{"id":"https://openalex.org/W4409460583","doi":"https://doi.org/10.1186/s12967-025-06420-7","title":"SF3B4 regulates proliferation and apoptosis in hepatocellular carcinoma via alternative splicing and interaction with TRIM28 and SETD5","display_name":"SF3B4 regulates proliferation and apoptosis in hepatocellular carcinoma via alternative splicing and interaction with TRIM28 and SETD5","publication_year":2025,"publication_date":"2025-04-15","ids":{"openalex":"https://openalex.org/W4409460583","doi":"https://doi.org/10.1186/s12967-025-06420-7","pmid":"https://pubmed.ncbi.nlm.nih.gov/40234915","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11998331"},"language":"en","primary_location":{"id":"doi:10.1186/s12967-025-06420-7","doi":"https://doi.org/10.1186/s12967-025-06420-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12967-025-06420-7","pdf_url":"https://translational-medicine.biomedcentral.com/counter/pdf/10.1186/s12967-025-06420-7","source":{"id":"https://openalex.org/S142026636","display_name":"Journal of Translational Medicine","issn_l":"1479-5876","issn":["1479-5876"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Translational Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://translational-medicine.biomedcentral.com/counter/pdf/10.1186/s12967-025-06420-7","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003825127","display_name":"Hanfei Huang","orcid":"https://orcid.org/0000-0003-3302-823X","observed_orcids":["https://orcid.org/0000-0003-3302-823X","https://orcid.org/0000-0002-0852-9596"]},"institutions":[{"id":"https://openalex.org/I4210120169","display_name":"First Affiliated Hospital of Kunming Medical University","ror":"https://ror.org/02g01ht84","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210120169"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"HanFei Huang","raw_affiliation_strings":["Organ Transplantation Center, The First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming, Yunnan Province, 650032, PR China. huanghanfei@kmmu.edu.cn"],"raw_orcid":"https://orcid.org/0000-0003-3302-823X","affiliations":[{"raw_affiliation_string":"Organ Transplantation Center, The First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming, Yunnan Province, 650032, PR China. huanghanfei@kmmu.edu.cn","institution_ids":["https://openalex.org/I4210120169"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101805124","display_name":"Yuan Fang","orcid":"https://orcid.org/0009-0005-3581-4455","observed_orcids":["https://orcid.org/0009-0005-3581-4455"]},"institutions":[{"id":"https://openalex.org/I4210120169","display_name":"First Affiliated Hospital of Kunming Medical University","ror":"https://ror.org/02g01ht84","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210120169"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuan Fang","raw_affiliation_strings":["Organ Transplantation Center, The First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming, Yunnan Province, 650032, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Organ Transplantation Center, The First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming, Yunnan Province, 650032, PR China","institution_ids":["https://openalex.org/I4210120169"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083429334","display_name":"ZhiTao Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210120169","display_name":"First Affiliated Hospital of Kunming Medical University","ror":"https://ror.org/02g01ht84","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210120169"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"ZhiTao Li","raw_affiliation_strings":["Organ Transplantation Center, The First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming, Yunnan Province, 650032, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Organ Transplantation Center, The First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming, Yunnan Province, 650032, PR China","institution_ids":["https://openalex.org/I4210120169"]}]},{"author_position":"middle","author":{"id":null,"display_name":"SiMing Qu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210120169","display_name":"First Affiliated Hospital of Kunming Medical University","ror":"https://ror.org/02g01ht84","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210120169"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"SiMing Qu","raw_affiliation_strings":["Organ Transplantation Center, The First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming, Yunnan Province, 650032, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Organ Transplantation Center, The First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming, Yunnan Province, 650032, PR China","institution_ids":["https://openalex.org/I4210120169"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102974193","display_name":"Bo Yuan","orcid":"https://orcid.org/0000-0003-4544-7802","observed_orcids":["https://orcid.org/0000-0003-4544-7802"]},"institutions":[{"id":"https://openalex.org/I4210120169","display_name":"First Affiliated Hospital of Kunming Medical University","ror":"https://ror.org/02g01ht84","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210120169"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bo Yuan","raw_affiliation_strings":["Organ Transplantation Center, The First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming, Yunnan Province, 650032, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Organ Transplantation Center, The First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming, Yunnan Province, 650032, PR China","institution_ids":["https://openalex.org/I4210120169"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061571440","display_name":"Kai Gan","orcid":"https://orcid.org/0009-0009-0286-907X","observed_orcids":["https://orcid.org/0009-0009-0286-907X"]},"institutions":[{"id":"https://openalex.org/I4210120169","display_name":"First Affiliated Hospital of Kunming Medical University","ror":"https://ror.org/02g01ht84","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210120169"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kai Gan","raw_affiliation_strings":["Organ Transplantation Center, The First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming, Yunnan Province, 650032, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Organ Transplantation Center, The First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming, Yunnan Province, 650032, PR China","institution_ids":["https://openalex.org/I4210120169"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081305232","display_name":"Chaochi Yue","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210120169","display_name":"First Affiliated Hospital of Kunming Medical University","ror":"https://ror.org/02g01ht84","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210120169"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"ChengLong Yue","raw_affiliation_strings":["Organ Transplantation Center, The First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming, Yunnan Province, 650032, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Organ Transplantation Center, The First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming, Yunnan Province, 650032, PR China","institution_ids":["https://openalex.org/I4210120169"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039438734","display_name":"Haijing Li","orcid":"https://orcid.org/0000-0001-9332-8993","observed_orcids":["https://orcid.org/0000-0001-9332-8993"]},"institutions":[{"id":"https://openalex.org/I4210120169","display_name":"First Affiliated Hospital of Kunming Medical University","ror":"https://ror.org/02g01ht84","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210120169"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"HaiJing Li","raw_affiliation_strings":["Organ Transplantation Center, The First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming, Yunnan Province, 650032, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Organ Transplantation Center, The First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming, Yunnan Province, 650032, PR China","institution_ids":["https://openalex.org/I4210120169"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011387822","display_name":"Yuqi Wen","orcid":"https://orcid.org/0000-0002-2391-3297","observed_orcids":["https://orcid.org/0000-0002-2391-3297"]},"institutions":[{"id":"https://openalex.org/I4210120169","display_name":"First Affiliated Hospital of Kunming Medical University","ror":"https://ror.org/02g01ht84","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210120169"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"YuBo Wen","raw_affiliation_strings":["Organ Transplantation Center, The First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming, Yunnan Province, 650032, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Organ Transplantation Center, The First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming, Yunnan Province, 650032, PR China","institution_ids":["https://openalex.org/I4210120169"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112536377","display_name":"Zhong Zeng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210120169","display_name":"First Affiliated Hospital of Kunming Medical University","ror":"https://ror.org/02g01ht84","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210120169"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhong Zeng","raw_affiliation_strings":["Organ Transplantation Center, The First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming, Yunnan Province, 650032, PR China. zengzhong@kmmu.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Organ Transplantation Center, The First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming, Yunnan Province, 650032, PR China. zengzhong@kmmu.edu.cn","institution_ids":["https://openalex.org/I4210120169"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5003825127","https://openalex.org/A5112536377"],"corresponding_institution_ids":["https://openalex.org/I4210120169"],"apc_list":{"value":3890,"currency":"USD","value_usd":3890},"apc_paid":{"value":3890,"currency":"USD","value_usd":3890},"fwci":2.2077,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.87722237,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"23","issue":"1","first_page":"441","last_page":"441"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sf3b4","display_name":"SF3B4","score":1.0},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9850000143051147},{"id":"https://openalex.org/keywords/alternative-splicing","display_name":"alternative splicing","score":0.9739999771118164},{"id":"https://openalex.org/keywords/trim28","display_name":"TRIM28","score":0.9290000200271606},{"id":"https://openalex.org/keywords/setd5","display_name":"SETD5","score":1.0},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9010000228881836},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":1.0},{"id":"https://openalex.org/keywords/pre-mrna-splicing","display_name":"pre-mRNA splicing","score":0.9079999923706055},{"id":"https://openalex.org/keywords/rna-binding-proteins","display_name":"RNA-binding proteins","score":0.7139999866485596},{"id":"https://openalex.org/keywords/transcriptome","display_name":"transcriptome","score":0.3400000035762787},{"id":"https://openalex.org/keywords/huh7-cells","display_name":"Huh7 cells","score":0.7720000147819519}],"concepts":[{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.8094291687011719},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6602684259414673},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5719634294509888},{"id":"https://openalex.org/C194583182","wikidata":"https://www.wikidata.org/wiki/Q21114084","display_name":"Alternative splicing","level":4,"score":0.519788384437561},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.39209312200546265},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3787662386894226},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.36205482482910156},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32456815242767334},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16069772839546204},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08483865857124329},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000072260","descriptor_name":"RNA Splicing Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000072260","descriptor_name":"RNA Splicing Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000076183","descriptor_name":"Tripartite Motif-Containing Protein 28","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000076183","descriptor_name":"Tripartite Motif-Containing Protein 28","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011495","descriptor_name":"Histone-Lysine N-Methyltransferase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017398","descriptor_name":"Alternative Splicing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12967-025-06420-7","doi":"https://doi.org/10.1186/s12967-025-06420-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12967-025-06420-7","pdf_url":"https://translational-medicine.biomedcentral.com/counter/pdf/10.1186/s12967-025-06420-7","source":{"id":"https://openalex.org/S142026636","display_name":"Journal of Translational Medicine","issn_l":"1479-5876","issn":["1479-5876"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Translational Medicine","raw_type":"journal-article"},{"id":"pmid:40234915","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40234915","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of translational medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11998331","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11998331/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Transl Med","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:3122a80d12804f13b5eeeae098af37e4","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/3122a80d12804f13b5eeeae098af37e4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Translational Medicine, Vol 23, Iss 1, Pp 1-13 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12967-025-06420-7","doi":"https://doi.org/10.1186/s12967-025-06420-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12967-025-06420-7","pdf_url":"https://translational-medicine.biomedcentral.com/counter/pdf/10.1186/s12967-025-06420-7","source":{"id":"https://openalex.org/S142026636","display_name":"Journal of Translational Medicine","issn_l":"1479-5876","issn":["1479-5876"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Translational Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6027953964","display_name":"HO-1\u8c03\u63a7\u809d\u7aa6\u5185\u76ae\u7ec6\u80deVEGF-VEGFR2-Id1\u4fe1\u53f7\u8f74\u4fc3\u8fdb\u809d\u518d\u751f\u7684\u673a\u5236\u7814\u7a76","funder_award_id":"81960124","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7406878059","display_name":"MSCs-exo\u4ecb\u5bfcmiR-210\u4fc3\u8fdb\u80c6\u9053\u7f3a\u8840\u518d\u704c\u6ce8\u635f\u4f24\u4fee\u590d\u7684\u673a\u5236\u7814\u7a76","funder_award_id":"81960123","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322268","display_name":"Kunming Medical University","ror":"https://ror.org/038c3w259"},{"id":"https://openalex.org/F4320323193","display_name":"Natural Science Foundation of Yunnan Province","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320324734","display_name":"Yunnan Provincial Department of Education","ror":"https://ror.org/02yrxdp92"},{"id":"https://openalex.org/F4320330390","display_name":"Yunnan Provincial Department of Education Science Research Fund Project","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4409460583.pdf","grobid_xml":"https://content.openalex.org/works/W4409460583.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W2167866392","https://openalex.org/W2410733405","https://openalex.org/W2603019688","https://openalex.org/W2739219841","https://openalex.org/W2753351580","https://openalex.org/W2788693573","https://openalex.org/W2898761942","https://openalex.org/W2964849163","https://openalex.org/W3021622833","https://openalex.org/W3028521173","https://openalex.org/W3176757911","https://openalex.org/W4205816714","https://openalex.org/W4210955410","https://openalex.org/W4211105405","https://openalex.org/W4214780164","https://openalex.org/W4214953362","https://openalex.org/W4221165332","https://openalex.org/W4232620598","https://openalex.org/W4285797291","https://openalex.org/W4379769509","https://openalex.org/W4385142935","https://openalex.org/W4388033951","https://openalex.org/W4399098282","https://openalex.org/W4400838227","https://openalex.org/W4403835833","https://openalex.org/W4404433748","https://openalex.org/W4407597387"],"related_works":["https://openalex.org/W7162007712","https://openalex.org/W3015106195","https://openalex.org/W2898761942","https://openalex.org/W2742083022","https://openalex.org/W2410733405","https://openalex.org/W4415035245","https://openalex.org/W4409889598","https://openalex.org/W3186314369","https://openalex.org/W4361730993","https://openalex.org/W7128923859"],"abstract_inverted_index":{"BACKGROUND:":[0],"SF3B4":[1,37,67,102,114,167,177,189,200],"encodes":[2],"a":[3,145,150,158],"core":[4],"subunit":[5],"of":[6,62,113,127,153,160],"the":[7,51,60,70,97,122,125,135],"U2-type":[8],"spliceosome":[9],"and":[10,17,26,72,106,117,209,217],"is":[11],"implicated":[12],"in":[13,22,29,41,76,82,109],"abnormal":[14],"cell":[15,119],"growth":[16],"tumorigenesis.":[18],"However,":[19],"its":[20,184],"role":[21,143],"regulating":[23,214],"gene":[24,104,215],"expression":[25,38,105,186,216],"alternative":[27,73,107,129,193,218],"splicing":[28,74,108,130,146,155,194],"hepatocellular":[30],"carcinoma":[31],"(HCC)":[32],"remains":[33],"inadequately":[34],"understood.":[35],"METHODS:":[36],"was":[39],"downregulated":[40],"HCC":[42,77,203],"cells,":[43],"followed":[44],"by":[45,55,66,100,166,195,205],"high-throughput":[46],"transcriptome":[47],"sequencing":[48],"to":[49,95,180,202],"capture":[50],"transcriptomic":[52],"changes":[53],"induced":[54],"SF3B4.":[56],"This":[57],"approach":[58],"facilitated":[59],"identification":[61],"potential":[63],"targets":[64,164],"regulated":[65,128],"at":[68],"both":[69],"transcriptional":[71],"levels":[75],"cells.":[78],"Additionally,":[79,188],"SF3B4-binding":[80],"RNAs":[81],"Huh7":[83],"cells":[84],"were":[85,92,168],"identified":[86],"through":[87],"iRIP-seq.":[88],"The":[89],"RNA-seq":[90,123,173],"data":[91,174],"subsequently":[93],"analyzed":[94],"elucidate":[96],"molecular":[98],"mechanisms":[99],"which":[101],"affects":[103],"HCC.":[110],"RESULTS:":[111],"Downregulation":[112],"promoted":[115],"apoptosis":[116],"inhibited":[118],"proliferation.":[120],"In":[121],"data,":[124],"number":[126],"events":[131],"(RASE)":[132],"significantly":[133],"outnumbered":[134],"differentially":[136],"expressed":[137],"genes":[138],"(DEGs),":[139],"consistent":[140],"with":[141,172,197,211],"SF3B4's":[142],"as":[144],"factor":[147],"that":[148,176],"regulates":[149],"wide":[151],"array":[152],"pre-mRNA":[154,192],"events.":[156],"Furthermore,":[157],"total":[159],"252":[161],"common":[162],"RNA":[163],"bound":[165],"identified.":[169],"Correlation":[170],"analysis":[171],"suggested":[175],"may":[178,190],"bind":[179],"TRIM28,":[181],"potentially":[182],"modulating":[183],"mRNA":[185],"levels.":[187],"influence":[191],"interacting":[196,210],"SETD5.":[198],"CONCLUSION:":[199],"contributes":[201],"progression":[204],"directly":[206],"binding":[207],"mRNAs":[208],"proteins,":[212],"thereby":[213],"splicing.":[219]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2025-04-16T00:00:00"}