{"id":"https://openalex.org/W4409620007","doi":"https://doi.org/10.1097/ms9.0000000000003314","title":"Investigating the association between initial blood product transfusion with a higher plasma-to-red blood cell ratio and mortality in adults with severe bleeding following trauma","display_name":"Investigating the association between initial blood product transfusion with a higher plasma-to-red blood cell ratio and mortality in adults with severe bleeding following trauma","publication_year":2025,"publication_date":"2025-04-21","ids":{"openalex":"https://openalex.org/W4409620007","doi":"https://doi.org/10.1097/ms9.0000000000003314","pmid":"https://pubmed.ncbi.nlm.nih.gov/40486573"},"language":"en","primary_location":{"id":"doi:10.1097/ms9.0000000000003314","doi":"https://doi.org/10.1097/ms9.0000000000003314","is_oa":true,"landing_page_url":"https://doi.org/10.1097/ms9.0000000000003314","pdf_url":null,"source":{"id":"https://openalex.org/S4210226177","display_name":"Annals of Medicine and Surgery","issn_l":"2049-0801","issn":["2049-0801"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Medicine &amp; Surgery","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1097/ms9.0000000000003314","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082033433","display_name":"Parham Khoshdani Farahani","orcid":"https://orcid.org/0009-0007-0175-9376","observed_orcids":["https://orcid.org/0009-0007-0175-9376"]},"institutions":[{"id":"https://openalex.org/I4387153077","display_name":"Alborz University of Medical Sciences","ror":"https://ror.org/03hh69c20","country_code":"IR","type":"education","lineage":["https://openalex.org/I4387153077"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Parham Khoshdani Farahani","raw_affiliation_strings":["Department of Surgery, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran","institution_ids":["https://openalex.org/I4387153077"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089494471","display_name":"Mohammad Kazem Shahmoradi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3121602497","display_name":"Lorestan University of Medical Sciences","ror":"https://ror.org/035t7rn63","country_code":"IR","type":"education","lineage":["https://openalex.org/I3121602497"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Mohammad Kazem Shahmoradi","raw_affiliation_strings":["Department of General Surgery, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran","institution_ids":["https://openalex.org/I3121602497"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026812946","display_name":"Masoud Sharifian","orcid":"https://orcid.org/0000-0002-4285-6558","observed_orcids":["https://orcid.org/0000-0002-4285-6558"]},"institutions":[{"id":"https://openalex.org/I3121602497","display_name":"Lorestan University of Medical Sciences","ror":"https://ror.org/035t7rn63","country_code":"IR","type":"education","lineage":["https://openalex.org/I3121602497"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Masoud Sharifian","raw_affiliation_strings":["Department of General Surgery, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran","institution_ids":["https://openalex.org/I3121602497"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015068206","display_name":"Haleh Pak","orcid":"https://orcid.org/0000-0003-2125-1856","observed_orcids":["https://orcid.org/0000-0003-2125-1856"]},"institutions":[{"id":"https://openalex.org/I3121602497","display_name":"Lorestan University of Medical Sciences","ror":"https://ror.org/035t7rn63","country_code":"IR","type":"education","lineage":["https://openalex.org/I3121602497"]}],"countries":["IR"],"is_corresponding":true,"raw_author_name":"Haleh Pak","raw_affiliation_strings":["Department of General Surgery, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran","institution_ids":["https://openalex.org/I3121602497"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5015068206"],"corresponding_institution_ids":["https://openalex.org/I3121602497"],"apc_list":{"value":1850,"currency":"USD","value_usd":1850},"apc_paid":{"value":1850,"currency":"USD","value_usd":1850},"fwci":2.9853,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.90007321,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"87","issue":"6","first_page":"3183","last_page":"3188"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11116","display_name":"Trauma, Hemostasis, Coagulopathy, Resuscitation","score":0.9599999785423279,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11116","display_name":"Trauma, Hemostasis, Coagulopathy, Resuscitation","score":0.9599999785423279,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":0.037700001150369644,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11467","display_name":"Trauma and Emergency Care Studies","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/traumatic-hemorrhage","display_name":"traumatic hemorrhage","score":0.6589999794960022},{"id":"https://openalex.org/keywords/massive-hemorrhage","display_name":"massive hemorrhage","score":0.8479999899864197},{"id":"https://openalex.org/keywords/fresh-frozen-plasma","display_name":"fresh frozen plasma","score":0.8259999752044678},{"id":"https://openalex.org/keywords/packed-red-blood-cells","display_name":"packed red blood cells","score":0.9679999947547913},{"id":"https://openalex.org/keywords/plasma-to-red-blood-cell-ratio","display_name":"plasma-to-red blood cell ratio","score":0.9480000138282776},{"id":"https://openalex.org/keywords/damage-control-resuscitation","display_name":"damage control resuscitation","score":0.9369999766349792},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.625},{"id":"https://openalex.org/keywords/mechanical-ventilation","display_name":"mechanical ventilation","score":0.8169999718666077},{"id":"https://openalex.org/keywords/intensive-care-unit-admission","display_name":"intensive care unit admission","score":0.8330000042915344},{"id":"https://openalex.org/keywords/length-of-hospital-stay","display_name":"length of hospital stay","score":0.7089999914169312},{"id":"https://openalex.org/keywords/blood-transfusion-strategy","display_name":"blood transfusion strategy","score":0.7519999742507935}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9671889543533325},{"id":"https://openalex.org/C2777396833","wikidata":"https://www.wikidata.org/wiki/Q886722","display_name":"Blood product","level":2,"score":0.766103982925415},{"id":"https://openalex.org/C2780014101","wikidata":"https://www.wikidata.org/wiki/Q183605","display_name":"Blood transfusion","level":2,"score":0.5988284349441528},{"id":"https://openalex.org/C2776557347","wikidata":"https://www.wikidata.org/wiki/Q37187","display_name":"Red blood cell","level":2,"score":0.5289307236671448},{"id":"https://openalex.org/C2911063046","wikidata":"https://www.wikidata.org/wiki/Q183605","display_name":"Red Blood Cell Transfusion","level":3,"score":0.519652247428894},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3736079931259155},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.34638798236846924},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3110979199409485}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1097/ms9.0000000000003314","doi":"https://doi.org/10.1097/ms9.0000000000003314","is_oa":true,"landing_page_url":"https://doi.org/10.1097/ms9.0000000000003314","pdf_url":null,"source":{"id":"https://openalex.org/S4210226177","display_name":"Annals of Medicine and Surgery","issn_l":"2049-0801","issn":["2049-0801"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Medicine &amp; Surgery","raw_type":"journal-article"},{"id":"pmid:40486573","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40486573","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of medicine and surgery (2012)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12140757","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12140757","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Ann Med Surg (Lond)","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1097/ms9.0000000000003314","doi":"https://doi.org/10.1097/ms9.0000000000003314","is_oa":true,"landing_page_url":"https://doi.org/10.1097/ms9.0000000000003314","pdf_url":null,"source":{"id":"https://openalex.org/S4210226177","display_name":"Annals of Medicine and Surgery","issn_l":"2049-0801","issn":["2049-0801"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Medicine &amp; Surgery","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1715550511","https://openalex.org/W1729719515","https://openalex.org/W1969097686","https://openalex.org/W1975962159","https://openalex.org/W1983515167","https://openalex.org/W1988570879","https://openalex.org/W2022045091","https://openalex.org/W2024526916","https://openalex.org/W2025117194","https://openalex.org/W2052379411","https://openalex.org/W2055315513","https://openalex.org/W2056645952","https://openalex.org/W2140813614","https://openalex.org/W2142052303","https://openalex.org/W2166133795","https://openalex.org/W2332848111","https://openalex.org/W2561982390","https://openalex.org/W2593409500","https://openalex.org/W2756604053","https://openalex.org/W2974933246","https://openalex.org/W2980793205","https://openalex.org/W2989427582","https://openalex.org/W3014733781","https://openalex.org/W3091048460"],"related_works":["https://openalex.org/W2386549591","https://openalex.org/W1974357119","https://openalex.org/W2365283358","https://openalex.org/W2029256668","https://openalex.org/W4387073039","https://openalex.org/W2506912477","https://openalex.org/W4205854606","https://openalex.org/W2896823209","https://openalex.org/W1998409931","https://openalex.org/W2385669310"],"abstract_inverted_index":{"Objective:":[0],"Trauma":[1],"patients":[2,59,201,230,243],"presenting":[3,77],"with":[4,60,78,221,231],"massive":[5,61,79,232],"bleeding":[6,81],"require":[7],"significant":[8],"blood":[9,26],"transfusions":[10],"to":[11,23,43,156,174,255,266],"restore":[12],"circulation":[13],"and":[14,35,54,123,135,147,164,166,224,265],"achieve":[15],"hemostasis.":[16],"The":[17,130,169],"ratio":[18,51,99,103,163,191,217],"of":[19,47,120,185,261],"fresh-frozen":[20],"plasma":[21],"(FFP)":[22],"packed":[24],"red":[25],"cells":[27],"(PRBC)":[28],"is":[29,219,253],"critical":[30],"in":[31,37,188,202,240,270],"determining":[32],"immediate":[33],"outcomes":[34,132,140],"mortality":[36,56,226],"these":[38],"patients.":[39],"This":[40,210],"study":[41,211],"aims":[42],"evaluate":[44,157],"the":[45,95,158,182,189,235,257],"impact":[46],"a":[48,214],"high":[49,98,161,190,215,262],"FFP:PRBC":[50,96,162,216,263],"on":[52,94,110],"24-hour":[53,134,165,223],"30-day":[55,136,167,225],"among":[57,228],"trauma":[58,229,271],"bleeding.":[62],"Methods:":[63],"In":[64],"this":[65,203],"retrospective":[66],"descriptive":[67],"study,":[68],"inclusion":[69],"criteria":[70],"involved":[71],"adults":[72],"aged":[73],"18":[74],"or":[75,101],"older":[76],"trauma-related":[80],"within":[82],"6":[83],"hours":[84],"after":[85],"trauma.":[86],"Patients":[87],"were":[88,128,133],"categorized":[89],"into":[90],"two":[91],"groups":[92],"based":[93],"ratio:":[97],"(>1:1.5)":[100,218],"low":[102],"(<1:1.5)":[104],"for":[105,125,237],"damage":[106],"control":[107],"resuscitation.":[108],"Data":[109],"demographic":[111],"characteristics,":[112],"mortality,":[113,137],"intensive":[114],"care":[115],"unit":[116],"(ICU)":[117],"admission,":[118,143],"length":[119],"hospital":[121,148],"stay,":[122],"need":[124,236],"mechanical":[126,144,186,238],"ventilation":[127,145,187,239],"collected.":[129],"primary":[131],"while":[138],"secondary":[139,176],"included":[141],"ICU":[142],"duration,":[146],"stay":[149],"length.":[150],"A":[151],"Chi-square":[152],"test":[153,171],"was":[154,172,193],"used":[155,173],"association":[159],"betweena":[160],"mortality.":[168],"Mann-Whitney":[170],"analyze":[175],"outcomes.":[177],"Results:":[178],"<":[179],"0.001).":[180],"However,":[181,234],"mean":[183],"duration":[184],"group":[192,204],"3.36":[194],"\u00b1":[195],"2.85":[196],"days,":[197],"indicating":[198],"that":[199,213,247],"some":[200,241],"still":[205],"required":[206],"ventilatory":[207],"support.":[208],"Conclusion:":[209],"demonstrates":[212],"associated":[220],"reduced":[222],"rates":[227],"hemorrhage.":[233],"high-ratio":[242],"suggests":[244],"potential":[245,258],"trade-offs":[246],"warrant":[248],"further":[249],"investigation.":[250],"Additional":[251],"research":[252],"needed":[254],"explore":[256],"adverse":[259],"effects":[260],"ratios":[264],"optimize":[267],"transfusion":[268],"strategies":[269],"care.":[272]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}