{"id":"https://openalex.org/W4409480604","doi":"https://doi.org/10.1016/j.htct.2025.103787","title":"EVALUATION OF THE AFFINITY OF RADIOLABELED PEPTIDE [\u00b9\u00b3\u00b9I]I-DEDEYFELV FOR EGFR-OVEREXPRESSING RECEPTORS IN ADULT-TYPE DIFFUSE GLIOMAS","display_name":"EVALUATION OF THE AFFINITY OF RADIOLABELED PEPTIDE [\u00b9\u00b3\u00b9I]I-DEDEYFELV FOR EGFR-OVEREXPRESSING RECEPTORS IN ADULT-TYPE DIFFUSE GLIOMAS","publication_year":2025,"publication_date":"2025-04-15","ids":{"openalex":"https://openalex.org/W4409480604","doi":"https://doi.org/10.1016/j.htct.2025.103787"},"language":"en","primary_location":{"id":"doi:10.1016/j.htct.2025.103787","doi":"https://doi.org/10.1016/j.htct.2025.103787","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.htct.2025.103787","pdf_url":null,"source":{"id":"https://openalex.org/S2898598332","display_name":"Hematology Transfusion and Cell Therapy","issn_l":"2531-1379","issn":["2531-1379","2531-1387"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","scielo"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hematology, Transfusion and Cell Therapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.1016/j.htct.2025.103787","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103085303","display_name":"J\u00falia Calviello Giordano","orcid":"https://orcid.org/0009-0003-5433-0590","observed_orcids":["https://orcid.org/0009-0003-5433-0590"]},"institutions":[{"id":"https://openalex.org/I4210112182","display_name":"Faculdade de Ci\u00eancias M\u00e9dicas da Santa Casa de S\u00e3o Paulo","ror":"https://ror.org/01z6qpb13","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210112182"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Julia Calviello Giordano","raw_affiliation_strings":["Faculdade de Ci\u00eancias M\u00e9dicas da Santa Casa de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculdade de Ci\u00eancias M\u00e9dicas da Santa Casa de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brazil","institution_ids":["https://openalex.org/I4210112182"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102662232","display_name":"Fernanda Paiva Augusto Rodrigues","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210112182","display_name":"Faculdade de Ci\u00eancias M\u00e9dicas da Santa Casa de S\u00e3o Paulo","ror":"https://ror.org/01z6qpb13","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210112182"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Fernanda Paiva Augusto Rodrigues","raw_affiliation_strings":["Faculdade de Ci\u00eancias M\u00e9dicas da Santa Casa de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculdade de Ci\u00eancias M\u00e9dicas da Santa Casa de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brazil","institution_ids":["https://openalex.org/I4210112182"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091555357","display_name":"Danielle Vieira Sobral","orcid":"https://orcid.org/0000-0002-5710-3612","observed_orcids":["https://orcid.org/0000-0002-5710-3612"]},"institutions":[{"id":"https://openalex.org/I4210112182","display_name":"Faculdade de Ci\u00eancias M\u00e9dicas da Santa Casa de S\u00e3o Paulo","ror":"https://ror.org/01z6qpb13","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210112182"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Danielle Vieira Sobral","raw_affiliation_strings":["Faculdade de Ci\u00eancias M\u00e9dicas da Santa Casa de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculdade de Ci\u00eancias M\u00e9dicas da Santa Casa de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brazil","institution_ids":["https://openalex.org/I4210112182"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007410784","display_name":"Leonardo Lima Fuscaldi","orcid":"https://orcid.org/0000-0001-7864-1324","observed_orcids":["https://orcid.org/0000-0001-7864-1324"]},"institutions":[{"id":"https://openalex.org/I4210112182","display_name":"Faculdade de Ci\u00eancias M\u00e9dicas da Santa Casa de S\u00e3o Paulo","ror":"https://ror.org/01z6qpb13","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210112182"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Leonardo Lima Fuscaldi","raw_affiliation_strings":["Faculdade de Ci\u00eancias M\u00e9dicas da Santa Casa de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculdade de Ci\u00eancias M\u00e9dicas da Santa Casa de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brazil","institution_ids":["https://openalex.org/I4210112182"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069339963","display_name":"F\u00e1bio Luiz Navarro Marques","orcid":"https://orcid.org/0000-0001-7383-926X","observed_orcids":["https://orcid.org/0000-0001-7383-926X"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Fabio Luiz Navarro Marques","raw_affiliation_strings":["Universidade de S\u00e3o Paulo (USP), S\u00e3o Paulo, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade de S\u00e3o Paulo (USP), S\u00e3o Paulo, SP, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102705026","display_name":"Marycel Figols de Barboza","orcid":"https://orcid.org/0000-0003-3389-1703","observed_orcids":["https://orcid.org/0000-0003-3389-1703"]},"institutions":[{"id":"https://openalex.org/I2800288331","display_name":"Hospital Israelita Albert Einstein","ror":"https://ror.org/04cwrbc27","country_code":"BR","type":"funder","lineage":["https://openalex.org/I2800288331"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Marycel Figols de Barboza","raw_affiliation_strings":["Hospital Albert Einstein, S\u00e3o Paulo, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Albert Einstein, S\u00e3o Paulo, SP, Brazil","institution_ids":["https://openalex.org/I2800288331"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101573999","display_name":"Jo\u00e3o Luiz Vitorino Ara\u00fajo","orcid":"https://orcid.org/0000-0002-6539-6718","observed_orcids":["https://orcid.org/0000-0002-6539-6718"]},"institutions":[{"id":"https://openalex.org/I4210112182","display_name":"Faculdade de Ci\u00eancias M\u00e9dicas da Santa Casa de S\u00e3o Paulo","ror":"https://ror.org/01z6qpb13","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210112182"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Jo\u00e3o Luiz vitorino Ara\u00fajo","raw_affiliation_strings":["Faculdade de Ci\u00eancias M\u00e9dicas da Santa Casa de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculdade de Ci\u00eancias M\u00e9dicas da Santa Casa de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brazil","institution_ids":["https://openalex.org/I4210112182"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059111677","display_name":"Luciana Malavolta","orcid":"https://orcid.org/0000-0002-5199-5760","observed_orcids":["https://orcid.org/0000-0002-5199-5760"]},"institutions":[{"id":"https://openalex.org/I4210112182","display_name":"Faculdade de Ci\u00eancias M\u00e9dicas da Santa Casa de S\u00e3o Paulo","ror":"https://ror.org/01z6qpb13","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210112182"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Luciana Malavolta","raw_affiliation_strings":["Faculdade de Ci\u00eancias M\u00e9dicas da Santa Casa de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculdade de Ci\u00eancias M\u00e9dicas da Santa Casa de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brazil","institution_ids":["https://openalex.org/I4210112182"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":0,"currency":"USD","value_usd":0},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0871393,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"47","issue":null,"first_page":"103787","last_page":"103787"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/iodine-131-labeling","display_name":"iodine-131 labeling","score":0.8899999856948853},{"id":"https://openalex.org/keywords/egfr-overexpression","display_name":"EGFR overexpression","score":0.7099999785423279},{"id":"https://openalex.org/keywords/adult-type-diffuse-glioma","display_name":"adult-type diffuse glioma","score":0.9229999780654907},{"id":"https://openalex.org/keywords/peptide-radiopharmaceuticals","display_name":"peptide radiopharmaceuticals","score":0.5049999952316284},{"id":"https://openalex.org/keywords/receptor-binding-affinity","display_name":"receptor binding affinity","score":0.7269999980926514},{"id":"https://openalex.org/keywords/radiochemical-yield","display_name":"radiochemical yield","score":0.5590000152587891},{"id":"https://openalex.org/keywords/solid-phase-peptide-synthesis","display_name":"solid-phase peptide synthesis","score":0.7649999856948853},{"id":"https://openalex.org/keywords/glioma-diagnosis","display_name":"glioma diagnosis","score":0.5350000262260437},{"id":"https://openalex.org/keywords/brain-tumors","display_name":"brain tumors","score":0.4269999861717224}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8406442403793335},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6703126430511475},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.5599826574325562},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.45896008610725403},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.4356740713119507},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34232714772224426},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3401554822921753},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3248031735420227},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09152352809906006},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.06770160794258118}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.htct.2025.103787","doi":"https://doi.org/10.1016/j.htct.2025.103787","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.htct.2025.103787","pdf_url":null,"source":{"id":"https://openalex.org/S2898598332","display_name":"Hematology Transfusion and Cell Therapy","issn_l":"2531-1379","issn":["2531-1379","2531-1387"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","scielo"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hematology, Transfusion and Cell Therapy","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:3e0f234a888f4129bc73067ea2008eed","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/3e0f234a888f4129bc73067ea2008eed","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Hematology, Transfusion and Cell Therapy, Vol 47, Iss , Pp 103787- (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.htct.2025.103787","doi":"https://doi.org/10.1016/j.htct.2025.103787","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.htct.2025.103787","pdf_url":null,"source":{"id":"https://openalex.org/S2898598332","display_name":"Hematology Transfusion and Cell Therapy","issn_l":"2531-1379","issn":["2531-1379","2531-1387"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","scielo"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hematology, Transfusion and Cell Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/2","score":0.6100000143051147,"display_name":"Zero hunger"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3208778134","https://openalex.org/W3005931108","https://openalex.org/W4386951147","https://openalex.org/W2887359201","https://openalex.org/W4308767530","https://openalex.org/W2362999506","https://openalex.org/W4205170363","https://openalex.org/W4223451915","https://openalex.org/W4220833452","https://openalex.org/W2353418361"],"abstract_inverted_index":{"Cancer":[0],"remains":[1],"one":[2],"of":[3,7,28,44,83,116,146,166,179,250,290,298,317,323,354,401],"the":[4,11,15,26,36,42,45,52,81,84,111,117,119,140,276,331,364,399],"leading":[5],"causes":[6],"death":[8],"worldwide.":[9],"Among":[10],"various":[12],"tumor":[13,99,211,373],"sites,":[14],"central":[16],"nervous":[17],"system":[18],"is":[19],"particularly":[20,392],"significant,":[21],"with":[22,57,68,88,135,168,247,282,292,375],"gliomas":[23,97],"accounting":[24],"for":[25,60,91,302,308,315,339,345,352,407],"majority":[27],"primary":[29],"brain":[30],"tumors.":[31],"In":[32],"gliomas,":[33],"alterations":[34],"in":[35,71,94,393,417],"tyrosine":[37],"kinase":[38],"pathway":[39],"lead":[40],"to":[41,79,221,275,335,371],"overexpression":[43],"Epidermal":[46],"Growth":[47],"Factor":[48],"receptor":[49],"(EGFr).":[50],"Over":[51],"past":[53],"decades,":[54],"radiolabeled":[55,87,134,365],"peptides":[56],"high":[58],"affinity":[59,82,378],"EGFr":[61],"have":[62],"emerged":[63],"as":[64,264,403],"promising":[65],"molecular":[66,272],"targets":[67],"potential":[69,400],"applications":[70],"both":[72],"diagnosis":[73],"and":[74,123,176,181,210,255,262,270,311,348,410,420],"therapy.":[75],"This":[76],"study":[77],"aimed":[78],"evaluate":[80],"peptide":[85,103,108,120,242,366],"DEDEYFELV,":[86],"iodine-131":[89],"(\u00b9\u00b3\u00b9I),":[90],"EGFr-overexpressing":[92,372],"receptors":[93],"adult-type":[95],"diffuse":[96],"using":[98,106,139,156,183,236],"tissue":[100,170,189,294],"samples.":[101],"The":[102,143,241,381],"was":[104,121,133,148,234,244,280],"synthesized":[105,246],"solid-phase":[107],"synthesis":[109],"following":[110,201],"Fmoc/tBu":[112],"strategy.":[113],"Upon":[114],"completion":[115],"synthesis,":[118,260],"characterized":[122],"purified":[124],"via":[125,150],"high-performance":[126],"liquid":[127],"chromatography":[128,151],"(HPLC).":[129],"DEDEYFELV":[130,243],"(20":[131],"nmol)":[132],"[\u00b9\u00b3\u00b9I]NaI":[136],"(18.5":[137],"MBq)":[138],"chloramine-T":[141],"method.":[142],"radiochemical":[144,284],"yield":[145,249,285],"[\u00b9\u00b3\u00b9I]I-DEDEYFELV":[147,167,291,367,402],"determined":[149],"on":[152],"Whatman":[153],"3MM":[154],"strips":[155],"a":[157,198,248,267,271,283,404],"95%":[158],"MeOH":[159],"/":[160],"5%":[161],"H\u2082O":[162],"eluent.":[163],"Binding":[164,288],"studies":[165,289],"neoplastic":[169,293],"homogenates":[171,190,295],"were":[172,191,205,213],"conducted":[173,235],"at":[174,215,320,385],"1":[175,321],"4":[177,329,386],"h":[178,322,387],"incubation":[180,324],"quantified":[182],"an":[184,376],"automatic":[185],"gamma":[186],"counter.":[187],"Tumor":[188],"obtained":[192],"from":[193],"surgical":[194],"resections":[195],"performed":[196],"by":[197,266],"designated":[199],"neurosurgeon,":[200],"informed":[202],"consent.":[203],"Gliomas":[204],"confirmed":[206,258],"through":[207],"pathological":[208],"analysis,":[209],"samples":[212],"preserved":[214],"-80\u00b0C.":[216],"All":[217],"human":[218],"protocols":[219],"adhered":[220],"local":[222],"ethical":[223],"guidelines":[224],"(Protocol":[225],"number":[226],"CEP":[227],"\u2013":[228],"FCMSCSP:":[229],"CAAE":[230],"79336124.7.0000.5479).":[231],"Statistical":[232],"analysis":[233],"ANOVA":[237],"or":[238],"Student's":[239],"t-test.":[240],"successfully":[245],"approximately":[251],"92%.":[252],"Mass":[253],"spectrometry":[254],"HPLC":[256],"analyses":[257],"efficient":[259],"cleavage,":[261],"purification,":[263],"evidenced":[265],"single":[268],"peak":[269],"mass":[273],"corresponding":[274],"expected":[277],"peptide.":[278],"Radiolabeling":[279],"achieved":[281],"exceeding":[286],"95%.":[287],"showed":[296],"values":[297,333],"3.25":[299],"\u00b1":[300,306,313,337,343,350],"0.31%":[301],"high-grade":[303,340],"tumors,":[304,310,341,347],"2.62":[305],"0.34%":[307],"low-grade":[309,346,394],"1.61":[312],"0.25%":[314],"tumors":[316,353],"unknown":[318,355],"grade":[319,356],"(n":[325,357],"=":[326,358],"5).":[327,359],"At":[328],"h,":[330],"binding":[332,370,383],"increased":[334],"6.45":[336],"0.66%":[338],"10.27":[342],"1.58%":[344],"7.74":[349],"1.21%":[351],"These":[360,396],"findings":[361],"demonstrate":[362],"that":[363],"exhibits":[368],"specific":[369],"tissues,":[374],"increasing":[377],"over":[379],"time.":[380],"higher":[382],"observed":[384],"suggests":[388],"favorable":[389],"interaction":[390],"dynamics,":[391],"gliomas.":[395],"results":[397],"highlight":[398],"theranostic":[405],"agent":[406],"EGFr-targeted":[408],"imaging":[409],"therapy,":[411],"warranting":[412],"further":[413],"investigations":[414],"into":[415],"its":[416],"vivo":[418],"stability":[419],"clinical":[421],"applicability.":[422]},"counts_by_year":[],"updated_date":"2026-09-09T07:26:56.047234","created_date":"2025-10-10T00:00:00"}
