{"id":"https://openalex.org/W4409465482","doi":"https://doi.org/10.47297/wspbdswsp2752-630520.20250501","title":"Balancing Efficacy and Safety: Modulating the Immune System with SUPRA CAR-T Cells for Cancer Therapy","display_name":"Balancing Efficacy and Safety: Modulating the Immune System with SUPRA CAR-T Cells for Cancer Therapy","publication_year":2025,"publication_date":"2025-01-01","ids":{"openalex":"https://openalex.org/W4409465482","doi":"https://doi.org/10.47297/wspbdswsp2752-630520.20250501"},"language":"en","primary_location":{"id":"doi:10.47297/wspbdswsp2752-630520.20250501","doi":"https://doi.org/10.47297/wspbdswsp2752-630520.20250501","is_oa":true,"landing_page_url":"https://doi.org/10.47297/wspbdswsp2752-630520.20250501","pdf_url":"https://www.wsp-publishing.com/rc-pub/front/front-article/download/89280519/lowqualitypdf/Balancing Efficacy and Safety: Modulating the Immune System with SUPRA CAR-T Cells for Cancer Therapy.pdf","source":{"id":"https://openalex.org/S4387288397","display_name":"Biomedical Data Science","issn_l":"2752-6305","issn":["2752-6305"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedical Data Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.wsp-publishing.com/rc-pub/front/front-article/download/89280519/lowqualitypdf/Balancing Efficacy and Safety: Modulating the Immune System with SUPRA CAR-T Cells for Cancer Therapy.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101419021","display_name":"Junming Chen","orcid":"https://orcid.org/0000-0001-6406-0924","observed_orcids":["https://orcid.org/0000-0001-6406-0924"]},"institutions":[{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Junming Chen","raw_affiliation_strings":["University of Bristol , Unite Kingdom , Senate House , Tyndall Avenue , Bristol , BS8 1TH , United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Bristol , Unite Kingdom , Senate House , Tyndall Avenue , Bristol , BS8 1TH , United Kingdom","institution_ids":["https://openalex.org/I36234482"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5101419021"],"corresponding_institution_ids":["https://openalex.org/I36234482"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.08229477,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"5","issue":"1","first_page":"88","last_page":"92"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chimeric-antigen-receptor-t-cells","display_name":"chimeric antigen receptor T cells","score":0.7129999995231628},{"id":"https://openalex.org/keywords/chimeric-antigen-receptor","display_name":"chimeric antigen receptor","score":0.8240000009536743},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.8849999904632568},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.6119999885559082},{"id":"https://openalex.org/keywords/treatment-safety","display_name":"treatment safety","score":0.5019999742507935},{"id":"https://openalex.org/keywords/off-target-toxicity","display_name":"off-target toxicity","score":0.5910000205039978},{"id":"https://openalex.org/keywords/t-cell-redirection","display_name":"T cell redirection","score":0.5600000023841858},{"id":"https://openalex.org/keywords/tumor-antigens","display_name":"tumor antigens","score":0.5559999942779541}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6539511680603027},{"id":"https://openalex.org/C2983331546","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer therapy","level":3,"score":0.5666897892951965},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4969489872455597},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.40617266297340393},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3677515685558319},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.27786797285079956},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20815929770469666}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.47297/wspbdswsp2752-630520.20250501","doi":"https://doi.org/10.47297/wspbdswsp2752-630520.20250501","is_oa":true,"landing_page_url":"https://doi.org/10.47297/wspbdswsp2752-630520.20250501","pdf_url":"https://www.wsp-publishing.com/rc-pub/front/front-article/download/89280519/lowqualitypdf/Balancing Efficacy and Safety: Modulating the Immune System with SUPRA CAR-T Cells for Cancer Therapy.pdf","source":{"id":"https://openalex.org/S4387288397","display_name":"Biomedical Data Science","issn_l":"2752-6305","issn":["2752-6305"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedical Data Science","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.47297/wspbdswsp2752-630520.20250501","doi":"https://doi.org/10.47297/wspbdswsp2752-630520.20250501","is_oa":true,"landing_page_url":"https://doi.org/10.47297/wspbdswsp2752-630520.20250501","pdf_url":"https://www.wsp-publishing.com/rc-pub/front/front-article/download/89280519/lowqualitypdf/Balancing Efficacy and Safety: Modulating the Immune System with SUPRA CAR-T Cells for Cancer Therapy.pdf","source":{"id":"https://openalex.org/S4387288397","display_name":"Biomedical Data Science","issn_l":"2752-6305","issn":["2752-6305"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedical Data Science","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.75,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4409465482.pdf","grobid_xml":"https://content.openalex.org/works/W4409465482.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W2052012061","https://openalex.org/W2130338247","https://openalex.org/W2132835748","https://openalex.org/W2473078810","https://openalex.org/W2515679023","https://openalex.org/W2800187318","https://openalex.org/W2888063816","https://openalex.org/W2903960245","https://openalex.org/W2913781203","https://openalex.org/W2947791653","https://openalex.org/W2967929847","https://openalex.org/W3021491495","https://openalex.org/W3044926293","https://openalex.org/W3093752130","https://openalex.org/W3107452708","https://openalex.org/W3128958811","https://openalex.org/W3159928825","https://openalex.org/W4281566469","https://openalex.org/W4303645565","https://openalex.org/W4312191227","https://openalex.org/W4320912708","https://openalex.org/W4401535285"],"related_works":["https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W3031052312","https://openalex.org/W4389568370","https://openalex.org/W3032375762","https://openalex.org/W1995515455","https://openalex.org/W2080531066","https://openalex.org/W3108674512","https://openalex.org/W1506200166","https://openalex.org/W4285386966"],"abstract_inverted_index":{"Cancer":[0],"poses":[1],"considerable":[2],"challenges":[3],"for":[4],"effective":[5],"treatment,":[6],"notwithstanding":[7],"the":[8,20,31,40,68,89],"existence":[9],"of":[10,33,42,70,88],"various":[11],"therapeutic":[12],"options.":[13],"Immunotherapy":[14,50],"is":[15],"a":[16],"strategy":[17],"that":[18,104],"employs":[19],"immune":[21],"system":[22],"to":[23,45,73,78],"detect":[24],"and":[25,39,47,95],"eradicate":[26],"cancer":[27,37],"cells.":[28,75],"This":[29],"entails":[30],"identification":[32],"specific":[34],"antigens":[35],"on":[36],"cells":[38,44],"direction":[41],"T":[43],"recognize":[46],"eliminate":[48],"them.":[49],"produces":[51],"fewer":[52],"side":[53],"effects":[54],"than":[55],"traditional":[56],"treatments":[57],"such":[58],"as":[59,84],"chemotherapy.":[60],"Nonetheless,":[61],"it":[62,101],"presents":[63],"inherent":[64],"safety":[65,94],"risks,":[66],"particularly":[67],"possibility":[69],"unintentional":[71],"damage":[72],"healthy":[74],"In":[76],"response":[77],"these":[79],"concerns,":[80],"developed":[81],"SUPRA":[82],"CAR":[83],"an":[85,98],"advanced":[86],"version":[87],"original":[90],"therapy,":[91],"offering":[92],"improved":[93],"efficacy.":[96],"As":[97],"emerging":[99],"technology,":[100],"possesses":[102],"limitations":[103],"necessitate":[105],"further":[106],"examination.":[107]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}