{"id":"https://openalex.org/W4409440595","doi":"https://doi.org/10.1007/s42452-025-06800-0","title":"The pharmacological and therapeutic versatility of Allium species: a comprehensive exploration of bioactive constituents and biological activities","display_name":"The pharmacological and therapeutic versatility of Allium species: a comprehensive exploration of bioactive constituents and biological activities","publication_year":2025,"publication_date":"2025-04-14","ids":{"openalex":"https://openalex.org/W4409440595","doi":"https://doi.org/10.1007/s42452-025-06800-0"},"language":"en","primary_location":{"id":"doi:10.1007/s42452-025-06800-0","doi":"https://doi.org/10.1007/s42452-025-06800-0","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s42452-025-06800-0","pdf_url":"https://link.springer.com/content/pdf/10.1007/s42452-025-06800-0.pdf","source":{"id":"https://openalex.org/S5407042868","display_name":"Discover Applied Sciences","issn_l":"3004-9261","issn":["3004-9261"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","jufo-1","norway-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Discover Applied Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://link.springer.com/content/pdf/10.1007/s42452-025-06800-0.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110121249","display_name":"Neeta Singh","orcid":"https://orcid.org/0000-0003-3329-6832","observed_orcids":["https://orcid.org/0000-0003-3329-6832"]},"institutions":[{"id":"https://openalex.org/I186246823","display_name":"University of Lucknow","ror":"https://ror.org/03bdeag60","country_code":"IN","type":"education","lineage":["https://openalex.org/I186246823"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Nisha Singh","raw_affiliation_strings":["Department of Biochemistry, Faculty of Science, University of Lucknow, Lucknow, 226007, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Faculty of Science, University of Lucknow, Lucknow, 226007, India","institution_ids":["https://openalex.org/I186246823"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Anjali Gusain","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185052938","display_name":"Hemwati Nandan Bahuguna Garhwal University","ror":"https://ror.org/00mvp1q86","country_code":"IN","type":"education","lineage":["https://openalex.org/I185052938"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Anjali Gusain","raw_affiliation_strings":["Department of Biochemistry, Hemvati Nandan Bahuguna Garhwal University (A Central University), Srinagar (Garhwal), Uttarakhand, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Hemvati Nandan Bahuguna Garhwal University (A Central University), Srinagar (Garhwal), Uttarakhand, India","institution_ids":["https://openalex.org/I185052938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031592425","display_name":"Manisha Nigam","orcid":"https://orcid.org/0000-0002-2405-9790","observed_orcids":["https://orcid.org/0000-0002-2405-9790"]},"institutions":[{"id":"https://openalex.org/I185052938","display_name":"Hemwati Nandan Bahuguna Garhwal University","ror":"https://ror.org/00mvp1q86","country_code":"IN","type":"education","lineage":["https://openalex.org/I185052938"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Manisha Nigam","raw_affiliation_strings":["Department of Biochemistry, Hemvati Nandan Bahuguna Garhwal University (A Central University), Srinagar (Garhwal), Uttarakhand, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Hemvati Nandan Bahuguna Garhwal University (A Central University), Srinagar (Garhwal), Uttarakhand, India","institution_ids":["https://openalex.org/I185052938"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019849992","display_name":"Abhay Prakash Mishra","orcid":"https://orcid.org/0000-0002-2224-0852","observed_orcids":["https://orcid.org/0000-0002-2224-0852"]},"institutions":[{"id":"https://openalex.org/I66200439","display_name":"Naresuan University","ror":"https://ror.org/03e2qe334","country_code":"TH","type":"education","lineage":["https://openalex.org/I66200439"]}],"countries":["TH"],"is_corresponding":true,"raw_author_name":"Abhay Prakash Mishra","raw_affiliation_strings":["Cosmetics and Natural Products Research Center (CosNat), Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok, 65000, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cosmetics and Natural Products Research Center (CosNat), Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok, 65000, Thailand","institution_ids":["https://openalex.org/I66200439"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5019849992"],"corresponding_institution_ids":["https://openalex.org/I66200439"],"apc_list":null,"apc_paid":null,"fwci":15.8499,"has_fulltext":true,"cited_by_count":31,"citation_normalized_percentile":{"value":0.99439252,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"7","issue":"4","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11979","display_name":"Garlic and Onion Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11979","display_name":"Garlic and Onion Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13124","display_name":"Chemical synthesis and alkaloids","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/allium","display_name":"Allium","score":0.921999990940094},{"id":"https://openalex.org/keywords/garlic","display_name":"garlic","score":0.9959999918937683},{"id":"https://openalex.org/keywords/allium-cepa","display_name":"onion","score":0.9929999709129333},{"id":"https://openalex.org/keywords/chives","display_name":"Allium schoenoprasum","score":0.9490000009536743},{"id":"https://openalex.org/keywords/organosulfur-compounds","display_name":"organosulfur compounds","score":0.9710000157356262},{"id":"https://openalex.org/keywords/allicin","display_name":"allicin","score":0.9729999899864197},{"id":"https://openalex.org/keywords/ajoene","display_name":"ajoene","score":0.9789999723434448},{"id":"https://openalex.org/keywords/s-allyl-cysteine","display_name":"S-allylcysteine","score":0.9900000095367432},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.9779999852180481},{"id":"https://openalex.org/keywords/phenolic-compounds","display_name":"phenolic compounds","score":0.8389999866485596},{"id":"https://openalex.org/keywords/phytosterols","display_name":"phytosterols","score":0.9810000061988831},{"id":"https://openalex.org/keywords/essential-oils","display_name":"essential oils","score":1.0},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.8629999756813049},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.9990000128746033},{"id":"https://openalex.org/keywords/antimicrobial-activity","display_name":"antimicrobial activity","score":0.996999979019165},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.9980000257492065},{"id":"https://openalex.org/keywords/antiviral-activity","display_name":"antiviral activity","score":0.9959999918937683},{"id":"https://openalex.org/keywords/antidiabetic-activity","display_name":"antidiabetic activity","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hepatoprotective-effect","display_name":"hepatoprotection","score":0.9679999947547913},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.9430000185966492},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.9919999837875366},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.9879999756813049},{"id":"https://openalex.org/keywords/nrf2-signaling-pathway","display_name":"Nrf2 signaling","score":0.9610000252723694},{"id":"https://openalex.org/keywords/bioavailability","display_name":"bioavailability","score":0.9459999799728394},{"id":"https://openalex.org/keywords/traditional-medicine","display_name":"traditional medicine","score":0.5529999732971191},{"id":"https://openalex.org/keywords/chronic-disease-prevention","display_name":"chronic disease prevention","score":0.5400000214576721}],"concepts":[{"id":"https://openalex.org/C2776460402","wikidata":"https://www.wikidata.org/wiki/Q49391","display_name":"Allium","level":2,"score":0.5776067972183228},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3551460802555084},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.194902241230011}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1007/s42452-025-06800-0","doi":"https://doi.org/10.1007/s42452-025-06800-0","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s42452-025-06800-0","pdf_url":"https://link.springer.com/content/pdf/10.1007/s42452-025-06800-0.pdf","source":{"id":"https://openalex.org/S5407042868","display_name":"Discover Applied Sciences","issn_l":"3004-9261","issn":["3004-9261"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","jufo-1","norway-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Discover Applied Sciences","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:e2fcf777a53f49d49f131d21fd05c585","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/e2fcf777a53f49d49f131d21fd05c585","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Discover Applied Sciences, Vol 7, Iss 4, Pp 1-29 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1007/s42452-025-06800-0","doi":"https://doi.org/10.1007/s42452-025-06800-0","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s42452-025-06800-0","pdf_url":"https://link.springer.com/content/pdf/10.1007/s42452-025-06800-0.pdf","source":{"id":"https://openalex.org/S5407042868","display_name":"Discover Applied Sciences","issn_l":"3004-9261","issn":["3004-9261"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","jufo-1","norway-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Discover Applied Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"sustainable_development_goals_aurora":[{"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2","score":0.7300000190734863}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1380533547","display_name":null,"funder_award_id":"R2566C053","funder_id":"https://openalex.org/F4320323020","funder_display_name":"Naresuan University"}],"funders":[{"id":"https://openalex.org/F4320323020","display_name":"Naresuan University","ror":"https://ror.org/03e2qe334"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4409440595.pdf","grobid_xml":"https://content.openalex.org/works/W4409440595.grobid-xml"},"referenced_works_count":152,"referenced_works":["https://openalex.org/W1049382","https://openalex.org/W1515590569","https://openalex.org/W1532320969","https://openalex.org/W1579888370","https://openalex.org/W1971881301","https://openalex.org/W1972666457","https://openalex.org/W1972965249","https://openalex.org/W1972996991","https://openalex.org/W2002219939","https://openalex.org/W2006734701","https://openalex.org/W2008086015","https://openalex.org/W2012036807","https://openalex.org/W2056498645","https://openalex.org/W2061056027","https://openalex.org/W2073625204","https://openalex.org/W2073688450","https://openalex.org/W2088156304","https://openalex.org/W2090720073","https://openalex.org/W2094845384","https://openalex.org/W2100337344","https://openalex.org/W2112747117","https://openalex.org/W2135548066","https://openalex.org/W2170814764","https://openalex.org/W2173893588","https://openalex.org/W2240125394","https://openalex.org/W2396661243","https://openalex.org/W2435056126","https://openalex.org/W2470061806","https://openalex.org/W2511809193","https://openalex.org/W2555798470","https://openalex.org/W2583555841","https://openalex.org/W2589764285","https://openalex.org/W2597544336","https://openalex.org/W2612802906","https://openalex.org/W2750503033","https://openalex.org/W2768781993","https://openalex.org/W2772579023","https://openalex.org/W2790815239","https://openalex.org/W2791862058","https://openalex.org/W2792130207","https://openalex.org/W2801785722","https://openalex.org/W2802806467","https://openalex.org/W2883601094","https://openalex.org/W2897535127","https://openalex.org/W2899052178","https://openalex.org/W2902783996","https://openalex.org/W2905584925","https://openalex.org/W2906879477","https://openalex.org/W2913872902","https://openalex.org/W2914865316","https://openalex.org/W2921435110","https://openalex.org/W2921494377","https://openalex.org/W2922384902","https://openalex.org/W2938767315","https://openalex.org/W2941488156","https://openalex.org/W2952166814","https://openalex.org/W2954364933","https://openalex.org/W2955644861","https://openalex.org/W2960859814","https://openalex.org/W2964105339","https://openalex.org/W2968874731","https://openalex.org/W2969666099","https://openalex.org/W2970408639","https://openalex.org/W2982513684","https://openalex.org/W3005388425","https://openalex.org/W3007167923","https://openalex.org/W3007904571","https://openalex.org/W3008425650","https://openalex.org/W3009877568","https://openalex.org/W3012124055","https://openalex.org/W3013025666","https://openalex.org/W3013726226","https://openalex.org/W3014512402","https://openalex.org/W3015815595","https://openalex.org/W3017826687","https://openalex.org/W3023842636","https://openalex.org/W3044467622","https://openalex.org/W3044693468","https://openalex.org/W3049640026","https://openalex.org/W3087137460","https://openalex.org/W3088446762","https://openalex.org/W3089443368","https://openalex.org/W3093043311","https://openalex.org/W3110630604","https://openalex.org/W3121524469","https://openalex.org/W3133863742","https://openalex.org/W3143823474","https://openalex.org/W3151278719","https://openalex.org/W3155079038","https://openalex.org/W3158720945","https://openalex.org/W3163661642","https://openalex.org/W3174005468","https://openalex.org/W3176089540","https://openalex.org/W3177751380","https://openalex.org/W3190394210","https://openalex.org/W3192412931","https://openalex.org/W3195506178","https://openalex.org/W3199668131","https://openalex.org/W3200075171","https://openalex.org/W3200104592","https://openalex.org/W3203966078","https://openalex.org/W3205631540","https://openalex.org/W3213718161","https://openalex.org/W4200308045","https://openalex.org/W4205626788","https://openalex.org/W4206053781","https://openalex.org/W4206292634","https://openalex.org/W4206553335","https://openalex.org/W4210687140","https://openalex.org/W4214891842","https://openalex.org/W4220937053","https://openalex.org/W4221050007","https://openalex.org/W4225285596","https://openalex.org/W4229454574","https://openalex.org/W4238310184","https://openalex.org/W4283819723","https://openalex.org/W4283833415","https://openalex.org/W4292559953","https://openalex.org/W4293382678","https://openalex.org/W4293527434","https://openalex.org/W4293559782","https://openalex.org/W4295021429","https://openalex.org/W4303446498","https://openalex.org/W4312057948","https://openalex.org/W4312874996","https://openalex.org/W4321332218","https://openalex.org/W4324290683","https://openalex.org/W4327980523","https://openalex.org/W4353092626","https://openalex.org/W4378515613","https://openalex.org/W4383496004","https://openalex.org/W4385971377","https://openalex.org/W4386117155","https://openalex.org/W4388348378","https://openalex.org/W4388591060","https://openalex.org/W4389056307","https://openalex.org/W4390704756","https://openalex.org/W4391166432","https://openalex.org/W4391311743","https://openalex.org/W4392200111","https://openalex.org/W4393125870","https://openalex.org/W4394764888","https://openalex.org/W4399296868","https://openalex.org/W4400942227","https://openalex.org/W4401055984","https://openalex.org/W4402919177","https://openalex.org/W4403137779","https://openalex.org/W4403574388","https://openalex.org/W4404257767","https://openalex.org/W4404718102","https://openalex.org/W4405175014","https://openalex.org/W6685852916"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2082860237","https://openalex.org/W2119695867","https://openalex.org/W2130076355","https://openalex.org/W1990804418","https://openalex.org/W1993764875","https://openalex.org/W2046158694","https://openalex.org/W2788277189","https://openalex.org/W2013243191","https://openalex.org/W1971568933"],"abstract_inverted_index":{"The":[0],"Allium":[1,36,144,155],"genus,":[2],"encompassing":[3],"garlic,":[4],"onion,":[5],"chives,":[6],"and":[7,50,69,78,105,117,127,134,141,160,167,178],"related":[8],"species,":[9,37,156],"has":[10],"been":[11],"an":[12],"integral":[13],"part":[14],"of":[15,35,59,119,143,154],"traditional":[16,176],"medicine":[17],"for":[18,164],"centuries":[19],"due":[20],"to":[21,114,171],"its":[22],"remarkable":[23],"pharmacological":[24,168],"properties.":[25],"This":[26,147],"review":[27,148],"consolidates":[28],"current":[29],"insights":[30],"into":[31],"the":[32,115,139,150,173],"therapeutic":[33],"potential":[34],"focusing":[38],"on":[39],"their":[40,165],"diverse":[41],"bioactive":[42,73],"compounds,":[43,46],"including":[44,62],"organosulfur":[45],"flavonoids,":[47],"phenolics,":[48],"phytosterols,":[49],"essential":[51],"oils.":[52],"These":[53],"constituents":[54],"confer":[55],"a":[56],"wide":[57],"range":[58],"biological":[60],"activities,":[61],"anti-inflammatory,":[63],"antioxidant,":[64],"antimicrobial,":[65],"anticancer,":[66],"antiviral,":[67],"antidiabetic,":[68],"hepatoprotective":[70],"effects.":[71],"Key":[72],"such":[74,122],"as":[75,123],"allicin,":[76],"ajoene,":[77],"S-allyl":[79],"cysteine":[80],"play":[81],"pivotal":[82],"roles":[83],"in":[84],"modulating":[85],"cellular":[86],"signaling":[87],"pathways":[88],"like":[89],"Nuclear":[90,106],"Factor":[91,107,110],"kappa":[92],"B":[93,102],"(NF-\u03baB),":[94],"Mitogen-Activated":[95],"Protein":[96],"Kinase":[97,101],"(MAPK),":[98],"Phosphoinositide":[99],"3-Kinase/Protein":[100],"(PI3":[103],"K/AKT),":[104],"Erythroid":[108],"2-Related":[109],"2":[111],"(Nrf2),":[112],"contributing":[113],"prevention":[116],"treatment":[118],"chronic":[120],"diseases":[121],"cancer,":[124],"cardiovascular":[125],"disorders,":[126],"inflammatory":[128],"conditions.":[129],"Species-specific":[130],"characteristics,":[131],"processing":[132],"methods,":[133],"environmental":[135],"factors":[136],"significantly":[137],"influence":[138],"bioavailability":[140],"efficacy":[142],"-derived":[145],"compounds.":[146],"underscores":[149],"multifaceted":[151],"health":[152],"benefits":[153],"highlights":[157],"knowledge":[158],"gaps,":[159],"identifies":[161],"future":[162],"directions":[163],"clinical":[166],"exploitation,":[169],"aiming":[170],"bridge":[172],"gap":[174],"between":[175],"applications":[177],"evidence-based":[179],"therapeutics.":[180]},"counts_by_year":[{"year":2026,"cited_by_count":22},{"year":2025,"cited_by_count":9}],"updated_date":"2026-10-06T10:28:23.643775","created_date":"2025-10-10T00:00:00"}
