{"id":"https://openalex.org/W4409443085","doi":"https://doi.org/10.1007/s11357-025-01594-w","title":"Systemic deficits in lipid homeostasis promote aging-associated impairments in B cell progenitor development","display_name":"Systemic deficits in lipid homeostasis promote aging-associated impairments in B cell progenitor development","publication_year":2025,"publication_date":"2025-04-15","ids":{"openalex":"https://openalex.org/W4409443085","doi":"https://doi.org/10.1007/s11357-025-01594-w","pmid":"https://pubmed.ncbi.nlm.nih.gov/39386685","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11463619"},"language":"en","primary_location":{"id":"doi:10.1007/s11357-025-01594-w","doi":"https://doi.org/10.1007/s11357-025-01594-w","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s11357-025-01594-w","pdf_url":"https://link.springer.com/content/pdf/10.1007/s11357-025-01594-w.pdf","source":{"id":"https://openalex.org/S4210237251","display_name":"GeroScience","issn_l":"2152-4041","issn":["2152-4041","2331-3773","2509-2715","2509-2723"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319972","host_organization_name":"Springer International Publishing","host_organization_lineage":["https://openalex.org/P4310319972","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer International Publishing","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"GeroScience","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s11357-025-01594-w.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027112699","display_name":"Silvia Vicenzi","orcid":"https://orcid.org/0000-0001-5670-7169","observed_orcids":["https://orcid.org/0000-0001-5670-7169"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4390039236","display_name":"Moores Cancer Center","ror":"https://ror.org/01qkmtm61","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959","https://openalex.org/I4390039236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Silvia Vicenzi","raw_affiliation_strings":["Division of Regenerative Medicine, Department of Medicine, University of California San Diego, La Jolla, CA, 92037, USA","Moores Cancer Center, University of California San Diego, La Jolla, CA, 92037, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Regenerative Medicine, Department of Medicine, University of California San Diego, La Jolla, CA, 92037, USA","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Moores Cancer Center, University of California San Diego, La Jolla, CA, 92037, USA","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4390039236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103185489","display_name":"Fangyuan Gao","orcid":"https://orcid.org/0000-0002-2108-9185","observed_orcids":["https://orcid.org/0000-0002-2108-9185"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fangyuan Gao","raw_affiliation_strings":["Center for Translational Vision Research, Departments of Physiology and Biophysics and Department of Ophthalmology, University of California, Irvine, CA, 92617, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Translational Vision Research, Departments of Physiology and Biophysics and Department of Ophthalmology, University of California, Irvine, CA, 92617, USA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107541655","display_name":"Parker C\u00f4t\u00e9","orcid":"https://orcid.org/0000-0001-7086-0573","observed_orcids":["https://orcid.org/0000-0001-7086-0573"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Parker C\u00f4t\u00e9","raw_affiliation_strings":["Department of Pediatrics, University of California San Diego, La Jolla, CA, 92037, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of California San Diego, La Jolla, CA, 92037, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113406272","display_name":"Joshua D. Hartman","orcid":"https://orcid.org/0000-0002-0664-5630","observed_orcids":["https://orcid.org/0000-0002-0664-5630"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4390039236","display_name":"Moores Cancer Center","ror":"https://ror.org/01qkmtm61","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959","https://openalex.org/I4390039236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua D. Hartman","raw_affiliation_strings":["Division of Regenerative Medicine, Department of Medicine, University of California San Diego, La Jolla, CA, 92037, USA","Moores Cancer Center, University of California San Diego, La Jolla, CA, 92037, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Regenerative Medicine, Department of Medicine, University of California San Diego, La Jolla, CA, 92037, USA","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Moores Cancer Center, University of California San Diego, La Jolla, CA, 92037, USA","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4390039236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006252364","display_name":"Lara C. Avsharian","orcid":"https://orcid.org/0009-0005-7287-8650","observed_orcids":["https://orcid.org/0009-0005-7287-8650"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4390039236","display_name":"Moores Cancer Center","ror":"https://ror.org/01qkmtm61","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959","https://openalex.org/I4390039236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lara C. Avsharian","raw_affiliation_strings":["Division of Regenerative Medicine, Department of Medicine, University of California San Diego, La Jolla, CA, 92037, USA","Moores Cancer Center, University of California San Diego, La Jolla, CA, 92037, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Regenerative Medicine, Department of Medicine, University of California San Diego, La Jolla, CA, 92037, USA","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Moores Cancer Center, University of California San Diego, La Jolla, CA, 92037, USA","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4390039236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003228841","display_name":"Ashni A. Vora","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4390039236","display_name":"Moores Cancer Center","ror":"https://ror.org/01qkmtm61","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959","https://openalex.org/I4390039236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ashni A. Vora","raw_affiliation_strings":["Division of Regenerative Medicine, Department of Medicine, University of California San Diego, La Jolla, CA, 92037, USA","Moores Cancer Center, University of California San Diego, La Jolla, CA, 92037, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Regenerative Medicine, Department of Medicine, University of California San Diego, La Jolla, CA, 92037, USA","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Moores Cancer Center, University of California San Diego, La Jolla, CA, 92037, USA","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4390039236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055084915","display_name":"R. Grant Rowe","orcid":"https://orcid.org/0000-0003-3620-2950","observed_orcids":["https://orcid.org/0000-0003-3620-2950"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210157861","display_name":"Harvard Stem Cell Institute","ror":"https://ror.org/04kj1hn59","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210157861"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Grant Rowe","raw_affiliation_strings":["Boston Children's Hospital, Dana-Farber Cancer Institute, Harvard Stem Cell Institute, and Harvard Medical School, Boston, MA, 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston Children's Hospital, Dana-Farber Cancer Institute, Harvard Stem Cell Institute, and Harvard Medical School, Boston, MA, 02115, USA","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210157861"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058731290","display_name":"Hojun Li","orcid":"https://orcid.org/0000-0002-8129-0390","observed_orcids":["https://orcid.org/0000-0002-8129-0390"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210087384","display_name":"Rady Children's Hospital-San Diego","ror":"https://ror.org/00414dg76","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087384"]},{"id":"https://openalex.org/I4390039236","display_name":"Moores Cancer Center","ror":"https://ror.org/01qkmtm61","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959","https://openalex.org/I4390039236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hojun Li","raw_affiliation_strings":["Department of Pediatrics, University of California San Diego, La Jolla, CA, 92037, USA","Division of Hematology/Oncology, Rady Children's Hospital, San Diego, CA, 92123, USA","Moores Cancer Center, University of California San Diego, La Jolla, CA, 92037, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of California San Diego, La Jolla, CA, 92037, USA","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Division of Hematology/Oncology, Rady Children's Hospital, San Diego, CA, 92123, USA","institution_ids":["https://openalex.org/I4210087384"]},{"raw_affiliation_string":"Moores Cancer Center, University of California San Diego, La Jolla, CA, 92037, USA","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4390039236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001513312","display_name":"Dorota Skowronska\u2010Krawczyk","orcid":"https://orcid.org/0000-0002-5758-4225","observed_orcids":["https://orcid.org/0000-0002-5758-4225"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Dorota Skowronska-Krawczyk","raw_affiliation_strings":["Center for Translational Vision Research, Departments of Physiology and Biophysics and Department of Ophthalmology, University of California, Irvine, CA, 92617, USA. dorotask@hs.uci.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Translational Vision Research, Departments of Physiology and Biophysics and Department of Ophthalmology, University of California, Irvine, CA, 92617, USA. dorotask@hs.uci.edu","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016355760","display_name":"Leslie\u00a0A. Crews","orcid":"https://orcid.org/0000-0003-0704-0067","observed_orcids":["https://orcid.org/0000-0003-0704-0067"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4390039236","display_name":"Moores Cancer Center","ror":"https://ror.org/01qkmtm61","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959","https://openalex.org/I4390039236"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Leslie A. Crews","raw_affiliation_strings":["Division of Regenerative Medicine, Department of Medicine, University of California San Diego, La Jolla, CA, 92037, USA. lcrews@ucsd.edu","Moores Cancer Center, University of California San Diego, La Jolla, CA, 92037, USA. lcrews@ucsd.edu","Sanford Stem Cell Institute, University of California San Diego, La Jolla, CA, 92037, USA. lcrews@ucsd.edu"],"raw_orcid":"https://orcid.org/0000-0003-0704-0067","affiliations":[{"raw_affiliation_string":"Division of Regenerative Medicine, Department of Medicine, University of California San Diego, La Jolla, CA, 92037, USA. lcrews@ucsd.edu","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Moores Cancer Center, University of California San Diego, La Jolla, CA, 92037, USA. lcrews@ucsd.edu","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4390039236"]},{"raw_affiliation_string":"Sanford Stem Cell Institute, University of California San Diego, La Jolla, CA, 92037, USA. lcrews@ucsd.edu","institution_ids":["https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5001513312","https://openalex.org/A5016355760"],"corresponding_institution_ids":["https://openalex.org/I204250578","https://openalex.org/I36258959","https://openalex.org/I4390039236"],"apc_list":{"value":2890,"currency":"USD","value_usd":2890},"apc_paid":{"value":2890,"currency":"USD","value_usd":2890},"fwci":4.5771,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.94503112,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"47","issue":"4","first_page":"5449","last_page":"5467"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.2808000147342682,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.2808000147342682,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.14399999380111694,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.06679999828338623,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immunosenescence","display_name":"immunosenescence","score":0.6959999799728394},{"id":"https://openalex.org/keywords/hematopoietic-stem-and-progenitor-cells","display_name":"hematopoietic stem and progenitor cells","score":0.8989999890327454},{"id":"https://openalex.org/keywords/b-cell-development","display_name":"B cell development","score":0.8730000257492065},{"id":"https://openalex.org/keywords/elovl2","display_name":"ELOVL2","score":0.8320000171661377},{"id":"https://openalex.org/keywords/polyunsaturated-fatty-acid-biosynthesis","display_name":"polyunsaturated fatty acid biosynthesis","score":0.890999972820282},{"id":"https://openalex.org/keywords/lipid-homeostasis","display_name":"lipid homeostasis","score":0.8460000157356262},{"id":"https://openalex.org/keywords/cd79b","display_name":"CD79b","score":0.8320000171661377},{"id":"https://openalex.org/keywords/membrane-fluidity","display_name":"membrane fluidity","score":0.5899999737739563},{"id":"https://openalex.org/keywords/saturated-fatty-acids","display_name":"saturated fatty acids","score":0.6819999814033508},{"id":"https://openalex.org/keywords/clonal-hematopoiesis-of-indeterminate-potential","display_name":"clonal hematopoiesis of indeterminate potential","score":0.8970000147819519},{"id":"https://openalex.org/keywords/bone-marrow","display_name":"bone marrow","score":0.46799999475479126},{"id":"https://openalex.org/keywords/lipidomics","display_name":"lipidomics","score":0.6480000019073486}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.753344714641571},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.6406384706497192},{"id":"https://openalex.org/C79904392","wikidata":"https://www.wikidata.org/wiki/Q5976738","display_name":"Lymphopoiesis","level":4,"score":0.6226253509521484},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.6090130805969238},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.5816423892974854},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5656968355178833},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.5511219501495361},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.5423458814620972},{"id":"https://openalex.org/C2778086970","wikidata":"https://www.wikidata.org/wiki/Q514525","display_name":"Hematopoietic stem cell","level":4,"score":0.5053234696388245},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.42991524934768677},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4297962784767151},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4010918140411377},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.18430554866790771},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.169139564037323},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11504572629928589}],"mesh":[],"locations_count":7,"locations":[{"id":"doi:10.1007/s11357-025-01594-w","doi":"https://doi.org/10.1007/s11357-025-01594-w","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s11357-025-01594-w","pdf_url":"https://link.springer.com/content/pdf/10.1007/s11357-025-01594-w.pdf","source":{"id":"https://openalex.org/S4210237251","display_name":"GeroScience","issn_l":"2152-4041","issn":["2152-4041","2331-3773","2509-2715","2509-2723"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319972","host_organization_name":"Springer International Publishing","host_organization_lineage":["https://openalex.org/P4310319972","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer International Publishing","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"GeroScience","raw_type":"journal-article"},{"id":"doi:10.1101/2024.09.26.614999","doi":"https://doi.org/10.1101/2024.09.26.614999","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2024.09.26.614999","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2024/09/26/2024.09.26.614999.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:europepmc.org:11205375","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12397465","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:39386685","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39386685","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmid:40232347","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40232347","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"GeroScience","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12397465","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12397465/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"GeroScience","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:11463619","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11463619","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1007/s11357-025-01594-w","doi":"https://doi.org/10.1007/s11357-025-01594-w","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s11357-025-01594-w","pdf_url":"https://link.springer.com/content/pdf/10.1007/s11357-025-01594-w.pdf","source":{"id":"https://openalex.org/S4210237251","display_name":"GeroScience","issn_l":"2152-4041","issn":["2152-4041","2331-3773","2509-2715","2509-2723"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319972","host_organization_name":"Springer International Publishing","host_organization_lineage":["https://openalex.org/P4310319972","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer International Publishing","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"GeroScience","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1476237564","display_name":null,"funder_award_id":"#S10 OD026929","funder_id":"https://openalex.org/F4320332603","funder_display_name":"University of California, San Diego"},{"id":"https://openalex.org/G2631912886","display_name":"Correlating Genomic AMD Risk Variants with Lipid Composition and Phagocytic Function of Patient-Derived Induced Pluripotent Stem Cell (iPSC)-derived Retinal Pigment Epithelium (RPE)","funder_award_id":"U01EY034594","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G3306396600","display_name":"Illumina NovaSeq 6000 Sequencing System","funder_award_id":"S10OD026929","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3659268279","display_name":null,"funder_award_id":"EDUC4-12804","funder_id":"https://openalex.org/F4320309885","funder_display_name":"California Institute of Regenerative Medicine"},{"id":"https://openalex.org/G7075883853","display_name":"Regulating proliferation and differentiation of erythroid progenitors","funder_award_id":"K08DK123414","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G7810585149","display_name":"Specialized Cancer Center Support Grant","funder_award_id":"P30CA023100","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000909623","display_name":"Core transcriptional regulators of malignant stem cell generation in multiple myeloma","funder_award_id":"R37CA252040","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000915136","display_name":"NEI UCI Center Core Grant for Vision Research","funder_award_id":"P30EY034070","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320306811","display_name":"Research to Prevent Blindness","ror":"https://ror.org/04drjs621"},{"id":"https://openalex.org/F4320308295","display_name":"Leukemia and Lymphoma Society","ror":"https://ror.org/04m0xav37"},{"id":"https://openalex.org/F4320309885","display_name":"California Institute of Regenerative Medicine","ror":"https://ror.org/033m8b439"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332603","display_name":"University of California, San Diego","ror":"https://ror.org/0168r3w48"},{"id":"https://openalex.org/F4320332688","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771"},{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4409443085.pdf","grobid_xml":"https://content.openalex.org/works/W4409443085.grobid-xml"},"referenced_works_count":62,"referenced_works":["https://openalex.org/W1966742362","https://openalex.org/W1980326316","https://openalex.org/W1981403111","https://openalex.org/W1989772629","https://openalex.org/W1992214487","https://openalex.org/W1993187404","https://openalex.org/W1993287310","https://openalex.org/W1998400885","https://openalex.org/W2009397177","https://openalex.org/W2011059916","https://openalex.org/W2028815852","https://openalex.org/W2032842463","https://openalex.org/W2045067923","https://openalex.org/W2075174748","https://openalex.org/W2089298476","https://openalex.org/W2097442766","https://openalex.org/W2099555659","https://openalex.org/W2102750142","https://openalex.org/W2117320661","https://openalex.org/W2123106337","https://openalex.org/W2124853042","https://openalex.org/W2130410032","https://openalex.org/W2131263031","https://openalex.org/W2157285575","https://openalex.org/W2172099178","https://openalex.org/W2289121900","https://openalex.org/W2516282811","https://openalex.org/W2563729022","https://openalex.org/W2587039580","https://openalex.org/W2595342131","https://openalex.org/W2607095333","https://openalex.org/W2799790653","https://openalex.org/W2799959526","https://openalex.org/W2805557070","https://openalex.org/W2945883683","https://openalex.org/W2981958899","https://openalex.org/W2996030950","https://openalex.org/W2998824887","https://openalex.org/W3038232074","https://openalex.org/W3122660020","https://openalex.org/W3156627462","https://openalex.org/W3171615890","https://openalex.org/W3176043285","https://openalex.org/W3196234584","https://openalex.org/W4210429572","https://openalex.org/W4313333706","https://openalex.org/W4385469239","https://openalex.org/W4387114589","https://openalex.org/W4387818710","https://openalex.org/W4388451947","https://openalex.org/W4392059717","https://openalex.org/W4392546333","https://openalex.org/W4392985322","https://openalex.org/W4394753092","https://openalex.org/W4400738566","https://openalex.org/W4401426504","https://openalex.org/W4402388021","https://openalex.org/W4402443304","https://openalex.org/W4404942347","https://openalex.org/W4405079562","https://openalex.org/W4414492692","https://openalex.org/W6645846774"],"related_works":["https://openalex.org/W4310108236","https://openalex.org/W7155105050","https://openalex.org/W7133126661","https://openalex.org/W2024971573","https://openalex.org/W3207386056","https://openalex.org/W3212992934","https://openalex.org/W1575237114","https://openalex.org/W3016682455","https://openalex.org/W2135285098","https://openalex.org/W7139948043"],"abstract_inverted_index":{"Abstract":[0],"Organismal":[1],"aging":[2,24,90,146,290,348],"has":[3,91],"been":[4,93],"associated":[5,94,238,377],"with":[6,95,191,239,313,378],"diverse":[7,96],"metabolic":[8,388],"and":[9,36,41,119,167,176,201,289,349,355],"functional":[10],"changes":[11,253],"across":[12,99,283],"tissues.":[13],"Within":[14],"the":[15,30,76,130,136,224,255,263,284,343,411],"immune":[16,169,241,350],"system,":[17],"key":[18,159],"features":[19],"of":[20,63,70,81,112,132,181,203,219,245,258,265,274,280,286,297,346,363,370],"physiological":[21],"hematopoietic":[22,34,145],"cell":[23,38,170,199,209,228,277,351,372,413],"include":[25],"increased":[26,113],"fat":[27],"deposition":[28],"in":[29,49,84,122,165,197,207,254,304,322,342,353,368,394],"bone":[31,56,182,270,307,329],"marrow,":[32],"impaired":[33,140],"stem":[35],"progenitor":[37,221],"(HSPC)":[39],"function,":[40],"a":[42,110,120,155,158,215,231,275,292,398],"propensity":[43],"towards":[44],"myeloid":[45,85],"differentiation.":[46],"This":[47,309],"shift":[48],"lineage":[50],"bias":[51],"can":[52],"lead":[53],"to":[54,138,144,226,268,402],"pre-malignant":[55],"marrow":[57,183,271,330],"conditions":[58,409],"such":[59,101],"as":[60,102,109,230,397],"clonal":[61,68],"hematopoiesis":[62],"indeterminate":[64],"potential":[65],"(CHIP)":[66],"or":[67,86,406],"cytopenias":[69],"undetermined":[71],"significance":[72],"(CCUS),":[73],"frequently":[74],"setting":[75],"stage":[77],"for":[78,157,338],"subsequent":[79],"development":[80,222,288],"age-related":[82,408],"cancers":[83,405],"lymphoid":[87,198,220],"lineages.":[88],"Human":[89],"also":[92,250,376],"lipid":[97,339],"alterations":[98],"tissues,":[100],"decreased":[103],"phospholipid":[104],"membrane":[105],"fluidity":[106],"that":[107,301,374,390],"arises":[108],"result":[111],"saturated":[114],"fatty":[115,125],"acid":[116,126],"(FA)":[117],"accumulation":[118],"decay":[121],"n-3":[123],"polyunsaturated":[124],"(PUFA)":[127],"species":[128],"by":[129],"age":[131],"80":[133],"years,":[134],"however":[135],"extent":[137],"which":[139],"FA":[141],"metabolism":[142,340],"contributes":[143],"is":[147,237],"less":[148],"clear.":[149],"Here,":[150],"comprehensive":[151],"multi-omics":[152],"analyses":[153,180,273],"uncovered":[154,291],"role":[156],"PUFA":[160],"biosynthesis":[161],"gene,":[162],"ELOVL2":[163,303,364],",":[164],"mouse":[166,354],"human":[168,269,281,287,356],"aging.":[171,242],"Whole":[172],"transcriptome":[173],"RNA-sequencing":[174],"studies":[175,212,396],"complementary":[177],"flow":[178],"cytometric":[179],"from":[184,223,327],"aged":[185],"Elovl2":[186],"mutant":[187,246],"(enzyme-deficient)":[188],"mice":[189,249],"compared":[190],"age-matched":[192],"controls":[193],"revealed":[194],"global":[195],"downregulation":[196,369],"markers":[200],"expression":[202],"genes":[204,373],"involved":[205],"specifically":[206],"B":[208,371,412],"development.":[210],"These":[211],"unveiled":[213],"CD79B,":[214],"vital":[216],"molecular":[217,344],"regulator":[218],"pro-B":[225],"pre-B":[227],"stage,":[229],"putative":[232],"surface":[233],"biomarker":[234],"whose":[235],"loss":[236,362],"accelerated":[240],"The":[243],"lipidome":[244],"versus":[247],"wild-type":[248],"displayed":[251],"significant":[252],"biophysical":[256],"properties":[257],"cellular":[259,347],"membranes.":[260],"To":[261],"investigate":[262],"relevance":[264],"these":[266,333],"finding":[267],"aging,":[272],"single":[276],"RNA-seq":[278],"dataset":[279],"HSPCs":[282,300],"spectrum":[285],"rare":[293],"subpopulation":[294],"(<":[295],"7%)":[296],"CD34":[298,323],"+":[299,324],"expresses":[302],"healthy":[305],"adult":[306],"marrow.":[308],"HSPC":[310],"subset,":[311],"along":[312],"CD79B":[314],"-expressing":[315],"lymphoid-committed":[316],"cells,":[317],"were":[318],"almost":[319],"completely":[320],"absent":[321],"cells":[325],"isolated":[326],"elderly":[328],"samples.":[331],"Together,":[332],"findings":[334],"uncover":[335],"new":[336],"roles":[337],"enzymes":[341],"regulation":[345],"function":[352],"hematopoiesis.":[357],"In":[358],"addition,":[359],"because":[360],"systemic":[361],"enzymatic":[365],"activity":[366],"resulted":[367],"are":[375],"lymphoproliferative":[379],"neoplasms,":[380],"this":[381],"study":[382],"sheds":[383],"light":[384],"on":[385],"an":[386],"intriguing":[387],"pathway":[389],"could":[391],"be":[392],"leveraged":[393],"future":[395],"novel":[399],"therapeutic":[400],"modality":[401],"target":[403],"blood":[404],"other":[407],"involving":[410],"lineage.":[414]},"counts_by_year":[{"year":2026,"cited_by_count":7}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2025-04-15T00:00:00"}
