{"id":"https://openalex.org/W4409502937","doi":"https://doi.org/10.1158/2326-6066.cir-24-1050","title":"Targeting Cancer-Associated Glycosylation for Adoptive T-cell Therapy of Solid Tumors","display_name":"Targeting Cancer-Associated Glycosylation for Adoptive T-cell Therapy of Solid Tumors","publication_year":2025,"publication_date":"2025-04-16","ids":{"openalex":"https://openalex.org/W4409502937","doi":"https://doi.org/10.1158/2326-6066.cir-24-1050","pmid":"https://pubmed.ncbi.nlm.nih.gov/40237717"},"language":"en","primary_location":{"id":"doi:10.1158/2326-6066.cir-24-1050","doi":"https://doi.org/10.1158/2326-6066.cir-24-1050","is_oa":false,"landing_page_url":"https://doi.org/10.1158/2326-6066.cir-24-1050","pdf_url":null,"source":{"id":"https://openalex.org/S2765010658","display_name":"Cancer Immunology Research","issn_l":"2326-6066","issn":["2326-6066","2326-6074"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Immunology Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.1101/2024.09.12.612750","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Andreas Zingg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]},{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Andreas Zingg","raw_affiliation_strings":["Department of Biomedicine, University Hospital and University of Basel, Switzerland","University of Basel, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedicine, University Hospital and University of Basel, Switzerland","institution_ids":["https://openalex.org/I1850255","https://openalex.org/I2802542264"]},{"raw_affiliation_string":"University of Basel, Basel, Switzerland","institution_ids":["https://openalex.org/I1850255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036753711","display_name":"Reto Ritschard","orcid":"https://orcid.org/0009-0001-3422-1587","observed_orcids":["https://orcid.org/0009-0001-3422-1587"]},"institutions":[{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]},{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Reto Ritschard","raw_affiliation_strings":["Department of Biomedicine, University Hospital and University of Basel, Switzerland","Division of Oncology, University Hospital Basel, Switzerland","University of Basel, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedicine, University Hospital and University of Basel, Switzerland","institution_ids":["https://openalex.org/I1850255","https://openalex.org/I2802542264"]},{"raw_affiliation_string":"Division of Oncology, University Hospital Basel, Switzerland","institution_ids":["https://openalex.org/I2802542264"]},{"raw_affiliation_string":"University of Basel, Basel, Switzerland","institution_ids":["https://openalex.org/I1850255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070820869","display_name":"Helen Thut","orcid":"https://orcid.org/0009-0003-7185-8311","observed_orcids":["https://orcid.org/0009-0003-7185-8311"]},"institutions":[{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]},{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Helen Thut","raw_affiliation_strings":["Department of Biomedicine, University Hospital and University of Basel, Switzerland","University of Basel, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedicine, University Hospital and University of Basel, Switzerland","institution_ids":["https://openalex.org/I1850255","https://openalex.org/I2802542264"]},{"raw_affiliation_string":"University of Basel, Basel, Switzerland","institution_ids":["https://openalex.org/I1850255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091717205","display_name":"M\u00e9lanie Buchi","orcid":"https://orcid.org/0000-0001-9958-9748","observed_orcids":["https://orcid.org/0000-0001-9958-9748"]},"institutions":[{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]},{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"M\u00e9lanie Buchi","raw_affiliation_strings":["Department of Biomedicine, University Hospital and University of Basel, Switzerland","Cancer Immunology, Department of Biomedicine, University of Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedicine, University Hospital and University of Basel, Switzerland","institution_ids":["https://openalex.org/I1850255","https://openalex.org/I2802542264"]},{"raw_affiliation_string":"Cancer Immunology, Department of Biomedicine, University of Basel, Switzerland","institution_ids":["https://openalex.org/I1850255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061049451","display_name":"Andreas Holbro","orcid":"https://orcid.org/0000-0002-2394-2223","observed_orcids":["https://orcid.org/0000-0002-2394-2223"]},"institutions":[{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]},{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Andreas Holbro","raw_affiliation_strings":["Blood donation center of Basel, Switzerland","Division of Hematology, University Hospital Basel, Switzerland","University of Basel, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blood donation center of Basel, Switzerland","institution_ids":[]},{"raw_affiliation_string":"Division of Hematology, University Hospital Basel, Switzerland","institution_ids":["https://openalex.org/I2802542264"]},{"raw_affiliation_string":"University of Basel, Basel, Switzerland","institution_ids":["https://openalex.org/I1850255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001886951","display_name":"Anton Oseledchyk","orcid":"https://orcid.org/0009-0008-8953-5103","observed_orcids":["https://orcid.org/0009-0008-8953-5103"]},"institutions":[{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]},{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Anton Oseledchyk","raw_affiliation_strings":["Department of Biomedicine, University Hospital and University of Basel, Switzerland","Division of Oncology, University Hospital Basel, Switzerland","University of Basel, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedicine, University Hospital and University of Basel, Switzerland","institution_ids":["https://openalex.org/I1850255","https://openalex.org/I2802542264"]},{"raw_affiliation_string":"Division of Oncology, University Hospital Basel, Switzerland","institution_ids":["https://openalex.org/I2802542264"]},{"raw_affiliation_string":"University of Basel, Basel, Switzerland","institution_ids":["https://openalex.org/I1850255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057030543","display_name":"Viola A Heinzelmann-Schwarz","orcid":"https://orcid.org/0000-0002-5613-8629","observed_orcids":["https://orcid.org/0000-0002-5613-8629"]},"institutions":[{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]},{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Viola Heinzelmann","raw_affiliation_strings":["Department of Biomedicine, University Hospital and University of Basel, Switzerland","Gynecological Oncology, University Hospital Basel, Switzerland","University Hospital of Basel, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedicine, University Hospital and University of Basel, Switzerland","institution_ids":["https://openalex.org/I1850255","https://openalex.org/I2802542264"]},{"raw_affiliation_string":"Gynecological Oncology, University Hospital Basel, Switzerland","institution_ids":["https://openalex.org/I2802542264"]},{"raw_affiliation_string":"University Hospital of Basel, Basel, Switzerland","institution_ids":["https://openalex.org/I2802542264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056698636","display_name":"Andreas S. Buser","orcid":"https://orcid.org/0000-0002-7942-6746","observed_orcids":["https://orcid.org/0000-0002-7942-6746"]},"institutions":[{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]},{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Andreas Buser","raw_affiliation_strings":["Blood donation center of Basel, Switzerland","Division of Hematology, University Hospital Basel, Switzerland","University of Basel, Basel, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-7942-6746","affiliations":[{"raw_affiliation_string":"Blood donation center of Basel, Switzerland","institution_ids":[]},{"raw_affiliation_string":"Division of Hematology, University Hospital Basel, Switzerland","institution_ids":["https://openalex.org/I2802542264"]},{"raw_affiliation_string":"University of Basel, Basel, Switzerland","institution_ids":["https://openalex.org/I1850255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077205301","display_name":"Mascha Binder","orcid":"https://orcid.org/0000-0003-0663-3004","observed_orcids":["https://orcid.org/0000-0003-0663-3004"]},"institutions":[{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]},{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Mascha Binder","raw_affiliation_strings":["Department of Biomedicine, University Hospital and University of Basel, Switzerland","Division of Oncology, University Hospital Basel, Switzerland","Division of Medical Oncology, University Hospital Basel, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedicine, University Hospital and University of Basel, Switzerland","institution_ids":["https://openalex.org/I1850255","https://openalex.org/I2802542264"]},{"raw_affiliation_string":"Division of Oncology, University Hospital Basel, Switzerland","institution_ids":["https://openalex.org/I2802542264"]},{"raw_affiliation_string":"Division of Medical Oncology, University Hospital Basel, Basel, Switzerland","institution_ids":["https://openalex.org/I2802542264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068350308","display_name":"Alfred Zippelius","orcid":"https://orcid.org/0000-0003-1933-8178","observed_orcids":["https://orcid.org/0000-0003-1933-8178"]},"institutions":[{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]},{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Alfred Zippelius","raw_affiliation_strings":["Department of Biomedicine, University Hospital and University of Basel, Switzerland","Division of Oncology, University Hospital Basel, Switzerland","University Hospital of Basel, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedicine, University Hospital and University of Basel, Switzerland","institution_ids":["https://openalex.org/I1850255","https://openalex.org/I2802542264"]},{"raw_affiliation_string":"Division of Oncology, University Hospital Basel, Switzerland","institution_ids":["https://openalex.org/I2802542264"]},{"raw_affiliation_string":"University Hospital of Basel, Basel, Switzerland","institution_ids":["https://openalex.org/I2802542264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052563437","display_name":"Nat\u00e1lia Rodrigues Mantuano","orcid":"https://orcid.org/0000-0002-1302-7013","observed_orcids":["https://orcid.org/0000-0002-1302-7013"]},"institutions":[{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]},{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Natalia Rodrigues Mantuano","raw_affiliation_strings":["Department of Biomedicine, University Hospital and University of Basel, Switzerland","University of Basel, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedicine, University Hospital and University of Basel, Switzerland","institution_ids":["https://openalex.org/I1850255","https://openalex.org/I2802542264"]},{"raw_affiliation_string":"University of Basel, Basel, Switzerland","institution_ids":["https://openalex.org/I1850255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037822732","display_name":"Matthias Sebastian Matter","orcid":"https://orcid.org/0000-0002-2005-5266","observed_orcids":["https://orcid.org/0000-0002-2005-5266"]},"institutions":[{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Matthias Matter","raw_affiliation_strings":["Department of Pathology, University Hospital Basel, Switzerland","University Hospital of Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University Hospital Basel, Switzerland","institution_ids":["https://openalex.org/I2802542264"]},{"raw_affiliation_string":"University Hospital of Basel, Switzerland","institution_ids":["https://openalex.org/I2802542264"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034706637","display_name":"Heinz Philipp Laubli","orcid":"https://orcid.org/0000-0002-8910-5620","observed_orcids":["https://orcid.org/0000-0002-8910-5620"]},"institutions":[{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]},{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Heinz L\u00e4ubli","raw_affiliation_strings":["Department of Biomedicine, University Hospital and University of Basel, Switzerland","Division of Oncology, University Hospital Basel, Switzerland","University of Basel, Basel, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-8910-5620","affiliations":[{"raw_affiliation_string":"Department of Biomedicine, University Hospital and University of Basel, Switzerland","institution_ids":["https://openalex.org/I1850255","https://openalex.org/I2802542264"]},{"raw_affiliation_string":"Division of Oncology, University Hospital Basel, Switzerland","institution_ids":["https://openalex.org/I2802542264"]},{"raw_affiliation_string":"University of Basel, Basel, Switzerland","institution_ids":["https://openalex.org/I1850255"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5034706637"],"corresponding_institution_ids":["https://openalex.org/I1850255","https://openalex.org/I2802542264"],"apc_list":null,"apc_paid":null,"fwci":4.3108,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.95178235,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"13","issue":"7","first_page":"990","last_page":"1003"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9688000082969666,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9688000082969666,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.017100000753998756,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.006300000008195639,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/car-t-cell-therapy","display_name":"CAR T-cell therapy","score":0.8019999861717224},{"id":"https://openalex.org/keywords/subthalamic-nucleus","display_name":"subthalamic nucleus","score":0.7279999852180481},{"id":"https://openalex.org/keywords/o-glycosylation","display_name":"O-glycosylation","score":0.671999990940094},{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.7839999794960022},{"id":"https://openalex.org/keywords/endometrial-cancer","display_name":"endometrial cancer","score":0.9959999918937683},{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":0.9649999737739563},{"id":"https://openalex.org/keywords/gastrointestinal-cancer","display_name":"gastrointestinal cancer","score":0.8790000081062317},{"id":"https://openalex.org/keywords/tumor-specific-antigens","display_name":"tumor-specific antigens","score":0.5220000147819519},{"id":"https://openalex.org/keywords/adoptive-t-cell-therapy","display_name":"adoptive T cell therapy","score":0.8489999771118164}],"concepts":[{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.6411378383636475},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.617043137550354},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5633500218391418},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5588579177856445},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.5369768738746643},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5026302337646484},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.4895702302455902},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48811063170433044},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4349225163459778},{"id":"https://openalex.org/C2777421810","wikidata":"https://www.wikidata.org/wiki/Q21145188","display_name":"MUC1","level":3,"score":0.4228900372982025},{"id":"https://openalex.org/C90375314","wikidata":"https://www.wikidata.org/wiki/Q3537484","display_name":"Adoptive cell transfer","level":4,"score":0.41802555322647095},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.41763538122177124},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32643812894821167},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2317255735397339},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16606128215789795},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000076962","descriptor_name":"Receptors, Chimeric Antigen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000076962","descriptor_name":"Receptors, Chimeric Antigen","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000076962","descriptor_name":"Receptors, Chimeric Antigen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000951","descriptor_name":"Antigens, Neoplasm","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006031","descriptor_name":"Glycosylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015295","descriptor_name":"Antigens, Tumor-Associated, Carbohydrate","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015295","descriptor_name":"Antigens, Tumor-Associated, Carbohydrate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016219","descriptor_name":"Immunotherapy, Adoptive","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1158/2326-6066.cir-24-1050","doi":"https://doi.org/10.1158/2326-6066.cir-24-1050","is_oa":false,"landing_page_url":"https://doi.org/10.1158/2326-6066.cir-24-1050","pdf_url":null,"source":{"id":"https://openalex.org/S2765010658","display_name":"Cancer Immunology Research","issn_l":"2326-6066","issn":["2326-6066","2326-6074"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Immunology Research","raw_type":"journal-article"},{"id":"doi:10.1101/2024.09.12.612750","doi":"https://doi.org/10.1101/2024.09.12.612750","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2024.09.12.612750","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:40237717","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40237717","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer immunology research","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1101/2024.09.12.612750","doi":"https://doi.org/10.1101/2024.09.12.612750","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2024.09.12.612750","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2830103222","display_name":null,"funder_award_id":"310030_184720/1","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"}],"funders":[{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","ror":"https://ror.org/00yjd3n13"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":74,"referenced_works":["https://openalex.org/W1583246305","https://openalex.org/W1626592142","https://openalex.org/W1967517831","https://openalex.org/W1984179274","https://openalex.org/W1990028811","https://openalex.org/W2003539449","https://openalex.org/W2009834607","https://openalex.org/W2012106289","https://openalex.org/W2053620210","https://openalex.org/W2084168547","https://openalex.org/W2090203931","https://openalex.org/W2118796952","https://openalex.org/W2144491853","https://openalex.org/W2148640160","https://openalex.org/W2156307820","https://openalex.org/W2159301196","https://openalex.org/W2165049964","https://openalex.org/W2301169192","https://openalex.org/W2401536218","https://openalex.org/W2463381696","https://openalex.org/W2465973558","https://openalex.org/W2589361793","https://openalex.org/W2592837580","https://openalex.org/W2761657464","https://openalex.org/W2786284951","https://openalex.org/W2802394123","https://openalex.org/W2864786814","https://openalex.org/W2883692867","https://openalex.org/W2888019042","https://openalex.org/W2888189535","https://openalex.org/W2892125791","https://openalex.org/W2906555241","https://openalex.org/W2922798588","https://openalex.org/W2936522106","https://openalex.org/W2944329810","https://openalex.org/W2945932464","https://openalex.org/W2954358631","https://openalex.org/W3012325124","https://openalex.org/W3040292335","https://openalex.org/W3089885799","https://openalex.org/W3092763811","https://openalex.org/W3154860673","https://openalex.org/W3178325975","https://openalex.org/W3204262467","https://openalex.org/W3211997326","https://openalex.org/W4214554658","https://openalex.org/W4220882995","https://openalex.org/W4280639036","https://openalex.org/W4282047255","https://openalex.org/W4292634531","https://openalex.org/W4297387081","https://openalex.org/W4298109511","https://openalex.org/W4308623143","https://openalex.org/W4312116120","https://openalex.org/W4313484994","https://openalex.org/W4321480081","https://openalex.org/W4322008873","https://openalex.org/W4323349483","https://openalex.org/W4360600671","https://openalex.org/W4362636088","https://openalex.org/W4366085943","https://openalex.org/W4367669357","https://openalex.org/W4385386722","https://openalex.org/W4388035659","https://openalex.org/W4389232854","https://openalex.org/W4393397090","https://openalex.org/W4393988864","https://openalex.org/W4399578578","https://openalex.org/W4399783526","https://openalex.org/W4400109242","https://openalex.org/W4402528896","https://openalex.org/W6636644976","https://openalex.org/W6677552913","https://openalex.org/W6719041612"],"related_works":["https://openalex.org/W4402563937","https://openalex.org/W4414055829","https://openalex.org/W4285019712","https://openalex.org/W3091129059","https://openalex.org/W2473876675","https://openalex.org/W4281672409","https://openalex.org/W4311928557","https://openalex.org/W4289861156","https://openalex.org/W2465973558","https://openalex.org/W2907104280"],"abstract_inverted_index":{"Chimeric":[0],"antigen":[1],"receptor":[2],"(CAR)":[3],"T-cell":[4,17],"therapy":[5],"has":[6,24],"improved":[7],"outcomes":[8],"for":[9],"patients":[10,20],"with":[11,21,72,132],"chemotherapy-resistant":[12],"B-cell":[13],"malignancies.":[14],"However,":[15],"CAR":[16,51,110,119,163],"treatment":[18],"of":[19,31,35,47,61,90,149],"solid":[22],"cancers":[23],"been":[25],"more":[26],"difficult,":[27],"in":[28,55,86,97,100,113,116,124,130,142,153,168,176],"part":[29],"because":[30],"the":[32,45,62],"heterogeneous":[33],"expression":[34,60,83,148],"tumor-specific":[36],"cell":[37],"surface":[38],"antigens.":[39],"In":[40],"this":[41,159],"study,":[42],"we":[43],"describe":[44],"generation":[46],"a":[48,73,87],"fully":[49,160],"human":[50,161],"targeting":[52],"altered":[53],"glycosylation":[54],"secretory":[56],"epithelial":[57],"cancers.":[58],"The":[59],"target":[63],"antigen-the":[64],"truncated,":[65],"sialylated":[66],"O-glycan":[67],"Sialyl-Thomsen-nouveau":[68],"(STn)":[69],"antigen-was":[70],"studied":[71],"highly":[74],"STn-specific":[75],"antibody":[76],"across":[77],"various":[78],"different":[79],"tumor":[80,170],"tissues.":[81],"Strong":[82],"was":[84,140,151],"found":[85,152],"high":[88],"proportion":[89],"gastrointestinal":[91,154],"cancers,":[92,95,99],"including":[93],"pancreatic":[94],"and":[96,103,115],"gynecologic":[98],"particular":[101],"ovarian":[102,134],"endometrial":[104],"tumors.":[105],"T":[106,120],"cells":[107,121],"expressing":[108],"anti-STn":[109,162],"were":[111],"tested":[112],"vitro":[114],"vivo.":[117],"Anti-STn":[118],"showed":[122],"activity":[123,167],"mouse":[125,143,155],"models,":[126,171],"as":[127,129],"well":[128],"assays":[131],"primary":[133],"cancer":[135],"samples.":[136],"No":[137],"considerable":[138],"toxicity":[139],"observed":[141],"models":[144],"although":[145],"some":[146],"intraluminal":[147],"STn":[150],"tissue.":[156],"Taken":[157],"together,":[158],"construct":[164],"shows":[165],"promising":[166],"preclinical":[169],"supporting":[172],"its":[173],"further":[174],"evaluation":[175],"early":[177],"clinical":[178],"trials.":[179]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":5}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2025-04-17T00:00:00"}
