{"id":"https://openalex.org/W4409450283","doi":"https://doi.org/10.1007/s42250-025-01274-4","title":"Customizing Indolin-2-One-Thiosemicarbazones: Design, Synthesis, Anti-proliferative Assessment Along with In Silico and Electrochemical Investigations","display_name":"Customizing Indolin-2-One-Thiosemicarbazones: Design, Synthesis, Anti-proliferative Assessment Along with In Silico and Electrochemical Investigations","publication_year":2025,"publication_date":"2025-04-15","ids":{"openalex":"https://openalex.org/W4409450283","doi":"https://doi.org/10.1007/s42250-025-01274-4"},"language":"en","primary_location":{"id":"doi:10.1007/s42250-025-01274-4","doi":"https://doi.org/10.1007/s42250-025-01274-4","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s42250-025-01274-4","pdf_url":null,"source":{"id":"https://openalex.org/S4210187402","display_name":"Chemistry Africa","issn_l":"2522-5758","issn":["2522-5758","2522-5766"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry Africa","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100759081","display_name":"Preeti Preeti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165682329","display_name":"Guru Nanak Dev University","ror":"https://ror.org/05ghzpa93","country_code":"IN","type":"education","lineage":["https://openalex.org/I165682329"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Preeti","raw_affiliation_strings":["Department of Chemistry, Guru Nanak Dev University, Amritsar, 143005, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Guru Nanak Dev University, Amritsar, 143005, India","institution_ids":["https://openalex.org/I165682329"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037947855","display_name":"Bharvi Sharma","orcid":"https://orcid.org/0000-0003-4864-1651","observed_orcids":["https://orcid.org/0000-0003-4864-1651"]},"institutions":[{"id":"https://openalex.org/I165682329","display_name":"Guru Nanak Dev University","ror":"https://ror.org/05ghzpa93","country_code":"IN","type":"education","lineage":["https://openalex.org/I165682329"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Bharvi Sharma","raw_affiliation_strings":["Department of Chemistry, Guru Nanak Dev University, Amritsar, 143005, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Guru Nanak Dev University, Amritsar, 143005, India","institution_ids":["https://openalex.org/I165682329"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046788775","display_name":"Sarbjeet Kaur","orcid":"https://orcid.org/0000-0002-4114-2617","observed_orcids":["https://orcid.org/0000-0002-4114-2617"]},"institutions":[{"id":"https://openalex.org/I165682329","display_name":"Guru Nanak Dev University","ror":"https://ror.org/05ghzpa93","country_code":"IN","type":"education","lineage":["https://openalex.org/I165682329"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sarbjeet Kaur","raw_affiliation_strings":["Department of Chemistry, Guru Nanak Dev University, Amritsar, 143005, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Guru Nanak Dev University, Amritsar, 143005, India","institution_ids":["https://openalex.org/I165682329"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082726084","display_name":"Shanen Perumal","orcid":"https://orcid.org/0000-0002-0848-1393","observed_orcids":["https://orcid.org/0000-0002-0848-1393"]},"institutions":[{"id":"https://openalex.org/I192619145","display_name":"University of the Witwatersrand","ror":"https://ror.org/03rp50x72","country_code":"ZA","type":"education","lineage":["https://openalex.org/I192619145"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Shanen Perumal","raw_affiliation_strings":["School of Molecular and Cell Biology, University of the Witwatersrand, Private Bag 3, Wits-2050, Johannesburg, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Molecular and Cell Biology, University of the Witwatersrand, Private Bag 3, Wits-2050, Johannesburg, South Africa","institution_ids":["https://openalex.org/I192619145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007568899","display_name":"Gabriella Palma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I192619145","display_name":"University of the Witwatersrand","ror":"https://ror.org/03rp50x72","country_code":"ZA","type":"education","lineage":["https://openalex.org/I192619145"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Gabriella Palma","raw_affiliation_strings":["School of Molecular and Cell Biology, University of the Witwatersrand, Private Bag 3, Wits-2050, Johannesburg, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Molecular and Cell Biology, University of the Witwatersrand, Private Bag 3, Wits-2050, Johannesburg, South Africa","institution_ids":["https://openalex.org/I192619145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031693565","display_name":"Mandeep Kaur","orcid":"https://orcid.org/0000-0002-9757-4048","observed_orcids":["https://orcid.org/0000-0002-9757-4048"]},"institutions":[{"id":"https://openalex.org/I192619145","display_name":"University of the Witwatersrand","ror":"https://ror.org/03rp50x72","country_code":"ZA","type":"education","lineage":["https://openalex.org/I192619145"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Mandeep Kaur","raw_affiliation_strings":["School of Molecular and Cell Biology, University of the Witwatersrand, Private Bag 3, Wits-2050, Johannesburg, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Molecular and Cell Biology, University of the Witwatersrand, Private Bag 3, Wits-2050, Johannesburg, South Africa","institution_ids":["https://openalex.org/I192619145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100696977","display_name":"Inderpreet Kaur","orcid":"https://orcid.org/0000-0001-7742-9575","observed_orcids":["https://orcid.org/0000-0001-7742-9575"]},"institutions":[{"id":"https://openalex.org/I165682329","display_name":"Guru Nanak Dev University","ror":"https://ror.org/05ghzpa93","country_code":"IN","type":"education","lineage":["https://openalex.org/I165682329"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Inderpreet Kaur","raw_affiliation_strings":["Department of Chemistry, Guru Nanak Dev University, Amritsar, 143005, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Guru Nanak Dev University, Amritsar, 143005, India","institution_ids":["https://openalex.org/I165682329"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052982799","display_name":"Vipan Kumar","orcid":"https://orcid.org/0000-0002-6164-7161","observed_orcids":["https://orcid.org/0000-0002-6164-7161","https://orcid.org/0009-0005-6192-405X"]},"institutions":[{"id":"https://openalex.org/I165682329","display_name":"Guru Nanak Dev University","ror":"https://ror.org/05ghzpa93","country_code":"IN","type":"education","lineage":["https://openalex.org/I165682329"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Vipan Kumar","raw_affiliation_strings":["Department of Chemistry, Guru Nanak Dev University, Amritsar, 143005, India"],"raw_orcid":"https://orcid.org/0000-0002-6164-7161","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Guru Nanak Dev University, Amritsar, 143005, India","institution_ids":["https://openalex.org/I165682329"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5052982799"],"corresponding_institution_ids":["https://openalex.org/I165682329"],"apc_list":{"value":3290,"currency":"USD","value_usd":3290},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.04273389,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"8","issue":"6","first_page":"2271","last_page":"2284"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10274","display_name":"Synthesis and biological activity","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10274","display_name":"Synthesis and biological activity","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14099","display_name":"Synthesis and Characterization of Heterocyclic Compounds","score":0.022199999541044235,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11440","display_name":"Click Chemistry and Applications","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/1h-1-2-3-triazole","display_name":"1H-1,2,3-triazole","score":0.8539999723434448},{"id":"https://openalex.org/keywords/antiproliferative-agents","display_name":"antiproliferative agents","score":0.7440000176429749},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9660000205039978},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.9129999876022339},{"id":"https://openalex.org/keywords/mda-mb-231-cells","display_name":"MDA-MB-231 cells","score":0.9890000224113464},{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.8679999709129333},{"id":"https://openalex.org/keywords/ribonucleotide-reductase-inhibition","display_name":"ribonucleotide reductase inhibition","score":0.8939999938011169},{"id":"https://openalex.org/keywords/iron-iii-chelation","display_name":"iron(III) chelation","score":0.8730000257492065},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.7979999780654907},{"id":"https://openalex.org/keywords/electrochemical-analysis","display_name":"electrochemical analysis","score":0.7350000143051147},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.5770000219345093},{"id":"https://openalex.org/keywords/anticancer-drug-design","display_name":"anticancer drug design","score":0.5950000286102295}],"concepts":[{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.9275919198989868},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.5544499754905701},{"id":"https://openalex.org/C52859227","wikidata":"https://www.wikidata.org/wiki/Q7877","display_name":"Electrochemistry","level":3,"score":0.4957042932510376},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4801725447177887},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46663981676101685},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3401409387588501},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3306020498275757},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23352912068367004},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19427913427352905},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C17525397","wikidata":"https://www.wikidata.org/wiki/Q176140","display_name":"Electrode","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/s42250-025-01274-4","doi":"https://doi.org/10.1007/s42250-025-01274-4","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s42250-025-01274-4","pdf_url":null,"source":{"id":"https://openalex.org/S4210187402","display_name":"Chemistry Africa","issn_l":"2522-5758","issn":["2522-5758","2522-5766"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry Africa","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1603242223","https://openalex.org/W1966040155","https://openalex.org/W1990724722","https://openalex.org/W1991001144","https://openalex.org/W1998474683","https://openalex.org/W1999823040","https://openalex.org/W2007686558","https://openalex.org/W2021832765","https://openalex.org/W2030020226","https://openalex.org/W2035105453","https://openalex.org/W2051381895","https://openalex.org/W2062811597","https://openalex.org/W2078526323","https://openalex.org/W2089440451","https://openalex.org/W2108427446","https://openalex.org/W2118382645","https://openalex.org/W2496511178","https://openalex.org/W2575733432","https://openalex.org/W2744937568","https://openalex.org/W2770369177","https://openalex.org/W2782559169","https://openalex.org/W2788528130","https://openalex.org/W2802528458","https://openalex.org/W2922993352","https://openalex.org/W2958146346","https://openalex.org/W3027259389","https://openalex.org/W3136966291","https://openalex.org/W3198244226","https://openalex.org/W3204186124","https://openalex.org/W3213573456","https://openalex.org/W4205341485","https://openalex.org/W4224990395","https://openalex.org/W4281482059","https://openalex.org/W4294189863","https://openalex.org/W4387109691","https://openalex.org/W4388116825"],"related_works":["https://openalex.org/W2513589746","https://openalex.org/W2153919606","https://openalex.org/W2003194288","https://openalex.org/W2213189664","https://openalex.org/W2074002899","https://openalex.org/W2062254828","https://openalex.org/W4237480606","https://openalex.org/W2936968863","https://openalex.org/W1971792277","https://openalex.org/W3026240506"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2025-10-10T00:00:00"}