{"id":"https://openalex.org/W4409437468","doi":"https://doi.org/10.21608/bfsa.2025.330779.2322","title":"Association between vitamin D levels and the treatment responses to sofosbuvir containing regimens in chronic HCV Egyptian patients","display_name":"Association between vitamin D levels and the treatment responses to sofosbuvir containing regimens in chronic HCV Egyptian patients","publication_year":2025,"publication_date":"2025-04-05","ids":{"openalex":"https://openalex.org/W4409437468","doi":"https://doi.org/10.21608/bfsa.2025.330779.2322"},"language":"en","primary_location":{"id":"doi:10.21608/bfsa.2025.330779.2322","doi":"https://doi.org/10.21608/bfsa.2025.330779.2322","is_oa":true,"landing_page_url":"https://doi.org/10.21608/bfsa.2025.330779.2322","pdf_url":null,"source":{"id":"https://openalex.org/S936776586","display_name":"Bulletin of Pharmaceutical Sciences Assiut","issn_l":"1110-0052","issn":["1110-0052","3009-7703"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4323237894","host_organization_name":"Egypts Presidential Specialized Council for Education and Scientific Research","host_organization_lineage":["https://openalex.org/P4323237894"],"host_organization_lineage_names":["Egypts Presidential Specialized Council for Education and Scientific Research"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bulletin of Pharmaceutical Sciences Assiut University","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.21608/bfsa.2025.330779.2322","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Demiana B Hanna","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Demiana B Hanna","raw_affiliation_strings":["Department of Chemistry, Faculty of Science, Cairo University, Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Faculty of Science, Cairo University, Cairo, Egypt","institution_ids":["https://openalex.org/I145487455"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Nourhan Shehata","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Nourhan Shehata","raw_affiliation_strings":["Department of Chemistry, Faculty of Science, Cairo University, Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Faculty of Science, Cairo University, Cairo, Egypt","institution_ids":["https://openalex.org/I145487455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046102019","display_name":"Sahar Mohamed","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210138334","display_name":"General Organization For Teaching Hospitals and Institutes","ror":"https://ror.org/040ejvh72","country_code":"EG","type":"government","lineage":["https://openalex.org/I4210138334"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Sahar Mohamed","raw_affiliation_strings":["Tropical department, National Hepatology and tropical medicine research institute, The general organization for teaching hospitals and institute Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tropical department, National Hepatology and tropical medicine research institute, The general organization for teaching hospitals and institute Cairo, Egypt","institution_ids":["https://openalex.org/I4210138334"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078892717","display_name":"Waleed Elagawy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I88017793","display_name":"Port Said University","ror":"https://ror.org/01vx5yq44","country_code":"EG","type":"education","lineage":["https://openalex.org/I88017793"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Waleed Elagawy","raw_affiliation_strings":["Infectious Diseases, Faculty of Medicine, Port Said University Cairo, Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Diseases, Faculty of Medicine, Port Said University Cairo, Cairo, Egypt","institution_ids":["https://openalex.org/I88017793"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112855856","display_name":"Wafaa Salah Mohamed Hegab","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210138334","display_name":"General Organization For Teaching Hospitals and Institutes","ror":"https://ror.org/040ejvh72","country_code":"EG","type":"government","lineage":["https://openalex.org/I4210138334"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Wafaa Hegab","raw_affiliation_strings":["Internal medicine department, National diabetes institute, The general organization for teaching hospitals and institute Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal medicine department, National diabetes institute, The general organization for teaching hospitals and institute Cairo, Egypt","institution_ids":["https://openalex.org/I4210138334"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046092274","display_name":"Mahmoud Maamoun Shaheen","orcid":"https://orcid.org/0000-0002-6144-6044","observed_orcids":["https://orcid.org/0000-0002-6144-6044"]},"institutions":[{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Mahmoud M Shaheen","raw_affiliation_strings":["Department of Internal Medicine, Faculty of Medicine, Cairo University, Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Faculty of Medicine, Cairo University, Cairo, Egypt","institution_ids":["https://openalex.org/I145487455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092623564","display_name":"Reem Elmahdy","orcid":"https://orcid.org/0009-0006-7120-4467","observed_orcids":["https://orcid.org/0009-0006-7120-4467"]},"institutions":[{"id":"https://openalex.org/I114794399","display_name":"Suez Canal University","ror":"https://ror.org/02m82p074","country_code":"EG","type":"education","lineage":["https://openalex.org/I114794399"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Reem Elmahdy","raw_affiliation_strings":["Department of Internal medicine, Faculty of Medicine, Suez Canal University, Suez, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal medicine, Faculty of Medicine, Suez Canal University, Suez, Egypt","institution_ids":["https://openalex.org/I114794399"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Amal Mohammed","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210138334","display_name":"General Organization For Teaching Hospitals and Institutes","ror":"https://ror.org/040ejvh72","country_code":"EG","type":"government","lineage":["https://openalex.org/I4210138334"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Amal Mohammed","raw_affiliation_strings":["Biochemistry and molecular biology department, National Hepatology and tropical medicine research institute, The general organization for teaching hospitals and institute Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry and molecular biology department, National Hepatology and tropical medicine research institute, The general organization for teaching hospitals and institute Cairo, Egypt","institution_ids":["https://openalex.org/I4210138334"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004717471","display_name":"Mohamed Ali El-Desouky","orcid":"https://orcid.org/0000-0001-5007-5455","observed_orcids":["https://orcid.org/0000-0001-5007-5455"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mohamed A. A. El Desouky","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"0","issue":"0","first_page":"0","last_page":"0"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vitamin-d","display_name":"vitamin D","score":0.8769999742507935},{"id":"https://openalex.org/keywords/chronic-hepatitis-c","display_name":"chronic hepatitis C","score":0.8050000071525574},{"id":"https://openalex.org/keywords/sofosbuvir","display_name":"sofosbuvir","score":0.9700000286102295},{"id":"https://openalex.org/keywords/direct-acting-antivirals","display_name":"direct-acting antivirals","score":0.8450000286102295},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.906000018119812},{"id":"https://openalex.org/keywords/serum-biomarkers","display_name":"serum biomarkers","score":0.527999997138977},{"id":"https://openalex.org/keywords/lipid-profile","display_name":"lipid profile","score":0.7789999842643738},{"id":"https://openalex.org/keywords/inflammatory-markers","display_name":"inflammatory markers","score":0.7940000295639038},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.7940000295639038},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9319999814033508},{"id":"https://openalex.org/keywords/sun-exposure","display_name":"sun exposure","score":0.6600000262260437},{"id":"https://openalex.org/keywords/thyroid-stimulating-hormone","display_name":"thyroid-stimulating hormone","score":0.8659999966621399},{"id":"https://openalex.org/keywords/liver-enzymes","display_name":"liver enzymes","score":0.6290000081062317},{"id":"https://openalex.org/keywords/egypt","display_name":"Egypt","score":0.44200000166893005}],"concepts":[{"id":"https://openalex.org/C2778390639","wikidata":"https://www.wikidata.org/wiki/Q2502747","display_name":"Sofosbuvir","level":5,"score":0.9574321508407593},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7177742719650269},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5189192295074463},{"id":"https://openalex.org/C3020491458","wikidata":"https://www.wikidata.org/wiki/Q131742","display_name":"Chronic hepatitis","level":3,"score":0.5055809020996094},{"id":"https://openalex.org/C2780040827","wikidata":"https://www.wikidata.org/wiki/Q421862","display_name":"Ribavirin","level":4,"score":0.4744254946708679},{"id":"https://openalex.org/C124490489","wikidata":"https://www.wikidata.org/wiki/Q7936963","display_name":"Vitamin D and neurology","level":2,"score":0.4200277328491211},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.36977657675743103},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3644278347492218},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3468676805496216},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.14903199672698975}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.21608/bfsa.2025.330779.2322","doi":"https://doi.org/10.21608/bfsa.2025.330779.2322","is_oa":true,"landing_page_url":"https://doi.org/10.21608/bfsa.2025.330779.2322","pdf_url":null,"source":{"id":"https://openalex.org/S936776586","display_name":"Bulletin of Pharmaceutical Sciences Assiut","issn_l":"1110-0052","issn":["1110-0052","3009-7703"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4323237894","host_organization_name":"Egypts Presidential Specialized Council for Education and Scientific Research","host_organization_lineage":["https://openalex.org/P4323237894"],"host_organization_lineage_names":["Egypts Presidential Specialized Council for Education and Scientific Research"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bulletin of Pharmaceutical Sciences Assiut University","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:385040ee99e04a1e9eff94bf86d36cee","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/385040ee99e04a1e9eff94bf86d36cee","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bulletin of Pharmaceutical Sciences. Assiut University, Vol 48, Iss 1, Pp 433-456 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.21608/bfsa.2025.330779.2322","doi":"https://doi.org/10.21608/bfsa.2025.330779.2322","is_oa":true,"landing_page_url":"https://doi.org/10.21608/bfsa.2025.330779.2322","pdf_url":null,"source":{"id":"https://openalex.org/S936776586","display_name":"Bulletin of Pharmaceutical Sciences Assiut","issn_l":"1110-0052","issn":["1110-0052","3009-7703"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4323237894","host_organization_name":"Egypts Presidential Specialized Council for Education and Scientific Research","host_organization_lineage":["https://openalex.org/P4323237894"],"host_organization_lineage_names":["Egypts Presidential Specialized Council for Education and Scientific Research"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bulletin of Pharmaceutical Sciences Assiut University","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2781083412","https://openalex.org/W3081772269","https://openalex.org/W2897388309","https://openalex.org/W4206836393","https://openalex.org/W2332332189","https://openalex.org/W2182671950","https://openalex.org/W2334244055","https://openalex.org/W2142883277","https://openalex.org/W4285005073","https://openalex.org/W2887847945"],"abstract_inverted_index":{"Background":[0],"Hepatitis":[1],"C":[2,27],"virus":[3],"(HCV)":[4],"is":[5,11,29],"a":[6,30,75,132,174,216],"worldwide":[7,51],"epidemic,":[8],"and":[9,47,100,116,154,159,187,191,223,244],"it":[10],"the":[12,22,59,67,84,106,120,150,166,198,204,220,224,239],"highest":[13,60],"widespread":[14],"blood-transmitted":[15],"infectious":[16],"viruses":[17],"which":[18],"replication":[19],"occurs":[20],"in":[21,72,78,111,161,193],"liver.":[23],"Nowadays,":[24],"chronic":[25],"hepatitis":[26],"(CHC)":[28],"very":[31],"serious":[32],"health":[33],"problem.":[34],"Every":[35],"year,":[36],"about":[37,89],"1.5":[38],"million":[39,49,86,91],"newly":[40],"identified":[41],"cases":[42],"of":[43,62,80,108,232],"CHC":[44],"are":[45],"reported,":[46],"58":[48],"individuals":[50,92],"live":[52],"with":[53,119],"this":[54],"condition.":[55],"Also,":[56,203],"Egypt":[57,73],"records":[58],"percentage":[61],"HCV":[63,114,162,194,221,233],"viral":[64],"infection":[65],"around":[66],"world.":[68],"The":[69,124],"national":[70],"program":[71],"achieved":[74],"remarkable":[76],"success":[77],"terms":[79],"participation":[81],"rate.":[82],"From":[83],"62.5":[85],"target":[87],"population,":[88],"49.6":[90],"(79.4%)":[93],"performed":[94],"screening":[95],"between":[96,219],"October":[97],"1,":[98],"2018,":[99],"April":[101],"30,":[102],"2019.":[103],"Objective:":[104],"Investigate":[105],"levels":[107,207],"vitamin":[109,205],"D":[110,206],"serum":[112],"among":[113],"patients":[115,163,195,222,234],"its":[117],"correlation":[118],"response":[121],"to":[122,136,165,178,197,214],"sofosbuvir.":[123],"current":[125],"study":[126],"results":[127],"showed":[128],"that":[129],"there":[130,172],"was":[131,173],"significant":[133,175,217],"increase":[134],"regarding":[135,177],"AST,":[137],"ALT,":[138],"AFP,":[139],"GGT,":[140],"direct":[141],"bilirubin,":[142,144],"total":[143,184],"creatinine,":[145],"urea,":[146],"HbA1c,":[147],"WBCs,":[148],"INR,":[149],"inflammatory":[151,245],"markers":[152],"(IL-6":[153],"TNF-\u03b1),":[155],"sun":[156],"exposure":[157],"levels,":[158],"TSH":[160],"compared":[164,196],"control":[167,199,225],"group":[168,200,226],"(P":[169,201,227],"<0.05).":[170,202],"While":[171],"decrease":[176],"lipid":[179,242],"profile":[180],"(such":[181],"as":[182],"triglycerides,":[183],"cholesterol,":[185],"LDL,":[186],"HDL),":[188],"albumin,":[189],"Hb,":[190],"platelets":[192],"were":[208],"slightly":[209],"decreased,":[210],"but":[211],"not":[212],"enough":[213],"be":[215],"change":[218],">":[228],"0.05).":[229],"Conclusion:":[230],"Treatment":[231],"using":[235],"sofosbuvir-containing":[236],"regimens":[237],"improved":[238],"liver,":[240],"renal,":[241],"profile,":[243],"parameters.":[246]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2025-04-15T00:00:00"}
