{"id":"https://openalex.org/W4409630664","doi":"https://doi.org/10.1158/1538-7445.am2025-4631","title":"Abstract 4631: Deciphering immunotherapy response variability and immune-related toxicities through longitudinal multimodal ctDNA analysis in advanced melanoma","display_name":"Abstract 4631: Deciphering immunotherapy response variability and immune-related toxicities through longitudinal multimodal ctDNA analysis in advanced melanoma","publication_year":2025,"publication_date":"2025-04-21","ids":{"openalex":"https://openalex.org/W4409630664","doi":"https://doi.org/10.1158/1538-7445.am2025-4631"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2025-4631","doi":"https://doi.org/10.1158/1538-7445.am2025-4631","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2025-4631","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Zhao Cheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Zhao Cheng","raw_affiliation_strings":["1University of Cambridge, Cambridge, United Kingdom;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Cambridge, Cambridge, United Kingdom;","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Sarah McDonald","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sarah McDonald","raw_affiliation_strings":["1University of Cambridge, Cambridge, United Kingdom;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Cambridge, Cambridge, United Kingdom;","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hannah Thomas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Hannah Thomas","raw_affiliation_strings":["1University of Cambridge, Cambridge, United Kingdom;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Cambridge, Cambridge, United Kingdom;","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ze Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ze Zhou","raw_affiliation_strings":["1University of Cambridge, Cambridge, United Kingdom;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Cambridge, Cambridge, United Kingdom;","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023589028","display_name":"Paulius D. Mennea","orcid":"https://orcid.org/0000-0002-6967-1975","observed_orcids":["https://orcid.org/0000-0002-6967-1975"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Paulius Mennea","raw_affiliation_strings":["1University of Cambridge, Cambridge, United Kingdom;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Cambridge, Cambridge, United Kingdom;","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Haichao wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Haichao wang","raw_affiliation_strings":["1University of Cambridge, Cambridge, United Kingdom;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Cambridge, Cambridge, United Kingdom;","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008496360","display_name":"Dmitry S. Shcherbo","orcid":"https://orcid.org/0000-0002-0266-7015","observed_orcids":["https://orcid.org/0000-0002-0266-7015"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Dmitry Shcherbo","raw_affiliation_strings":["1University of Cambridge, Cambridge, United Kingdom;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Cambridge, Cambridge, United Kingdom;","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062482251","display_name":"Christina Zhang","orcid":"https://orcid.org/0009-0004-5293-0274","observed_orcids":["https://orcid.org/0009-0004-5293-0274"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Christina Zhang","raw_affiliation_strings":["1University of Cambridge, Cambridge, United Kingdom;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Cambridge, Cambridge, United Kingdom;","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Grainne McAndrew","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Grainne McAndrew","raw_affiliation_strings":["1University of Cambridge, Cambridge, United Kingdom;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Cambridge, Cambridge, United Kingdom;","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059759472","display_name":"Fazlur Rahman Talukdar","orcid":"https://orcid.org/0000-0002-6558-5543","observed_orcids":["https://orcid.org/0000-0002-6558-5543"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Fazlur Talukdar","raw_affiliation_strings":["1University of Cambridge, Cambridge, United Kingdom;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Cambridge, Cambridge, United Kingdom;","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008751369","display_name":"Wendy N. Cooper","orcid":"https://orcid.org/0000-0003-3416-9982","observed_orcids":["https://orcid.org/0000-0003-3416-9982"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Wendy N. Cooper","raw_affiliation_strings":["1University of Cambridge, Cambridge, United Kingdom;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Cambridge, Cambridge, United Kingdom;","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035426620","display_name":"Hui Zhao","orcid":"https://orcid.org/0009-0009-2818-2911","observed_orcids":["https://orcid.org/0009-0009-2818-2911"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Hui Zhao","raw_affiliation_strings":["1University of Cambridge, Cambridge, United Kingdom;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Cambridge, Cambridge, United Kingdom;","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059136338","display_name":"Nitzan Rosenfeld","orcid":"https://orcid.org/0000-0002-2825-4788","observed_orcids":["https://orcid.org/0000-0002-2825-4788"]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nitzan Rosenfeld","raw_affiliation_strings":["2Queen Mary University of London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Queen Mary University of London, London, United Kingdom","institution_ids":["https://openalex.org/I166337079"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Philippa G. Corrie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Philippa G. Corrie","raw_affiliation_strings":["1University of Cambridge, Cambridge, United Kingdom;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Cambridge, Cambridge, United Kingdom;","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011962750","display_name":"Amit Roshan","orcid":"https://orcid.org/0000-0002-2034-2759","observed_orcids":["https://orcid.org/0000-0002-2034-2759"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Amit Roshan","raw_affiliation_strings":["1University of Cambridge, Cambridge, United Kingdom;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Cambridge, Cambridge, United Kingdom;","institution_ids":["https://openalex.org/I241749"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"85","issue":"8_Supplement_1","first_page":"4631","last_page":"4631"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.009399999864399433,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/advanced-melanoma","display_name":"advanced melanoma","score":0.7699999809265137},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.9229999780654907},{"id":"https://openalex.org/keywords/circulating-tumor-dna","display_name":"circulating tumor DNA","score":0.9700000286102295},{"id":"https://openalex.org/keywords/liquid-biopsy","display_name":"liquid biopsy","score":0.6240000128746033},{"id":"https://openalex.org/keywords/immune-related-adverse-events","display_name":"immune-related adverse events","score":0.8759999871253967},{"id":"https://openalex.org/keywords/pembrolizumab","display_name":"pembrolizumab","score":0.9559999704360962},{"id":"https://openalex.org/keywords/ipilimumab","display_name":"ipilimumab","score":0.8230000138282776},{"id":"https://openalex.org/keywords/nivolumab","display_name":"nivolumab","score":1.0},{"id":"https://openalex.org/keywords/pd-1-pd-l1-expression","display_name":"PD-1/PD-L1 expression","score":0.8270000219345093},{"id":"https://openalex.org/keywords/copy-number-alterations","display_name":"copy number alterations","score":0.7680000066757202},{"id":"https://openalex.org/keywords/fragmentomics","display_name":"fragmentomics","score":0.8429999947547913},{"id":"https://openalex.org/keywords/tcr-repertoire","display_name":"T cell receptor repertoire","score":0.7450000047683716},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.6940000057220459},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.7379999756813049}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6488679647445679},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.6475481390953064},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5884395241737366},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.5435642004013062},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.41647934913635254},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3889450430870056},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3243112564086914}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2025-4631","doi":"https://doi.org/10.1158/1538-7445.am2025-4631","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2025-4631","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7162549156","https://openalex.org/W4323050295","https://openalex.org/W7128781224","https://openalex.org/W4401514555","https://openalex.org/W4393095358","https://openalex.org/W4409258302","https://openalex.org/W7219598455","https://openalex.org/W4403242744","https://openalex.org/W4379280972","https://openalex.org/W2900406319"],"abstract_inverted_index":{"Abstract":[0],"Background:":[1],"Immune":[2],"checkpoint":[3],"inhibitors":[4],"(ICIs)":[5],"have":[6],"revolutionized":[7],"treatment":[8,45],"of":[9,54,76,107,143,221,229,287,356,432],"advanced":[10,322,427],"cutaneous":[11],"melanoma":[12,128,323,428],"by":[13,204,261],"leveraging":[14],"the":[15,36,49,64,130,186,222,240,285,433],"host":[16],"immune":[17],"system":[18],"to":[19,31,38,170,197,259],"target":[20],"and":[21,52,86,98,145,158,189,209,284,301,360,373,418],"eliminate":[22],"tumour":[23,83,96,151,168,183,211,334,345],"cells.":[24],"However,":[25],"predictive":[26],"biomarkers":[27],"for":[28,67,73,321,369,436],"clinical":[29,325],"response":[30,200,416],"ICIs":[32],"remain":[33],"elusive,":[34],"limiting":[35],"ability":[37],"stratify":[39],"patients":[40,59,121,134],"effectively.":[41],"The":[42],"heterogeneity":[43],"in":[44,58,94,103,149,279,328,426],"outcomes,":[46],"coupled":[47],"with":[48,60,122,137,181,234,264,271,312,337,348,353],"limited":[50],"sensitivity":[51,339],"timeliness":[53],"radiographic":[55],"assessments,":[56],"particularly":[57],"stable":[61],"disease,":[62],"underscores":[63],"urgent":[65],"need":[66],"molecularly":[68],"guided,":[69],"minimally":[70],"invasive":[71],"approaches":[72,364],"real-time":[74],"monitoring":[75,196,370],"therapeutic":[77,371],"efficacy.":[78],"Biomarkers,":[79],"such":[80],"as":[81,202],"circulating":[82],"DNA":[84],"(ctDNA)":[85],"T-cell":[87,224,357],"clonal":[88,358],"dynamics,":[89],"offer":[90,366],"promise":[91],"not":[92],"only":[93],"assessing":[95],"burden":[97],"dynamics":[99,201,318,359],"but":[100,340],"also":[101],"potentially":[102],"providing":[104],"early":[105],"indicators":[106],"immune-related":[108,374,419],"adverse":[109,375],"events":[110,376],"(irAEs).":[111],"Methods:":[112],"We":[113],"analysed":[114],"70":[115],"longitudinal":[116,219,422],"plasma":[117,235],"samples":[118,152,184],"from":[119,129,257],"13":[120],"resectable":[123],"or":[124,140,344],"unresectable,":[125],"Stage":[126],"III":[127],"MELResist":[131],"study.":[132],"These":[133],"were":[135,216,310],"treated":[136],"either":[138],"pembrolizumab":[139],"a":[141,252,296],"combination":[142],"ipilimumab":[144],"nivolumab.":[146],"PD1/PDL1":[147],"expression":[148,237],"FFPE":[150],"was":[153,165],"quantified":[154],"using":[155,185,227,333],"digital":[156],"pathology,":[157],"deep":[159],"whole-genome":[160],"sequencing":[161],"(around":[162],"30x":[163],"coverage)":[164,180],"performed":[166],"on":[167],"tissue":[169],"profile":[171],"genomic":[172],"alterations.":[173],"By":[174],"integrating":[175],"ctDNA":[176,247,317,329,424],"analysis":[177,276,425],"(>10x":[178],"WGS":[179],"matched":[182],"cfDNAPro,":[187],"ichorCNA":[188,262],"INVAR2":[190],"pipelines,":[191],"we":[192,250],"conducted":[193],"serial":[194],"WGS-based":[195],"evaluate":[198],"molecular":[199,248],"measured":[203],"copy":[205,253],"number":[206,254],"alterations,":[207],"fragmentomics":[208],"patient-specific":[210],"mutations":[212],"respectively.":[213],"Additionally,":[214],"irAEs":[215],"assessed":[217],"through":[218,421],"tracking":[220],"peripheral":[223],"repertoire":[225],"(TCR)":[226],"TCR-sequencing":[228],"buffy":[230],"coat":[231],"samples,":[232],"alongside":[233],"protein":[236],"profiling":[238],"via":[239],"Olink":[241],"Explore":[242],"panel.":[243],"Results:":[244],"In":[245],"evaluating":[246],"response,":[249],"found":[251],"fraction":[255],"ranging":[256],"0":[258],"42%":[260],"analysis,":[263],"higher":[265],"fractions":[266],"at":[267,307,341],"later":[268,308],"timepoints":[269,309],"correlating":[270],"poorer":[272,313],"overall":[273,314],"survival.":[274,315],"Fragmentomic":[275],"revealed":[277],"changes":[278],"4-mer":[280],"end":[281],"motif":[282,299],"frequencies":[283],"ratio":[286,306],"short-to-long":[288,304],"fragments":[289],"(100-150":[290],"bp":[291],"vs.":[292],"151-220":[293],"bp).":[294],"Specifically,":[295],"decreased":[297],"CCCA":[298],"frequency":[300],"an":[302],"increased":[303],"fragment":[305],"associated":[311],"Conclusion:":[316],"during":[319,378],"immunotherapy":[320,415],"reflect":[324],"outcomes.":[326],"Changes":[327],"can":[330],"be":[331],"identified":[332],"informed":[335],"methods":[336,347],"high":[338],"additional":[342],"cost":[343],"agnostic":[346],"lower":[349],"logistical":[350],"burden.":[351],"Together":[352],"our":[354],"assessment":[355],"proteomic":[361],"changes,":[362],"these":[363],"will":[365],"valuable":[367],"insights":[368],"benefits":[372],"(irAEs)":[377],"immunotherapy.":[379],"Citation":[380],"Format:":[381],"Zhao":[382],"Cheng,":[383],"Sarah":[384],"McDonald,":[385],"Hannah":[386],"Thomas,":[387],"Ze":[388],"Zhou,":[389],"Paulius":[390],"Mennea,":[391],"Haichao":[392],"wang,":[393],"Dmitry":[394],"Shcherbo,":[395],"Christina":[396],"Zhang,":[397],"Grainne":[398],"McAndrew,":[399],"Fazlur":[400],"Talukdar,":[401],"Wendy":[402],"N.":[403],"Cooper,":[404],"Hui":[405],"Zhao,":[406],"Nitzan":[407],"Rosenfeld,":[408],"Philippa":[409],"G.":[410],"Corrie,":[411],"Amit":[412],"Roshan.":[413],"Deciphering":[414],"variability":[417],"toxicities":[420],"multimodal":[423],"[abstract].":[429],"In:":[430],"Proceedings":[431],"American":[434],"Association":[435],"Cancer":[437,454],"Research":[438],"Annual":[439],"Meeting":[440],"2025;":[441],"Part":[442],"1":[443],"(Regular":[444],"Abstracts);":[445],"2025":[446],"Apr":[447],"25-30;":[448],"Chicago,":[449],"IL.":[450],"Philadelphia":[451],"(PA):":[452],"AACR;":[453],"Res":[455],"2025;85(8_Suppl_1):Abstract":[456],"nr":[457],"4631.":[458]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2025-04-21T00:00:00"}
