{"id":"https://openalex.org/W4409625751","doi":"https://doi.org/10.1158/1538-7445.am2025-1277","title":"Abstract 1277: Ex ovo system for rapid and quantitative modelling of immunotherapy responses in pre-clinical and patient-derived xenografts: PDXovo","display_name":"Abstract 1277: Ex ovo system for rapid and quantitative modelling of immunotherapy responses in pre-clinical and patient-derived xenografts: PDXovo","publication_year":2025,"publication_date":"2025-04-21","ids":{"openalex":"https://openalex.org/W4409625751","doi":"https://doi.org/10.1158/1538-7445.am2025-1277"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2025-1277","doi":"https://doi.org/10.1158/1538-7445.am2025-1277","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2025-1277","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007381737","display_name":"Olivia R. Grafinger","orcid":"https://orcid.org/0000-0001-8082-1594","observed_orcids":["https://orcid.org/0000-0001-8082-1594"]},"institutions":[{"id":"https://openalex.org/I4210167439","display_name":"Sunnybrook Hospital","ror":"https://ror.org/008kn1a71","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1323843004","https://openalex.org/I4210167439"]},{"id":"https://openalex.org/I4391768120","display_name":"Sunnybrook Research Institute","ror":"https://ror.org/05n0tzs53","country_code":"CA","type":"facility","lineage":["https://openalex.org/I1323843004","https://openalex.org/I185261750","https://openalex.org/I4391768120"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Olivia R. Grafinger","raw_affiliation_strings":["Sunnybrook Research Institute, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sunnybrook Research Institute, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I4210167439","https://openalex.org/I4391768120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062557624","display_name":"Kabir A. Khan","orcid":"https://orcid.org/0000-0001-8453-3485","observed_orcids":["https://orcid.org/0000-0001-8453-3485"]},"institutions":[{"id":"https://openalex.org/I4210167439","display_name":"Sunnybrook Hospital","ror":"https://ror.org/008kn1a71","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1323843004","https://openalex.org/I4210167439"]},{"id":"https://openalex.org/I4391768120","display_name":"Sunnybrook Research Institute","ror":"https://ror.org/05n0tzs53","country_code":"CA","type":"facility","lineage":["https://openalex.org/I1323843004","https://openalex.org/I185261750","https://openalex.org/I4391768120"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Kabir A. Khan","raw_affiliation_strings":["Sunnybrook Research Institute, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sunnybrook Research Institute, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I4210167439","https://openalex.org/I4391768120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038987098","display_name":"Esther I. Matus","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210167439","display_name":"Sunnybrook Hospital","ror":"https://ror.org/008kn1a71","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1323843004","https://openalex.org/I4210167439"]},{"id":"https://openalex.org/I4391768120","display_name":"Sunnybrook Research Institute","ror":"https://ror.org/05n0tzs53","country_code":"CA","type":"facility","lineage":["https://openalex.org/I1323843004","https://openalex.org/I185261750","https://openalex.org/I4391768120"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Esther I. Matus","raw_affiliation_strings":["Sunnybrook Research Institute, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sunnybrook Research Institute, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I4210167439","https://openalex.org/I4391768120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014222028","display_name":"Sara A. Mar","orcid":"https://orcid.org/0000-0002-6970-8029","observed_orcids":["https://orcid.org/0000-0002-6970-8029"]},"institutions":[{"id":"https://openalex.org/I4210167439","display_name":"Sunnybrook Hospital","ror":"https://ror.org/008kn1a71","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1323843004","https://openalex.org/I4210167439"]},{"id":"https://openalex.org/I4391768120","display_name":"Sunnybrook Research Institute","ror":"https://ror.org/05n0tzs53","country_code":"CA","type":"facility","lineage":["https://openalex.org/I1323843004","https://openalex.org/I185261750","https://openalex.org/I4391768120"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Sara Mar","raw_affiliation_strings":["Sunnybrook Research Institute, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sunnybrook Research Institute, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I4210167439","https://openalex.org/I4391768120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101808344","display_name":"Yan Li","orcid":"https://orcid.org/0000-0002-7784-9788","observed_orcids":["https://orcid.org/0000-0002-7784-9788"]},"institutions":[{"id":"https://openalex.org/I4210167439","display_name":"Sunnybrook Hospital","ror":"https://ror.org/008kn1a71","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1323843004","https://openalex.org/I4210167439"]},{"id":"https://openalex.org/I4391768120","display_name":"Sunnybrook Research Institute","ror":"https://ror.org/05n0tzs53","country_code":"CA","type":"facility","lineage":["https://openalex.org/I1323843004","https://openalex.org/I185261750","https://openalex.org/I4391768120"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Yan Li","raw_affiliation_strings":["Sunnybrook Research Institute, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sunnybrook Research Institute, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I4210167439","https://openalex.org/I4391768120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073574474","display_name":"David E. Goertz","orcid":"https://orcid.org/0000-0003-1511-5233","observed_orcids":["https://orcid.org/0000-0003-1511-5233"]},"institutions":[{"id":"https://openalex.org/I4210167439","display_name":"Sunnybrook Hospital","ror":"https://ror.org/008kn1a71","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1323843004","https://openalex.org/I4210167439"]},{"id":"https://openalex.org/I4391768120","display_name":"Sunnybrook Research Institute","ror":"https://ror.org/05n0tzs53","country_code":"CA","type":"facility","lineage":["https://openalex.org/I1323843004","https://openalex.org/I185261750","https://openalex.org/I4391768120"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"David Goertz","raw_affiliation_strings":["Sunnybrook Research Institute, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sunnybrook Research Institute, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I4210167439","https://openalex.org/I4391768120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006919436","display_name":"Jean Gari\u00e9py","orcid":"https://orcid.org/0000-0003-2217-2981","observed_orcids":["https://orcid.org/0000-0003-2217-2981"]},"institutions":[{"id":"https://openalex.org/I4210167439","display_name":"Sunnybrook Hospital","ror":"https://ror.org/008kn1a71","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1323843004","https://openalex.org/I4210167439"]},{"id":"https://openalex.org/I4391768120","display_name":"Sunnybrook Research Institute","ror":"https://ror.org/05n0tzs53","country_code":"CA","type":"facility","lineage":["https://openalex.org/I1323843004","https://openalex.org/I185261750","https://openalex.org/I4391768120"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Jean Gari\u00e9py","raw_affiliation_strings":["Sunnybrook Research Institute, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sunnybrook Research Institute, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I4210167439","https://openalex.org/I4391768120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057024351","display_name":"Katarzyna Joanna Jerzak","orcid":"https://orcid.org/0000-0002-3995-0308","observed_orcids":["https://orcid.org/0000-0002-3995-0308"]},"institutions":[{"id":"https://openalex.org/I4210167439","display_name":"Sunnybrook Hospital","ror":"https://ror.org/008kn1a71","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1323843004","https://openalex.org/I4210167439"]},{"id":"https://openalex.org/I4391768120","display_name":"Sunnybrook Research Institute","ror":"https://ror.org/05n0tzs53","country_code":"CA","type":"facility","lineage":["https://openalex.org/I1323843004","https://openalex.org/I185261750","https://openalex.org/I4391768120"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Katarzyna J. Jerzak","raw_affiliation_strings":["Sunnybrook Research Institute, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sunnybrook Research Institute, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I4210167439","https://openalex.org/I4391768120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010799165","display_name":"Robert S. Kerbel","orcid":"https://orcid.org/0000-0002-6015-2570","observed_orcids":["https://orcid.org/0000-0002-6015-2570"]},"institutions":[{"id":"https://openalex.org/I4210167439","display_name":"Sunnybrook Hospital","ror":"https://ror.org/008kn1a71","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1323843004","https://openalex.org/I4210167439"]},{"id":"https://openalex.org/I4391768120","display_name":"Sunnybrook Research Institute","ror":"https://ror.org/05n0tzs53","country_code":"CA","type":"facility","lineage":["https://openalex.org/I1323843004","https://openalex.org/I185261750","https://openalex.org/I4391768120"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Robert Kerbel","raw_affiliation_strings":["Sunnybrook Research Institute, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sunnybrook Research Institute, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I4210167439","https://openalex.org/I4391768120"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066931453","display_name":"Hon Sing Leong","orcid":"https://orcid.org/0000-0001-7801-1402","observed_orcids":["https://orcid.org/0000-0001-7801-1402"]},"institutions":[{"id":"https://openalex.org/I4210167439","display_name":"Sunnybrook Hospital","ror":"https://ror.org/008kn1a71","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1323843004","https://openalex.org/I4210167439"]},{"id":"https://openalex.org/I4391768120","display_name":"Sunnybrook Research Institute","ror":"https://ror.org/05n0tzs53","country_code":"CA","type":"facility","lineage":["https://openalex.org/I1323843004","https://openalex.org/I185261750","https://openalex.org/I4391768120"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Hon S. Leong","raw_affiliation_strings":["Sunnybrook Research Institute, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sunnybrook Research Institute, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I4210167439","https://openalex.org/I4391768120"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"85","issue":"8_Supplement_1","first_page":"1277","last_page":"1277"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9682999849319458,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9682999849319458,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.008799999952316284,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/patient-derived-xenografts","display_name":"patient-derived xenografts","score":0.9190000295639038},{"id":"https://openalex.org/keywords/chorioallantoic-membrane","display_name":"chorioallantoic membrane","score":0.9049999713897705},{"id":"https://openalex.org/keywords/pembrolizumab","display_name":"pembrolizumab","score":0.8939999938011169},{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.8980000019073486},{"id":"https://openalex.org/keywords/precision-oncology","display_name":"precision oncology","score":0.8550000190734863},{"id":"https://openalex.org/keywords/adoptive-immunotherapy","display_name":"adoptive immunotherapy","score":0.7459999918937683},{"id":"https://openalex.org/keywords/tumor-infiltrating-lymphocytes","display_name":"tumor-infiltrating lymphocytes","score":0.871999979019165},{"id":"https://openalex.org/keywords/immunotherapy-response-prediction","display_name":"immunotherapy response prediction","score":0.753000020980835},{"id":"https://openalex.org/keywords/chick-embryo","display_name":"chick embryo","score":0.40799999237060547},{"id":"https://openalex.org/keywords/murine-mammary-carcinoma","display_name":"murine mammary carcinoma","score":0.6420000195503235},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.4020000100135803},{"id":"https://openalex.org/keywords/tumor-immunology","display_name":"tumor immunology","score":0.3089999854564667}],"concepts":[{"id":"https://openalex.org/C2778765379","wikidata":"https://www.wikidata.org/wiki/Q17055931","display_name":"In ovo","level":3,"score":0.9183453917503357},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5873658061027527},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5250884294509888},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.4561762511730194},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4251921772956848},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3819795846939087},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2883416414260864},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.27167439460754395},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08677804470062256},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.057634323835372925},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2025-1277","doi":"https://doi.org/10.1158/1538-7445.am2025-1277","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2025-1277","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7149163468","https://openalex.org/W3028883710","https://openalex.org/W1516377592","https://openalex.org/W2885030384","https://openalex.org/W2824729085","https://openalex.org/W2593949476","https://openalex.org/W3087427417","https://openalex.org/W4404181180","https://openalex.org/W4323570071","https://openalex.org/W4393075367"],"abstract_inverted_index":{"Abstract":[0],"Precision":[1],"oncology":[2],"for":[3,121,266,325,346],"triple-negative":[4],"breast":[5],"cancer":[6,114],"(TNBC)":[7],"is":[8,72],"urgently":[9],"needed":[10],"because":[11],"not":[12,33,248],"all":[13],"patients":[14],"will":[15],"benefit":[16],"from":[17,173,228],"PDL1-based":[18],"immunotherapy.":[19],"Unfortunately,":[20],"the":[21,69,75,101,127,209,259,272,280,343],"expression":[22,252],"of":[23,27,79,103,201,204,212,261,330,342],"PDL1":[24,251],"or":[25],"abundance":[26],"tumor":[28],"infiltrated":[29],"lymphocytes":[30],"(TILs)":[31],"does":[32],"correlate":[34,249],"with":[35,110,142,186,198,208,231,250],"objective":[36,284],"response":[37,59,164,285],"rates":[38],"and/or":[39],"overall":[40,293],"survival.":[41,294],"We":[42,130,155,192,239],"have":[43,218,240],"developed":[44],"a":[45,111,119,202,263,276],"novel":[46],"patient-derived":[47,199,226,336],"xenograft":[48,237],"(PDX)":[49],"model":[50,67,84,133,159,197,265],"system":[51,324],"that":[52],"offers":[53,85],"phenotype-based":[54],"metrics":[55],"to":[56,61,134,152,160,165,222,244,274],"predict":[57,162],"immunotherapy":[58,137,331],"prior":[60],"receiving":[62],"treatment.":[63],"In":[64],"our":[65,132,158],"PDX":[66,83],"(PDXovo),":[68],"patient\u2019s":[70],"tumour":[71,175,220],"engrafted":[73,184],"onto":[74],"chorioallantoic":[76],"membrane":[77],"(CAM)":[78],"chick":[80],"embryos.":[81],"Our":[82],"significant":[86],"advantages":[87],"over":[88],"mouse":[89],"PDXs":[90],"which":[91,246],"are":[92,193],"expensive,":[93],"time-consuming,":[94],"and":[95,123,178,182,282,291,327,335],"cannot":[96],"evaluate":[97],"immunotherapies.":[98],"To":[99,215],"test":[100],"efficacy":[102],"this":[104,196],"model,":[105],"we":[106,217],"implanted":[107,124],"immunocompetent":[108],"mice":[109],"murine":[112,174,188],"mammary":[113,189],"cell":[115,167],"line":[116],"(serving":[117],"as":[118,150],"surrogate":[120],"patients),":[122],"tumours":[125,144,200],"into":[126],"PDXovo":[128,338],"system.":[129],"found":[131,157],"reliably":[135,161],"recapitulate":[136],"responses":[138,221,243,332],"observed":[139,241],"in":[140,148,180,206,224,236,255,279,333],"mice,":[141],"anti-PDL1-treated":[143],"being":[145],"significantly":[146],"smaller":[147],"volume":[149],"compared":[151],"IgG-treated":[153],"tumours.":[154],"also":[156],"patient":[163],"adoptive":[166],"therapy,":[168],"wherein":[169],"TILs":[170,254],"were":[171],"FACS-sorted":[172],"digests,":[176],"activated":[177],"expanded":[179],"vitro,":[181],"then":[183],"together":[185],"cultured":[187],"carcinoma":[190],"cells.":[191],"now":[194],"testing":[195],"variety":[203],"origins,":[205],"partnership":[207],"Ontario":[210],"Institute":[211],"Cancer":[213,347,364],"Research.":[214],"date":[216],"tested":[219],"Pembrolizumab":[223],"five":[225],"samples":[227],"various":[229],"sites,":[230],"an":[232],"80%":[233],"success":[234],"rate":[235],"formation.":[238],"varied":[242],"immunotherapy,":[245],"did":[247],"on":[253],"these":[256],"samples,":[257],"highlighting":[258],"importance":[260],"such":[262],"qualitative":[264],"precision":[267],"oncology.":[268],"This":[269],"technology":[270],"has":[271],"potential":[273],"make":[275],"positive":[277],"impact":[278],"clinic":[281],"improve":[283],"rates,":[286],"increase":[287,292],"progression-free":[288],"survival":[289],"intervals,":[290],"Citation":[295],"Format:":[296],"Olivia":[297],"R.":[298],"Grafinger,":[299],"Kabir":[300],"A.":[301],"Khan,":[302],"Esther":[303],"I.":[304],"Matus,":[305],"Sara":[306],"Mar,":[307],"Yan":[308],"Li,":[309],"David":[310],"Goertz,":[311],"Jean":[312],"Gari\u00e9py,":[313],"Katarzyna":[314],"J.":[315],"Jerzak,":[316],"Robert":[317],"Kerbel,":[318],"Hon":[319],"S.":[320],"Leong.":[321],"Ex":[322],"ovo":[323],"rapid":[326],"quantitative":[328],"modelling":[329],"pre-clinical":[334],"xenografts:":[337],"[abstract].":[339],"In:":[340],"Proceedings":[341],"American":[344],"Association":[345],"Research":[348],"Annual":[349],"Meeting":[350],"2025;":[351],"Part":[352],"1":[353],"(Regular":[354],"Abstracts);":[355],"2025":[356],"Apr":[357],"25-30;":[358],"Chicago,":[359],"IL.":[360],"Philadelphia":[361],"(PA):":[362],"AACR;":[363],"Res":[365],"2025;85(8_Suppl_1):Abstract":[366],"nr":[367],"1277.":[368]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2025-04-21T00:00:00"}