{"id":"https://openalex.org/W4409503199","doi":"https://doi.org/10.1093/eurheartjsupp/suaf030","title":"The advantages of physiological pacing","display_name":"The advantages of physiological pacing","publication_year":2025,"publication_date":"2025-03-01","ids":{"openalex":"https://openalex.org/W4409503199","doi":"https://doi.org/10.1093/eurheartjsupp/suaf030","pmid":"https://pubmed.ncbi.nlm.nih.gov/40248289","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12001782"},"language":"en","primary_location":{"id":"doi:10.1093/eurheartjsupp/suaf030","doi":"https://doi.org/10.1093/eurheartjsupp/suaf030","is_oa":true,"landing_page_url":"https://doi.org/10.1093/eurheartjsupp/suaf030","pdf_url":"https://academic.oup.com/eurheartjsupp/article-pdf/27/Supplement_3/iii126/62939348/suaf030.pdf","source":{"id":"https://openalex.org/S81127","display_name":"European Heart Journal Supplements","issn_l":"1520-765X","issn":["1520-765X","1554-2815"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Heart Journal Supplements","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/eurheartjsupp/article-pdf/27/Supplement_3/iii126/62939348/suaf030.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078761671","display_name":"Ilaria Finamora","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ilaria Finamora","raw_affiliation_strings":["Cardiology Unit, G.B. Grassi Hospital , Rome ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology Unit, G.B. Grassi Hospital , Rome ,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091972271","display_name":"Carlo Colaiaco","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carlo Colaiaco","raw_affiliation_strings":["Cardiology Unit, G.B. Grassi Hospital , Rome ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology Unit, G.B. Grassi Hospital , Rome ,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111826559","display_name":"Karim Mahfouz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Karim Mahfouz","raw_affiliation_strings":["Cardiology Unit, G.B. Grassi Hospital , Rome ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology Unit, G.B. Grassi Hospital , Rome ,","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Francesco Adamo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Francesco Adamo","raw_affiliation_strings":["Cardiology Unit, G.B. Grassi Hospital , Rome ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology Unit, G.B. Grassi Hospital , Rome ,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040334736","display_name":"Nicola Danisi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nicola Danisi","raw_affiliation_strings":["Cardiology Unit, G.B. Grassi Hospital , Rome ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology Unit, G.B. Grassi Hospital , Rome ,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069125897","display_name":"Carmine De Lucia","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carmine De Lucia","raw_affiliation_strings":["Cardiology Unit, G.B. Grassi Hospital , Rome ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology Unit, G.B. Grassi Hospital , Rome ,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109794113","display_name":"Alessio Nardini","orcid":"https://orcid.org/0009-0004-7207-142X","observed_orcids":["https://orcid.org/0009-0004-7207-142X"]},"institutions":[{"id":"https://openalex.org/I2801313885","display_name":"Ministero della Salute","ror":"https://ror.org/00789fa95","country_code":"IT","type":"government","lineage":["https://openalex.org/I2801313885","https://openalex.org/I4210104593"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessio Nardini","raw_affiliation_strings":["General Direction of the Mission Unit for the Implementation of PNRR Interventions, Italian Ministry of Health , Rome ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"General Direction of the Mission Unit for the Implementation of PNRR Interventions, Italian Ministry of Health , Rome ,","institution_ids":["https://openalex.org/I2801313885"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013772562","display_name":"Fabrizio Ammirati","orcid":"https://orcid.org/0009-0002-4824-2757","observed_orcids":["https://orcid.org/0009-0002-4824-2757"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fabrizio Ammirati","raw_affiliation_strings":["Cardiology Unit, G.B. Grassi Hospital , Rome ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology Unit, G.B. Grassi Hospital , Rome ,","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067368242","display_name":"Luca Santini","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Luca Santini","raw_affiliation_strings":["Cardiology Unit, G.B. Grassi Hospital , Rome ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology Unit, G.B. Grassi Hospital , Rome ,","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5078761671"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6189,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.66235022,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"27","issue":"Supplement_3","first_page":"iii126","last_page":"iii130"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10598","display_name":"Cardiac pacing and defibrillation studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10598","display_name":"Cardiac pacing and defibrillation studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10645","display_name":"Cardiac Arrest and Resuscitation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/physiological-pacing","display_name":"physiological pacing","score":0.9649999737739563},{"id":"https://openalex.org/keywords/his-bundle-pacing","display_name":"His bundle pacing","score":0.9100000262260437},{"id":"https://openalex.org/keywords/left-bundle-branch-area-pacing","display_name":"left bundle branch area pacing","score":0.9829999804496765},{"id":"https://openalex.org/keywords/conduction-system-pacing","display_name":"conduction system pacing","score":0.8109999895095825},{"id":"https://openalex.org/keywords/right-ventricular-pacing","display_name":"right ventricular pacing","score":0.847000002861023},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.46700000762939453},{"id":"https://openalex.org/keywords/cardiomyopathy","display_name":"cardiomyopathy","score":0.8320000171661377},{"id":"https://openalex.org/keywords/cardiac-resynchronization-therapy","display_name":"cardiac resynchronization therapy","score":0.7559999823570251},{"id":"https://openalex.org/keywords/pacing-site-selection","display_name":"pacing site selection","score":0.7049999833106995},{"id":"https://openalex.org/keywords/pacing-complications","display_name":"pacing complications","score":0.4090000092983246},{"id":"https://openalex.org/keywords/atrioventricular-block","display_name":"atrioventricular block","score":0.7319999933242798},{"id":"https://openalex.org/keywords/reduced-ejection-fraction","display_name":"reduced ejection fraction","score":0.7599999904632568},{"id":"https://openalex.org/keywords/dyssynchrony","display_name":"dyssynchrony","score":0.8190000057220459}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9024006128311157},{"id":"https://openalex.org/C2776034619","wikidata":"https://www.wikidata.org/wiki/Q3428020","display_name":"Cardiac resynchronization therapy","level":4,"score":0.8192431926727295},{"id":"https://openalex.org/C111773187","wikidata":"https://www.wikidata.org/wiki/Q1969239","display_name":"QRS complex","level":2,"score":0.6424261331558228},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5732097625732422},{"id":"https://openalex.org/C2992910135","wikidata":"https://www.wikidata.org/wiki/Q372713","display_name":"Cardiac pacing","level":2,"score":0.5059415698051453},{"id":"https://openalex.org/C78085059","wikidata":"https://www.wikidata.org/wiki/Q641303","display_name":"Ejection fraction","level":3,"score":0.46903595328330994},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.46857738494873047},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.46047985553741455}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1093/eurheartjsupp/suaf030","doi":"https://doi.org/10.1093/eurheartjsupp/suaf030","is_oa":true,"landing_page_url":"https://doi.org/10.1093/eurheartjsupp/suaf030","pdf_url":"https://academic.oup.com/eurheartjsupp/article-pdf/27/Supplement_3/iii126/62939348/suaf030.pdf","source":{"id":"https://openalex.org/S81127","display_name":"European Heart Journal Supplements","issn_l":"1520-765X","issn":["1520-765X","1554-2815"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Heart Journal Supplements","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12001782","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12001782","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Eur Heart J Suppl","raw_type":"Text"},{"id":"pmid:40248289","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40248289","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European heart journal supplements : journal of the European Society of Cardiology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1093/eurheartjsupp/suaf030","doi":"https://doi.org/10.1093/eurheartjsupp/suaf030","is_oa":true,"landing_page_url":"https://doi.org/10.1093/eurheartjsupp/suaf030","pdf_url":"https://academic.oup.com/eurheartjsupp/article-pdf/27/Supplement_3/iii126/62939348/suaf030.pdf","source":{"id":"https://openalex.org/S81127","display_name":"European Heart Journal Supplements","issn_l":"1520-765X","issn":["1520-765X","1554-2815"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Heart Journal Supplements","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4409503199.pdf","grobid_xml":"https://content.openalex.org/works/W4409503199.grobid-xml"},"referenced_works_count":15,"referenced_works":["https://openalex.org/W2794003858","https://openalex.org/W2886431158","https://openalex.org/W2913869328","https://openalex.org/W2943202108","https://openalex.org/W3114984049","https://openalex.org/W3207338189","https://openalex.org/W3212035261","https://openalex.org/W3215508457","https://openalex.org/W3217576295","https://openalex.org/W4206206804","https://openalex.org/W4292241965","https://openalex.org/W4308405176","https://openalex.org/W4365997939","https://openalex.org/W4377142171","https://openalex.org/W4388583152"],"related_works":["https://openalex.org/W4323830938","https://openalex.org/W4386478703","https://openalex.org/W4281779029","https://openalex.org/W4396690905","https://openalex.org/W7160983114","https://openalex.org/W4414629805","https://openalex.org/W4319335576","https://openalex.org/W3121381481","https://openalex.org/W3020436321","https://openalex.org/W4360872570"],"abstract_inverted_index":{"The":[0,95,122],"evidence":[1],"that":[2,115],"conventional":[3,39,186],"right":[4,232,248],"ventricular":[5,233,241,249],"pacing":[6,25,29,40,72,78,234,250],"can":[7],"result":[8],"in":[9,104,210,235],"the":[10,21,36,90,119,131,135,152,156,168,222],"development":[11],"of":[12,38,54,92,106,137,147,155,212,214,218,254],"cardiomyopathy":[13],"and":[14,41,51,73,83,101,129,174,224,245],"heart":[15],"failure":[16,213],"over":[17],"time":[18,136],"has":[19],"prompted":[20],"search":[22],"for":[23,46,56,63,167],"alternative":[24,45,208,230],"sites.":[26],"Conduction":[27],"system":[28],"(CSP)":[30],"represents":[31],"an":[32,44,163,207,229,246],"attempt":[33],"to":[34,42,88,110,118,144,151,202,231],"overcome":[35],"limitations":[37],"provide":[43],"patients":[47,236],"with":[48,80,162,185,237],"reduced":[49],"EF":[50],"various":[52],"degrees":[53],"dyssynchrony":[55],"whom":[57],"resynchronization":[58,215],"therapy":[59,216],"is":[60,116,139,142,195],"not":[61],"feasible":[62],"technical":[64,132],"or":[65,227],"anatomical":[66],"reasons.":[67],"In":[68],"particular,":[69],"His":[70,203],"bundle":[71,75],"left":[74,240],"branch":[76],"area":[77],"(LBBAP),":[79],"their":[81],"advantages":[82],"disadvantages,":[84],"have":[85],"been":[86],"shown":[87],"meet":[89],"criteria":[91],"physiological":[93],"pacing.":[94,187],"former,":[96],"although":[97,130,177],"technically":[98],"more":[99],"challenging":[100],"less":[102],"satisfactory":[103],"terms":[105],"electrical":[107],"parameters,":[108],"allows":[109],"obtain":[111],"a":[112,125,145,172,180],"QRS":[113,128],"complex":[114],"identical":[117],"spontaneous":[120],"one.":[121],"latter":[123],"produces":[124],"wider":[126],"paced":[127],"complexity":[133],"at":[134],"implantation":[138],"significantly":[140],"reduced,":[141],"subject":[143],"series":[146],"mechanical":[148],"complications":[149],"related":[150],"trans-septal":[153],"positioning":[154],"lead.":[157],"Careful":[158],"patient":[159],"selection":[160],"along":[161],"adequate":[164],"learning":[165],"curve":[166],"operators":[169],"make":[170],"CSP":[171],"safe":[173],"effective":[175],"procedure,":[176],"burdened":[178],"by":[179,198],"higher":[181],"complication":[182],"rate":[183],"compared":[184],"Future":[188],"studies":[189],"will":[190],"clarify":[191],"its":[192],"role,":[193],"which":[194],"currently":[196],"limited":[197],"current":[199],"ESC":[200],"guidelines":[201],"Pacing":[204],"only":[205],"as":[206,228],"procedure":[209,226],"case":[211],"(class":[217,253],"recommendation":[219,255],"IIa),":[220],"after":[221],"'ablate":[223],"pace'":[225],"AV":[238],"block,":[239],"ejection":[242],"fraction":[243],"<40%":[244],"expected":[247],"percentage":[251],">20%":[252],"IIb).":[256]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2025-04-17T00:00:00"}