{"id":"https://openalex.org/W4409506738","doi":"https://doi.org/10.1080/02699052.2025.2492751","title":"Post-cerebral ischemia energy crisis: the role of glucose metabolism in the energetic crisis","display_name":"Post-cerebral ischemia energy crisis: the role of glucose metabolism in the energetic crisis","publication_year":2025,"publication_date":"2025-04-16","ids":{"openalex":"https://openalex.org/W4409506738","doi":"https://doi.org/10.1080/02699052.2025.2492751","pmid":"https://pubmed.ncbi.nlm.nih.gov/40237246"},"language":"en","primary_location":{"id":"doi:10.1080/02699052.2025.2492751","doi":"https://doi.org/10.1080/02699052.2025.2492751","is_oa":false,"landing_page_url":"https://doi.org/10.1080/02699052.2025.2492751","pdf_url":null,"source":{"id":"https://openalex.org/S166957603","display_name":"Brain Injury","issn_l":"0269-9052","issn":["0269-9052","1362-301X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Injury","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104265657","display_name":"Jia-Ting Li","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jia-Ting Li","raw_affiliation_strings":["Hunan University of Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hunan University of Chinese Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102636293","display_name":"Dian Ou","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dian Ou","raw_affiliation_strings":["Hunan University of Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hunan University of Chinese Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016524417","display_name":"Yi\u2010Ming Shi","orcid":"https://orcid.org/0000-0001-6933-4971","observed_orcids":["https://orcid.org/0000-0001-6933-4971"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yi-Ming Shi","raw_affiliation_strings":["Hunan University of Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hunan University of Chinese Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Le Bao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Le Bao","raw_affiliation_strings":["Hunan University of Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hunan University of Chinese Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yan-Ling Li","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yan-Ling Li","raw_affiliation_strings":["Hunan University of Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hunan University of Chinese Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100572984","display_name":"Tingting Xiong","orcid":"https://orcid.org/0009-0002-6697-1566","observed_orcids":["https://orcid.org/0009-0002-6697-1566"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ting-Ting Xiong","raw_affiliation_strings":["Hunan University of Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hunan University of Chinese Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102784100","display_name":"Yang Bai","orcid":"https://orcid.org/0000-0002-3789-0540","observed_orcids":["https://orcid.org/0000-0002-3789-0540","https://orcid.org/0000-0003-1690-2132"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yang Bai","raw_affiliation_strings":["Hunan University of Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hunan University of Chinese Medicine","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112249176","display_name":"Ding Huang","orcid":"https://orcid.org/0009-0001-8688-2723","observed_orcids":["https://orcid.org/0009-0001-8688-2723"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Huang Ding","raw_affiliation_strings":["Hunan University of Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hunan University of Chinese Medicine","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5112249176"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5798,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.5652921,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":98},"biblio":{"volume":"39","issue":"11","first_page":"893","last_page":"903"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13796","display_name":"Neurological Disorders and Treatments","score":0.4408999979496002,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13796","display_name":"Neurological Disorders and Treatments","score":0.4408999979496002,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.21629999577999115,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.15440000593662262,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cerebral-ischemia","display_name":"cerebral ischemia","score":0.984000027179718},{"id":"https://openalex.org/keywords/ischemic-stroke","display_name":"ischemic stroke","score":0.8069999814033508},{"id":"https://openalex.org/keywords/glycolytic-reprogramming","display_name":"glycolytic reprogramming","score":0.8679999709129333},{"id":"https://openalex.org/keywords/glucose-metabolism","display_name":"glucose metabolism","score":0.9509999752044678},{"id":"https://openalex.org/keywords/oxidative-phosphorylation","display_name":"oxidative phosphorylation","score":0.7940000295639038},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.6819999814033508},{"id":"https://openalex.org/keywords/lactic-acidosis","display_name":"lactic acidosis","score":0.8730000257492065},{"id":"https://openalex.org/keywords/ischemia-reperfusion-injury","display_name":"ischemia-reperfusion injury","score":0.8859999775886536},{"id":"https://openalex.org/keywords/glucose-transport","display_name":"glucose transport","score":0.7820000052452087},{"id":"https://openalex.org/keywords/cell-types","display_name":"cell types","score":0.3100000023841858},{"id":"https://openalex.org/keywords/metabolic-switch","display_name":"metabolic switch","score":0.4880000054836273},{"id":"https://openalex.org/keywords/energy-crisis","display_name":"energy crisis","score":0.35100001096725464}],"concepts":[{"id":"https://openalex.org/C2986317502","wikidata":"https://www.wikidata.org/wiki/Q570714","display_name":"Energy metabolism","level":2,"score":0.6140373945236206},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.5837023854255676},{"id":"https://openalex.org/C17093226","wikidata":"https://www.wikidata.org/wiki/Q2734081","display_name":"Carbohydrate metabolism","level":2,"score":0.47706568241119385},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42863625288009644},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3169875741004944}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002545","descriptor_name":"Brain Ischemia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006019","descriptor_name":"Glycolysis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1080/02699052.2025.2492751","doi":"https://doi.org/10.1080/02699052.2025.2492751","is_oa":false,"landing_page_url":"https://doi.org/10.1080/02699052.2025.2492751","pdf_url":null,"source":{"id":"https://openalex.org/S166957603","display_name":"Brain Injury","issn_l":"0269-9052","issn":["0269-9052","1362-301X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Injury","raw_type":"journal-article"},{"id":"pmid:40237246","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40237246","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain injury","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1857969831","display_name":null,"funder_award_id":"2024JJ8134","funder_id":"https://openalex.org/F4320322866","funder_display_name":"Natural Science Foundation of Hainan Province"},{"id":"https://openalex.org/G8839460308","display_name":null,"funder_award_id":"82305031","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322866","display_name":"Natural Science Foundation of Hainan Province","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":81,"referenced_works":["https://openalex.org/W2896247268","https://openalex.org/W2902833455","https://openalex.org/W2921975506","https://openalex.org/W2954501529","https://openalex.org/W2970235324","https://openalex.org/W2990872516","https://openalex.org/W2995491805","https://openalex.org/W3008718092","https://openalex.org/W3013401843","https://openalex.org/W3024580289","https://openalex.org/W3039800133","https://openalex.org/W3041337213","https://openalex.org/W3044114834","https://openalex.org/W3087345577","https://openalex.org/W3114447894","https://openalex.org/W3138382274","https://openalex.org/W3148415985","https://openalex.org/W3154021297","https://openalex.org/W3164524418","https://openalex.org/W3165884213","https://openalex.org/W3171756541","https://openalex.org/W3183259062","https://openalex.org/W3186188872","https://openalex.org/W3193569746","https://openalex.org/W3196715727","https://openalex.org/W3200512192","https://openalex.org/W3205955396","https://openalex.org/W3206671773","https://openalex.org/W3213843875","https://openalex.org/W4200424802","https://openalex.org/W4205579039","https://openalex.org/W4206300018","https://openalex.org/W4206498075","https://openalex.org/W4223536888","https://openalex.org/W4224860122","https://openalex.org/W4229015821","https://openalex.org/W4281250943","https://openalex.org/W4281983771","https://openalex.org/W4283119554","https://openalex.org/W4283451863","https://openalex.org/W4283752617","https://openalex.org/W4284891982","https://openalex.org/W4289520075","https://openalex.org/W4290999138","https://openalex.org/W4294031309","https://openalex.org/W4295754065","https://openalex.org/W4304187679","https://openalex.org/W4306687841","https://openalex.org/W4306730271","https://openalex.org/W4308957185","https://openalex.org/W4313237205","https://openalex.org/W4317605926","https://openalex.org/W4320917912","https://openalex.org/W4321495830","https://openalex.org/W4321599515","https://openalex.org/W4323322184","https://openalex.org/W4353084906","https://openalex.org/W4365511952","https://openalex.org/W4366984816","https://openalex.org/W4375864398","https://openalex.org/W4379536589","https://openalex.org/W4380873945","https://openalex.org/W4381309409","https://openalex.org/W4389245411","https://openalex.org/W4389507418","https://openalex.org/W4389564290","https://openalex.org/W4390535037","https://openalex.org/W4390655934","https://openalex.org/W4393254907","https://openalex.org/W4394818446","https://openalex.org/W4396520573","https://openalex.org/W4399682766","https://openalex.org/W4400279497","https://openalex.org/W4400381064","https://openalex.org/W4400748253","https://openalex.org/W4402047337","https://openalex.org/W4403086333","https://openalex.org/W4403609500","https://openalex.org/W4404541294","https://openalex.org/W4406235504","https://openalex.org/W4406724696"],"related_works":["https://openalex.org/W4391573898","https://openalex.org/W4415813959","https://openalex.org/W4410841641","https://openalex.org/W4406809898","https://openalex.org/W4214481372","https://openalex.org/W4403417381","https://openalex.org/W1554025904","https://openalex.org/W4200424802","https://openalex.org/W7170167146","https://openalex.org/W4406062897"],"abstract_inverted_index":{"BACKGROUND:":[0],"Cells":[1],"universally":[2],"employ":[3],"an":[4],"efficiency-driven":[5],"metabolic":[6,99],"switch":[7],"mechanism":[8],"during":[9],"nutritional":[10],"changes,":[11],"growth,":[12],"and":[13,40,70,102,109,158],"differentiation,":[14],"transitioning":[15],"from":[16],"oxidative":[17],"phosphorylation":[18],"(OXPHOS)":[19],"to":[20,22,46,50,65,134,145],"glycolysis":[21,79,160],"ensure":[23],"survival":[24],"under":[25,150],"hypoxic":[26],"conditions":[27],"or":[28],"high":[29],"energy":[30,41,53],"demands.":[31],"In":[32],"cerebral":[33],"ischemia,":[34],"inadequate":[35],"blood":[36],"supply":[37],"causes":[38],"oxygen":[39],"deprivation,":[42],"prompting":[43],"brain":[44,82],"cells":[45,140],"initiate":[47],"glycolytic":[48,119],"reprogramming":[49,149,157],"meet":[51],"urgent":[52],"needs.":[54],"While":[55],"this":[56],"adaptation":[57],"is":[58],"a":[59,123],"temporary":[60],"solution,":[61],"it":[62],"may":[63,161],"lead":[64],"lactic":[66],"acidosis,":[67],"aggravated":[68],"inflammation,":[69],"increased":[71],"free":[72],"radical":[73],"production.":[74],"Prolonged":[75],"reperfusion":[76],"with":[77,114],"sustained":[78],"can":[80],"exacerbate":[81],"cell":[83],"damage,":[84],"potentially":[85],"causing":[86],"irreversible":[87],"harm.":[88],"OBJECTIVES:":[89],"This":[90],"review":[91],"systematically":[92],"examines":[93],"the":[94,103,129,163],"dynamic":[95],"changes":[96],"in":[97,118],"glucose":[98,147,155],"transport":[100],"mechanisms":[101],"roles":[104],"of":[105,166],"immediate,":[106],"early,":[107],"intermediate,":[108],"late":[110],"responder":[111],"cells,":[112],"along":[113],"their":[115],"regulatory":[116],"factors,":[117],"reprogramming.":[120],"METHODS:":[121],"Using":[122],"temporal":[124],"analysis":[125],"framework":[126],"based":[127],"on":[128],"body's":[130],"natural":[131],"response":[132],"sequence":[133],"pathological":[135,151,164],"events,":[136],"we":[137],"elucidate":[138],"how":[139],"at":[141],"different":[142],"stages":[143],"collaborate":[144],"address":[146],"metabolism":[148,156],"conditions.":[152],"CONCLUSIONS:":[153],"Reversing":[154],"inhibiting":[159],"improve":[162],"processes":[165],"ischemic":[167],"stroke,":[168],"offering":[169],"potential":[170],"therapeutic":[171],"benefits.":[172]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2025-04-17T00:00:00"}
