{"id":"https://openalex.org/W4409440973","doi":"https://doi.org/10.3390/cryst15040355","title":"Process Design for Continuous Crystallization of l-Tryptophan in Water\u2013Alcohol Solvent Mixtures","display_name":"Process Design for Continuous Crystallization of l-Tryptophan in Water\u2013Alcohol Solvent Mixtures","publication_year":2025,"publication_date":"2025-04-12","ids":{"openalex":"https://openalex.org/W4409440973","doi":"https://doi.org/10.3390/cryst15040355"},"language":"en","primary_location":{"id":"doi:10.3390/cryst15040355","doi":"https://doi.org/10.3390/cryst15040355","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cryst15040355","pdf_url":"https://www.mdpi.com/2073-4352/15/4/355/pdf?version=1744469080","source":{"id":"https://openalex.org/S4210196485","display_name":"Crystals","issn_l":"2073-4352","issn":["2073-4352"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Crystals","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2073-4352/15/4/355/pdf?version=1744469080","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044852000","display_name":"Lukas Hohmann","orcid":"https://orcid.org/0000-0002-3224-6262","observed_orcids":["https://orcid.org/0000-0002-3224-6262"]},"institutions":[{"id":"https://openalex.org/I200332995","display_name":"TU Dortmund University","ror":"https://ror.org/01k97gp34","country_code":"DE","type":"education","lineage":["https://openalex.org/I200332995"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Lukas Hohmann","raw_affiliation_strings":["Laboratory of Equipment Design, Department of Chemical and Biochemical Engineering, TU Dortmund University, Emil-Figge-Street 68, 44227 Dortmund, Germany"],"raw_orcid":"https://orcid.org/0000-0002-3224-6262","affiliations":[{"raw_affiliation_string":"Laboratory of Equipment Design, Department of Chemical and Biochemical Engineering, TU Dortmund University, Emil-Figge-Street 68, 44227 Dortmund, Germany","institution_ids":["https://openalex.org/I200332995"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5117148342","display_name":"Robert Antpusat","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200332995","display_name":"TU Dortmund University","ror":"https://ror.org/01k97gp34","country_code":"DE","type":"education","lineage":["https://openalex.org/I200332995"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Robert Antpusat (n\u00e9e Hampel)","raw_affiliation_strings":["Laboratory of Equipment Design, Department of Chemical and Biochemical Engineering, TU Dortmund University, Emil-Figge-Street 68, 44227 Dortmund, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Equipment Design, Department of Chemical and Biochemical Engineering, TU Dortmund University, Emil-Figge-Street 68, 44227 Dortmund, Germany","institution_ids":["https://openalex.org/I200332995"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011882007","display_name":"Norbert Kockmann","orcid":"https://orcid.org/0000-0002-8852-3812","observed_orcids":["https://orcid.org/0000-0002-8852-3812"]},"institutions":[{"id":"https://openalex.org/I200332995","display_name":"TU Dortmund University","ror":"https://ror.org/01k97gp34","country_code":"DE","type":"education","lineage":["https://openalex.org/I200332995"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Norbert Kockmann","raw_affiliation_strings":["Laboratory of Equipment Design, Department of Chemical and Biochemical Engineering, TU Dortmund University, Emil-Figge-Street 68, 44227 Dortmund, Germany"],"raw_orcid":"https://orcid.org/0000-0002-8852-3812","affiliations":[{"raw_affiliation_string":"Laboratory of Equipment Design, Department of Chemical and Biochemical Engineering, TU Dortmund University, Emil-Figge-Street 68, 44227 Dortmund, Germany","institution_ids":["https://openalex.org/I200332995"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5011882007"],"corresponding_institution_ids":["https://openalex.org/I200332995"],"apc_list":{"value":2100,"currency":"CHF","value_usd":2534},"apc_paid":{"value":2100,"currency":"CHF","value_usd":2534},"fwci":0.4239,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.47850149,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":"15","issue":"4","first_page":"355","last_page":"355"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11881","display_name":"Crystallization and Solubility Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11881","display_name":"Crystallization and Solubility Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10402","display_name":"Phase Equilibria and Thermodynamics","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11936","display_name":"Chemical and Physical Properties in Aqueous Solutions","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1506","display_name":"Filtration and Separation"},"field":{"id":"https://openalex.org/fields/15","display_name":"Chemical Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tryptophan","display_name":"tryptophan","score":0.9900000095367432},{"id":"https://openalex.org/keywords/continuous-crystallization","display_name":"continuous crystallization","score":0.996999979019165},{"id":"https://openalex.org/keywords/solid-liquid-equilibrium","display_name":"solid-liquid equilibrium","score":0.9079999923706055},{"id":"https://openalex.org/keywords/solubility","display_name":"solubility","score":0.8889999985694885},{"id":"https://openalex.org/keywords/solvent-selection","display_name":"solvent selection","score":0.5839999914169312},{"id":"https://openalex.org/keywords/batch-crystallization","display_name":"batch crystallization","score":0.6019999980926514},{"id":"https://openalex.org/keywords/downstream-processing","display_name":"downstream processing","score":0.7120000123977661},{"id":"https://openalex.org/keywords/fermentation-product-recovery","display_name":"fermentation product recovery","score":0.49399998784065247},{"id":"https://openalex.org/keywords/process-design","display_name":"process design","score":0.5239999890327454},{"id":"https://openalex.org/keywords/molecular-interactions","display_name":"molecular interactions","score":0.5329999923706055}],"concepts":[{"id":"https://openalex.org/C203036418","wikidata":"https://www.wikidata.org/wiki/Q284256","display_name":"Crystallization","level":2,"score":0.8121618032455444},{"id":"https://openalex.org/C2781066024","wikidata":"https://www.wikidata.org/wiki/Q156","display_name":"Alcohol","level":2,"score":0.6613427400588989},{"id":"https://openalex.org/C2780471494","wikidata":"https://www.wikidata.org/wiki/Q146505","display_name":"Solvent","level":2,"score":0.6137134432792664},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.5706136226654053},{"id":"https://openalex.org/C2776706248","wikidata":"https://www.wikidata.org/wiki/Q181003","display_name":"Tryptophan","level":3,"score":0.4563300311565399},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4373440146446228},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.38159802556037903},{"id":"https://openalex.org/C21880701","wikidata":"https://www.wikidata.org/wiki/Q2144042","display_name":"Process engineering","level":1,"score":0.323635995388031},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.3087254762649536},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.15137624740600586},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.11325478553771973},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08592495322227478},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.07851588726043701},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.3390/cryst15040355","doi":"https://doi.org/10.3390/cryst15040355","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cryst15040355","pdf_url":"https://www.mdpi.com/2073-4352/15/4/355/pdf?version=1744469080","source":{"id":"https://openalex.org/S4210196485","display_name":"Crystals","issn_l":"2073-4352","issn":["2073-4352"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Crystals","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:4c74a795d3ab44b59c14325557fcc281","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/4c74a795d3ab44b59c14325557fcc281","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Crystals, Vol 15, Iss 4, p 355 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/cryst15040355","doi":"https://doi.org/10.3390/cryst15040355","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cryst15040355","pdf_url":"https://www.mdpi.com/2073-4352/15/4/355/pdf?version=1744469080","source":{"id":"https://openalex.org/S4210196485","display_name":"Crystals","issn_l":"2073-4352","issn":["2073-4352"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Crystals","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4303701741","display_name":"Bundesministerium f\u00fcr Wirtschaft und Klimaschutz","ror":"https://ror.org/02vgg2808"},{"id":"https://openalex.org/F4320329559","display_name":"Technische Universit\u00e4t Dortmund","ror":"https://ror.org/01k97gp34"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4409440973.pdf","grobid_xml":"https://content.openalex.org/works/W4409440973.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W650911692","https://openalex.org/W1556320747","https://openalex.org/W1573168641","https://openalex.org/W1775935166","https://openalex.org/W1963885647","https://openalex.org/W1967469430","https://openalex.org/W1976343164","https://openalex.org/W1986433261","https://openalex.org/W1986900949","https://openalex.org/W1995050552","https://openalex.org/W2010320650","https://openalex.org/W2013549100","https://openalex.org/W2022489208","https://openalex.org/W2024701089","https://openalex.org/W2033823038","https://openalex.org/W2089041533","https://openalex.org/W2149601459","https://openalex.org/W2316028778","https://openalex.org/W2336368497","https://openalex.org/W2393187264","https://openalex.org/W2480977950","https://openalex.org/W2601271529","https://openalex.org/W2612297997","https://openalex.org/W2786473804","https://openalex.org/W2897545310","https://openalex.org/W2913208782","https://openalex.org/W2970222036","https://openalex.org/W2981204100","https://openalex.org/W2995250733","https://openalex.org/W3140372160","https://openalex.org/W3154346959","https://openalex.org/W3194446603","https://openalex.org/W3196760487","https://openalex.org/W4256423716","https://openalex.org/W4281924767","https://openalex.org/W4285304557","https://openalex.org/W4324087986","https://openalex.org/W4386647545","https://openalex.org/W6771239896"],"related_works":["https://openalex.org/W1975066220","https://openalex.org/W2361648762","https://openalex.org/W1522547568","https://openalex.org/W2564874675","https://openalex.org/W2385571654","https://openalex.org/W2751847288","https://openalex.org/W1486875326","https://openalex.org/W2019305471","https://openalex.org/W2387760173","https://openalex.org/W1970053198"],"abstract_inverted_index":{"The":[0,113],"study":[1],"of":[2,43,101],"solid\u2013liquid":[3],"equilibria":[4],"in":[5,40,91],"small":[6],"molecules":[7],"such":[8],"as":[9],"l-tryptophan":[10],"(l-Trp),":[11],"which":[12],"possesses":[13],"an":[14,17,22],"\u03b1-amino":[15],"group,":[16,20],"\u03b1-carboxylic":[18],"acid":[19],"and":[21,38,60,80,84,94,105,111,127],"indole":[23],"compound,":[24],"presents":[25],"significant":[26],"challenges.":[27],"This":[28],"research":[29],"introduces":[30],"several":[31],"findings":[32],"aimed":[33],"at":[34],"enhancing":[35],"process":[36,86,103,110,117],"efficiency":[37],"sustainability":[39],"downstream":[41],"processing":[42],"l-Trp":[44],"from":[45,51,70],"fermentative":[46],"origin":[47],"via":[48],"crystallization.":[49],"Transitioning":[50],"batch":[52,93],"to":[53],"continuous":[54,95],"processes":[55],"allows":[56],"for":[57,82,98],"improved":[58],"scalability":[59],"resource":[61],"management.":[62],"Furthermore,":[63],"solubility":[64],"measurements":[65],"combined":[66],"with":[67],"thermodynamic":[68],"data":[69],"the":[71,99,102,109],"literature":[72],"will":[73],"provide":[74],"deeper":[75],"insights":[76],"into":[77],"molecular":[78],"interactions":[79],"allow":[81,97],"systematic":[83],"data-driven":[85],"design.":[87],"Lab-scale":[88],"crystallization":[89],"experiments":[90],"both":[92],"operation":[96],"assessment":[100],"feasibility":[104],"solvent":[106,125],"impacts":[107],"on":[108,116],"product.":[112],"focus":[114],"is":[115],"development":[118],"that":[119],"emphasizes":[120],"material":[121],"savings":[122],"through":[123],"strategic":[124],"selection":[126],"co-solvent":[128],"choices.":[129]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-02T10:15:12.560889","created_date":"2025-10-10T00:00:00"}