{"id":"https://openalex.org/W4409688912","doi":"https://doi.org/10.22377/ajp.v19i01.6081","title":"Investigating the Role of Experimental Variables in Characterization of Lidocaine Hydrochloride Cubosomes by QbD","display_name":"Investigating the Role of Experimental Variables in Characterization of Lidocaine Hydrochloride Cubosomes by QbD","publication_year":2025,"publication_date":"2025-03-01","ids":{"openalex":"https://openalex.org/W4409688912","doi":"https://doi.org/10.22377/ajp.v19i01.6081"},"language":"en","primary_location":{"id":"doi:10.22377/ajp.v19i01.6081","doi":"https://doi.org/10.22377/ajp.v19i01.6081","is_oa":true,"landing_page_url":"https://doi.org/10.22377/ajp.v19i01.6081","pdf_url":"https://www.asiapharmaceutics.info/index.php/ajp/article/download/6081/1771","source":{"id":"https://openalex.org/S66408587","display_name":"Asian Journal of Pharmaceutics","issn_l":"0973-8398","issn":["0973-8398","1998-409X"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Journal of Pharmaceutics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.asiapharmaceutics.info/index.php/ajp/article/download/6081/1771","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103136490","display_name":"Chakravarthi Guntupalli","orcid":"https://orcid.org/0000-0003-3777-3157","observed_orcids":["https://orcid.org/0000-0003-3777-3157"]},"institutions":[{"id":"https://openalex.org/I875944469","display_name":"Koneru Lakshmaiah Education Foundation","ror":"https://ror.org/02k949197","country_code":"IN","type":"education","lineage":["https://openalex.org/I875944469"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Chakravarthi Guntupalli","raw_affiliation_strings":["Department of Pharmacy , K L College of Pharmacy , KLEF , Guntur , Andhra Pradesh , India,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy , K L College of Pharmacy , KLEF , Guntur , Andhra Pradesh , India,","institution_ids":["https://openalex.org/I875944469"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5103136490"],"corresponding_institution_ids":["https://openalex.org/I875944469"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.05069359,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"19","issue":"01","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.4943999946117401,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.4943999946117401,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.156700000166893,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.14259999990463257,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lidocaine-hydrochloride","display_name":"lidocaine hydrochloride","score":0.9710000157356262},{"id":"https://openalex.org/keywords/cubosomes","display_name":"cubosomes","score":0.9959999918937683},{"id":"https://openalex.org/keywords/quality-by-design","display_name":"quality by design","score":0.875},{"id":"https://openalex.org/keywords/homogenization-speed","display_name":"homogenization speed","score":0.9409999847412109},{"id":"https://openalex.org/keywords/sonication-time","display_name":"sonication time","score":0.9890000224113464},{"id":"https://openalex.org/keywords/glycerol-monooleate","display_name":"glycerol monooleate","score":0.8510000109672546},{"id":"https://openalex.org/keywords/pluronic-f127","display_name":"Pluronic F127","score":0.9139999747276306},{"id":"https://openalex.org/keywords/encapsulation-efficiency","display_name":"encapsulation efficiency","score":0.9340000152587891},{"id":"https://openalex.org/keywords/vesicle-size","display_name":"vesicle size","score":0.7680000066757202},{"id":"https://openalex.org/keywords/zeta-potential","display_name":"zeta potential","score":0.9900000095367432},{"id":"https://openalex.org/keywords/polydispersity-index","display_name":"polydispersity index","score":0.8159999847412109},{"id":"https://openalex.org/keywords/factorial-design","display_name":"factorial design","score":0.6179999709129333},{"id":"https://openalex.org/keywords/top-down-approach","display_name":"top-down approach","score":0.5830000042915344},{"id":"https://openalex.org/keywords/drug-delivery-systems","display_name":"drug delivery systems","score":0.42800000309944153}],"concepts":[{"id":"https://openalex.org/C2780149897","wikidata":"https://www.wikidata.org/wiki/Q216935","display_name":"Lidocaine","level":2,"score":0.5610314011573792},{"id":"https://openalex.org/C2910703761","wikidata":"https://www.wikidata.org/wiki/Q216935","display_name":"Lidocaine Hydrochloride","level":3,"score":0.5357915759086609},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.5010812282562256},{"id":"https://openalex.org/C2780841128","wikidata":"https://www.wikidata.org/wiki/Q5073781","display_name":"Characterization (materials science)","level":2,"score":0.429909884929657},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4050729274749756},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3334869146347046},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.24934744834899902},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.22932612895965576},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.17478477954864502},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16084158420562744}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.22377/ajp.v19i01.6081","doi":"https://doi.org/10.22377/ajp.v19i01.6081","is_oa":true,"landing_page_url":"https://doi.org/10.22377/ajp.v19i01.6081","pdf_url":"https://www.asiapharmaceutics.info/index.php/ajp/article/download/6081/1771","source":{"id":"https://openalex.org/S66408587","display_name":"Asian Journal of Pharmaceutics","issn_l":"0973-8398","issn":["0973-8398","1998-409X"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Journal of Pharmaceutics","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.22377/ajp.v19i01.6081","doi":"https://doi.org/10.22377/ajp.v19i01.6081","is_oa":true,"landing_page_url":"https://doi.org/10.22377/ajp.v19i01.6081","pdf_url":"https://www.asiapharmaceutics.info/index.php/ajp/article/download/6081/1771","source":{"id":"https://openalex.org/S66408587","display_name":"Asian Journal of Pharmaceutics","issn_l":"0973-8398","issn":["0973-8398","1998-409X"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Journal of Pharmaceutics","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4409688912.pdf","grobid_xml":"https://content.openalex.org/works/W4409688912.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3016878273","https://openalex.org/W2359094561","https://openalex.org/W2065300475","https://openalex.org/W2006893647","https://openalex.org/W2236801789","https://openalex.org/W2380471908","https://openalex.org/W2873156491","https://openalex.org/W2032549800","https://openalex.org/W2123051202","https://openalex.org/W1990197573"],"abstract_inverted_index":{"Aim:":[0],"The":[1,37,97],"objective":[2],"of":[3,12,18,22,27,84,91,108,140,145,150,157,171,186,193,201,203,209,220,229,231,237],"this":[4],"research":[5],"work":[6],"was":[7,40,61,102,133,164,195],"to":[8,42,63,135,212],"analyze":[9],"the":[10,25,66,78,85,89,119,123,128,169,214,218,227],"effect":[11],"experimental":[13],"components":[14],"(homogenization":[15],"time,":[16],"speed":[17,73,107,161,202,228],"homogenization,":[19],"and":[20,35,74,95,111,154,205,234],"time":[21,76,113,211,236],"sonication)":[23],"on":[24],"characterization":[26,170,175,219],"cubosomes":[28,45],"loaded":[29],"with":[30,53,182,197],"Lidocaine":[31],"Hydrochloride":[32],"(LH).":[33],"Materials":[34],"Methods:":[36],"Top-down":[38],"method":[39],"adopted":[41,62,126],"prepare":[43],"LH":[44,194],"using":[46],"lipid":[47],"(Glyceryl":[48],"Monooleate),":[49],"stabilizer":[50],"(Poloxamer-407)":[51],"along":[52],"water":[54],"in":[55,168,179,241],"varied":[56,82],"proportions.":[57],"32":[58,129],"factorial":[59,130],"design":[60],"explain":[64],"how":[65],"two":[67],"independent":[68],"factors,":[69],"that":[70,226],"is,":[71],"homogenization":[72,106,204,230],"sonication":[75,112,187,210,235],"affect":[77],"four":[79],"responses":[80],"at":[81,104],"levels":[83],"processing":[86],"parameters":[87,176,216],"for":[88,115,118,217],"preparation":[90],"drug-encapsulated":[92],"cubosomes.":[93,221],"Results":[94],"Discussion:":[96],"most":[98],"acceptable":[99],"entrapment":[100],"capacity":[101],"found":[103,134],"a":[105,165,183,198,206,242],"50":[109,232],"rpm":[110,233],"employed":[114],"10":[116,238],"min":[117,239],"formulation":[120],"LT8":[121,132],"within":[122],"confidence":[124],"intervals":[125],"by":[127],"design.":[131],"have":[136],"Entrapment":[137],"efficiency":[138],"(EE)":[139],"75":[141],"percent,":[142],"Zeta":[143],"potential":[144],"21.5":[146],"mV,":[147],"vesicle":[148],"size":[149],"150.3\u00b1":[151],"0.77":[152],"nm,":[153],"PolyDispersibility":[155],"Index":[156],"0.278.":[158],"As":[159],"Hominization":[160],"increased":[162],"there":[163],"noticeable":[166],"improvement":[167],"cubosomes,":[172],"however,":[173],"enhanced":[174],"were":[177],"observed":[178],"dispersions":[180],"prepared":[181],"medium":[184,207],"level":[185,200,208],"time.":[188],"Conclusion:":[189],"A":[190],"steady":[191],"dispersion":[192],"formed":[196],"high":[199],"attain":[213],"desired":[215],"Therefore,":[222],"it":[223],"is":[224],"concluded":[225],"resulted":[240],"stable":[243],"dispersion.":[244]},"counts_by_year":[],"updated_date":"2026-08-25T07:29:55.448023","created_date":"2025-10-10T00:00:00"}
