{"id":"https://openalex.org/W4409466285","doi":"https://doi.org/10.3389/fimmu.2025.1524382","title":"Life\u2019s Crucial 9 and psoriasis: a mediation analysis of systemic inflammation response index using NHANES cohort data","display_name":"Life\u2019s Crucial 9 and psoriasis: a mediation analysis of systemic inflammation response index using NHANES cohort data","publication_year":2025,"publication_date":"2025-04-15","ids":{"openalex":"https://openalex.org/W4409466285","doi":"https://doi.org/10.3389/fimmu.2025.1524382","pmid":"https://pubmed.ncbi.nlm.nih.gov/40303403"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2025.1524382","doi":"https://doi.org/10.3389/fimmu.2025.1524382","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2025.1524382","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1524382/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1524382/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5115595720","display_name":"Xinyan Liu","orcid":"https://orcid.org/0009-0000-0160-3178","observed_orcids":["https://orcid.org/0009-0000-0160-3178"]},"institutions":[{"id":"https://openalex.org/I4210098425","display_name":"The First People's Hospital of Shunde","ror":"https://ror.org/00wwb2b69","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210098425"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinyan Liu","raw_affiliation_strings":["Department of Dermatology, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde), Foshan, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde), Foshan, Guangdong, China","institution_ids":["https://openalex.org/I4210098425","https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102617418","display_name":"Qirui Deng","orcid":"https://orcid.org/0009-0007-6532-0880","observed_orcids":["https://orcid.org/0009-0007-6532-0880"]},"institutions":[{"id":"https://openalex.org/I4210098425","display_name":"The First People's Hospital of Shunde","ror":"https://ror.org/00wwb2b69","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210098425"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qirui Deng","raw_affiliation_strings":["Department of Dermatology, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde), Foshan, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde), Foshan, Guangdong, China","institution_ids":["https://openalex.org/I4210098425","https://openalex.org/I58200834"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101718605","display_name":"Hongfeng Tang","orcid":"https://orcid.org/0000-0002-9735-8724","observed_orcids":["https://orcid.org/0000-0002-9735-8724"]},"institutions":[{"id":"https://openalex.org/I4210098425","display_name":"The First People's Hospital of Shunde","ror":"https://ror.org/00wwb2b69","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210098425"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hongfeng Tang","raw_affiliation_strings":["Department of Dermatology, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde), Foshan, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde), Foshan, Guangdong, China","institution_ids":["https://openalex.org/I4210098425","https://openalex.org/I58200834"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5101718605"],"corresponding_institution_ids":["https://openalex.org/I4210098425","https://openalex.org/I58200834"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":1.2201,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.77262898,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":97},"biblio":{"volume":"16","issue":null,"first_page":"1524382","last_page":"1524382"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11092","display_name":"Spondyloarthritis Studies and Treatments","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/psoriasis","display_name":"psoriasis","score":0.9419999718666077},{"id":"https://openalex.org/keywords/systemic-inflammation","display_name":"systemic inflammation","score":0.9399999976158142},{"id":"https://openalex.org/keywords/mediation-analysis","display_name":"mediation analysis","score":0.7110000252723694},{"id":"https://openalex.org/keywords/cardiovascular-health","display_name":"cardiovascular health","score":0.6650000214576721},{"id":"https://openalex.org/keywords/lifestyle-factors","display_name":"lifestyle factors","score":0.7860000133514404},{"id":"https://openalex.org/keywords/chronic-inflammation","display_name":"chronic inflammation","score":0.4790000021457672},{"id":"https://openalex.org/keywords/nhanes","display_name":"NHANES","score":0.7020000219345093}],"concepts":[{"id":"https://openalex.org/C2780564577","wikidata":"https://www.wikidata.org/wiki/Q179945","display_name":"Psoriasis","level":2,"score":0.9190815091133118},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8176664113998413},{"id":"https://openalex.org/C2779874844","wikidata":"https://www.wikidata.org/wiki/Q1967281","display_name":"National Health and Nutrition Examination Survey","level":3,"score":0.7017050981521606},{"id":"https://openalex.org/C179420905","wikidata":"https://www.wikidata.org/wiki/Q223871","display_name":"Mediation","level":2,"score":0.6852178573608398},{"id":"https://openalex.org/C2777011040","wikidata":"https://www.wikidata.org/wiki/Q390643","display_name":"Psoriasis Area and Severity Index","level":3,"score":0.6828224658966064},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.6431080102920532},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5325530767440796},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.5122243762016296},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.46579158306121826},{"id":"https://openalex.org/C142853389","wikidata":"https://www.wikidata.org/wiki/Q744778","display_name":"Association (psychology)","level":2,"score":0.454522043466568},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.41487547755241394},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.3297874629497528},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2019910216331482},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.15985408425331116},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.15771812200546265},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.10981824994087219},{"id":"https://openalex.org/C542102704","wikidata":"https://www.wikidata.org/wiki/Q183257","display_name":"Psychotherapist","level":1,"score":0.0},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000081983","descriptor_name":"Mediation Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000081983","descriptor_name":"Mediation Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000081983","descriptor_name":"Mediation Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009749","descriptor_name":"Nutrition Surveys","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009749","descriptor_name":"Nutrition Surveys","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009749","descriptor_name":"Nutrition Surveys","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011565","descriptor_name":"Psoriasis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D011565","descriptor_name":"Psoriasis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D011565","descriptor_name":"Psoriasis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D011565","descriptor_name":"Psoriasis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D011565","descriptor_name":"Psoriasis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D011565","descriptor_name":"Psoriasis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D011565","descriptor_name":"Psoriasis","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D011565","descriptor_name":"Psoriasis","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D011565","descriptor_name":"Psoriasis","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015995","descriptor_name":"Prevalence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015995","descriptor_name":"Prevalence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015995","descriptor_name":"Prevalence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3389/fimmu.2025.1524382","doi":"https://doi.org/10.3389/fimmu.2025.1524382","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2025.1524382","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1524382/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmid:40303403","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40303403","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in immunology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12037584","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12037584","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Front Immunol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:7db2de4dc6634a8e8afa24ff4bdb80df","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/7db2de4dc6634a8e8afa24ff4bdb80df","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 16 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2025.1524382","doi":"https://doi.org/10.3389/fimmu.2025.1524382","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2025.1524382","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1524382/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/2","score":0.7699999809265137,"display_name":"Zero hunger"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320326228","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4409466285.pdf","grobid_xml":"https://content.openalex.org/works/W4409466285.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W1690616900","https://openalex.org/W1973302470","https://openalex.org/W2001160854","https://openalex.org/W2019270353","https://openalex.org/W2022665587","https://openalex.org/W2057448387","https://openalex.org/W2103724612","https://openalex.org/W2417594999","https://openalex.org/W2754430781","https://openalex.org/W2759013423","https://openalex.org/W2924895007","https://openalex.org/W2964207622","https://openalex.org/W2980214381","https://openalex.org/W3004928355","https://openalex.org/W3017119232","https://openalex.org/W3113069834","https://openalex.org/W3168620798","https://openalex.org/W3213219020","https://openalex.org/W3215993066","https://openalex.org/W4211202219","https://openalex.org/W4241802495","https://openalex.org/W4283695009","https://openalex.org/W4283774165","https://openalex.org/W4313855047","https://openalex.org/W4366158538","https://openalex.org/W4385664440","https://openalex.org/W4386568712","https://openalex.org/W4388615993","https://openalex.org/W4391783812","https://openalex.org/W4392153769","https://openalex.org/W4393220554","https://openalex.org/W4394681024","https://openalex.org/W4396596606","https://openalex.org/W4399355142","https://openalex.org/W4399438892","https://openalex.org/W4399892257","https://openalex.org/W4400119516","https://openalex.org/W4400348767","https://openalex.org/W4400981810","https://openalex.org/W4402248153","https://openalex.org/W4402380930","https://openalex.org/W4403217821","https://openalex.org/W4403854257","https://openalex.org/W4403953234","https://openalex.org/W4405055554","https://openalex.org/W4407228927","https://openalex.org/W4408054081","https://openalex.org/W4408102715"],"related_works":["https://openalex.org/W3176363967","https://openalex.org/W3022724713","https://openalex.org/W2588369178","https://openalex.org/W2343185506","https://openalex.org/W2781166685","https://openalex.org/W2032633556","https://openalex.org/W2165746902","https://openalex.org/W4226346397","https://openalex.org/W2331028526","https://openalex.org/W2783490784"],"abstract_inverted_index":{"Background:":[0],"Psoriasis":[1],"is":[2],"a":[3,118],"chronic,":[4],"recurrent,":[5],"inflammatory":[6],"disease.":[7],"The":[8],"aim":[9],"of":[10,28,36,82,131,181,209],"this":[11,58,184],"study":[12,59,105],"was":[13,122,186],"to":[14,31,56,72,89,199],"investigate":[15,90],"the":[16,19,26,33,46,74,80,96,125,129,151,162,179,207],"association":[17,163,185],"between":[18,76,98,124,164],"Life's":[20],"Crucial":[21],"9":[22],"(LC9)":[23],"score":[24,127],"and":[25,30,49,68,79,101,128,166,205],"risk":[27,180],"psoriasis":[29,112,132,167],"examine":[32],"mediating":[34],"role":[35],"system":[37],"inflammation":[38],"response":[39],"index":[40],"(SIRI).":[41],"Methods:":[42],"Utilizing":[43],"data":[44],"from":[45],"National":[47],"Health":[48],"Nutrition":[50],"Examination":[51],"Survey":[52],"(NHANES)":[53],"spanning":[54],"2009":[55],"2014,":[57],"employed":[60],"multifactor":[61],"logistic":[62],"regression,":[63],"restricted":[64],"triple":[65],"spline":[66],"analysis,":[67],"various":[69],"subgroup":[70,152],"analyses":[71,86],"evaluate":[73],"correlation":[75],"LC9":[77,99,126,165,176],"scores":[78,100,177],"occurrence":[81],"psoriasis.":[83,102,182,210],"Furthermore,":[84],"mediation":[85,156],"were":[87,148],"executed":[88],"SIRI's":[91],"possible":[92],"intermediary":[93],"effect":[94],"in":[95,150],"linkage":[97],"Results:":[103],"This":[104,190],"included":[106],"11,499":[107],"US":[108],"adults":[109],"with":[110],"345":[111],"patients.":[113],"In":[114,154],"fully":[115],"adjusted":[116],"models,":[117],"notable":[119],"inverse":[120],"relationship":[121],"identified":[123],"prevalence":[130],"(OR":[133],"=":[134,172],"0.90,":[135],"95%":[136],"CI:":[137],"0.80,":[138],"0.99).":[139],"After":[140],"adjusting":[141],"for":[142],"all":[143],"covariates,":[144],"no":[145],"significant":[146],"interactions":[147],"found":[149],"analyses.":[153],"addition,":[155],"analysis":[157],"showed":[158],"that":[159,192],"SIRI":[160],"mediated":[161,187],"(mediation":[168],"ratio:":[169],"7.02%,":[170],"p":[171],"0.004).":[173],"Conclusions:":[174],"Higher":[175],"reduce":[178],"And,":[183],"by":[188],"SIRI.":[189],"suggests":[191],"we":[193],"should":[194],"actively":[195],"regulate":[196],"our":[197],"lifestyles":[198],"improve":[200],"cardiovascular":[201],"health,":[202],"thereby":[203],"preventing":[204],"delaying":[206],"onset":[208]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2}],"updated_date":"2026-09-21T07:43:02.447757","created_date":"2025-10-10T00:00:00"}