{"id":"https://openalex.org/W4409595286","doi":"https://doi.org/10.1016/j.mucimm.2025.04.006","title":"PAD4 inhibition impacts immune responses in SARS-CoV-2 infection","display_name":"PAD4 inhibition impacts immune responses in SARS-CoV-2 infection","publication_year":2025,"publication_date":"2025-04-19","ids":{"openalex":"https://openalex.org/W4409595286","doi":"https://doi.org/10.1016/j.mucimm.2025.04.006","pmid":"https://pubmed.ncbi.nlm.nih.gov/40258416"},"language":"en","primary_location":{"id":"doi:10.1016/j.mucimm.2025.04.006","doi":"https://doi.org/10.1016/j.mucimm.2025.04.006","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.mucimm.2025.04.006","pdf_url":null,"source":{"id":"https://openalex.org/S68384121","display_name":"Mucosal Immunology","issn_l":"1933-0219","issn":["1933-0219","1935-3456"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-200","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mucosal Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.mucimm.2025.04.006","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024153483","display_name":"Caio Santos Bonilha","orcid":"https://orcid.org/0000-0003-1168-8392","observed_orcids":["https://orcid.org/0000-0003-1168-8392"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]}],"countries":["BR","GB"],"is_corresponding":true,"raw_author_name":"Caio Santos Bonilha","raw_affiliation_strings":["Center for Research in Inflammatory Diseases, Ribeirao Preto Medical School, University of Sao Paulo, 14049-900, Brazil; Institute of Infection, Immunity and Inflammation, University of Glasgow, G12 8TA, UK; Institute of Developmental & Regenerative Medicine, University of Oxford, OX3 7TY, UK. Electronic address: Caio.Bonilha@usp.br"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Research in Inflammatory Diseases, Ribeirao Preto Medical School, University of Sao Paulo, 14049-900, Brazil; Institute of Infection, Immunity and Inflammation, University of Glasgow, G12 8TA, UK; Institute of Developmental & Regenerative Medicine, University of Oxford, OX3 7TY, UK. Electronic address: Caio.Bonilha@usp.br","institution_ids":["https://openalex.org/I17974374","https://openalex.org/I40120149","https://openalex.org/I7882870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036583809","display_name":"Flavio Protasio Veras","orcid":"https://orcid.org/0000-0002-6222-4064","observed_orcids":["https://orcid.org/0000-0002-6222-4064"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]},{"id":"https://openalex.org/I23925101","display_name":"Universidade Federal de Alfenas","ror":"https://ror.org/034vpja60","country_code":"BR","type":"education","lineage":["https://openalex.org/I23925101"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Flavio Protasio Veras","raw_affiliation_strings":["Center for Research in Inflammatory Diseases, Ribeirao Preto Medical School, University of Sao Paulo, 14049-900, Brazil; Institute of Biomedical Sciences, Federal University of Alfenas, 37130-001, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Research in Inflammatory Diseases, Ribeirao Preto Medical School, University of Sao Paulo, 14049-900, Brazil; Institute of Biomedical Sciences, Federal University of Alfenas, 37130-001, Brazil","institution_ids":["https://openalex.org/I17974374","https://openalex.org/I23925101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067691350","display_name":"Anderson dos Santos Ramos","orcid":"https://orcid.org/0000-0002-3487-7914","observed_orcids":["https://orcid.org/0000-0002-3487-7914"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Anderson dos Santos Ramos","raw_affiliation_strings":["Center for Research in Inflammatory Diseases, Ribeirao Preto Medical School, University of Sao Paulo, 14049-900, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Research in Inflammatory Diseases, Ribeirao Preto Medical School, University of Sao Paulo, 14049-900, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055104716","display_name":"Giovanni Freitas Gomes","orcid":"https://orcid.org/0000-0002-4855-3056","observed_orcids":["https://orcid.org/0000-0002-4855-3056"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Giovanni Freitas Gomes","raw_affiliation_strings":["Center for Research in Inflammatory Diseases, Ribeirao Preto Medical School, University of Sao Paulo, 14049-900, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Research in Inflammatory Diseases, Ribeirao Preto Medical School, University of Sao Paulo, 14049-900, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088112630","display_name":"Robertha Mariana Rodrigues Lemes","orcid":"https://orcid.org/0000-0001-9322-4262","observed_orcids":["https://orcid.org/0000-0001-9322-4262"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Robertha Mariana Rodrigues Lemes","raw_affiliation_strings":["Center for Research in Inflammatory Diseases, Ribeirao Preto Medical School, University of Sao Paulo, 14049-900, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Research in Inflammatory Diseases, Ribeirao Preto Medical School, University of Sao Paulo, 14049-900, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070023618","display_name":"Eurico Arruda","orcid":"https://orcid.org/0000-0002-0978-410X","observed_orcids":["https://orcid.org/0000-0002-0978-410X"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Eurico Arruda","raw_affiliation_strings":["Virology Research Center, Ribeirao Preto Medical School, University of Sao Paulo 14049-900, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Virology Research Center, Ribeirao Preto Medical School, University of Sao Paulo 14049-900, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006994441","display_name":"Jos\u00e9 Carlos Alves-Filho","orcid":"https://orcid.org/0000-0002-9918-8714","observed_orcids":["https://orcid.org/0000-0002-9918-8714"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 Carlos Alves-Filho","raw_affiliation_strings":["Center for Research in Inflammatory Diseases, Ribeirao Preto Medical School, University of Sao Paulo, 14049-900, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Research in Inflammatory Diseases, Ribeirao Preto Medical School, University of Sao Paulo, 14049-900, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017615120","display_name":"Thiago M. Cunha","orcid":"https://orcid.org/0000-0003-1084-0065","observed_orcids":["https://orcid.org/0000-0003-1084-0065"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Thiago Mattar Cunha","raw_affiliation_strings":["Center for Research in Inflammatory Diseases, Ribeirao Preto Medical School, University of Sao Paulo, 14049-900, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Research in Inflammatory Diseases, Ribeirao Preto Medical School, University of Sao Paulo, 14049-900, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050684767","display_name":"Fernando Q. Cunha","orcid":"https://orcid.org/0000-0003-4755-1670","observed_orcids":["https://orcid.org/0000-0003-4755-1670"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Fernando Queiroz Cunha","raw_affiliation_strings":["Center for Research in Inflammatory Diseases, Ribeirao Preto Medical School, University of Sao Paulo, 14049-900, Brazil. Electronic address: fdqcunha@fmrp.usp.br"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Research in Inflammatory Diseases, Ribeirao Preto Medical School, University of Sao Paulo, 14049-900, Brazil. Electronic address: fdqcunha@fmrp.usp.br","institution_ids":["https://openalex.org/I17974374"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5024153483","https://openalex.org/A5050684767"],"corresponding_institution_ids":["https://openalex.org/I17974374","https://openalex.org/I40120149","https://openalex.org/I7882870"],"apc_list":{"value":4370,"currency":"USD","value_usd":4370},"apc_paid":{"value":4370,"currency":"USD","value_usd":4370},"fwci":6.7924,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.9775677,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"18","issue":"4","first_page":"861","last_page":"873"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.9717000126838684,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.9717000126838684,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.006599999964237213,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.005900000222027302,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pad4-inhibition","display_name":"PAD4 inhibition","score":0.8320000171661377},{"id":"https://openalex.org/keywords/covid-19","display_name":"COVID-19 pandemic","score":0.9330000281333923},{"id":"https://openalex.org/keywords/neutrophil-extracellular-traps","display_name":"neutrophil extracellular traps","score":0.9980000257492065},{"id":"https://openalex.org/keywords/lung-injury","display_name":"lung injury","score":0.6460000276565552},{"id":"https://openalex.org/keywords/adaptive-immunity","display_name":"adaptive immunity","score":0.765999972820282},{"id":"https://openalex.org/keywords/t-cell-response","display_name":"T cell response","score":0.800000011920929},{"id":"https://openalex.org/keywords/dendritic-cell-antigen-presentation","display_name":"dendritic cell antigen presentation","score":0.9929999709129333},{"id":"https://openalex.org/keywords/il-2-signaling","display_name":"IL-2 signaling","score":0.9980000257492065},{"id":"https://openalex.org/keywords/recombinant-human-dnase","display_name":"recombinant human DNase","score":0.9639999866485596},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.7149999737739563}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6883636713027954},{"id":"https://openalex.org/C3007834351","wikidata":"https://www.wikidata.org/wiki/Q82069695","display_name":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","level":5,"score":0.6496235728263855},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.6461362838745117},{"id":"https://openalex.org/C3006700255","wikidata":"https://www.wikidata.org/wiki/Q81068910","display_name":"2019-20 coronavirus outbreak","level":3,"score":0.5527696013450623},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5264652371406555},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49419453740119934},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4449811577796936},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.44172805547714233},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.43678203225135803},{"id":"https://openalex.org/C3020799909","wikidata":"https://www.wikidata.org/wiki/Q85438966","display_name":"Sars virus","level":5,"score":0.4323533773422241},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.16080042719841003},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.13541150093078613},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1292414367198944},{"id":"https://openalex.org/C116675565","wikidata":"https://www.wikidata.org/wiki/Q3241045","display_name":"Outbreak","level":2,"score":0.10564962029457092}],"mesh":[{"descriptor_ui":"D000080002","descriptor_name":"Protein-Arginine Deiminase Type 4","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D000080002","descriptor_name":"Protein-Arginine Deiminase Type 4","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D000080002","descriptor_name":"Protein-Arginine Deiminase Type 4","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000080002","descriptor_name":"Protein-Arginine Deiminase Type 4","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000080002","descriptor_name":"Protein-Arginine Deiminase Type 4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000080002","descriptor_name":"Protein-Arginine Deiminase Type 4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000093485","descriptor_name":"COVID-19 Drug Treatment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000093485","descriptor_name":"COVID-19 Drug Treatment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007376","descriptor_name":"Interleukin-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007376","descriptor_name":"Interleukin-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017951","descriptor_name":"Antigen Presentation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017951","descriptor_name":"Antigen Presentation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056704","descriptor_name":"Adaptive Immunity","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D056704","descriptor_name":"Adaptive Immunity","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D065206","descriptor_name":"Extracellular Traps","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D065206","descriptor_name":"Extracellular Traps","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D065206","descriptor_name":"Extracellular Traps","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D065206","descriptor_name":"Extracellular Traps","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D065206","descriptor_name":"Extracellular Traps","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D065206","descriptor_name":"Extracellular Traps","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.mucimm.2025.04.006","doi":"https://doi.org/10.1016/j.mucimm.2025.04.006","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.mucimm.2025.04.006","pdf_url":null,"source":{"id":"https://openalex.org/S68384121","display_name":"Mucosal Immunology","issn_l":"1933-0219","issn":["1933-0219","1935-3456"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-200","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mucosal Immunology","raw_type":"journal-article"},{"id":"pmid:40258416","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40258416","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mucosal immunology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.mucimm.2025.04.006","doi":"https://doi.org/10.1016/j.mucimm.2025.04.006","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.mucimm.2025.04.006","pdf_url":null,"source":{"id":"https://openalex.org/S68384121","display_name":"Mucosal Immunology","issn_l":"1933-0219","issn":["1933-0219","1935-3456"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-200","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mucosal Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1477489864","display_name":"Neutrophil extracelular traps (NETs): role in the pathophysiology and potential as a therapeutic target on COVID-19","funder_award_id":"20/05601-6","funder_id":"https://openalex.org/F4320320997","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo"},{"id":"https://openalex.org/G3673464575","display_name":null,"funder_award_id":"2021/09539-6","funder_id":"https://openalex.org/F4320320997","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo"},{"id":"https://openalex.org/G3874708113","display_name":null,"funder_award_id":"2013/08216- 2","funder_id":"https://openalex.org/F4320320997","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo"}],"funders":[{"id":"https://openalex.org/F4320320997","display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","ror":"https://ror.org/02ddkpn78"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":57,"referenced_works":["https://openalex.org/W1497894656","https://openalex.org/W2009644403","https://openalex.org/W2030095596","https://openalex.org/W2036782104","https://openalex.org/W2046781420","https://openalex.org/W2050708499","https://openalex.org/W2054287302","https://openalex.org/W2102221395","https://openalex.org/W2110751735","https://openalex.org/W2120365315","https://openalex.org/W2164304811","https://openalex.org/W2168020443","https://openalex.org/W2170904230","https://openalex.org/W2537984487","https://openalex.org/W2621491385","https://openalex.org/W2789026035","https://openalex.org/W2902436089","https://openalex.org/W2910233510","https://openalex.org/W2983166327","https://openalex.org/W3081413731","https://openalex.org/W3085958090","https://openalex.org/W3100456347","https://openalex.org/W3160506795","https://openalex.org/W3165625585","https://openalex.org/W3175436048","https://openalex.org/W3191178640","https://openalex.org/W3191601662","https://openalex.org/W3200186452","https://openalex.org/W3204794681","https://openalex.org/W3216146155","https://openalex.org/W4210655750","https://openalex.org/W4213034782","https://openalex.org/W4213337326","https://openalex.org/W4224219253","https://openalex.org/W4285793875","https://openalex.org/W4289597474","https://openalex.org/W4294142667","https://openalex.org/W4294916268","https://openalex.org/W4297254638","https://openalex.org/W4322772207","https://openalex.org/W4323348018","https://openalex.org/W4366290728","https://openalex.org/W4384501513","https://openalex.org/W4386986695","https://openalex.org/W4387092751","https://openalex.org/W4387231955","https://openalex.org/W4387855408","https://openalex.org/W4388657644","https://openalex.org/W4389076144","https://openalex.org/W4389936157","https://openalex.org/W4390569788","https://openalex.org/W4392769596","https://openalex.org/W4394808413","https://openalex.org/W4395072764","https://openalex.org/W4406622312","https://openalex.org/W6799559515","https://openalex.org/W6852223518"],"related_works":["https://openalex.org/W4404084015","https://openalex.org/W3156916261","https://openalex.org/W3092656880","https://openalex.org/W3214333824","https://openalex.org/W4206249207","https://openalex.org/W3015777742","https://openalex.org/W4256095626","https://openalex.org/W3209591042","https://openalex.org/W3165952552","https://openalex.org/W3013867929"],"abstract_inverted_index":{"Protein":[0],"arginine":[1],"deiminase":[2],"4":[3],"(PAD4)":[4],"has":[5],"emerged":[6],"as":[7,34,156],"a":[8,35,142,157],"potential":[9,164],"therapeutic":[10,158],"target":[11,159],"for":[12,171],"various":[13],"diseases":[14],"due":[15],"to":[16,88,102,165],"its":[17,123,163],"role":[18],"in":[19,47,100,141,160],"promoting":[20],"neutrophil":[21],"extracellular":[22],"trap":[23],"(NET)":[24],"formation.":[25],"NETs,":[26],"composed":[27],"of":[28,57,69,144,152],"DNA":[29],"and":[30,63,83,117],"antimicrobial":[31],"proteins,":[32],"serve":[33],"defense":[36],"mechanism":[37],"against":[38],"pathogens":[39],"but":[40],"can":[41],"also":[42],"drive":[43],"lung":[44,80,145],"injury,":[45],"particularly":[46],"SARS-CoV-2":[48,70],"infection.":[49,71],"In":[50,128],"this":[51],"study,":[52],"we":[53],"examined":[54],"the":[55,67,150,173],"effects":[56],"PAD4":[58,76,104,133,155],"inhibition":[59,78,135],"on":[60],"clinical":[61,85],"outcomes":[62],"adaptive":[64,167],"immunity":[65],"within":[66],"context":[68],"Our":[72],"results":[73],"show":[74],"that":[75],"pharmacological":[77,134],"reduced":[79],"NET":[81,97],"concentration":[82],"improved":[84],"outcomes,":[86],"similar":[87],"treatment":[89],"with":[90,130],"recombinant":[91],"human":[92],"DNase":[93],"(rhDNase),":[94],"which":[95],"degrades":[96],"structure.":[98],"However,":[99],"contrast":[101],"rhDNase,":[103],"targeting":[105],"diminished":[106,136],"virus-specific":[107],"T":[108,126,138],"cell":[109,114,139],"responses":[110,140,169],"by":[111,121,125],"impairing":[112],"dendritic":[113],"antigen":[115],"presentation":[116],"reducing":[118],"IL-2":[119],"signaling":[120],"affecting":[122],"production":[124],"cells.":[127],"line":[129],"these":[131],"observations,":[132],"antigen-specific":[137],"model":[143],"inflammation.":[146],"These":[147],"findings":[148],"highlight":[149],"importance":[151],"carefully":[153],"evaluating":[154],"COVID-19,":[161],"given":[162],"compromise":[166],"immune":[168],"crucial":[170],"fighting":[172],"virus.":[174]},"counts_by_year":[{"year":2026,"cited_by_count":19},{"year":2025,"cited_by_count":4}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}