{"id":"https://openalex.org/W4409631033","doi":"https://doi.org/10.1182/blood.2024026936","title":"Coordinated regulation of self-renewal and cell cycle during human lympho-myeloid lineage restriction","display_name":"Coordinated regulation of self-renewal and cell cycle during human lympho-myeloid lineage restriction","publication_year":2025,"publication_date":"2025-04-21","ids":{"openalex":"https://openalex.org/W4409631033","doi":"https://doi.org/10.1182/blood.2024026936","pmid":"https://pubmed.ncbi.nlm.nih.gov/40258184","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12824658"},"language":"en","primary_location":{"id":"doi:10.1182/blood.2024026936","doi":"https://doi.org/10.1182/blood.2024026936","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood.2024026936","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1182/blood.2024026936","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073932733","display_name":"Fangwu Wang","orcid":"https://orcid.org/0000-0003-1416-851X","observed_orcids":["https://orcid.org/0000-0003-1416-851X"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Fangwu Wang","raw_affiliation_strings":["1Department of Medical Genetics, The University of British Columbia, Vancouver, BC, Canada","2Department of Microbiology and Immunology, The University of British Columbia, Vancouver, BC, Canada","3Michael Smith Laboratories, The University of British Columbia, Vancouver, BC, Canada","University of British Columbia, Vancouver, Canada"],"raw_orcid":"https://orcid.org/0000-0003-1416-851X","affiliations":[{"raw_affiliation_string":"1Department of Medical Genetics, The University of British Columbia, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I141945490"]},{"raw_affiliation_string":"2Department of Microbiology and Immunology, The University of British Columbia, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I141945490"]},{"raw_affiliation_string":"3Michael Smith Laboratories, The University of British Columbia, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I141945490"]},{"raw_affiliation_string":"University of British Columbia, Vancouver, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124435542","display_name":"Laura Gonzalez","orcid":"https://orcid.org/0009-0004-8158-8201","observed_orcids":["https://orcid.org/0009-0004-8158-8201"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Laura Gonzalez","raw_affiliation_strings":["4School of Biomedical Engineering, The University of British Columbia, Vancouver, BC, Canada","University of British Columbia, Vancouver, Canada"],"raw_orcid":"https://orcid.org/0009-0004-8158-8201","affiliations":[{"raw_affiliation_string":"4School of Biomedical Engineering, The University of British Columbia, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I141945490"]},{"raw_affiliation_string":"University of British Columbia, Vancouver, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072095533","display_name":"Qiuyu Lian","orcid":"https://orcid.org/0000-0002-5279-1989","observed_orcids":["https://orcid.org/0000-0002-5279-1989"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I2801782436","display_name":"The Gurdon Institute","ror":"https://ror.org/00fp3ce15","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I2801316944","https://openalex.org/I2801782436","https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Qiuyu Lian","raw_affiliation_strings":["5Gurdon Institute, University of Cambridge, Cambridge, United Kingdom","University of Cambridge, Cambridge, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0002-5279-1989","affiliations":[{"raw_affiliation_string":"5Gurdon Institute, University of Cambridge, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749","https://openalex.org/I2801782436"]},{"raw_affiliation_string":"University of Cambridge, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028626276","display_name":"Colin A. Hammond","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094500","display_name":"Terry Fox Research Institute","ror":"https://ror.org/00mtf6c40","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4210094500"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Colin A. Hammond","raw_affiliation_strings":["6Terry Fox Laboratory, BC Cancer Research Institute, Vancouver, BC, Canada","Terry Fox Laboratory, Vancouver, British Columbia, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6Terry Fox Laboratory, BC Cancer Research Institute, Vancouver, BC, Canada","institution_ids":[]},{"raw_affiliation_string":"Terry Fox Laboratory, Vancouver, British Columbia, Canada","institution_ids":["https://openalex.org/I4210094500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113356606","display_name":"Yasmine Yuen Man Lau","orcid":"https://orcid.org/0009-0006-5723-6243","observed_orcids":["https://orcid.org/0009-0006-5723-6243"]},"institutions":[{"id":"https://openalex.org/I4210094500","display_name":"Terry Fox Research Institute","ror":"https://ror.org/00mtf6c40","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4210094500"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Yasmine Y. M. Lau","raw_affiliation_strings":["6Terry Fox Laboratory, BC Cancer Research Institute, Vancouver, BC, Canada","Terry Fox Laboratory, Vancouver, Canada"],"raw_orcid":"https://orcid.org/0009-0006-5723-6243","affiliations":[{"raw_affiliation_string":"6Terry Fox Laboratory, BC Cancer Research Institute, Vancouver, BC, Canada","institution_ids":[]},{"raw_affiliation_string":"Terry Fox Laboratory, Vancouver, Canada","institution_ids":["https://openalex.org/I4210094500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032141728","display_name":"Benjamin D. Simons","orcid":"https://orcid.org/0000-0002-3875-7071","observed_orcids":["https://orcid.org/0000-0002-3875-7071"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I2801782436","display_name":"The Gurdon Institute","ror":"https://ror.org/00fp3ce15","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I2801316944","https://openalex.org/I2801782436","https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Benjamin D. Simons","raw_affiliation_strings":["5Gurdon Institute, University of Cambridge, Cambridge, United Kingdom","7Department of Applied Mathematics and Theoretical Physics, Centre for Mathematical Sciences, University of Cambridge, Cambridge, United Kingdom","University of Cambridge, Cambridge, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0002-3875-7071","affiliations":[{"raw_affiliation_string":"5Gurdon Institute, University of Cambridge, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749","https://openalex.org/I2801782436"]},{"raw_affiliation_string":"7Department of Applied Mathematics and Theoretical Physics, Centre for Mathematical Sciences, University of Cambridge, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"University of Cambridge, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072313250","display_name":"Martin Hirst","orcid":"https://orcid.org/0000-0001-9136-9054","observed_orcids":["https://orcid.org/0000-0001-9136-9054"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I4210133112","display_name":"Canada's Michael Smith Genome Sciences Centre","ror":"https://ror.org/0333j0897","country_code":"CA","type":"other","lineage":["https://openalex.org/I4210133112"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Martin Hirst","raw_affiliation_strings":["2Department of Microbiology and Immunology, The University of British Columbia, Vancouver, BC, Canada","3Michael Smith Laboratories, The University of British Columbia, Vancouver, BC, Canada","8Canada\u2019s Michael Smith Genome Sciences Centre, BC Cancer Research Institute, Vancouver, BC, Canada","University of British Columbia, Vancouver, British Columbia, Canada"],"raw_orcid":"https://orcid.org/0000-0001-9136-9054","affiliations":[{"raw_affiliation_string":"2Department of Microbiology and Immunology, The University of British Columbia, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I141945490"]},{"raw_affiliation_string":"3Michael Smith Laboratories, The University of British Columbia, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I141945490"]},{"raw_affiliation_string":"8Canada\u2019s Michael Smith Genome Sciences Centre, BC Cancer Research Institute, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I4210133112"]},{"raw_affiliation_string":"University of British Columbia, Vancouver, British Columbia, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009814106","display_name":"Connie J. Eaves","orcid":"https://orcid.org/0000-0002-3452-1926","observed_orcids":["https://orcid.org/0000-0002-3452-1926"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Connie J. Eaves","raw_affiliation_strings":["1Department of Medical Genetics, The University of British Columbia, Vancouver, BC, Canada","4School of Biomedical Engineering, The University of British Columbia, Vancouver, BC, Canada","6Terry Fox Laboratory, BC Cancer Research Institute, Vancouver, BC, Canada","BC Cancer Research Institute, Vancouver, British Columbia, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Medical Genetics, The University of British Columbia, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I141945490"]},{"raw_affiliation_string":"4School of Biomedical Engineering, The University of British Columbia, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I141945490"]},{"raw_affiliation_string":"6Terry Fox Laboratory, BC Cancer Research Institute, Vancouver, BC, Canada","institution_ids":[]},{"raw_affiliation_string":"BC Cancer Research Institute, Vancouver, British Columbia, Canada","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5072313250"],"corresponding_institution_ids":["https://openalex.org/I141945490","https://openalex.org/I4210133112"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":{"value":5500,"currency":"USD","value_usd":5500},"fwci":2.1474,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.8650648,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"146","issue":"6","first_page":"693","last_page":"706"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/self-renewal","display_name":"self-renewal","score":0.8450000286102295},{"id":"https://openalex.org/keywords/cell-cycle","display_name":"cell cycle","score":0.8180000185966492},{"id":"https://openalex.org/keywords/cord-blood-cd34-cells","display_name":"cord blood CD34+ cells","score":0.8740000128746033},{"id":"https://openalex.org/keywords/single-cell-transcriptomics","display_name":"single-cell transcriptomics","score":0.7139999866485596},{"id":"https://openalex.org/keywords/dendritic-cell-precursors","display_name":"dendritic cell precursors","score":0.9470000267028809},{"id":"https://openalex.org/keywords/proliferation-control","display_name":"proliferation control","score":0.6949999928474426},{"id":"https://openalex.org/keywords/transcriptional-heterogeneity","display_name":"transcriptional heterogeneity","score":0.7960000038146973},{"id":"https://openalex.org/keywords/hematopoietic-differentiation","display_name":"hematopoietic differentiation","score":0.6050000190734863}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7591924071311951},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.708620548248291},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.6359877586364746},{"id":"https://openalex.org/C2776817793","wikidata":"https://www.wikidata.org/wiki/Q6553369","display_name":"Lineage (genetic)","level":3,"score":0.6003350019454956},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5547093152999878},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.4752350151538849},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.46614447236061096},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4310447573661804},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.41256991028785706},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2940104603767395},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.20372113585472107}],"mesh":[{"descriptor_ui":"D000066673","descriptor_name":"Cell Self Renewal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005312","descriptor_name":"Fetal Blood","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019070","descriptor_name":"Cell Lineage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D022423","descriptor_name":"Myeloid Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D022423","descriptor_name":"Myeloid Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1182/blood.2024026936","doi":"https://doi.org/10.1182/blood.2024026936","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood.2024026936","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"doi:10.1101/2024.02.18.580894","doi":"https://doi.org/10.1101/2024.02.18.580894","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2024.02.18.580894","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2024/02/21/2024.02.18.580894.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:40258184","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40258184","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12824658","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12824658/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1182/blood.2024026936","doi":"https://doi.org/10.1182/blood.2024026936","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood.2024026936","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321386","display_name":"Terry Fox Foundation","ror":"https://ror.org/05vd00053"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4409631033.pdf","grobid_xml":"https://content.openalex.org/works/W4409631033.grobid-xml"},"referenced_works_count":76,"referenced_works":["https://openalex.org/W551869","https://openalex.org/W105094313","https://openalex.org/W106629669","https://openalex.org/W129232635","https://openalex.org/W159317543","https://openalex.org/W1573525843","https://openalex.org/W1776259239","https://openalex.org/W1818313483","https://openalex.org/W1964142235","https://openalex.org/W1972662519","https://openalex.org/W1976021347","https://openalex.org/W1980860344","https://openalex.org/W1982581888","https://openalex.org/W1985119900","https://openalex.org/W1991477381","https://openalex.org/W2014677321","https://openalex.org/W2019270557","https://openalex.org/W2023729886","https://openalex.org/W2026721712","https://openalex.org/W2033687970","https://openalex.org/W2037995476","https://openalex.org/W2057403210","https://openalex.org/W2067700202","https://openalex.org/W2069332674","https://openalex.org/W2069501059","https://openalex.org/W2073539659","https://openalex.org/W2074426771","https://openalex.org/W2078618584","https://openalex.org/W2081692985","https://openalex.org/W2084407030","https://openalex.org/W2091971381","https://openalex.org/W2100126911","https://openalex.org/W2106209530","https://openalex.org/W2108207978","https://openalex.org/W2109848822","https://openalex.org/W2116112428","https://openalex.org/W2134812776","https://openalex.org/W2136920402","https://openalex.org/W2140254135","https://openalex.org/W2153485112","https://openalex.org/W2161213095","https://openalex.org/W2166724005","https://openalex.org/W2166773843","https://openalex.org/W2171446873","https://openalex.org/W2398322608","https://openalex.org/W2409664558","https://openalex.org/W2443840802","https://openalex.org/W2514448720","https://openalex.org/W2517949416","https://openalex.org/W2549518011","https://openalex.org/W2553864385","https://openalex.org/W2602848567","https://openalex.org/W2616630127","https://openalex.org/W2766291844","https://openalex.org/W2770925092","https://openalex.org/W2784395700","https://openalex.org/W2791337382","https://openalex.org/W2800392236","https://openalex.org/W2801527818","https://openalex.org/W2909553215","https://openalex.org/W2944994066","https://openalex.org/W2948104182","https://openalex.org/W2951799803","https://openalex.org/W2990741917","https://openalex.org/W3024088690","https://openalex.org/W3036206386","https://openalex.org/W3044388039","https://openalex.org/W3075220616","https://openalex.org/W3197199162","https://openalex.org/W4223906335","https://openalex.org/W4280567411","https://openalex.org/W4285030160","https://openalex.org/W4312065796","https://openalex.org/W4317350983","https://openalex.org/W4385841161","https://openalex.org/W4386304274"],"related_works":["https://openalex.org/W4392189723","https://openalex.org/W3217750548","https://openalex.org/W4389228902","https://openalex.org/W6904818483","https://openalex.org/W2894613732","https://openalex.org/W6986876834","https://openalex.org/W2586004935","https://openalex.org/W3021705772","https://openalex.org/W2771466783","https://openalex.org/W2579456962"],"abstract_inverted_index":{"ABSTRACT:":[0],"Recent":[1],"studies":[2],"indicate":[3],"the":[4,23,42,69,112],"human":[5,56,130],"lympho-myeloid":[6],"restriction":[7,51],"process":[8],"to":[9,40],"be":[10],"a":[11,80,123,135],"different":[12],"and":[13,27,37,44,73,83,88,103,117,145,152],"more":[14],"heterogeneous":[15,106],"one":[16],"than":[17],"historically":[18],"inferred.":[19],"Here":[20],"we":[21,133],"describe":[22],"development":[24],"of":[25,54,64,71,90,99,108,114,138],"bulk":[26],"clonal":[28],"culture":[29,125],"systems":[30],"that":[31,47,68,127],"efficiently":[32],"support":[33],"early":[34,129],"B-lymphoid":[35],"differentiation":[36],"its":[38],"use":[39],"elucidate":[41],"biological":[43,144],"molecular":[45],"changes":[46,66],"accompany":[48],"their":[49],"initial":[50],"from":[52],"subsets":[53],"CD34+":[55],"cord":[57],"blood":[58],"cells":[59,149],"with":[60,142],"lympho-myeloid-limited":[61],"potential.":[62,92],"Analyses":[63],"these":[65],"revealed":[67],"acquisition":[70],"B-lymphoid-":[72],"neutrophil/monocyte":[74],"(NM)-restricted":[75],"properties":[76],"are":[77],"accompanied":[78],"by":[79],"concomitantly":[81],"accelerated":[82],"lineage-shared":[84],"cell":[85,119],"cycling":[86],"activity":[87],"loss":[89],"self-renewal":[91],"Single-cell":[93],"transcriptome":[94],"analysis":[95],"identified":[96],"reduced":[97],"expression":[98],"multiple":[100],"self-renewal-associated":[101],"genes":[102],"an":[104],"accompanying":[105],"activation":[107],"lineage-regulatory":[109],"modules":[110],"during":[111],"production":[113],"B,":[115],"NM,":[116],"dendritic":[118],"precursors.":[120],"By":[121],"applying":[122],"novel":[124],"system":[126],"supports":[128],"lymphoid":[131],"differentiation,":[132],"uncovered":[134],"shared":[136],"mechanism":[137],"proliferation":[139],"control,":[140],"along":[141],"persistent":[143],"transcriptional":[146],"heterogeneity":[147],"in":[148],"undergoing":[150],"B-":[151],"NM-lineage":[153],"restriction.":[154]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-04-21T00:00:00"}