{"id":"https://openalex.org/W4409464656","doi":"https://doi.org/10.53555/4zsset98","title":"INFLAMMATORY MARKERS AND HEMOGLOBIN A1C IN TYPE 2 DIABETIC PATIENTS AND PATIENTS WITH DIABETIC FOOT ULCERS IN KARACHI, PAKISTAN","display_name":"INFLAMMATORY MARKERS AND HEMOGLOBIN A1C IN TYPE 2 DIABETIC PATIENTS AND PATIENTS WITH DIABETIC FOOT ULCERS IN KARACHI, PAKISTAN","publication_year":2025,"publication_date":"2025-04-15","ids":{"openalex":"https://openalex.org/W4409464656","doi":"https://doi.org/10.53555/4zsset98"},"language":"en","primary_location":{"id":"doi:10.53555/4zsset98","doi":"https://doi.org/10.53555/4zsset98","is_oa":true,"landing_page_url":"https://doi.org/10.53555/4zsset98","pdf_url":"https://www.jptcp.com/index.php/jptcp/article/download/9831/9167","source":{"id":"https://openalex.org/S4210224141","display_name":"Journal of Population Therapeutics and Clinical Pharmacology","issn_l":"1710-6222","issn":["1710-6222","1198-581X","2561-8741"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310318016","host_organization_name":"Codon Publications","host_organization_lineage":["https://openalex.org/P4310318016"],"host_organization_lineage_names":["Codon Publications"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Population Therapeutics and Clinical Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.jptcp.com/index.php/jptcp/article/download/9831/9167","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015864002","display_name":"Saleem Ullah Abro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25974024","display_name":"Baqai Medical University","ror":"https://ror.org/01v2x9m21","country_code":"PK","type":"education","lineage":["https://openalex.org/I25974024"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Saleem Ullah Abro","raw_affiliation_strings":["Assistant Professor, Department of Physiology , Baqai Medical University , Karachi , Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Assistant Professor, Department of Physiology , Baqai Medical University , Karachi , Pakistan","institution_ids":["https://openalex.org/I25974024"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032513584","display_name":"Qamar Aziz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25974024","display_name":"Baqai Medical University","ror":"https://ror.org/01v2x9m21","country_code":"PK","type":"education","lineage":["https://openalex.org/I25974024"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Qamar Aziz","raw_affiliation_strings":["Professor, Department of Physiology , Baqai Medical University , Karachi"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Professor, Department of Physiology , Baqai Medical University , Karachi","institution_ids":["https://openalex.org/I25974024"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082013594","display_name":"Iftikhar Ahmed","orcid":"https://orcid.org/0000-0003-0969-7927","observed_orcids":["https://orcid.org/0000-0003-0969-7927"]},"institutions":[{"id":"https://openalex.org/I25974024","display_name":"Baqai Medical University","ror":"https://ror.org/01v2x9m21","country_code":"PK","type":"education","lineage":["https://openalex.org/I25974024"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Iftikhar Ahmed","raw_affiliation_strings":["Professor of Biochemistry and research department & Vice-Chancellor , Baqai Medical University , Karachi"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Professor of Biochemistry and research department & Vice-Chancellor , Baqai Medical University , Karachi","institution_ids":["https://openalex.org/I25974024"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084787165","display_name":"Qurratulain Saleem","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1312995270","display_name":"Karachi Medical and Dental College","ror":"https://ror.org/02afbf040","country_code":"PK","type":"education","lineage":["https://openalex.org/I1312995270"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Qurratulain Saleem","raw_affiliation_strings":["Assistant Professor, Department of Community Medicine Health Sciences , KMDC , Karachi ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Assistant Professor, Department of Community Medicine Health Sciences , KMDC , Karachi ,","institution_ids":["https://openalex.org/I1312995270"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039505219","display_name":"Kashif Ikram","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25974024","display_name":"Baqai Medical University","ror":"https://ror.org/01v2x9m21","country_code":"PK","type":"education","lineage":["https://openalex.org/I25974024"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Kashif Ikram","raw_affiliation_strings":["Professor of Oral & Maxillofacial Surgery Department & Pro Vice Chancellor , Baqai Medical University , Karachi "],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Professor of Oral & Maxillofacial Surgery Department & Pro Vice Chancellor , Baqai Medical University , Karachi ","institution_ids":["https://openalex.org/I25974024"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081659947","display_name":"Ruqaya Nangrejo","orcid":"https://orcid.org/0000-0002-4007-689X","observed_orcids":["https://orcid.org/0000-0002-4007-689X"]},"institutions":[{"id":"https://openalex.org/I25974024","display_name":"Baqai Medical University","ror":"https://ror.org/01v2x9m21","country_code":"PK","type":"education","lineage":["https://openalex.org/I25974024"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Ruqaya Nangrejo","raw_affiliation_strings":["Associate Professor Department of Physiology , Baqai Medical University , Karachi","Metropolitan University , Karachi"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Associate Professor Department of Physiology , Baqai Medical University , Karachi","institution_ids":["https://openalex.org/I25974024"]},{"raw_affiliation_string":"Metropolitan University , Karachi","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.07986147,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11227","display_name":"Diabetic Foot Ulcer Assessment and Management","score":0.9409000277519226,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11227","display_name":"Diabetic Foot Ulcer Assessment and Management","score":0.9409000277519226,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12433","display_name":"Skin Diseases and Diabetes","score":0.013000000268220901,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.010200000368058681,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9909999966621399},{"id":"https://openalex.org/keywords/diabetic-foot-ulcer","display_name":"diabetic foot ulcer","score":0.9070000052452087},{"id":"https://openalex.org/keywords/inflammatory-markers","display_name":"inflammatory markers","score":0.9049999713897705},{"id":"https://openalex.org/keywords/hba1c","display_name":"HbA1c","score":0.9879999756813049},{"id":"https://openalex.org/keywords/superoxide-dismutase","display_name":"superoxide dismutase","score":0.9739999771118164},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":1.0},{"id":"https://openalex.org/keywords/neutrophil-to-lymphocyte-ratio","display_name":"neutrophil-to-lymphocyte ratio","score":0.9980000257492065},{"id":"https://openalex.org/keywords/glycemic-control","display_name":"glycemic control","score":0.7940000295639038}],"concepts":[{"id":"https://openalex.org/C2777858829","wikidata":"https://www.wikidata.org/wiki/Q52856","display_name":"Diabetic foot","level":3,"score":0.807160496711731},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7728223204612732},{"id":"https://openalex.org/C2778917026","wikidata":"https://www.wikidata.org/wiki/Q43041","display_name":"Hemoglobin","level":2,"score":0.6846114993095398},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6021755933761597},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.5825269818305969},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.43831369280815125},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.381406307220459},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.16222000122070312}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.53555/4zsset98","doi":"https://doi.org/10.53555/4zsset98","is_oa":true,"landing_page_url":"https://doi.org/10.53555/4zsset98","pdf_url":"https://www.jptcp.com/index.php/jptcp/article/download/9831/9167","source":{"id":"https://openalex.org/S4210224141","display_name":"Journal of Population Therapeutics and Clinical Pharmacology","issn_l":"1710-6222","issn":["1710-6222","1198-581X","2561-8741"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310318016","host_organization_name":"Codon Publications","host_organization_lineage":["https://openalex.org/P4310318016"],"host_organization_lineage_names":["Codon Publications"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Population Therapeutics and Clinical Pharmacology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.53555/4zsset98","doi":"https://doi.org/10.53555/4zsset98","is_oa":true,"landing_page_url":"https://doi.org/10.53555/4zsset98","pdf_url":"https://www.jptcp.com/index.php/jptcp/article/download/9831/9167","source":{"id":"https://openalex.org/S4210224141","display_name":"Journal of Population Therapeutics and Clinical Pharmacology","issn_l":"1710-6222","issn":["1710-6222","1198-581X","2561-8741"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310318016","host_organization_name":"Codon Publications","host_organization_lineage":["https://openalex.org/P4310318016"],"host_organization_lineage_names":["Codon Publications"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Population Therapeutics and Clinical Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.5799999833106995,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4409464656.pdf","grobid_xml":"https://content.openalex.org/works/W4409464656.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2413574007","https://openalex.org/W4235499160","https://openalex.org/W1975155354","https://openalex.org/W2350944202","https://openalex.org/W2152119596","https://openalex.org/W1999189760","https://openalex.org/W2085546626","https://openalex.org/W2020590919","https://openalex.org/W338497432","https://openalex.org/W4390515809"],"abstract_inverted_index":{"Objective:":[0],"To":[1],"evaluate":[2],"the":[3,32,46,56,102,122,141,154,177,196,200,236],"inflammatory":[4],"markers":[5],"and":[6,15,51,71,82,108,140,182,205,214,228],"hemoglobin":[7,106,133,180],"A1c":[8,181],"levels":[9,217,230],"in":[10,21,53,176,235,242],"type":[11,78,243],"2":[12,79,244],"diabetic":[13,18,75,245],"patients":[14,68],"those":[16],"with":[17,55,74],"foot":[19,76,239],"ulcers":[20,91],"Karachi,":[22,64],"Pakistan.":[23,65],"Study":[24],"design:":[25],"cross-sectional":[26],"study.":[27],"Place":[28],"&":[29],"duration":[30],"of":[31,49,58,199,238],"study:":[33],"The":[34,94,128],"study":[35,224],"will":[36],"take":[37],"place":[38],"from":[39],"June":[40,43],"2023":[41],"to":[42,120,153],"2024":[44],"at":[45,60],"Baqai":[47,61],"Institute":[48],"Diabetes":[50],"Endocrinology,":[52],"collaboration":[54],"Department":[57],"Physiology":[59],"Medical":[62],"University,":[63],"Methodology:":[66],"138":[67],"were":[69,92,113],"included":[70],"grouped":[72],"into":[73],"ulcers,":[77],"diabetes":[80,86],"mellitus,":[81,87],"control":[83],"subjects.":[84],"Insulin-dependent":[85],"or":[88],"lower":[89],"limb":[90],"excluded.":[93],"ELISA":[95],"assay":[96],"technique":[97],"for":[98,105,132],"superoxide":[99,135,215],"dismutase":[100,136,216],"analysis,":[101],"HPLC":[103],"method":[104],"A1c,":[107,134,213],"complete":[109],"blood":[110],"count":[111],"analyzer":[112],"used.":[114],"SPSS":[115],"version":[116],"23":[117],"was":[118,125,169,191],"used":[119],"analyze":[121],"data":[123],"that":[124,167],"gathered.":[126],"Results:":[127],"three":[129,187],"groups'":[130],"medians":[131],"(SOD),":[137],"C-reactive":[138,206],"protein,":[139],"neutrophil-to-lymphocyte":[142],"ratio":[143],"(NLR)":[144],"all":[145,186],"showed":[146],"significant":[147,171,193,221],"differences":[148],"(p":[149,173,202,208],"<":[150,174],"0.01)":[151,175],"according":[152],"Kruskal-Wallis":[155],"test.":[156],"Nevertheless,":[157],"a":[158,170,219,232],"post":[159],"hoc":[160],"analysis":[161],"employing":[162],"Tukey's":[163],"HSD":[164],"test":[165],"revealed":[166],"there":[168,190],"difference":[172,194],"median":[178,197],"serum":[179],"SOD":[183,229],"values":[184],"across":[185],"groups.":[188],"Conversely,":[189],"no":[192],"between":[195],"concentration":[198],"NLR":[201],"=":[203,209],"0.84)":[204],"protein":[207],"0.90).":[210],"Conclusion:":[211],"Hemoglobin":[212,226],"show":[218],"statistically":[220],"association":[222],"among":[223],"participants.":[225],"A1C":[227],"have":[231],"critical":[233],"role":[234],"pathogenesis":[237],"ulcer":[240],"development":[241],"patients.":[246]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2025-10-10T00:00:00"}