":0.6899999976158142},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.7739999890327454},{"id":"https://openalex.org/keywords/tumor-infiltrating-lymphocytes","display_name":"tumor-infiltrating lymphocytes","score":0.7260000109672546},{"id":"https://openalex.org/keywords/tcr-repertoire","display_name":"T cell receptor repertoire","score":0.9120000004768372},{"id":"https://openalex.org/keywords/tumor-spheroids","display_name":"tumor spheroids","score":0.7369999885559082},{"id":"https://openalex.org/keywords/tumor-organoids","display_name":"tumor organoids","score":0.9380000233650208},{"id":"https://openalex.org/keywords/endometrial-cancer","display_name":"endometrial cancer","score":0.8870000243186951},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":1.0},{"id":"https://openalex.org/keywords/gastric-cancer","display_name":"gastric cancer","score":0.8399999737739563},{"id":"https://openalex.org/keywords/peptide-identification","display_name":"peptide identification","score":0.5509999990463257}],"concepts":[{"id":"https://openalex.org/C187191949","wikidata":"https://www.wikidata.org/wiki/Q1138496","display_name":"Profiling (computer programming)","level":2,"score":0.5136439204216003},{"id":"https://openalex.org/C179933525","wikidata":"https://www.wikidata.org/wiki/Q1144664","display_name":"Cryopreservation","level":3,"score":0.49328774213790894},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4760468006134033},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4296518564224243},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3398939371109009},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3138664960861206},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.11491191387176514},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.07784926891326904},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2025-2843","doi":"https://doi.org/10.1158/1538-7445.am2025-2843","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2025-2843","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1993038879","https://openalex.org/W2136697025","https://openalex.org/W3045600643","https://openalex.org/W2102962539","https://openalex.org/W2395116956","https://openalex.org/W3123264629","https://openalex.org/W2127199585","https://openalex.org/W1968032681","https://openalex.org/W13423357","https://openalex.org/W2354800684"],"abstract_inverted_index":{"Abstract":[0],"Genomic":[1],"instability":[2,160,163],"is":[3,55,73,91,98],"a":[4,110,140,155,254,269],"hallmark":[5],"of":[6,11,26,34,42,48,52,158,170,232,304],"cancer":[7,45,152,175],"where":[8],"the":[9,24,31,40,49,58,71,77,113,123,227,230,262,305],"acquisition":[10],"numerous":[12],"genetic":[13,129],"alterations":[14,21,130],"leads":[15],"to":[16,79,93,101,115,209,216,240,257,265],"transformation":[17],"and":[18,30,68,106,131,173,180,195,200,235,247,260,271],"carcinogenesis.":[19],"These":[20,222],"result":[22],"in":[23,44,60,81,94,109,268,291],"generation":[25,51],"potentially":[27],"immunogenic":[28],"neoantigens,":[29],"clinical":[32],"success":[33],"checkpoint":[35],"inhibitor":[36],"therapies":[37,54],"has":[38],"highlighted":[39],"importance":[41],"neoantigens":[43,135,259],"immunotherapy.":[46],"Evaluation":[47],"next":[50],"neoantigen":[53],"complicated":[56],"by":[57],"difficulty":[59],"sourcing":[61],"primary":[62],"patient":[63],"material.":[64],"During":[65],"tumor":[66,124],"resection":[67],"pathology":[69],"review,":[70],"tissue":[72,90,295],"fixed,":[74],"which":[75],"prevents":[76],"ability":[78],"test":[80,144],"vitro":[82,95],"model":[83],"systems":[84,239],"for":[85,112,128,161,188,229,308],"therapy":[86],"efficacy.":[87],"While":[88],"fresh":[89],"amendable":[92,208],"culture,":[96],"it":[97],"not":[99],"possible":[100],"perform":[102],"large":[103,297],"scale":[104,298],"genomic":[105,159],"proteomic":[107,299],"screens":[108],"timeframe":[111],"culture":[114,238],"occur.":[116],"By":[117],"leveraging":[118],"viably":[119,292],"cryopreserved":[120,293],"dissociated":[121,149,294],"tissue,":[122],"can":[125],"be":[126],"analyzed":[127,187],"then,":[132],"when":[133],"novel":[134],"are":[136],"determined,":[137],"cultured":[138],"at":[139],"later":[141],"date.":[142],"To":[143],"this":[145,251],"workflow,":[146],"we":[147],"profiled":[148],"tissues":[150],"from":[151],"indications":[153],"with":[154,166],"high":[156],"degree":[157],"microsatellite":[162,181],"(MSI).":[164],"Consistent":[165],"previous":[167],"studies,":[168],"17-55%":[169],"endometrial,":[171],"colorectal,":[172],"gastric":[174],"samples":[176,184],"were":[177,185,203,206],"MSI-high.":[178],"MSI-high":[179],"stable":[182],"(MSS)":[183],"further":[186],"peptide":[189],"identification":[190],"using":[191,244],"LC-MS/MS":[192],"(Orbitrap":[193],"Astral)":[194],"over":[196],"10,000":[197],"protein":[198],"groups":[199],"80,000":[201],"peptides":[202],"identified.":[204],"Samples":[205],"also":[207],"T":[210,219],"cell":[211,220],"receptor":[212],"(TCR)":[213],"repertoire":[214],"sequencing":[215],"uncover":[217],"tumor-reactive":[218],"clones.":[221],"deep":[223],"molecular":[224],"analyses":[225],"provided":[226],"foundation":[228],"development":[231],"short-term":[233],"spheroid":[234],"long-term":[236],"tumoroid":[237],"understand":[241],"immune":[242,263],"responses":[243],"autologous":[245],"tumor-infiltrating":[246],"peripheral":[248],"lymphocytes.":[249],"Collectively,":[250],"workflow":[252],"provides":[253],"scalable":[255],"system":[256],"identify":[258],"evaluate":[261],"response":[264],"these":[266],"antigens":[267],"robust":[270],"reproducible":[272],"pipeline.":[273],"Citation":[274],"Format:":[275],"Shawn":[276],"P.":[277],"Fahl,":[278],"Casey":[279],"Smith,":[280],"Kerri":[281],"Colwell,":[282],"Jessica":[283],"Moore,":[284],"Jaison":[285],"Arivalagan,":[286],"Danielle":[287],"Gutierrez.":[288],"Neoantigen":[289],"evaluation":[290],"via":[296],"profiling":[300],"[abstract].":[301],"In:":[302],"Proceedings":[303],"American":[306],"Association":[307],"Cancer":[309,326],"Research":[310],"Annual":[311],"Meeting":[312],"2025;":[313],"Part":[314],"1":[315],"(Regular":[316],"Abstracts);":[317],"2025":[318],"Apr":[319],"25-30;":[320],"Chicago,":[321],"IL.":[322],"Philadelphia":[323],"(PA):":[324],"AACR;":[325],"Res":[327],"2025;85(8_Suppl_1):Abstract":[328],"nr":[329],"2843.":[330]},"counts_by_year":[],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2025-10-10T00:00:00"}
