{"id":"https://openalex.org/W4409688910","doi":"https://doi.org/10.1158/1538-7445.am2025-1170","title":"Abstract 1170: Decitabine (DAC) induces a DNA damage response (DDR) and synergizes with replication checkpoint inhibitors in acute myeloid leukemia (AML)","display_name":"Abstract 1170: Decitabine (DAC) induces a DNA damage response (DDR) and synergizes with replication checkpoint inhibitors in acute myeloid leukemia (AML)","publication_year":2025,"publication_date":"2025-04-21","ids":{"openalex":"https://openalex.org/W4409688910","doi":"https://doi.org/10.1158/1538-7445.am2025-1170"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2025-1170","doi":"https://doi.org/10.1158/1538-7445.am2025-1170","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2025-1170","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048704704","display_name":"Clifford Michael Csizmar","orcid":"https://orcid.org/0000-0002-1221-8854","observed_orcids":["https://orcid.org/0000-0002-1221-8854"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Clifford M. Csizmar","raw_affiliation_strings":["1Mayo Clinic, Rochester, MN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Mayo Clinic, Rochester, MN;","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002877688","display_name":"Antoine N. Saliba","orcid":"https://orcid.org/0000-0001-5134-7336","observed_orcids":["https://orcid.org/0000-0001-5134-7336","https://orcid.org/0000-0003-3566-6518"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Antoine N. Saliba","raw_affiliation_strings":["1Mayo Clinic, Rochester, MN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Mayo Clinic, Rochester, MN;","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5117257585","display_name":"Olivia K. Rossman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Olivia K. Rossman","raw_affiliation_strings":["1Mayo Clinic, Rochester, MN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Mayo Clinic, Rochester, MN;","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103451073","display_name":"Kevin L. Peterson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin L. Peterson","raw_affiliation_strings":["1Mayo Clinic, Rochester, MN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Mayo Clinic, Rochester, MN;","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023565676","display_name":"X. Wei Meng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"X. Wei Meng","raw_affiliation_strings":["1Mayo Clinic, Rochester, MN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Mayo Clinic, Rochester, MN;","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012395020","display_name":"Bruce Douglas Smith","orcid":"https://orcid.org/0000-0002-0903-7390","observed_orcids":["https://orcid.org/0000-0002-0903-7390"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I4210164401","display_name":"Sidney Kimmel Comprehensive Cancer Center","ror":"https://ror.org/05m5b8x20","country_code":"US","type":"facility","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210164401"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B. Douglas Smith","raw_affiliation_strings":["2Sidney Kimmel Cancer Center at Johns Hopkins, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Sidney Kimmel Cancer Center at Johns Hopkins, Baltimore, MD","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210164401"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069374229","display_name":"Gabriel Ghiaur","orcid":"https://orcid.org/0000-0002-3955-7944","observed_orcids":["https://orcid.org/0000-0002-3955-7944"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I4210164401","display_name":"Sidney Kimmel Comprehensive Cancer Center","ror":"https://ror.org/05m5b8x20","country_code":"US","type":"facility","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210164401"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gabriel Ghiaur","raw_affiliation_strings":["2Sidney Kimmel Cancer Center at Johns Hopkins, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Sidney Kimmel Cancer Center at Johns Hopkins, Baltimore, MD","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210164401"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068544225","display_name":"Jonathan Allen Webster","orcid":"https://orcid.org/0000-0003-3647-6345","observed_orcids":["https://orcid.org/0000-0003-3647-6345"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I4210164401","display_name":"Sidney Kimmel Comprehensive Cancer Center","ror":"https://ror.org/05m5b8x20","country_code":"US","type":"facility","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210164401"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan A. Webster","raw_affiliation_strings":["2Sidney Kimmel Cancer Center at Johns Hopkins, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Sidney Kimmel Cancer Center at Johns Hopkins, Baltimore, MD","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210164401"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072463255","display_name":"Mrinal M. Patnaik","orcid":"https://orcid.org/0000-0001-6998-662X","observed_orcids":["https://orcid.org/0000-0001-6998-662X"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mrinal M. Patnaik","raw_affiliation_strings":["1Mayo Clinic, Rochester, MN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Mayo Clinic, Rochester, MN;","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008422091","display_name":"Aref Al\u2010Kali","orcid":"https://orcid.org/0000-0002-0824-3715","observed_orcids":["https://orcid.org/0000-0002-0824-3715"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aref Al-Kali","raw_affiliation_strings":["1Mayo Clinic, Rochester, MN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Mayo Clinic, Rochester, MN;","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054370710","display_name":"Scott H. Kaufmann","orcid":"https://orcid.org/0000-0002-4900-7145","observed_orcids":["https://orcid.org/0000-0002-4900-7145"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott H. Kaufmann","raw_affiliation_strings":["1Mayo Clinic, Rochester, MN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Mayo Clinic, Rochester, MN;","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"85","issue":"8_Supplement_1","first_page":"1170","last_page":"1170"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/decitabine","display_name":"decitabine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9800000190734863},{"id":"https://openalex.org/keywords/dna-damage-response","display_name":"DNA damage response","score":0.9929999709129333},{"id":"https://openalex.org/keywords/atr-inhibitors","display_name":"ATR inhibitors","score":0.7839999794960022},{"id":"https://openalex.org/keywords/chk1-inhibitor","display_name":"CHK1 inhibitor","score":0.9990000128746033},{"id":"https://openalex.org/keywords/wee1-inhibitor","display_name":"WEE1 inhibitor","score":0.9990000128746033},{"id":"https://openalex.org/keywords/dna-protein-cross-linking","display_name":"DNA-protein cross-linking","score":0.7260000109672546},{"id":"https://openalex.org/keywords/dnmt1","display_name":"DNMT1","score":0.9089999794960022},{"id":"https://openalex.org/keywords/p53-loss","display_name":"p53 deficiency","score":0.6460000276565552},{"id":"https://openalex.org/keywords/drug-synergy","display_name":"drug synergy","score":0.6819999814033508},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.5929999947547913},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.44699999690055847},{"id":"https://openalex.org/keywords/h2ax-phosphorylation","display_name":"H2AX phosphorylation","score":0.6660000085830688},{"id":"https://openalex.org/keywords/crispr-screening","display_name":"CRISPR screen","score":0.5289999842643738},{"id":"https://openalex.org/keywords/dependency-mapping","display_name":"dependency mapping","score":0.3779999911785126},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.44600000977516174},{"id":"https://openalex.org/keywords/u937-cells","display_name":"U937 cells","score":0.7129999995231628}],"concepts":[{"id":"https://openalex.org/C2780235182","wikidata":"https://www.wikidata.org/wiki/Q1181878","display_name":"Decitabine","level":5,"score":0.9447758197784424},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.7676110863685608},{"id":"https://openalex.org/C2776239401","wikidata":"https://www.wikidata.org/wiki/Q416451","display_name":"Azacitidine","level":5,"score":0.618392288684845},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5622356534004211},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4570905566215515},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.4489235579967499},{"id":"https://openalex.org/C54086632","wikidata":"https://www.wikidata.org/wiki/Q5512671","display_name":"G2-M DNA damage checkpoint","level":5,"score":0.43602418899536133},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.43455222249031067},{"id":"https://openalex.org/C105696609","wikidata":"https://www.wikidata.org/wiki/Q1068809","display_name":"Cell cycle checkpoint","level":4,"score":0.23499968647956848},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.23148134350776672},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22382056713104248},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.21401143074035645},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.2129766345024109},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.17953643202781677},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.13168463110923767},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11205160617828369},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10272040963172913},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09400758147239685},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2025-1170","doi":"https://doi.org/10.1158/1538-7445.am2025-1170","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2025-1170","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9907000064849854}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2127289529","https://openalex.org/W2127851369","https://openalex.org/W2750605634","https://openalex.org/W2054507167","https://openalex.org/W2167485228","https://openalex.org/W2999114056","https://openalex.org/W3214341925","https://openalex.org/W4391645188","https://openalex.org/W2083462343","https://openalex.org/W4388673960"],"abstract_inverted_index":{"Abstract":[0],"DAC":[1,9,43,204,239,249,280,541],"combinations":[2,555],"serve":[3],"as":[4],"frontline":[5],"therapies":[6],"for":[7,55,88,147,209,621],"AML.":[8,50,300,549],"forms":[10],"DNA-DNMT1":[11],"crosslinks":[12],"and":[13,58,163,193,216,231,281,284,292,340,546,558,603],"activates":[14],"the":[15,39,328,331,618],"ATR-CHK1-WEE1":[16],"DDR.":[17,269],"Combinations":[18],"of":[19,42,198,214,238,272,299,330,617],"DNA-protein":[20],"crosslinking":[21],"agents":[22],"with":[23,93,114,143,203,235,254,266,437,543,605],"ATR,":[24,191,337],"CHK1,":[25,192],"or":[26,47,95,117,145],"WEE1":[27,194,517],"inhibitors":[28,295,608],"(i)":[29],"have":[30],"shown":[31],"efficacy":[32],"in":[33,49,80,91,137,171,223,296,321,548,556,609],"solid":[34],"tumors.":[35],"This":[36],"study":[37,126],"evaluates":[38],"cytotoxic":[40],"synergy":[41,278],"plus":[44],"ATRi,":[45,229,282,544],"CHK1i,":[46,230,283,545],"WEE1i":[48,232,547],"Public":[51],"datasets":[52],"were":[53,67,73,78,86,123,135,186,220,233,259,312],"queried":[54],"mRNA":[56],"expression":[57,101,167],"dependency.":[59],"Commercial":[60],"cell":[61,184,200],"lines":[62,185,201],"(U937,":[63],"KG1a,":[64],"Molm13,":[65],"MV-4-11)":[66],"genomically":[68],"validated.":[69],"Molm13":[70,244,376,378],"TP53-/-":[71],"clones":[72],"generated":[74],"via":[75],"CRISPR.":[76],"Cells":[77],"cultured":[79,87],"complete":[81],"RPMI.":[82],"To":[83],"treat,":[84],"cells":[85,133,323],"48":[89],"h":[90,211],"RPMI":[92],"drugs":[94],"diluent":[96],"(0.2%":[97],"v/v":[98],"DMSO).":[99],"Protein":[100],"was":[102,109,151,169,252],"evaluated":[103],"by":[104,111,153],"Western":[105],"blotting":[106],"(WB).":[107],"Apoptosis":[108],"assayed":[110],"flow":[112],"cytometry":[113],"annexin":[115,315],"V":[116],"propidium":[118],"iodide.":[119],"Primary":[120,384],"AML":[121,172,183,199,274,385],"samples":[122,275],"obtained":[124],"at":[125],"centers":[127],"after":[128],"informed":[129],"consent.":[130],"Isolated":[131],"mononuclear":[132],"(Ficoll)":[134],"used":[136],"colony":[138],"forming":[139],"unit":[140],"(CFU)":[141],"assays":[142,271],"DMSO":[144],"drug":[146,325],"12-16":[148],"days.":[149],"Synergy":[150,289],"determined":[152],"median-effect":[154],"(CalcuSyn)":[155],"where":[156],"a":[157,267,598],"combination":[158,255,350],"index":[159],"<1":[160],"is":[161],"synergistic":[162,234,262],">1":[164],"antagonistic.":[165],"DNMT1":[166,390],"(TCGA)":[168],"highest":[170],"vs":[173],"all":[174],"other":[175],"tumor":[176],"types":[177],"(p<0.001).":[178],"In":[179,226,242],"CRISPR":[180],"screens":[181],"(DepMap),":[182],"increasingly":[187],"dependent":[188],"on":[189],"DNMT1,":[190,354],"(ANOVA":[195],"p<0.001).":[196],"WB":[197],"treated":[202],"(25":[205],"-":[206],"200":[207,393],"nM)":[208],"24":[210],"showed":[212,277,318],"phosphorylations":[213],"H2AX":[215],"CHK1":[217,268,333,483,503],"S296/S345":[218],"that":[219,251],"most":[221],"pronounced":[222],"TP53MT":[224],"lines.":[225],"apoptosis":[227,308],"assays,":[228],"clinical":[236],"concentrations":[237],"(Table":[240],"1).":[241],"isogenic":[243],"lines,":[245],"TP53":[246],"loss":[247],"conferred":[248],"resistance":[250],"overcome":[253],"treatment.":[256],"Selective":[257],"CHK1i":[258],"generally":[260],"more":[261],"than":[263],"CHK1/2i,":[264],"consistent":[265],"CFU":[270],"primary":[273],"also":[276],"between":[279,290],"especially":[285],"WEE1i.":[286],"Table":[287],"1.":[288],"decitabine":[291,438],"replication":[293,606],"checkpoint":[294,344,607],"preclinical":[297],"models":[298],"Cell":[301],"line":[302],"data":[303,311],"are":[304],"derived":[305],"from":[306],"subdiploid":[307],"assays.":[309],"U937":[310,380],"replicated":[313],"using":[314],"V.":[316],"Prexasertib":[317,460],"no":[319],"activity":[320],"KG1a":[322,382],"(suggesting":[324],"efflux)":[326],"requiring":[327],"use":[329],"alternate":[332],"inhibitor,":[334],"rabusertib.":[335],"Abbreviations:":[336],"ataxia":[338],"telangiectasia":[339],"Rad3":[341],"related;":[342],"CHK1/2,":[343],"kinase":[345],"1":[346,628],"and/or":[347],"2;":[348],"CI,":[349],"index;":[351],"Conc,":[352],"concentration;":[353],"DNA":[355,599],"methylatransferase":[356],"1;":[357],"IQR,":[358],"interquartile":[359],"range;":[360],"MT,":[361],"mutated;":[362],"ND,":[363],"not":[364],"determined;":[365],"SD,":[366],"standard":[367],"deviation;":[368],"WT,":[369],"wild":[370],"type.":[371],"Drug":[372],"Target":[373],"Conc.":[374],"(nM)":[375],"(TP53WT)":[377],"(TP53-/-)":[379],"(TP53G187fs*/-)":[381],"(TP53V225fs*/-)":[383],"(TP53WT":[386],"orTP53MT)":[387],"Units":[388],"Decitabine":[389,595],"6.25":[391],"\u2013":[392,414,418,422,426,430,434,444,448,452,456,463,467,471,475,480,485,490,494,498,505,513,519,523,527,531,535,539],"25":[394],"\u00b1":[395,398,401,404],"11":[396],"350":[397],"260":[399],"310":[400],"180":[402],"6.1":[403],"1.6":[405],"ND":[406,458,459,477,500,501,508,509,510,515],"EC50,":[407],"nM":[408],"(mean,":[409],"SD)":[410],"Ceralasertib":[411],"ATR":[412,442],"250":[413,484],"500":[415],"0.93":[416],"(0.66":[417],"1.24)":[419],"0.90":[420],"(0.84":[421],"0.96)":[423],"0.15":[424],"(0.08":[425],"0.21)":[427],"0.74":[428],"(0.63":[429,522],"1.02)":[431],"0.66":[432],"(0.43":[433,538],"2.43)":[435],"CI":[436],"(median,":[439],"IQR)":[440],"Camonsertib":[441],"10":[443],"100":[445,518],"0.27":[446],"(0.19":[447],"0.59)":[449],"0.24":[450],"(0.22":[451],"0.34)":[453],"0.34":[454],"(0.21":[455],"0.39)":[457],"CHK1/2":[461],"1.0":[462],"6.0":[464],"0.89":[465,496],"(0.82":[466],"1.06)":[468],"0.78":[469],"(0.68":[470],"0.90)":[472],"0.95":[473],"(0.93":[474],"1.08)":[476],"0.88":[478],"(0.29":[479],"1.28)":[481],"MK-8776":[482],"1,":[486,506],"000":[487,507],"0.57":[488],"(0.48":[489,512],"0.80)":[491],"0.76":[492],"(0.73":[493],"1.19)":[495],"(0.57":[497],"1.39)":[499],"Rabusertib":[502],"600":[504],"0.51":[511],"0.56)":[514],"Adavosertib":[516],"400":[520],"0.70":[521],"1.11)":[524],"0.99":[525],"(0.78":[526],"1.14)":[528],"0.67":[529,533],"(0.60":[530],"0.74)":[532],"(0.37":[534],"0.93)":[536],"0.65":[537],"0.88)":[540],"synergizes":[542,604],"Future":[550],"work":[551],"will":[552],"test":[553],"these":[554],"vivo":[557],"incorporate":[559],"BH3":[560],"mimetics.":[561],"Citation":[562],"Format:":[563],"Clifford":[564],"M.":[565,588],"Csizmar,":[566],"Antoine":[567],"N.":[568],"Saliba,":[569],"Olivia":[570],"K.":[571],"Rossman,":[572],"Kevin":[573],"L.":[574],"Peterson,":[575],"X.":[576],"Wei":[577],"Meng,":[578],"B.":[579],"Douglas":[580],"Smith,":[581],"Gabriel":[582],"Ghiaur,":[583],"Jonathan":[584],"A.":[585],"Webster,":[586],"Mrinal":[587],"Patnaik,":[589],"Aref":[590],"Al-Kali,":[591],"Scott":[592],"H.":[593],"Kaufmann.":[594],"(DAC)":[596],"induces":[597],"damage":[600],"response":[601],"(DDR)":[602],"acute":[610],"myeloid":[611],"leukemia":[612],"(AML)":[613],"[abstract].":[614],"In:":[615],"Proceedings":[616],"American":[619],"Association":[620],"Cancer":[622,639],"Research":[623],"Annual":[624],"Meeting":[625],"2025;":[626],"Part":[627],"(Regular":[629],"Abstracts);":[630],"2025":[631],"Apr":[632],"25-30;":[633],"Chicago,":[634],"IL.":[635],"Philadelphia":[636],"(PA):":[637],"AACR;":[638],"Res":[640],"2025;85(8_Suppl_1):Abstract":[641],"nr":[642],"1170.":[643]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}
