{"id":"https://openalex.org/W4409565523","doi":"https://doi.org/10.1038/s41589-025-01883-7","title":"Expanding catalytic versatility of modular polyketide synthases for alcohol biosynthesis","display_name":"Expanding catalytic versatility of modular polyketide synthases for alcohol biosynthesis","publication_year":2025,"publication_date":"2025-04-18","ids":{"openalex":"https://openalex.org/W4409565523","doi":"https://doi.org/10.1038/s41589-025-01883-7","pmid":"https://pubmed.ncbi.nlm.nih.gov/40251435"},"language":"en","primary_location":{"id":"doi:10.1038/s41589-025-01883-7","doi":"https://doi.org/10.1038/s41589-025-01883-7","is_oa":false,"landing_page_url":"https://doi.org/10.1038/s41589-025-01883-7","pdf_url":null,"source":{"id":"https://openalex.org/S51309854","display_name":"Nature Chemical Biology","issn_l":"1552-4450","issn":["1552-4450","1552-4469"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Chemical Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-4004371/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089528027","display_name":"S. Yao","orcid":"https://orcid.org/0009-0004-6328-8504","observed_orcids":["https://orcid.org/0009-0004-6328-8504"]},"institutions":[{"id":"https://openalex.org/I3133055985","display_name":"Westlake University","ror":"https://ror.org/05hfa4n20","country_code":"CN","type":"education","lineage":["https://openalex.org/I3133055985"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shunyu Yao","raw_affiliation_strings":["Department of Chemistry, Zhejiang University, Hangzhou, China","Zhejiang Key Laboratory of Precise Synthesis of Functional Molecules, Department of Chemistry, School of Science and Research Center for Industries of the Future, Westlake University, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"Zhejiang Key Laboratory of Precise Synthesis of Functional Molecules, Department of Chemistry, School of Science and Research Center for Industries of the Future, Westlake University, Hangzhou, China","institution_ids":["https://openalex.org/I3133055985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060133023","display_name":"Shengling Xie","orcid":"https://orcid.org/0000-0001-5316-9393","observed_orcids":["https://orcid.org/0000-0001-5316-9393"]},"institutions":[{"id":"https://openalex.org/I3133055985","display_name":"Westlake University","ror":"https://ror.org/05hfa4n20","country_code":"CN","type":"education","lineage":["https://openalex.org/I3133055985"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shengling Xie","raw_affiliation_strings":["Department of Chemistry, Zhejiang University, Hangzhou, China","Zhejiang Key Laboratory of Precise Synthesis of Functional Molecules, Department of Chemistry, School of Science and Research Center for Industries of the Future, Westlake University, Hangzhou, China"],"raw_orcid":"https://orcid.org/0000-0001-5316-9393","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"Zhejiang Key Laboratory of Precise Synthesis of Functional Molecules, Department of Chemistry, School of Science and Research Center for Industries of the Future, Westlake University, Hangzhou, China","institution_ids":["https://openalex.org/I3133055985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002900455","display_name":"Run\u2010Zhou Liu","orcid":"https://orcid.org/0000-0001-8421-3166","observed_orcids":["https://orcid.org/0000-0001-8421-3166"]},"institutions":[{"id":"https://openalex.org/I3133055985","display_name":"Westlake University","ror":"https://ror.org/05hfa4n20","country_code":"CN","type":"education","lineage":["https://openalex.org/I3133055985"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Run-Zhou Liu","raw_affiliation_strings":["Zhejiang Key Laboratory of Precise Synthesis of Functional Molecules, Department of Chemistry, School of Science and Research Center for Industries of the Future, Westlake University, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zhejiang Key Laboratory of Precise Synthesis of Functional Molecules, Department of Chemistry, School of Science and Research Center for Industries of the Future, Westlake University, Hangzhou, China","institution_ids":["https://openalex.org/I3133055985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102628573","display_name":"Zilei Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3133055985","display_name":"Westlake University","ror":"https://ror.org/05hfa4n20","country_code":"CN","type":"education","lineage":["https://openalex.org/I3133055985"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zilei Huang","raw_affiliation_strings":["Department of Chemistry, Zhejiang University, Hangzhou, China","Zhejiang Key Laboratory of Precise Synthesis of Functional Molecules, Department of Chemistry, School of Science and Research Center for Industries of the Future, Westlake University, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"Zhejiang Key Laboratory of Precise Synthesis of Functional Molecules, Department of Chemistry, School of Science and Research Center for Industries of the Future, Westlake University, Hangzhou, China","institution_ids":["https://openalex.org/I3133055985"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012940856","display_name":"Lihan Zhang","orcid":"https://orcid.org/0000-0003-4364-6242","observed_orcids":["https://orcid.org/0000-0003-4364-6242"]},"institutions":[{"id":"https://openalex.org/I3133055985","display_name":"Westlake University","ror":"https://ror.org/05hfa4n20","country_code":"CN","type":"education","lineage":["https://openalex.org/I3133055985"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lihan Zhang","raw_affiliation_strings":["Institute of Natural Sciences, Westlake Institute for Advanced Study, Hangzhou, China. zhanglihan@westlake.edu.cn","Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China. zhanglihan@westlake.edu.cn","Zhejiang Key Laboratory of Precise Synthesis of Functional Molecules, Department of Chemistry, School of Science and Research Center for Industries of the Future, Westlake University, Hangzhou, China. zhanglihan@westlake.edu.cn"],"raw_orcid":"https://orcid.org/0000-0003-4364-6242","affiliations":[{"raw_affiliation_string":"Institute of Natural Sciences, Westlake Institute for Advanced Study, Hangzhou, China. zhanglihan@westlake.edu.cn","institution_ids":["https://openalex.org/I3133055985"]},{"raw_affiliation_string":"Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China. zhanglihan@westlake.edu.cn","institution_ids":["https://openalex.org/I3133055985"]},{"raw_affiliation_string":"Zhejiang Key Laboratory of Precise Synthesis of Functional Molecules, Department of Chemistry, School of Science and Research Center for Industries of the Future, Westlake University, Hangzhou, China. zhanglihan@westlake.edu.cn","institution_ids":["https://openalex.org/I3133055985"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5012940856"],"corresponding_institution_ids":["https://openalex.org/I3133055985"],"apc_list":{"value":12690,"currency":"USD","value_usd":12690},"apc_paid":null,"fwci":4.5849,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.96619767,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"21","issue":"9","first_page":"1368","last_page":"1375"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.8076000213623047,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.8076000213623047,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.12960000336170197,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10404","display_name":"Enzyme Catalysis and Immobilization","score":0.01860000006854534,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/modular-polyketide-synthases","display_name":"modular polyketide synthases","score":0.9950000047683716},{"id":"https://openalex.org/keywords/acyl-carrier-protein","display_name":"acyl carrier protein","score":0.7070000171661377},{"id":"https://openalex.org/keywords/1-3-butanediol","display_name":"1,3-butanediol","score":0.9350000023841858}],"concepts":[{"id":"https://openalex.org/C2778635478","wikidata":"https://www.wikidata.org/wiki/Q516751","display_name":"Polyketide","level":4,"score":0.8711607456207275},{"id":"https://openalex.org/C553450214","wikidata":"https://www.wikidata.org/wiki/Q851162","display_name":"Biosynthesis","level":3,"score":0.7418245077133179},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5580781698226929},{"id":"https://openalex.org/C101468663","wikidata":"https://www.wikidata.org/wiki/Q1620158","display_name":"Modular design","level":2,"score":0.5426852703094482},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4915972650051117},{"id":"https://openalex.org/C2781066024","wikidata":"https://www.wikidata.org/wiki/Q156","display_name":"Alcohol","level":2,"score":0.4304019510746002},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.42181509733200073},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35935425758361816},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.1940923035144806},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.1808691918849945},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000438","descriptor_name":"Alcohols","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000438","descriptor_name":"Alcohols","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002384","descriptor_name":"Catalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020134","descriptor_name":"Catalytic Domain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048630","descriptor_name":"Polyketide Synthases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D048630","descriptor_name":"Polyketide Synthases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D048630","descriptor_name":"Polyketide Synthases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D055162","descriptor_name":"Biocatalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1038/s41589-025-01883-7","doi":"https://doi.org/10.1038/s41589-025-01883-7","is_oa":false,"landing_page_url":"https://doi.org/10.1038/s41589-025-01883-7","pdf_url":null,"source":{"id":"https://openalex.org/S51309854","display_name":"Nature Chemical Biology","issn_l":"1552-4450","issn":["1552-4450","1552-4469"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Chemical Biology","raw_type":"journal-article"},{"id":"doi:10.21203/rs.3.rs-4004371/v1","doi":"https://doi.org/10.21203/rs.3.rs-4004371/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-4004371/v1","pdf_url":"https://www.researchsquare.com/article/rs-4004371/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"pmid:40251435","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40251435","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature chemical biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-4004371/v1","doi":"https://doi.org/10.21203/rs.3.rs-4004371/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-4004371/v1","pdf_url":"https://www.researchsquare.com/article/rs-4004371/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G274809553","display_name":null,"funder_award_id":"2023SDXHDX0007","funder_id":"https://openalex.org/F4320338110","funder_display_name":"Science and Technology Department of Zhejiang Province"},{"id":"https://openalex.org/G3699820904","display_name":null,"funder_award_id":"22177092","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320318567","display_name":"Westlake University","ror":null},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320338110","display_name":"Science and Technology Department of Zhejiang Province","ror":"https://ror.org/05yj3y977"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4409565523.pdf","grobid_xml":"https://content.openalex.org/works/W4409565523.grobid-xml"},"referenced_works_count":75,"referenced_works":["https://openalex.org/W1827848435","https://openalex.org/W1966227839","https://openalex.org/W1974329558","https://openalex.org/W1978119727","https://openalex.org/W1979287129","https://openalex.org/W1981263132","https://openalex.org/W1981740353","https://openalex.org/W1982793579","https://openalex.org/W1984537179","https://openalex.org/W1990226486","https://openalex.org/W1995570904","https://openalex.org/W2008387708","https://openalex.org/W2016426194","https://openalex.org/W2044284218","https://openalex.org/W2055472811","https://openalex.org/W2061190458","https://openalex.org/W2064466082","https://openalex.org/W2076915648","https://openalex.org/W2078331982","https://openalex.org/W2081057262","https://openalex.org/W2091007201","https://openalex.org/W2095928844","https://openalex.org/W2103820737","https://openalex.org/W2105329815","https://openalex.org/W2120619526","https://openalex.org/W2121603293","https://openalex.org/W2127730346","https://openalex.org/W2160378127","https://openalex.org/W2170889268","https://openalex.org/W2201191303","https://openalex.org/W2216946896","https://openalex.org/W2255657663","https://openalex.org/W2335148691","https://openalex.org/W2507772087","https://openalex.org/W2515002125","https://openalex.org/W2575918694","https://openalex.org/W2602567340","https://openalex.org/W2606755062","https://openalex.org/W2765094271","https://openalex.org/W2766707489","https://openalex.org/W2779189714","https://openalex.org/W2784440420","https://openalex.org/W2791371712","https://openalex.org/W2804822363","https://openalex.org/W2809596707","https://openalex.org/W2898249997","https://openalex.org/W2908831754","https://openalex.org/W2917137781","https://openalex.org/W2938072319","https://openalex.org/W2949225855","https://openalex.org/W3024254824","https://openalex.org/W3033007973","https://openalex.org/W3033699872","https://openalex.org/W3036284296","https://openalex.org/W3046961624","https://openalex.org/W3048475900","https://openalex.org/W3048941347","https://openalex.org/W3129994103","https://openalex.org/W3177828909","https://openalex.org/W3194561032","https://openalex.org/W3200029613","https://openalex.org/W3211302022","https://openalex.org/W4214508227","https://openalex.org/W4220812327","https://openalex.org/W4237027811","https://openalex.org/W4246025194","https://openalex.org/W4309305948","https://openalex.org/W4309511459","https://openalex.org/W4310592695","https://openalex.org/W4324044833","https://openalex.org/W4378673921","https://openalex.org/W4387464217","https://openalex.org/W4388087833","https://openalex.org/W4390579570","https://openalex.org/W7074578514"],"related_works":["https://openalex.org/W2423552194","https://openalex.org/W1963792247","https://openalex.org/W6944092926","https://openalex.org/W4407377985","https://openalex.org/W2400242658","https://openalex.org/W7155188287","https://openalex.org/W69560716","https://openalex.org/W2068275245","https://openalex.org/W2470349522","https://openalex.org/W2914792159"],"abstract_inverted_index":{"Abstract":[0],"Modular":[1],"polyketide":[2,33,75,99,123,133],"synthases":[3,134],"biosynthesize":[4],"structurally":[5],"diverse":[6],"natural":[7],"products":[8],"by":[9,118],"a":[10,54,61,103],"set":[11],"of":[12,31,53,66,83,97,109,122,131,141],"catalytic":[13,42,129],"domains":[14],"that":[15,79],"operate":[16],"in":[17],"an":[18],"assembly":[19,46,73],"line":[20,74],"fashion.":[21],"Although":[22],"extensive":[23],"research":[24],"has":[25,36],"focused":[26],"on":[27,44],"the":[28,45,51,67,72,80,84,120,128,137],"rational":[29],"reprogramming":[30],"modular":[32,132],"synthases,":[34],"little":[35],"been":[37],"attempted":[38],"to":[39],"introduce":[40],"uncanonical":[41],"reactions":[43],"line.":[47],"Here,":[48],"we":[49],"demonstrate":[50],"insertion":[52,82],"thioester":[55,89],"reductase":[56,90],"domain,":[57],"which":[58],"can":[59],"generate":[60],"terminal":[62],"alcohol":[63],"group":[64],"instead":[65],"canonical":[68],"carboxylic":[69],"acid,":[70],"onto":[71],"synthases.":[76,124],"We":[77],"show":[78],"didomain":[81],"acyl":[85],"carrier":[86],"protein":[87],"and":[88,106,114,135],"pair":[91],"is":[92],"generally":[93],"effective":[94],"for":[95],"engineering":[96],"various":[98],"synthase":[100],"pathways.":[101],"As":[102],"proof-of-concept,":[104],"stereoselective":[105],"stereodivergent":[107],"bioproduction":[108],"non-natural":[110],"diols,":[111],"namely":[112],"1,3-butanediols":[113],"2-methyl-1,3-butanediols":[115],"was":[116],"achieved":[117],"harnessing":[119],"modularity":[121],"Our":[125],"study":[126],"expands":[127],"versatility":[130],"paves":[136],"way":[138],"towards":[139],"biosynthesis":[140],"designer":[142],"alcohols.":[143]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":5}],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2025-04-18T00:00:00"}