{"id":"https://openalex.org/W4409466159","doi":"https://doi.org/10.3389/fphar.2025.1586845","title":"Safety and efficacy of intravesical instillation of botulinum toxin-A in the treatment of interstitial cystitis/bladder pain syndrome and overactive bladder: a systematic review and meta-analysis","display_name":"Safety and efficacy of intravesical instillation of botulinum toxin-A in the treatment of interstitial cystitis/bladder pain syndrome and overactive bladder: a systematic review and meta-analysis","publication_year":2025,"publication_date":"2025-04-15","ids":{"openalex":"https://openalex.org/W4409466159","doi":"https://doi.org/10.3389/fphar.2025.1586845","pmid":"https://pubmed.ncbi.nlm.nih.gov/40303921","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12037478"},"language":"en","primary_location":{"id":"doi:10.3389/fphar.2025.1586845","doi":"https://doi.org/10.3389/fphar.2025.1586845","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2025.1586845","pdf_url":"https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1586845/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1586845/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077386862","display_name":"Yongheng Zhou","orcid":"https://orcid.org/0000-0002-6668-886X","observed_orcids":["https://orcid.org/0000-0002-6668-886X"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I2802459333","display_name":"China Rehabilitation Research Center","ror":"https://ror.org/02bpqmq41","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802459333"]},{"id":"https://openalex.org/I4210161528","display_name":"Qilu Hospital of Shandong University","ror":"https://ror.org/056ef9489","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161528"]},{"id":"https://openalex.org/I4405280210","display_name":"University of Health and Rehabilitation Sciences","ror":"https://ror.org/02kjtx631","country_code":"CN","type":"education","lineage":["https://openalex.org/I4405280210"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongheng Zhou","raw_affiliation_strings":["Beijing Key Laboratory of Neural Injury and Rehabilitation, Beijing, China","Department of Urology, China Rehabilitation Research Center, Beijing, China","Department of Urology, China Rehabilitation Science Institute, Beijing, China","Department of Urology, Qilu hospital of Shandong University, Jinan, Shandong, China","Department of Urology, University of Health and Rehabilitation Sciences, Qingdao, Shandong, China","School of Rehabilitation, Capital Medical University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Key Laboratory of Neural Injury and Rehabilitation, Beijing, China","institution_ids":[]},{"raw_affiliation_string":"Department of Urology, China Rehabilitation Research Center, Beijing, China","institution_ids":["https://openalex.org/I2802459333"]},{"raw_affiliation_string":"Department of Urology, China Rehabilitation Science Institute, Beijing, China","institution_ids":["https://openalex.org/I2802459333"]},{"raw_affiliation_string":"Department of Urology, Qilu hospital of Shandong University, Jinan, Shandong, China","institution_ids":["https://openalex.org/I4210161528"]},{"raw_affiliation_string":"Department of Urology, University of Health and Rehabilitation Sciences, Qingdao, Shandong, China","institution_ids":["https://openalex.org/I4405280210"]},{"raw_affiliation_string":"School of Rehabilitation, Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I183519381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034628564","display_name":"Zitian He","orcid":"https://orcid.org/0009-0008-7233-7936","observed_orcids":["https://orcid.org/0009-0008-7233-7936"]},"institutions":[{"id":"https://openalex.org/I2802459333","display_name":"China Rehabilitation Research Center","ror":"https://ror.org/02bpqmq41","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802459333"]},{"id":"https://openalex.org/I4210099512","display_name":"Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University","ror":"https://ror.org/0156rhd17","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099512"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zitian He","raw_affiliation_strings":["Department of Rehabilitation, Yuying Children's Hospital, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China","Department of Urology, China Rehabilitation Science Institute, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rehabilitation, Yuying Children's Hospital, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China","institution_ids":["https://openalex.org/I4210099512"]},{"raw_affiliation_string":"Department of Urology, China Rehabilitation Science Institute, Beijing, China","institution_ids":["https://openalex.org/I2802459333"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081798115","display_name":"Tianyu Xiang","orcid":"https://orcid.org/0000-0002-0967-0823","observed_orcids":["https://orcid.org/0000-0002-0967-0823"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I2802459333","display_name":"China Rehabilitation Research Center","ror":"https://ror.org/02bpqmq41","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802459333"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tianyu Xiang","raw_affiliation_strings":["Department of Urology, China Rehabilitation Science Institute, Beijing, China","School of Rehabilitation, Capital Medical University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, China Rehabilitation Science Institute, Beijing, China","institution_ids":["https://openalex.org/I2802459333"]},{"raw_affiliation_string":"School of Rehabilitation, Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I183519381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113748491","display_name":"Xiaoyan Cao","orcid":"https://orcid.org/0009-0006-3815-5587","observed_orcids":["https://orcid.org/0009-0006-3815-5587"]},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]},{"id":"https://openalex.org/I4210132375","display_name":"First Affiliated Hospital of Chinese PLA General Hospital","ror":"https://ror.org/039713658","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210132375"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoyan Cao","raw_affiliation_strings":["Department of Quality Management, The First Medical Center of PLA General Hospital, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Quality Management, The First Medical Center of PLA General Hospital, Beijing, China","institution_ids":["https://openalex.org/I2802939634","https://openalex.org/I4210132375"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006939126","display_name":"Huiling Cong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I2802459333","display_name":"China Rehabilitation Research Center","ror":"https://ror.org/02bpqmq41","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802459333"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huiling Cong","raw_affiliation_strings":["Department of Urology, China Rehabilitation Research Center, Beijing, China","School of Rehabilitation, Capital Medical University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, China Rehabilitation Research Center, Beijing, China","institution_ids":["https://openalex.org/I2802459333"]},{"raw_affiliation_string":"School of Rehabilitation, Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I183519381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103027799","display_name":"Qinggang Liu","orcid":"https://orcid.org/0000-0002-7839-6813","observed_orcids":["https://orcid.org/0000-0002-7839-6813"]},"institutions":[{"id":"https://openalex.org/I4210119987","display_name":"Qingdao Municipal Hospital","ror":"https://ror.org/02jqapy19","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210119987"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qinggang Liu","raw_affiliation_strings":["Department of Urology, Qingdao Municipal Hospital, Qingdao, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Qingdao Municipal Hospital, Qingdao, China","institution_ids":["https://openalex.org/I4210119987"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084713893","display_name":"Haoyu Sun","orcid":"https://orcid.org/0009-0007-0304-098X","observed_orcids":["https://orcid.org/0009-0007-0304-098X"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210161528","display_name":"Qilu Hospital of Shandong University","ror":"https://ror.org/056ef9489","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161528"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haoyu Sun","raw_affiliation_strings":["Department of Urology, Qilu hospital of Shandong University, Jinan, Shandong, China","School of Rehabilitation, Capital Medical University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Qilu hospital of Shandong University, Jinan, Shandong, China","institution_ids":["https://openalex.org/I4210161528"]},{"raw_affiliation_string":"School of Rehabilitation, Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I183519381"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112162639","display_name":"Limin Liao","orcid":"https://orcid.org/0009-0007-0369-9725","observed_orcids":["https://orcid.org/0009-0007-0369-9725"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I2802459333","display_name":"China Rehabilitation Research Center","ror":"https://ror.org/02bpqmq41","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802459333"]},{"id":"https://openalex.org/I4210161528","display_name":"Qilu Hospital of Shandong University","ror":"https://ror.org/056ef9489","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161528"]},{"id":"https://openalex.org/I4405280210","display_name":"University of Health and Rehabilitation Sciences","ror":"https://ror.org/02kjtx631","country_code":"CN","type":"education","lineage":["https://openalex.org/I4405280210"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Limin Liao","raw_affiliation_strings":["Beijing Key Laboratory of Neural Injury and Rehabilitation, Beijing, China","Department of Urology, China Rehabilitation Research Center, Beijing, China","Department of Urology, China Rehabilitation Science Institute, Beijing, China","Department of Urology, Qilu hospital of Shandong University, Jinan, Shandong, China","Department of Urology, University of Health and Rehabilitation Sciences, Qingdao, Shandong, China","School of Rehabilitation, Capital Medical University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Key Laboratory of Neural Injury and Rehabilitation, Beijing, China","institution_ids":[]},{"raw_affiliation_string":"Department of Urology, China Rehabilitation Research Center, Beijing, China","institution_ids":["https://openalex.org/I2802459333"]},{"raw_affiliation_string":"Department of Urology, China Rehabilitation Science Institute, Beijing, China","institution_ids":["https://openalex.org/I2802459333"]},{"raw_affiliation_string":"Department of Urology, Qilu hospital of Shandong University, Jinan, Shandong, China","institution_ids":["https://openalex.org/I4210161528"]},{"raw_affiliation_string":"Department of Urology, University of Health and Rehabilitation Sciences, Qingdao, Shandong, China","institution_ids":["https://openalex.org/I4405280210"]},{"raw_affiliation_string":"School of Rehabilitation, Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I183519381"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5112162639"],"corresponding_institution_ids":["https://openalex.org/I183519381","https://openalex.org/I2802459333","https://openalex.org/I4210161528","https://openalex.org/I4405280210"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":1.3096,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.76091082,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"16","issue":null,"first_page":"1586845","last_page":"1586845"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11232","display_name":"Urinary Tract Infections Management","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10418","display_name":"Pelvic floor disorders treatments","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/botulinum-toxin-type-a","display_name":"botulinum toxin type A","score":0.9110000133514404},{"id":"https://openalex.org/keywords/intravesical-instillation","display_name":"intravesical instillation","score":0.9860000014305115},{"id":"https://openalex.org/keywords/interstitial-cystitis","display_name":"interstitial cystitis","score":0.996999979019165},{"id":"https://openalex.org/keywords/overactive-bladder","display_name":"overactive bladder","score":1.0},{"id":"https://openalex.org/keywords/urge-urinary-incontinence","display_name":"urge urinary incontinence","score":0.9309999942779541},{"id":"https://openalex.org/keywords/voiding-volume","display_name":"voiding volume","score":0.7540000081062317},{"id":"https://openalex.org/keywords/urinary-tract-infection","display_name":"urinary tract infection","score":0.8259999752044678},{"id":"https://openalex.org/keywords/post-void-residual-urine","display_name":"post-void residual urine","score":0.972000002861023},{"id":"https://openalex.org/keywords/treatment-safety","display_name":"treatment safety","score":0.5329999923706055},{"id":"https://openalex.org/keywords/dose-comparison","display_name":"dose comparison","score":0.4099999964237213},{"id":"https://openalex.org/keywords/bladder-dysfunction-treatment","display_name":"bladder dysfunction treatment","score":0.38600000739097595},{"id":"https://openalex.org/keywords/minimally-invasive-treatment","display_name":"minimally invasive treatment","score":0.4009999930858612},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.42800000309944153},{"id":"https://openalex.org/keywords/patient-satisfaction","display_name":"patient satisfaction","score":0.33399999141693115},{"id":"https://openalex.org/keywords/treatment-adherence","display_name":"medication adherence","score":0.3499999940395355}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8710971474647522},{"id":"https://openalex.org/C2778508898","wikidata":"https://www.wikidata.org/wiki/Q1671412","display_name":"Interstitial cystitis","level":3,"score":0.8405883312225342},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.7952195405960083},{"id":"https://openalex.org/C187960798","wikidata":"https://www.wikidata.org/wiki/Q7631152","display_name":"Subgroup analysis","level":3,"score":0.7814968824386597},{"id":"https://openalex.org/C2778941218","wikidata":"https://www.wikidata.org/wiki/Q331231","display_name":"Overactive bladder","level":3,"score":0.7709821462631226},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.6504212617874146},{"id":"https://openalex.org/C2776478404","wikidata":"https://www.wikidata.org/wiki/Q1105187","display_name":"Cochrane Library","level":3,"score":0.5468910336494446},{"id":"https://openalex.org/C2778531004","wikidata":"https://www.wikidata.org/wiki/Q281490","display_name":"Urinary incontinence","level":2,"score":0.4925838112831116},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.48585841059684753},{"id":"https://openalex.org/C2777478456","wikidata":"https://www.wikidata.org/wiki/Q208413","display_name":"Botulinum toxin","level":2,"score":0.46853819489479065},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.34306785464286804},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.30008018016815186},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.2665979564189911},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.053874194622039795},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fphar.2025.1586845","doi":"https://doi.org/10.3389/fphar.2025.1586845","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2025.1586845","pdf_url":"https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1586845/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},{"id":"pmid:40303921","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40303921","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12037478","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12037478/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Pharmacol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:a77ac53fef1c46cc942e60549ce82d4c","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/a77ac53fef1c46cc942e60549ce82d4c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Pharmacology, Vol 16 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fphar.2025.1586845","doi":"https://doi.org/10.3389/fphar.2025.1586845","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2025.1586845","pdf_url":"https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1586845/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"},{"display_name":"Meta-Analysis","id":"https://openalex.org/study-designs/meta-analysis"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4409466159.pdf","grobid_xml":"https://content.openalex.org/works/W4409466159.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1257881779","https://openalex.org/W1534181333","https://openalex.org/W1966909918","https://openalex.org/W1970886028","https://openalex.org/W1986703328","https://openalex.org/W2000253258","https://openalex.org/W2001662015","https://openalex.org/W2037232981","https://openalex.org/W2044294974","https://openalex.org/W2054316901","https://openalex.org/W2071052332","https://openalex.org/W2075335601","https://openalex.org/W2086599259","https://openalex.org/W2132968602","https://openalex.org/W2134833483","https://openalex.org/W2170892587","https://openalex.org/W2265262375","https://openalex.org/W2344251979","https://openalex.org/W2517158196","https://openalex.org/W2588046785","https://openalex.org/W2901283882","https://openalex.org/W2903612881","https://openalex.org/W2943739269","https://openalex.org/W2970839747","https://openalex.org/W3134818619","https://openalex.org/W3194413528","https://openalex.org/W3205111431","https://openalex.org/W4212845674","https://openalex.org/W4283817070","https://openalex.org/W4285801359","https://openalex.org/W4379094710","https://openalex.org/W4386847157","https://openalex.org/W4401730180","https://openalex.org/W4404246578"],"related_works":["https://openalex.org/W2905088926","https://openalex.org/W4206400951","https://openalex.org/W2520513036","https://openalex.org/W2114299128","https://openalex.org/W2007959805","https://openalex.org/W2970839747","https://openalex.org/W1781773981","https://openalex.org/W2744236200","https://openalex.org/W2343723837","https://openalex.org/W1985527805"],"abstract_inverted_index":{"Background:":[0],"The":[1,17,46,65,84,93,110,119,242],"effectiveness":[2],"and":[3,25,55,113,121,258,277],"safety":[4,26],"of":[5,8,15,27,32,76,134,141,146,177,213,224,245,265,269,275],"the":[6,23,56,69,73,100,106,132,135,206,217,282],"instillation":[7,31,75,140,244,268],"botulinum":[9],"toxin":[10],"A":[11],"(BTX-A)":[12],"remain":[13],"subjects":[14],"controversy.":[16],"meta-analysis":[18,120,136],"was":[19,87,97,187],"performed":[20],"to":[21,61,104,163,185,190,201,205,232,248,260,281],"assess":[22],"efficacy":[24],"a":[28,235,250,272],"novel":[29],"intravesical":[30,74,139,243,267],"BTX-A":[33,77,142,225,246,270],"for":[34,99],"managing":[35],"overactive":[36],"bladder":[37],"(OAB)":[38],"or":[39,82,222],"interstitial":[40],"cystitis/bladder":[41],"pain":[42],"syndrome":[43],"(IC/BPS).":[44],"Method:":[45],"randomized":[47],"controlled":[48],"trials":[49],"were":[50,116],"retrieved":[51],"from":[52],"PubMed,":[53],"EMBASE,":[54],"Cochrane":[57],"Library":[58],"databases":[59],"up":[60],"29":[62],"January":[63],"2024.":[64],"studies":[66],"included":[67],"in":[68,78,102,170,216,239],"analysis":[70,123],"focused":[71],"on":[72],"patients":[79,215],"with":[80],"OAB":[81],"IC/BPS.":[83],"data":[85],"extraction":[86],"independently":[88],"conducted":[89],"by":[90],"two":[91],"reviewers.":[92],"random":[94],"effects":[95],"model":[96],"utilized":[98],"assessment":[101],"order":[103],"compute":[105],"overall":[107],"effect":[108],"sizes.":[109],"heterogeneity":[111],"tests":[112],"subgroup":[114,122,166],"analyses":[115],"conducted.":[117],"Results:":[118],"did":[124],"not":[125],"reveal":[126],"any":[127],"statistically":[128],"significant":[129],"differences.":[130],"However,":[131],"results":[133],"indicated":[137],"that":[138,191,254],"could":[143],"reduce":[144,256],"episodes":[145],"urgency":[147],"urinary":[148],"incontinence":[149],"(UUI)":[150],"(overall":[151],"weighted":[152],"mean":[153],"difference":[154],"[WMD]":[155],"=":[156,180,196,227],"-0.85;":[157],"95%":[158,182,198,229],"confidence":[159],"interval":[160],"[CI]:":[161],"-2.99":[162],"1.29).":[164],"In":[165,203,263],"analysis,":[167],"an":[168],"increase":[169,238],"void":[171],"volume":[172],"(VV)":[173],"at":[174,192],"4":[175],"weeks":[176,194],"follow-up":[178],"(WMD":[179,195,226],"-31.99;":[181],"CI:":[183,199,230],"-70.53":[184],"6.54)":[186],"observed":[188],"compared":[189,280],"12":[193],"-1.73;":[197],"-16.98":[200],"13.53).":[202],"contrast":[204],"groups":[207],"receiving":[208,219],"more":[209],"than":[210],"200":[211,220],"units":[212,221],"BTX-A,":[214],"group":[218],"fewer":[223],"-16.89;":[228],"-41.14":[231],"7.35)":[233],"exhibited":[234],"significantly":[236],"greater":[237],"VV.":[240],"Conslusion:":[241],"appears":[247],"be":[249],"viable":[251],"administration":[252],"route":[253],"may":[255],"UUI":[257],"VV":[259],"some":[261],"extent.":[262],"terms":[264],"safety,":[266],"demonstrated":[271],"reduced":[273],"risk":[274],"UTI":[276],"post-void":[278],"residual":[279],"placebo":[283],"group.":[284],"Systematic":[285],"Review":[286],"registration:":[287],"https://www.crd.york.ac.uk/PROSPERO/view/CRD42024517877.":[288]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2025-04-16T00:00:00"}