{"id":"https://openalex.org/W4409453036","doi":"https://doi.org/10.1016/j.jacc.2025.03.144","title":"TCTAP A-097 The In-Silico Analysis of Andrographolide and Its Derivatives to Mitigate Hypertensive-Induced Cardiac Remodeling: Insights From Differential Gene Expression and Computational Modeling","display_name":"TCTAP A-097 The In-Silico Analysis of Andrographolide and Its Derivatives to Mitigate Hypertensive-Induced Cardiac Remodeling: Insights From Differential Gene Expression and Computational Modeling","publication_year":2025,"publication_date":"2025-04-01","ids":{"openalex":"https://openalex.org/W4409453036","doi":"https://doi.org/10.1016/j.jacc.2025.03.144"},"language":"en","primary_location":{"id":"doi:10.1016/j.jacc.2025.03.144","doi":"https://doi.org/10.1016/j.jacc.2025.03.144","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jacc.2025.03.144","pdf_url":null,"source":{"id":"https://openalex.org/S60865174","display_name":"Journal of the American College of Cardiology","issn_l":"0735-1097","issn":["0735-1097","1558-3597"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American College of Cardiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.1016/j.jacc.2025.03.144","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001922981","display_name":"Muhamad Rizqy Fadhillah","orcid":"https://orcid.org/0000-0002-3388-4864","observed_orcids":["https://orcid.org/0000-0002-3388-4864"]},"institutions":[{"id":"https://openalex.org/I29617571","display_name":"University of Indonesia","ror":"https://ror.org/0116zj450","country_code":"ID","type":"education","lineage":["https://openalex.org/I29617571"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Muhamad Rizqy Fadhillah","raw_affiliation_strings":["Universitas Indonesia, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universitas Indonesia, Indonesia","institution_ids":["https://openalex.org/I29617571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014285586","display_name":"Wawaimuli Arozal","orcid":"https://orcid.org/0000-0002-8071-9001","observed_orcids":["https://orcid.org/0000-0002-8071-9001"]},"institutions":[{"id":"https://openalex.org/I29617571","display_name":"University of Indonesia","ror":"https://ror.org/0116zj450","country_code":"ID","type":"education","lineage":["https://openalex.org/I29617571"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Wawaimuli Arozal","raw_affiliation_strings":["Universitas Indonesia, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universitas Indonesia, Indonesia","institution_ids":["https://openalex.org/I29617571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007587259","display_name":"Heri Wibowo","orcid":"https://orcid.org/0000-0001-7708-5135","observed_orcids":["https://orcid.org/0000-0001-7708-5135"]},"institutions":[{"id":"https://openalex.org/I29617571","display_name":"University of Indonesia","ror":"https://ror.org/0116zj450","country_code":"ID","type":"education","lineage":["https://openalex.org/I29617571"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Heri Wibowo","raw_affiliation_strings":["Universitas Indonesia, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universitas Indonesia, Indonesia","institution_ids":["https://openalex.org/I29617571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039238378","display_name":"Aryo Tedjo","orcid":"https://orcid.org/0000-0001-8998-3418","observed_orcids":["https://orcid.org/0000-0001-8998-3418"]},"institutions":[{"id":"https://openalex.org/I29617571","display_name":"University of Indonesia","ror":"https://ror.org/0116zj450","country_code":"ID","type":"education","lineage":["https://openalex.org/I29617571"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Aryo Tedjo","raw_affiliation_strings":["Universitas Indonesia, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universitas Indonesia, Indonesia","institution_ids":["https://openalex.org/I29617571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028600467","display_name":"Suci Widya Primadhani","orcid":"https://orcid.org/0009-0004-0354-1176","observed_orcids":["https://orcid.org/0009-0004-0354-1176"]},"institutions":[{"id":"https://openalex.org/I2801942171","display_name":"Panti Rapih Hospital","ror":"https://ror.org/03ta1q534","country_code":"ID","type":"healthcare","lineage":["https://openalex.org/I2801942171"]},{"id":"https://openalex.org/I4210121023","display_name":"Chifeng Municipal Hospital","ror":"https://ror.org/02j136k79","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121023"]},{"id":"https://openalex.org/I4405255602","display_name":"Chigasaki Municipal Hospital","ror":"https://ror.org/036vh1t90","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405255602"]},{"id":"https://openalex.org/I4405267151","display_name":"Pusat Mata Nasional Rumah Sakit Mata Cicendo","ror":"https://ror.org/01dmnaf35","country_code":"ID","type":"healthcare","lineage":["https://openalex.org/I4405267151"]},{"id":"https://openalex.org/I4405275734","display_name":"Sekolah Tinggi Ilmu Kesehatan Cirebon","ror":"https://ror.org/046jjbr46","country_code":"ID","type":"education","lineage":["https://openalex.org/I4405275734"]}],"countries":["CN","ID","JP"],"is_corresponding":false,"raw_author_name":"Suci Widya Primadhani","raw_affiliation_strings":["Cileungsi Public Regional Hospital, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cileungsi Public Regional Hospital, Indonesia","institution_ids":["https://openalex.org/I2801942171","https://openalex.org/I4210121023","https://openalex.org/I4405255602","https://openalex.org/I4405267151","https://openalex.org/I4405275734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5099296812","display_name":"Nurul Gusti Khatimah","orcid":"https://orcid.org/0009-0000-8274-4158","observed_orcids":["https://orcid.org/0009-0000-8274-4158"]},"institutions":[{"id":"https://openalex.org/I29617571","display_name":"University of Indonesia","ror":"https://ror.org/0116zj450","country_code":"ID","type":"education","lineage":["https://openalex.org/I29617571"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Nurul Gusti Khatimah","raw_affiliation_strings":["Universitas Indonesia, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universitas Indonesia, Indonesia","institution_ids":["https://openalex.org/I29617571"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091781566","display_name":"Clara Riski Amanda","orcid":"https://orcid.org/0009-0005-2657-9342","observed_orcids":["https://orcid.org/0009-0005-2657-9342"]},"institutions":[{"id":"https://openalex.org/I29617571","display_name":"University of Indonesia","ror":"https://ror.org/0116zj450","country_code":"ID","type":"education","lineage":["https://openalex.org/I29617571"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Clara Riski Amanda","raw_affiliation_strings":["Universitas Indonesia, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universitas Indonesia, Indonesia","institution_ids":["https://openalex.org/I29617571"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":7166,"currency":"USD","value_usd":7166},"apc_paid":null,"fwci":0.9865,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.71191402,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"85","issue":"15","first_page":"S67","last_page":"S67"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13281","display_name":"Andrographolide Research and Applications","score":0.5054000020027161,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13281","display_name":"Andrographolide Research and Applications","score":0.5054000020027161,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.4165000021457672,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11709","display_name":"Traditional Chinese Medicine Analysis","score":0.012500000186264515,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/andrographolide","display_name":"andrographolide","score":0.996999979019165},{"id":"https://openalex.org/keywords/andrographolide-derivatives","display_name":"andrographolide derivatives","score":0.9860000014305115},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.7310000061988831},{"id":"https://openalex.org/keywords/cardiac-remodeling","display_name":"cardiac remodeling","score":0.9789999723434448},{"id":"https://openalex.org/keywords/differential-gene-expression","display_name":"differential gene expression","score":0.9269999861717224},{"id":"https://openalex.org/keywords/computational-modeling","display_name":"computational modeling","score":0.8339999914169312},{"id":"https://openalex.org/keywords/computer-aided-drug-design","display_name":"computer-aided drug design","score":0.6019999980926514},{"id":"https://openalex.org/keywords/cardioprotection","display_name":"cardioprotection","score":0.8090000152587891}],"concepts":[{"id":"https://openalex.org/C2781357234","wikidata":"https://www.wikidata.org/wiki/Q4759444","display_name":"Andrographolide","level":2,"score":0.9690752625465393},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.873108983039856},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.8564246892929077},{"id":"https://openalex.org/C93226319","wikidata":"https://www.wikidata.org/wiki/Q193137","display_name":"Differential (mechanical device)","level":2,"score":0.5382082462310791},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.45547887682914734},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4265635013580322},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.27690988779067993},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1202383041381836},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.05248481035232544},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C146978453","wikidata":"https://www.wikidata.org/wiki/Q3798668","display_name":"Aerospace engineering","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jacc.2025.03.144","doi":"https://doi.org/10.1016/j.jacc.2025.03.144","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jacc.2025.03.144","pdf_url":null,"source":{"id":"https://openalex.org/S60865174","display_name":"Journal of the American College of Cardiology","issn_l":"0735-1097","issn":["0735-1097","1558-3597"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American College of Cardiology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.jacc.2025.03.144","doi":"https://doi.org/10.1016/j.jacc.2025.03.144","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jacc.2025.03.144","pdf_url":null,"source":{"id":"https://openalex.org/S60865174","display_name":"Journal of the American College of Cardiology","issn_l":"0735-1097","issn":["0735-1097","1558-3597"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American College of Cardiology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3041714200","https://openalex.org/W4206639919","https://openalex.org/W7196940119","https://openalex.org/W3016189260","https://openalex.org/W4251255361","https://openalex.org/W2027177656","https://openalex.org/W4323048608","https://openalex.org/W2082737736","https://openalex.org/W355639018","https://openalex.org/W4312192555"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2025-04-16T00:00:00"}