{"id":"https://openalex.org/W4409598152","doi":"https://doi.org/10.1007/s10620-025-09044-5","title":"Obeticholic Acid vs Fibrates as Second-Line Therapy for Primary Biliary Cholangitis: Systematic Review and Meta-Analysis","display_name":"Obeticholic Acid vs Fibrates as Second-Line Therapy for Primary Biliary Cholangitis: Systematic Review and Meta-Analysis","publication_year":2025,"publication_date":"2025-04-19","ids":{"openalex":"https://openalex.org/W4409598152","doi":"https://doi.org/10.1007/s10620-025-09044-5","pmid":"https://pubmed.ncbi.nlm.nih.gov/40253557"},"language":"en","primary_location":{"id":"doi:10.1007/s10620-025-09044-5","doi":"https://doi.org/10.1007/s10620-025-09044-5","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10620-025-09044-5","pdf_url":null,"source":{"id":"https://openalex.org/S194656152","display_name":"Digestive Diseases and Sciences","issn_l":"0163-2116","issn":["0163-2116","1573-2568"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Digestive Diseases and Sciences","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057280812","display_name":"Eliabe Silva de Abreu","orcid":"https://orcid.org/0000-0002-8398-3553","observed_orcids":["https://orcid.org/0000-0002-8398-3553"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Eliabe S. Abreu","raw_affiliation_strings":["Division of Gastroenterology & Hepatology, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA. abreu.eliabe@mayo.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology & Hepatology, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA. abreu.eliabe@mayo.edu","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107125229","display_name":"Pedro Henrique Reginato","orcid":"https://orcid.org/0009-0004-3406-0770","observed_orcids":["https://orcid.org/0009-0004-3406-0770"]},"institutions":[{"id":"https://openalex.org/I52418104","display_name":"Universidade Federal do Paran\u00e1","ror":"https://ror.org/05syd6y78","country_code":"BR","type":"education","lineage":["https://openalex.org/I52418104"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Pedro Henrique Reginato","raw_affiliation_strings":["Universidade Federal Do Paran\u00e1, Curitiba, PR, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal Do Paran\u00e1, Curitiba, PR, Brazil","institution_ids":["https://openalex.org/I52418104"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115035159","display_name":"Jorge Ferreira Jasmineiro Pitanga","orcid":"https://orcid.org/0009-0009-6222-4142","observed_orcids":["https://orcid.org/0009-0009-6222-4142"]},"institutions":[{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Jorge Ferreira Jasmineiro Pitanga","raw_affiliation_strings":["Facultad de Ciencias M\u00e9dicas, Universidad de Buenos Aires, Ciudad Aut\u00f3noma de Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Facultad de Ciencias M\u00e9dicas, Universidad de Buenos Aires, Ciudad Aut\u00f3noma de Buenos Aires, Argentina","institution_ids":["https://openalex.org/I24354313"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Pedro Neves Borges","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161127581","display_name":"Universidade Federal Fluminense","ror":"https://ror.org/02rjhbb08","country_code":"BR","type":"education","lineage":["https://openalex.org/I161127581"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Pedro Neves Borges","raw_affiliation_strings":["Universidade Federal Fluminense, Niter\u00f3i, RJ, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal Fluminense, Niter\u00f3i, RJ, Brazil","institution_ids":["https://openalex.org/I161127581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040437364","display_name":"Pierre\u2010Antoine Soret","orcid":"https://orcid.org/0009-0006-7808-906X","observed_orcids":["https://orcid.org/0009-0006-7808-906X"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210102928","display_name":"H\u00f4pital Saint-Antoine","ror":"https://ror.org/01875pg84","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210102928"]},{"id":"https://openalex.org/I4210134622","display_name":"Centre de Recherche Saint-Antoine","ror":"https://ror.org/03wxndv36","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I39804081","https://openalex.org/I4210097159","https://openalex.org/I4210129850","https://openalex.org/I4210134622"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Pierre-Antoine Soret","raw_affiliation_strings":["Reference Center for Inflammatory Biliary Diseases and Autoimmune Hepatitis, European Reference Network On Hepatological Diseases (ERN Rare-Liver), Saint-Antoine Hospital, Assistance Publique - H\u00f4pitaux de Paris, Inserm UMR_S938, Saint-Antoine Research Center, Sorbonne University, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Reference Center for Inflammatory Biliary Diseases and Autoimmune Hepatitis, European Reference Network On Hepatological Diseases (ERN Rare-Liver), Saint-Antoine Hospital, Assistance Publique - H\u00f4pitaux de Paris, Inserm UMR_S938, Saint-Antoine Research Center, Sorbonne University, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I39804081","https://openalex.org/I4210097159","https://openalex.org/I4210102928","https://openalex.org/I4210134622"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090413862","display_name":"Christophe Corpechot","orcid":"https://orcid.org/0000-0002-7920-9784","observed_orcids":["https://orcid.org/0000-0002-7920-9784"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210102928","display_name":"H\u00f4pital Saint-Antoine","ror":"https://ror.org/01875pg84","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210102928"]},{"id":"https://openalex.org/I4210134622","display_name":"Centre de Recherche Saint-Antoine","ror":"https://ror.org/03wxndv36","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I39804081","https://openalex.org/I4210097159","https://openalex.org/I4210129850","https://openalex.org/I4210134622"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Christophe Corpechot","raw_affiliation_strings":["Reference Center for Inflammatory Biliary Diseases and Autoimmune Hepatitis, European Reference Network On Hepatological Diseases (ERN Rare-Liver), Saint-Antoine Hospital, Assistance Publique - H\u00f4pitaux de Paris, Inserm UMR_S938, Saint-Antoine Research Center, Sorbonne University, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Reference Center for Inflammatory Biliary Diseases and Autoimmune Hepatitis, European Reference Network On Hepatological Diseases (ERN Rare-Liver), Saint-Antoine Hospital, Assistance Publique - H\u00f4pitaux de Paris, Inserm UMR_S938, Saint-Antoine Research Center, Sorbonne University, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I39804081","https://openalex.org/I4210097159","https://openalex.org/I4210102928","https://openalex.org/I4210134622"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071398336","display_name":"Guilherme Grossi Lopes Can\u00e7ado","orcid":"https://orcid.org/0000-0002-7824-2152","observed_orcids":["https://orcid.org/0000-0002-7824-2152"]},"institutions":[{"id":"https://openalex.org/I4210134014","display_name":"Hospital das Cl\u00ednicas da Universidade Federal de Minas Gerais","ror":"https://ror.org/035rpst33","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210134014"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Guilherme Grossi Lopes Can\u00e7ado","raw_affiliation_strings":["Hospital da Pol\u00edcia Militar de Minas Gerais, Belo Horizonte, MG, Brazil","Hospital das Cl\u00ednicas da Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital da Pol\u00edcia Militar de Minas Gerais, Belo Horizonte, MG, Brazil","institution_ids":[]},{"raw_affiliation_string":"Hospital das Cl\u00ednicas da Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil","institution_ids":["https://openalex.org/I4210134014"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5057280812"],"corresponding_institution_ids":["https://openalex.org/I1330342723"],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":null,"fwci":0.5127,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.52168367,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":92,"max":98},"biblio":{"volume":"70","issue":"8","first_page":"2843","last_page":"2851"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11834","display_name":"Liver Diseases and Immunity","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11834","display_name":"Liver Diseases and Immunity","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12460","display_name":"Pediatric Hepatobiliary Diseases and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/obeticholic-acid","display_name":"obeticholic acid","score":0.9160000085830688},{"id":"https://openalex.org/keywords/fibrates","display_name":"fibrates","score":0.9980000257492065},{"id":"https://openalex.org/keywords/primary-biliary-cholangitis","display_name":"primary biliary cirrhosis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/second-line-treatment","display_name":"second-line therapy","score":0.8679999709129333},{"id":"https://openalex.org/keywords/ursodeoxycholic-acid","display_name":"ursodeoxycholic acid","score":0.9629999995231628},{"id":"https://openalex.org/keywords/adjunctive-therapy","display_name":"adjunctive therapy","score":0.875},{"id":"https://openalex.org/keywords/liver-biochemistry","display_name":"liver biochemistry","score":0.6439999938011169},{"id":"https://openalex.org/keywords/treatment-response-criteria","display_name":"treatment response criteria","score":0.7009999752044678},{"id":"https://openalex.org/keywords/bile-acid-sequestrants","display_name":"bile acid sequestrants","score":0.6480000019073486}],"concepts":[{"id":"https://openalex.org/C2777067796","wikidata":"https://www.wikidata.org/wiki/Q15708271","display_name":"Obeticholic acid","level":4,"score":0.9808264374732971},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7640254497528076},{"id":"https://openalex.org/C2909339193","wikidata":"https://www.wikidata.org/wiki/Q105196","display_name":"Transplant surgery","level":3,"score":0.7591197490692139},{"id":"https://openalex.org/C2780965833","wikidata":"https://www.wikidata.org/wiki/Q241374","display_name":"Ursodeoxycholic acid","level":2,"score":0.6820213794708252},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.6643763780593872},{"id":"https://openalex.org/C41260117","wikidata":"https://www.wikidata.org/wiki/Q668064","display_name":"Hepatology","level":2,"score":0.6626073718070984},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6580604910850525},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5698790550231934},{"id":"https://openalex.org/C2778110834","wikidata":"https://www.wikidata.org/wiki/Q419724","display_name":"Fenofibrate","level":2,"score":0.4270392060279846},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D002635","descriptor_name":"Chenodeoxycholic Acid","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D002635","descriptor_name":"Chenodeoxycholic Acid","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008105","descriptor_name":"Liver Cirrhosis, Biliary","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D008105","descriptor_name":"Liver Cirrhosis, Biliary","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D014580","descriptor_name":"Ursodeoxycholic Acid","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058607","descriptor_name":"Fibric Acids","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1007/s10620-025-09044-5","doi":"https://doi.org/10.1007/s10620-025-09044-5","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10620-025-09044-5","pdf_url":null,"source":{"id":"https://openalex.org/S194656152","display_name":"Digestive Diseases and Sciences","issn_l":"0163-2116","issn":["0163-2116","1573-2568"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Digestive Diseases and Sciences","raw_type":"journal-article"},{"id":"pmid:40253557","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40253557","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Digestive diseases and sciences","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"},{"id":"https://openalex.org/study-designs/meta-analysis","display_name":"Meta-Analysis"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1247968195","https://openalex.org/W1534181333","https://openalex.org/W1988012657","https://openalex.org/W2058865320","https://openalex.org/W2063975050","https://openalex.org/W2108326867","https://openalex.org/W2170892587","https://openalex.org/W2170952317","https://openalex.org/W2518389324","https://openalex.org/W2531269403","https://openalex.org/W2807617765","https://openalex.org/W2915002008","https://openalex.org/W2964683056","https://openalex.org/W2993976670","https://openalex.org/W3007762014","https://openalex.org/W3040342452","https://openalex.org/W3094646688","https://openalex.org/W3097914939","https://openalex.org/W3111759537","https://openalex.org/W3118615836","https://openalex.org/W3122123611","https://openalex.org/W3135843567","https://openalex.org/W3137256548","https://openalex.org/W3154020224","https://openalex.org/W3174888168","https://openalex.org/W4206905543","https://openalex.org/W4288013674","https://openalex.org/W4291708356","https://openalex.org/W4304117279","https://openalex.org/W4379184395","https://openalex.org/W4383058381","https://openalex.org/W4388621682","https://openalex.org/W4392015136","https://openalex.org/W4396556561"],"related_works":["https://openalex.org/W3008987860","https://openalex.org/W3174888168","https://openalex.org/W3137256548","https://openalex.org/W4414569064","https://openalex.org/W2912104429","https://openalex.org/W4205219971","https://openalex.org/W4396556561","https://openalex.org/W4291708356","https://openalex.org/W7162340450","https://openalex.org/W3213046821"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2025-04-20T00:00:00"}
