{"id":"https://openalex.org/W4409464950","doi":"https://doi.org/10.1080/0886022x.2025.2486564","title":"The impact of rising peripheral blood na\u00efve CD8 + T cell levels on chronic kidney disease onset: a Mendelian randomization study","display_name":"The impact of rising peripheral blood na\u00efve CD8 + T cell levels on chronic kidney disease onset: a Mendelian randomization study","publication_year":2025,"publication_date":"2025-04-14","ids":{"openalex":"https://openalex.org/W4409464950","doi":"https://doi.org/10.1080/0886022x.2025.2486564","pmid":"https://pubmed.ncbi.nlm.nih.gov/40230080"},"language":"en","primary_location":{"id":"doi:10.1080/0886022x.2025.2486564","doi":"https://doi.org/10.1080/0886022x.2025.2486564","is_oa":true,"landing_page_url":"https://doi.org/10.1080/0886022x.2025.2486564","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/0886022X.2025.2486564?needAccess=true","source":{"id":"https://openalex.org/S159051371","display_name":"Renal Failure","issn_l":"0886-022X","issn":["0886-022X","1525-6049"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Renal Failure","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.tandfonline.com/doi/pdf/10.1080/0886022X.2025.2486564?needAccess=true","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066733145","display_name":"Jianbo Qing","orcid":"https://orcid.org/0000-0002-6146-3389","observed_orcids":["https://orcid.org/0000-0002-6146-3389"]},"institutions":[{"id":"https://openalex.org/I2802390878","display_name":"Sir Run Run Shaw Hospital","ror":"https://ror.org/00ka6rp58","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802390878"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianbo Qing","raw_affiliation_strings":["Department of Nephrology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine","institution_ids":["https://openalex.org/I2802390878","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100945912","display_name":"Yiting Zhao","orcid":"https://orcid.org/0009-0006-1905-6962","observed_orcids":["https://orcid.org/0009-0006-1905-6962"]},"institutions":[{"id":"https://openalex.org/I2802390878","display_name":"Sir Run Run Shaw Hospital","ror":"https://ror.org/00ka6rp58","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802390878"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yiting Zhao","raw_affiliation_strings":["Department of Nephrology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine","institution_ids":["https://openalex.org/I2802390878","https://openalex.org/I76130692"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065510367","display_name":"Junnan Wu","orcid":"https://orcid.org/0000-0002-0624-2057","observed_orcids":["https://orcid.org/0000-0002-0624-2057"]},"institutions":[{"id":"https://openalex.org/I2802390878","display_name":"Sir Run Run Shaw Hospital","ror":"https://ror.org/00ka6rp58","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802390878"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Junnan Wu","raw_affiliation_strings":["Department of Nephrology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine","institution_ids":["https://openalex.org/I2802390878","https://openalex.org/I76130692"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5065510367"],"corresponding_institution_ids":["https://openalex.org/I2802390878","https://openalex.org/I76130692"],"apc_list":{"value":1880,"currency":"GBP","value_usd":2306},"apc_paid":{"value":1880,"currency":"GBP","value_usd":2306},"fwci":0.62,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.66142894,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"47","issue":"1","first_page":"2486564","last_page":"2486564"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.7207000255584717,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.7207000255584717,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.20980000495910645,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.01860000006854534,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.9440000057220459},{"id":"https://openalex.org/keywords/naive-cd8-t-cells","display_name":"naive CD8+ T cells","score":0.8820000290870667},{"id":"https://openalex.org/keywords/immune-cell-phenotypes","display_name":"immune cell phenotypes","score":0.871999979019165},{"id":"https://openalex.org/keywords/cd45ra","display_name":"CD45RA","score":0.7480000257492065},{"id":"https://openalex.org/keywords/cd28","display_name":"CD28","score":0.8220000267028809},{"id":"https://openalex.org/keywords/t-cell-subsets","display_name":"T cell subsets","score":0.5709999799728394},{"id":"https://openalex.org/keywords/estimated-glomerular-filtration-rate","display_name":"estimated glomerular filtration rate","score":0.847000002861023},{"id":"https://openalex.org/keywords/causal-relationship","display_name":"causal relationship","score":0.34200000762939453}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9277154207229614},{"id":"https://openalex.org/C2779901538","wikidata":"https://www.wikidata.org/wiki/Q6816584","display_name":"Mendelian randomization","level":5,"score":0.805027961730957},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.6609331965446472},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.509755551815033},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.449984073638916},{"id":"https://openalex.org/C46762472","wikidata":"https://www.wikidata.org/wiki/Q178648","display_name":"Peripheral","level":2,"score":0.43277448415756226},{"id":"https://openalex.org/C204243189","wikidata":"https://www.wikidata.org/wiki/Q1363085","display_name":"Randomization","level":3,"score":0.41880926489830017},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.3708987236022949},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2498474419116974},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17234262824058533},{"id":"https://openalex.org/C2993967602","wikidata":"https://www.wikidata.org/wiki/Q5532932","display_name":"Genetic variants","level":4,"score":0.10487353801727295},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D005919","descriptor_name":"Glomerular Filtration Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005919","descriptor_name":"Glomerular Filtration Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005919","descriptor_name":"Glomerular Filtration Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005919","descriptor_name":"Glomerular Filtration Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017493","descriptor_name":"Leukocyte Common Antigens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017493","descriptor_name":"Leukocyte Common Antigens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017493","descriptor_name":"Leukocyte Common Antigens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017493","descriptor_name":"Leukocyte Common Antigens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018106","descriptor_name":"CD28 Antigens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018106","descriptor_name":"CD28 Antigens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018106","descriptor_name":"CD28 Antigens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018106","descriptor_name":"CD28 Antigens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051436","descriptor_name":"Renal Insufficiency, Chronic","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D051436","descriptor_name":"Renal Insufficiency, Chronic","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D051436","descriptor_name":"Renal Insufficiency, Chronic","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D051436","descriptor_name":"Renal Insufficiency, Chronic","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D051436","descriptor_name":"Renal Insufficiency, Chronic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051436","descriptor_name":"Renal Insufficiency, Chronic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051436","descriptor_name":"Renal Insufficiency, Chronic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051436","descriptor_name":"Renal Insufficiency, Chronic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051436","descriptor_name":"Renal Insufficiency, Chronic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D051436","descriptor_name":"Renal Insufficiency, Chronic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D051436","descriptor_name":"Renal Insufficiency, Chronic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D051436","descriptor_name":"Renal Insufficiency, Chronic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057182","descriptor_name":"Mendelian Randomization Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057182","descriptor_name":"Mendelian Randomization Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057182","descriptor_name":"Mendelian Randomization Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057182","descriptor_name":"Mendelian Randomization Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1080/0886022x.2025.2486564","doi":"https://doi.org/10.1080/0886022x.2025.2486564","is_oa":true,"landing_page_url":"https://doi.org/10.1080/0886022x.2025.2486564","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/0886022X.2025.2486564?needAccess=true","source":{"id":"https://openalex.org/S159051371","display_name":"Renal Failure","issn_l":"0886-022X","issn":["0886-022X","1525-6049"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Renal Failure","raw_type":"journal-article"},{"id":"pmid:40230080","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40230080","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Renal failure","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12001844","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12001844","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Ren Fail","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:c014149051444a1385b18c6a7fa8e2df","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/c014149051444a1385b18c6a7fa8e2df","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Renal Failure, Vol 47, Iss 1 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1080/0886022x.2025.2486564","doi":"https://doi.org/10.1080/0886022x.2025.2486564","is_oa":true,"landing_page_url":"https://doi.org/10.1080/0886022x.2025.2486564","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/0886022X.2025.2486564?needAccess=true","source":{"id":"https://openalex.org/S159051371","display_name":"Renal Failure","issn_l":"0886-022X","issn":["0886-022X","1525-6049"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Renal Failure","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G3070824696","display_name":null,"funder_award_id":"2022YFC2505400","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G5439059038","display_name":null,"funder_award_id":"81871709","funder_id":"https://openalex.org/F4320338464","funder_display_name":"Natural Science Foundation of Zhejiang Province"},{"id":"https://openalex.org/G7154230651","display_name":null,"funder_award_id":"81871709","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G800128210","display_name":"\u57fa\u4e8e\u591a\u7ec4\u5b66\u7814\u7a76\u9274\u5b9a\u8db3\u7ec6\u80de\u635f\u4f24\u5173\u952e\u4fe1\u53f7\u901a\u8def","funder_award_id":"LZ23H050001","funder_id":"https://openalex.org/F4320338464","funder_display_name":"Natural Science Foundation of Zhejiang Province"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null},{"id":"https://openalex.org/F4320338464","display_name":"Natural Science Foundation of Zhejiang Province","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4409464950.pdf","grobid_xml":"https://content.openalex.org/works/W4409464950.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W2057320783","https://openalex.org/W2076646346","https://openalex.org/W2084286425","https://openalex.org/W2220658969","https://openalex.org/W2324862792","https://openalex.org/W2395845086","https://openalex.org/W2516337081","https://openalex.org/W2614566443","https://openalex.org/W2792067435","https://openalex.org/W2890160268","https://openalex.org/W2898009865","https://openalex.org/W2921513648","https://openalex.org/W2921747719","https://openalex.org/W2947278243","https://openalex.org/W2948845640","https://openalex.org/W3082080695","https://openalex.org/W3086825014","https://openalex.org/W3095099370","https://openalex.org/W3126919822","https://openalex.org/W3129223336","https://openalex.org/W3131410378","https://openalex.org/W3175144511","https://openalex.org/W3186721658","https://openalex.org/W3198169944","https://openalex.org/W3199682713","https://openalex.org/W3200530198","https://openalex.org/W3208523646","https://openalex.org/W4200507892","https://openalex.org/W4206030832","https://openalex.org/W4211136945","https://openalex.org/W4221013537","https://openalex.org/W4228997070","https://openalex.org/W4238030285","https://openalex.org/W4280554493","https://openalex.org/W4281767226","https://openalex.org/W4294679006","https://openalex.org/W4304809004","https://openalex.org/W4307031794","https://openalex.org/W4315631231","https://openalex.org/W4318479365","https://openalex.org/W4362704620"],"related_works":["https://openalex.org/W2901309888","https://openalex.org/W2169283889","https://openalex.org/W4210703904","https://openalex.org/W2052821216","https://openalex.org/W4404875725","https://openalex.org/W2036527494","https://openalex.org/W2610080820","https://openalex.org/W4294125588","https://openalex.org/W2416849719","https://openalex.org/W2015148400"],"abstract_inverted_index":{"Background":[0],"The":[1],"global":[2],"incidence":[3],"of":[4,23,43,69,103,108,124,140,146,161,167,189,223,241],"chronic":[5],"kidney":[6],"disease":[7],"(CKD)":[8],"is":[9],"rising":[10],"rapidly.":[11],"Immune":[12],"cells":[13,129,145,149,166,170,194,227],"play":[14],"a":[15,203,216],"crucial":[16],"role":[17],"in":[18,57,62],"the":[19,26,39,63,67,101,106,121,138,159,187,212,221],"onset":[20,68,107],"and":[21,29,41,46,87,158,182,228,239],"progression":[22],"CKD,":[24],"however,":[25],"causal":[27,206],"relationships":[28],"underlying":[30],"immunological":[31],"mechanisms":[32],"remain":[33],"incompletely":[34],"elucidated.":[35],"This":[36,231],"deficiency":[37],"hinders":[38],"development":[40],"application":[42],"early":[44,237],"interventions":[45],"immunotherapies":[47],"for":[48,79,85,236],"CKD.Methods":[49],"In":[50],"this":[51],"study,":[52],"we":[53,99],"hypothesize":[54],"that":[55],"alterations":[56],"immune":[58],"cell":[59],"phenotypes":[60],"(ICPs)":[61],"blood":[64],"may":[65],"influence":[66],"CKD.":[70,242],"We":[71,210],"collated":[72],"Genome":[73],"Wide":[74],"Association":[75],"Studies":[76],"(GWAS)":[77],"data":[78,84],"731":[80],"ICPs,":[81],"alongside":[82],"summary":[83],"CKD":[86,119,229],"estimated":[88],"glomerular":[89],"filtration":[90],"rate":[91],"(eGFR).":[92],"Utilizing":[93],"bidirectional":[94],"mendelian":[95],"randomization":[96],"analysis":[97],"(MR),":[98],"identified":[100],"impact":[102,207],"ICPs":[104,115],"on":[105,208],"CKD.Results":[109],"Preliminary":[110],"MR":[111,184],"analyses":[112],"revealed":[113],"three":[114],"positively":[116],"associated":[117],"with":[118],"onset:":[120],"absolute":[122],"number":[123],"CD45RA+":[125,142,191],"CD28\u2212":[126,163],"CD8+":[127,143,164,192,196,225],"T":[128,144,148,165,169,193,197,226],"(p":[130,150,171],"=":[131,151,172],"1.209":[132],"\u00d7":[133,153,174],"10\u221215,":[134],"95%":[135,155,176],"CI:":[136,156,177],"1.0002\u20131.0003),":[137],"percentage":[139,160,188,222],"CD28+":[141,190],"total":[147,168],"5.831":[152],"10\u22126,":[154],"1.0028\u20131.0070),":[157],"CD45RA\u2212":[162],"4.292":[173],"10\u22125,":[175],"1.0005\u20131.0015).":[178],"After":[179],"conducting":[180],"sensitivity":[181],"reverse":[183],"analyses,":[185],"only":[186],"(na\u00efve":[195],"Cells)":[198],"was":[199],"found":[200],"to":[201,214],"have":[202],"sufficiently":[204],"robust":[205],"CKD.Conclusion":[209],"are":[211],"first":[213],"demonstrate":[215],"significant":[217],"positive":[218],"association":[219],"between":[220],"na\u00efve":[224],"onset.":[230],"finding":[232],"offers":[233],"new":[234],"insights":[235],"prevention":[238],"treatment":[240]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-09-30T09:27:27.532063","created_date":"2025-04-16T00:00:00"}