{"id":"https://openalex.org/W4409602992","doi":"https://doi.org/10.1186/s12974-025-03423-5","title":"Targeting SARM1 as a novel neuroprotective therapy in neurotropic viral infections","display_name":"Targeting SARM1 as a novel neuroprotective therapy in neurotropic viral infections","publication_year":2025,"publication_date":"2025-04-20","ids":{"openalex":"https://openalex.org/W4409602992","doi":"https://doi.org/10.1186/s12974-025-03423-5","pmid":"https://pubmed.ncbi.nlm.nih.gov/40254576","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12010687"},"language":"en","primary_location":{"id":"doi:10.1186/s12974-025-03423-5","doi":"https://doi.org/10.1186/s12974-025-03423-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12974-025-03423-5","pdf_url":null,"source":{"id":"https://openalex.org/S199572710","display_name":"Journal of Neuroinflammation","issn_l":"1742-2094","issn":["1742-2094"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroinflammation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/s12974-025-03423-5","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100680823","display_name":"Sheng He","orcid":"https://orcid.org/0000-0001-9710-5228","observed_orcids":["https://orcid.org/0000-0001-9710-5228"]},"institutions":[{"id":"https://openalex.org/I4210109945","display_name":"Yue Bei People's Hospital","ror":"https://ror.org/0149pmh27","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210109945"]},{"id":"https://openalex.org/I4210120522","display_name":"Shantou University Medical College","ror":"https://ror.org/02gxych78","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210120522"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Sheng He","raw_affiliation_strings":["Department of Laboratory Medicine, Yuebei People's Hospital, Affiliated to Shantou University Medical College, Shaoguan, 512025, China","Laboratory for Diagnosis of Clinical Microbiology and Infection, Yuebei People's Hospital, Affiliated to Shantou University Medical College, Shaoguan, 512025, China","Research Center for Interdisciplinary & High-quality Innovative Development in Laboratory Medicine, Shaoguan, 512025, China","Shaoguan Engineering Research Center for Research and Development of Molecular and Cellular Technology in Rapid Diagnosis of Infectious Diseases and Cancer, Shaoguan, 512025, China","Shaoguan Municipal Quality Control Center for Laboratory Medicine, Yuebei People's Hospital, Affiliated to Shantou University Medical College, Shaoguan, 512025, China","Shaoguan Municipal Quality Control Center for Surveillance of Bacterial Resistance, Shaoguan, 512025, China","Yuebei People's Hospital, Affiliated to Shantou University Medical College, No 133, Huimin Road South, Wujiang District, Shaoguan, 512025, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Yuebei People's Hospital, Affiliated to Shantou University Medical College, Shaoguan, 512025, China","institution_ids":["https://openalex.org/I4210109945","https://openalex.org/I4210120522"]},{"raw_affiliation_string":"Laboratory for Diagnosis of Clinical Microbiology and Infection, Yuebei People's Hospital, Affiliated to Shantou University Medical College, Shaoguan, 512025, China","institution_ids":["https://openalex.org/I4210109945","https://openalex.org/I4210120522"]},{"raw_affiliation_string":"Research Center for Interdisciplinary & High-quality Innovative Development in Laboratory Medicine, Shaoguan, 512025, China","institution_ids":[]},{"raw_affiliation_string":"Shaoguan Engineering Research Center for Research and Development of Molecular and Cellular Technology in Rapid Diagnosis of Infectious Diseases and Cancer, Shaoguan, 512025, China","institution_ids":[]},{"raw_affiliation_string":"Shaoguan Municipal Quality Control Center for Laboratory Medicine, Yuebei People's Hospital, Affiliated to Shantou University Medical College, Shaoguan, 512025, China","institution_ids":["https://openalex.org/I4210109945","https://openalex.org/I4210120522"]},{"raw_affiliation_string":"Shaoguan Municipal Quality Control Center for Surveillance of Bacterial Resistance, Shaoguan, 512025, China","institution_ids":[]},{"raw_affiliation_string":"Yuebei People's Hospital, Affiliated to Shantou University Medical College, No 133, Huimin Road South, Wujiang District, Shaoguan, 512025, China","institution_ids":["https://openalex.org/I4210109945","https://openalex.org/I4210120522"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yanyan Zhu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210109945","display_name":"Yue Bei People's Hospital","ror":"https://ror.org/0149pmh27","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210109945"]},{"id":"https://openalex.org/I4210120522","display_name":"Shantou University Medical College","ror":"https://ror.org/02gxych78","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210120522"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanyan Zhu","raw_affiliation_strings":["Department of Laboratory Medicine, Yuebei People's Hospital, Affiliated to Shantou University Medical College, Shaoguan, 512025, China","Laboratory for Diagnosis of Clinical Microbiology and Infection, Yuebei People's Hospital, Affiliated to Shantou University Medical College, Shaoguan, 512025, China","Research Center for Interdisciplinary & High-quality Innovative Development in Laboratory Medicine, Shaoguan, 512025, China","Shaoguan Engineering Research Center for Research and Development of Molecular and Cellular Technology in Rapid Diagnosis of Infectious Diseases and Cancer, Shaoguan, 512025, China","Shaoguan Municipal Quality Control Center for Laboratory Medicine, Yuebei People's Hospital, Affiliated to Shantou University Medical College, Shaoguan, 512025, China","Shaoguan Municipal Quality Control Center for Surveillance of Bacterial Resistance, Shaoguan, 512025, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Yuebei People's Hospital, Affiliated to Shantou University Medical College, Shaoguan, 512025, China","institution_ids":["https://openalex.org/I4210109945","https://openalex.org/I4210120522"]},{"raw_affiliation_string":"Laboratory for Diagnosis of Clinical Microbiology and Infection, Yuebei People's Hospital, Affiliated to Shantou University Medical College, Shaoguan, 512025, China","institution_ids":["https://openalex.org/I4210109945","https://openalex.org/I4210120522"]},{"raw_affiliation_string":"Research Center for Interdisciplinary & High-quality Innovative Development in Laboratory Medicine, Shaoguan, 512025, China","institution_ids":[]},{"raw_affiliation_string":"Shaoguan Engineering Research Center for Research and Development of Molecular and Cellular Technology in Rapid Diagnosis of Infectious Diseases and Cancer, Shaoguan, 512025, China","institution_ids":[]},{"raw_affiliation_string":"Shaoguan Municipal Quality Control Center for Laboratory Medicine, Yuebei People's Hospital, Affiliated to Shantou University Medical College, Shaoguan, 512025, China","institution_ids":["https://openalex.org/I4210109945","https://openalex.org/I4210120522"]},{"raw_affiliation_string":"Shaoguan Municipal Quality Control Center for Surveillance of Bacterial Resistance, Shaoguan, 512025, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100408877","display_name":"Xinyue Wang","orcid":"https://orcid.org/0000-0002-8025-1760","observed_orcids":["https://orcid.org/0000-0002-8025-1760"]},"institutions":[{"id":"https://openalex.org/I4210109945","display_name":"Yue Bei People's Hospital","ror":"https://ror.org/0149pmh27","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210109945"]},{"id":"https://openalex.org/I4210120522","display_name":"Shantou University Medical College","ror":"https://ror.org/02gxych78","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210120522"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinyue Wang","raw_affiliation_strings":["Department of Laboratory Medicine, Yuebei People's Hospital, Affiliated to Shantou University Medical College, Shaoguan, 512025, China","Laboratory for Diagnosis of Clinical Microbiology and Infection, Yuebei People's Hospital, Affiliated to Shantou University Medical College, Shaoguan, 512025, China","Research Center for Interdisciplinary & High-quality Innovative Development in Laboratory Medicine, Shaoguan, 512025, China","Shaoguan Engineering Research Center for Research and Development of Molecular and Cellular Technology in Rapid Diagnosis of Infectious Diseases and Cancer, Shaoguan, 512025, China","Shaoguan Municipal Quality Control Center for Laboratory Medicine, Yuebei People's Hospital, Affiliated to Shantou University Medical College, Shaoguan, 512025, China","Shaoguan Municipal Quality Control Center for Surveillance of Bacterial Resistance, Shaoguan, 512025, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Yuebei People's Hospital, Affiliated to Shantou University Medical College, Shaoguan, 512025, China","institution_ids":["https://openalex.org/I4210109945","https://openalex.org/I4210120522"]},{"raw_affiliation_string":"Laboratory for Diagnosis of Clinical Microbiology and Infection, Yuebei People's Hospital, Affiliated to Shantou University Medical College, Shaoguan, 512025, China","institution_ids":["https://openalex.org/I4210109945","https://openalex.org/I4210120522"]},{"raw_affiliation_string":"Research Center for Interdisciplinary & High-quality Innovative Development in Laboratory Medicine, Shaoguan, 512025, China","institution_ids":[]},{"raw_affiliation_string":"Shaoguan Engineering Research Center for Research and Development of Molecular and Cellular Technology in Rapid Diagnosis of Infectious Diseases and Cancer, Shaoguan, 512025, China","institution_ids":[]},{"raw_affiliation_string":"Shaoguan Municipal Quality Control Center for Laboratory Medicine, Yuebei People's Hospital, Affiliated to Shantou University Medical College, Shaoguan, 512025, China","institution_ids":["https://openalex.org/I4210109945","https://openalex.org/I4210120522"]},{"raw_affiliation_string":"Shaoguan Municipal Quality Control Center for Surveillance of Bacterial Resistance, Shaoguan, 512025, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101760531","display_name":"Gaofeng Zhang","orcid":"https://orcid.org/0009-0006-4530-3963","observed_orcids":["https://orcid.org/0009-0006-4530-3963"]},"institutions":[{"id":"https://openalex.org/I4210109945","display_name":"Yue Bei People's Hospital","ror":"https://ror.org/0149pmh27","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210109945"]},{"id":"https://openalex.org/I4210120522","display_name":"Shantou University Medical College","ror":"https://ror.org/02gxych78","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210120522"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Gaofeng Zhang","raw_affiliation_strings":["Department of Laboratory Medicine, Yuebei People's Hospital, Affiliated to Shantou University Medical College, Shaoguan, 512025, China","Laboratory for Diagnosis of Clinical Microbiology and Infection, Yuebei People's Hospital, Affiliated to Shantou University Medical College, Shaoguan, 512025, China","Research Center for Interdisciplinary & High-quality Innovative Development in Laboratory Medicine, Shaoguan, 512025, China","Shaoguan Engineering Research Center for Research and Development of Molecular and Cellular Technology in Rapid Diagnosis of Infectious Diseases and Cancer, Shaoguan, 512025, China","Shaoguan Municipal Quality Control Center for Laboratory Medicine, Yuebei People's Hospital, Affiliated to Shantou University Medical College, Shaoguan, 512025, China","Shaoguan Municipal Quality Control Center for Surveillance of Bacterial Resistance, Shaoguan, 512025, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Yuebei People's Hospital, Affiliated to Shantou University Medical College, Shaoguan, 512025, China","institution_ids":["https://openalex.org/I4210109945","https://openalex.org/I4210120522"]},{"raw_affiliation_string":"Laboratory for Diagnosis of Clinical Microbiology and Infection, Yuebei People's Hospital, Affiliated to Shantou University Medical College, Shaoguan, 512025, China","institution_ids":["https://openalex.org/I4210109945","https://openalex.org/I4210120522"]},{"raw_affiliation_string":"Research Center for Interdisciplinary & High-quality Innovative Development in Laboratory Medicine, Shaoguan, 512025, China","institution_ids":[]},{"raw_affiliation_string":"Shaoguan Engineering Research Center for Research and Development of Molecular and Cellular Technology in Rapid Diagnosis of Infectious Diseases and Cancer, Shaoguan, 512025, China","institution_ids":[]},{"raw_affiliation_string":"Shaoguan Municipal Quality Control Center for Laboratory Medicine, Yuebei People's Hospital, Affiliated to Shantou University Medical College, Shaoguan, 512025, China","institution_ids":["https://openalex.org/I4210109945","https://openalex.org/I4210120522"]},{"raw_affiliation_string":"Shaoguan Municipal Quality Control Center for Surveillance of Bacterial Resistance, Shaoguan, 512025, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kaijian Hou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32574673","display_name":"Shantou University","ror":"https://ror.org/01a099706","country_code":"CN","type":"education","lineage":["https://openalex.org/I32574673"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kaijian Hou","raw_affiliation_strings":["School of Public Health, Shantou University, Shantou, 515041, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Public Health, Shantou University, Shantou, 515041, China","institution_ids":["https://openalex.org/I32574673"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034517280","display_name":"Xianzhu Xia","orcid":"https://orcid.org/0000-0001-5090-1358","observed_orcids":["https://orcid.org/0000-0001-5090-1358"]},"institutions":[{"id":"https://openalex.org/I4210109945","display_name":"Yue Bei People's Hospital","ror":"https://ror.org/0149pmh27","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210109945"]},{"id":"https://openalex.org/I4210120522","display_name":"Shantou University Medical College","ror":"https://ror.org/02gxych78","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210120522"]},{"id":"https://openalex.org/I4210138501","display_name":"Chinese Academy of Agricultural Sciences","ror":"https://ror.org/0313jb750","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210127390","https://openalex.org/I4210138501","https://openalex.org/I4210151987"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xianzhu Xia","raw_affiliation_strings":["Department of Laboratory Medicine, Yuebei People's Hospital, Affiliated to Shantou University Medical College, Shaoguan, 512025, China","Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, China","Laboratory for Diagnosis of Clinical Microbiology and Infection, Yuebei People's Hospital, Affiliated to Shantou University Medical College, Shaoguan, 512025, China","Research Center for Interdisciplinary & High-quality Innovative Development in Laboratory Medicine, Shaoguan, 512025, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Yuebei People's Hospital, Affiliated to Shantou University Medical College, Shaoguan, 512025, China","institution_ids":["https://openalex.org/I4210109945","https://openalex.org/I4210120522"]},{"raw_affiliation_string":"Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, China","institution_ids":["https://openalex.org/I4210138501"]},{"raw_affiliation_string":"Laboratory for Diagnosis of Clinical Microbiology and Infection, Yuebei People's Hospital, Affiliated to Shantou University Medical College, Shaoguan, 512025, China","institution_ids":["https://openalex.org/I4210109945","https://openalex.org/I4210120522"]},{"raw_affiliation_string":"Research Center for Interdisciplinary & High-quality Innovative Development in Laboratory Medicine, Shaoguan, 512025, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077900771","display_name":"Zhenyou Jiang","orcid":"https://orcid.org/0000-0002-9941-2990","observed_orcids":["https://orcid.org/0000-0002-9941-2990"]},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhenyou Jiang","raw_affiliation_strings":["Key Laboratory of Viral Pathogenesis & Infection Prevention and Control (Jinan University), Ministry of Education, Guangzhou, 510632, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Viral Pathogenesis & Infection Prevention and Control (Jinan University), Ministry of Education, Guangzhou, 510632, China","institution_ids":["https://openalex.org/I159948400"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Xiaoqian Gong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210109945","display_name":"Yue Bei People's Hospital","ror":"https://ror.org/0149pmh27","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210109945"]},{"id":"https://openalex.org/I4210120522","display_name":"Shantou University Medical College","ror":"https://ror.org/02gxych78","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210120522"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiaoqian Gong","raw_affiliation_strings":["Yuebei People's Hospital, Affiliated to Shantou University Medical College, No 133, Huimin Road South, Wujiang District, Shaoguan, 512025, China. drgx8008@163.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yuebei People's Hospital, Affiliated to Shantou University Medical College, No 133, Huimin Road South, Wujiang District, Shaoguan, 512025, China. drgx8008@163.com","institution_ids":["https://openalex.org/I4210109945","https://openalex.org/I4210120522"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085806556","display_name":"Pingsen Zhao","orcid":"https://orcid.org/0000-0001-5178-3664","observed_orcids":["https://orcid.org/0000-0001-5178-3664"]},"institutions":[{"id":"https://openalex.org/I4210109945","display_name":"Yue Bei People's Hospital","ror":"https://ror.org/0149pmh27","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210109945"]},{"id":"https://openalex.org/I4210120522","display_name":"Shantou University Medical College","ror":"https://ror.org/02gxych78","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210120522"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Pingsen Zhao","raw_affiliation_strings":["Department of Laboratory Medicine, Yuebei People's Hospital, Affiliated to Shantou University Medical College, Shaoguan, 512025, China. zhaopingsen01@163.com","Laboratory for Diagnosis of Clinical Microbiology and Infection, Yuebei People's Hospital, Affiliated to Shantou University Medical College, Shaoguan, 512025, China. zhaopingsen01@163.com","Research Center for Interdisciplinary & High-quality Innovative Development in Laboratory Medicine, Shaoguan, 512025, China. zhaopingsen01@163.com","Shaoguan Engineering Research Center for Research and Development of Molecular and Cellular Technology in Rapid Diagnosis of Infectious Diseases and Cancer, Shaoguan, 512025, China. zhaopingsen01@163.com","Shaoguan Municipal Quality Control Center for Laboratory Medicine, Yuebei People's Hospital, Affiliated to Shantou University Medical College, Shaoguan, 512025, China. zhaopingsen01@163.com","Shaoguan Municipal Quality Control Center for Surveillance of Bacterial Resistance, Shaoguan, 512025, China. zhaopingsen01@163.com","Yuebei People's Hospital, Affiliated to Shantou University Medical College, No 133, Huimin Road South, Wujiang District, Shaoguan, 512025, China. zhaopingsen01@163.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Yuebei People's Hospital, Affiliated to Shantou University Medical College, Shaoguan, 512025, China. zhaopingsen01@163.com","institution_ids":["https://openalex.org/I4210109945","https://openalex.org/I4210120522"]},{"raw_affiliation_string":"Laboratory for Diagnosis of Clinical Microbiology and Infection, Yuebei People's Hospital, Affiliated to Shantou University Medical College, Shaoguan, 512025, China. zhaopingsen01@163.com","institution_ids":["https://openalex.org/I4210109945","https://openalex.org/I4210120522"]},{"raw_affiliation_string":"Research Center for Interdisciplinary & High-quality Innovative Development in Laboratory Medicine, Shaoguan, 512025, China. zhaopingsen01@163.com","institution_ids":[]},{"raw_affiliation_string":"Shaoguan Engineering Research Center for Research and Development of Molecular and Cellular Technology in Rapid Diagnosis of Infectious Diseases and Cancer, Shaoguan, 512025, China. zhaopingsen01@163.com","institution_ids":[]},{"raw_affiliation_string":"Shaoguan Municipal Quality Control Center for Laboratory Medicine, Yuebei People's Hospital, Affiliated to Shantou University Medical College, Shaoguan, 512025, China. zhaopingsen01@163.com","institution_ids":["https://openalex.org/I4210109945","https://openalex.org/I4210120522"]},{"raw_affiliation_string":"Shaoguan Municipal Quality Control Center for Surveillance of Bacterial Resistance, Shaoguan, 512025, China. zhaopingsen01@163.com","institution_ids":[]},{"raw_affiliation_string":"Yuebei People's Hospital, Affiliated to Shantou University Medical College, No 133, Huimin Road South, Wujiang District, Shaoguan, 512025, China. zhaopingsen01@163.com","institution_ids":["https://openalex.org/I4210109945","https://openalex.org/I4210120522"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5085806556"],"corresponding_institution_ids":["https://openalex.org/I4210109945","https://openalex.org/I4210120522"],"apc_list":{"value":4090,"currency":"USD","value_usd":4090},"apc_paid":{"value":4090,"currency":"USD","value_usd":4090},"fwci":3.3098,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.91693839,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"22","issue":"1","first_page":"113","last_page":"113"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.4909999966621399,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.4909999966621399,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.12370000034570694,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13201","display_name":"Infectious Encephalopathies and Encephalitis","score":0.08649999648332596,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sarm1","display_name":"SARM1","score":1.0},{"id":"https://openalex.org/keywords/viral-encephalitis","display_name":"viral encephalitis","score":0.8790000081062317},{"id":"https://openalex.org/keywords/neurotropic-virus","display_name":"neurotropic viruses","score":0.9470000267028809},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.7770000100135803},{"id":"https://openalex.org/keywords/axon-degeneration","display_name":"axonal degeneration","score":0.9850000143051147},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.8830000162124634},{"id":"https://openalex.org/keywords/japanese-encephalitis-virus","display_name":"Japanese encephalitis virus","score":0.9750000238418579},{"id":"https://openalex.org/keywords/herpes-simplex-virus-type-1","display_name":"herpes simplex virus type 1","score":0.9559999704360962},{"id":"https://openalex.org/keywords/rabies-virus","display_name":"rabies virus","score":1.0},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.8539999723434448},{"id":"https://openalex.org/keywords/cortical-neurons","display_name":"cortical neurons","score":0.7039999961853027},{"id":"https://openalex.org/keywords/leukocyte-infiltration","display_name":"leukocyte infiltration","score":0.7300000190734863}],"concepts":[{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.8749294281005859},{"id":"https://openalex.org/C16568411","wikidata":"https://www.wikidata.org/wiki/Q83042","display_name":"Neurology","level":2,"score":0.6553567051887512},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.548021137714386},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4762278199195862},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.443220317363739},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26099899411201477},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.24926161766052246}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001369","descriptor_name":"Axons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003598","descriptor_name":"Cytoskeletal Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D003598","descriptor_name":"Cytoskeletal Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003598","descriptor_name":"Cytoskeletal Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018259","descriptor_name":"Herpesvirus 1, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D018792","descriptor_name":"Encephalitis, Viral","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D018792","descriptor_name":"Encephalitis, Viral","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018792","descriptor_name":"Encephalitis, Viral","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D051186","descriptor_name":"Armadillo Domain Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D051186","descriptor_name":"Armadillo Domain Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051186","descriptor_name":"Armadillo Domain Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12974-025-03423-5","doi":"https://doi.org/10.1186/s12974-025-03423-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12974-025-03423-5","pdf_url":null,"source":{"id":"https://openalex.org/S199572710","display_name":"Journal of Neuroinflammation","issn_l":"1742-2094","issn":["1742-2094"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroinflammation","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12010687","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12010687/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12010687/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Neuroinflammation","raw_type":"Text"},{"id":"pmid:40254576","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40254576","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neuroinflammation","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:f2316769e23147319f79c85387c6025a","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/f2316769e23147319f79c85387c6025a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Neuroinflammation, Vol 22, Iss 1, Pp 1-23 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12974-025-03423-5","doi":"https://doi.org/10.1186/s12974-025-03423-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12974-025-03423-5","pdf_url":null,"source":{"id":"https://openalex.org/S199572710","display_name":"Journal of Neuroinflammation","issn_l":"1742-2094","issn":["1742-2094"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroinflammation","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321921","display_name":"Natural Science Foundation of Guangdong Province","ror":null},{"id":"https://openalex.org/F4320327310","display_name":"Shantou University Medical College","ror":"https://ror.org/02gxych78"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4409602992.pdf","grobid_xml":"https://content.openalex.org/works/W4409602992.grobid-xml"},"referenced_works_count":77,"referenced_works":["https://openalex.org/W1997393571","https://openalex.org/W1998421929","https://openalex.org/W1999878533","https://openalex.org/W2008072593","https://openalex.org/W2012448604","https://openalex.org/W2025444660","https://openalex.org/W2032229848","https://openalex.org/W2042776153","https://openalex.org/W2050359676","https://openalex.org/W2066260623","https://openalex.org/W2075189940","https://openalex.org/W2120965258","https://openalex.org/W2131673631","https://openalex.org/W2137842754","https://openalex.org/W2141344764","https://openalex.org/W2169697627","https://openalex.org/W2170921124","https://openalex.org/W2171534203","https://openalex.org/W2194524172","https://openalex.org/W2257942016","https://openalex.org/W2493259891","https://openalex.org/W2528703423","https://openalex.org/W2537687146","https://openalex.org/W2594356439","https://openalex.org/W2602599682","https://openalex.org/W2778016195","https://openalex.org/W2792467059","https://openalex.org/W2800899442","https://openalex.org/W2802440763","https://openalex.org/W2886306143","https://openalex.org/W2910963998","https://openalex.org/W2944111278","https://openalex.org/W2969526404","https://openalex.org/W2984519822","https://openalex.org/W2999774834","https://openalex.org/W3007223603","https://openalex.org/W3008840800","https://openalex.org/W3008947151","https://openalex.org/W3010352845","https://openalex.org/W3023698680","https://openalex.org/W3082438395","https://openalex.org/W3084174900","https://openalex.org/W3092992656","https://openalex.org/W3118724494","https://openalex.org/W3119346562","https://openalex.org/W3122928618","https://openalex.org/W3133905451","https://openalex.org/W3137084308","https://openalex.org/W3163504032","https://openalex.org/W3177479326","https://openalex.org/W3177596245","https://openalex.org/W3196342433","https://openalex.org/W3213248403","https://openalex.org/W4200141491","https://openalex.org/W4200385110","https://openalex.org/W4205860172","https://openalex.org/W4214751909","https://openalex.org/W4223483998","https://openalex.org/W4226263799","https://openalex.org/W4283588567","https://openalex.org/W4283738867","https://openalex.org/W4294238269","https://openalex.org/W4295027538","https://openalex.org/W4296325260","https://openalex.org/W4307343124","https://openalex.org/W4311176879","https://openalex.org/W4366236809","https://openalex.org/W4366353524","https://openalex.org/W4366750877","https://openalex.org/W4376226288","https://openalex.org/W4378215128","https://openalex.org/W4385715435","https://openalex.org/W4387114684","https://openalex.org/W4390658771","https://openalex.org/W4391296517","https://openalex.org/W4396758968","https://openalex.org/W4402748246"],"related_works":["https://openalex.org/W3008947151","https://openalex.org/W4223483998","https://openalex.org/W7214547709","https://openalex.org/W2955427056","https://openalex.org/W2800367047","https://openalex.org/W2102242769","https://openalex.org/W3038722185","https://openalex.org/W4367053715","https://openalex.org/W3007315125","https://openalex.org/W4410989032"],"abstract_inverted_index":{"Viral":[0],"encephalitis,":[1,138],"resulting":[2],"from":[3],"neurotropic":[4,112,210],"viral":[5,77,90,137,191,211],"infections,":[6],"leads":[7],"to":[8],"severe":[9],"neurological":[10],"impairment,":[11],"inflammation,":[12],"and":[13,51,101,121,148,170,183,199],"exhibits":[14],"high":[15],"mortality":[16],"rates":[17],"with":[18],"poor":[19],"prognosis.":[20],"Currently,":[21],"there":[22],"is":[23],"a":[24,35],"lack":[25],"of":[26,48,73,89,131,136,142,157,190,209],"effective":[27],"targeted":[28],"treatments":[29],"for":[30,202],"this":[31,83],"disease,":[32],"which":[33],"poses":[34],"significant":[36],"public":[37],"health":[38],"concern.":[39],"SARM1":[40,143,195],"has":[41],"been":[42],"identified":[43],"as":[44,105,197],"the":[45,61,71,129,155,162,187,207],"pivotal":[46],"mediator":[47],"axonal":[49,117,146,181],"degeneration":[50,182],"inflammation":[52,185],"across":[53],"various":[54],"neuropathies,":[55],"activated":[56],"by":[57],"an":[58],"elevation":[59],"in":[60,67,76,125,161,174,206],"NMN/NAD":[62],"+":[63,159],"ratio.":[64],"However,":[65],"comprehensive":[66],"vivo":[68],"investigations":[69],"into":[70],"role":[72],"SARM1-mediated":[74,180],"pathogenesis":[75],"encephalitis":[78,91,94],"are":[79],"still":[80],"lacking.":[81],"In":[82,133],"study,":[84],"we":[85],"established":[86],"mouse":[87,134],"models":[88,135],"using":[92],"Japanese":[93],"virus":[95,103,113],"(JEV),":[96],"herpes":[97],"simplex":[98],"virus-1":[99],"(HSV-1),":[100],"rabies":[102],"(RABV)":[104],"representative":[106],"pathogens.":[107],"Our":[108,176],"findings":[109,177],"demonstrate":[110],"that":[111,179],"infections":[114],"elicit":[115],"robust":[116],"degeneration,":[118],"mitochondrial":[119,150],"dysfunction,":[120],"profound":[122],"neuropathological":[123,168],"damage":[124,169],"cortical":[126],"neurons":[127],"via":[128],"activation":[130],"SARM1.":[132],"deletion":[139],"or":[140],"inhibition":[141],"effectively":[144],"preserved":[145],"morphology":[147],"maintained":[149],"homeostasis,":[151],"while":[152],"also":[153],"attenuating":[154],"infiltration":[156],"CD45":[158],"leukocytes":[160],"cortex.":[163],"Consequently,":[164],"these":[165],"interventions":[166],"ameliorated":[167],"enhanced":[171],"survival":[172],"outcomes":[173],"mice.":[175],"suggest":[178],"brain":[184],"exacerbate":[186],"pathological":[188],"progression":[189],"encephalitis.":[192],"Therapies":[193],"targeting":[194],"emerge":[196],"viable":[198],"promising":[200],"strategies":[201],"protecting":[203],"neuronal":[204],"function":[205],"context":[208],"infections.":[212]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":4}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2025-04-20T00:00:00"}