{"id":"https://openalex.org/W4409433385","doi":"https://doi.org/10.1016/j.euroneuro.2025.03.013","title":"Longitudinal brain age in first-episode mania youth treated with lithium or quetiapine","display_name":"Longitudinal brain age in first-episode mania youth treated with lithium or quetiapine","publication_year":2025,"publication_date":"2025-04-14","ids":{"openalex":"https://openalex.org/W4409433385","doi":"https://doi.org/10.1016/j.euroneuro.2025.03.013","pmid":"https://pubmed.ncbi.nlm.nih.gov/40222151"},"language":"en","primary_location":{"id":"doi:10.1016/j.euroneuro.2025.03.013","doi":"https://doi.org/10.1016/j.euroneuro.2025.03.013","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.euroneuro.2025.03.013","pdf_url":null,"source":{"id":"https://openalex.org/S168041952","display_name":"European Neuropsychopharmacology","issn_l":"0924-977X","issn":["0924-977X","1873-7862"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Neuropsychopharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.euroneuro.2025.03.013","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005159847","display_name":"Laura K. M. Han","orcid":"https://orcid.org/0000-0001-9647-3723","observed_orcids":["https://orcid.org/0000-0001-9647-3723"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I4210108594","display_name":"Amsterdam Neuroscience","ror":"https://ror.org/01x2d9f70","country_code":"NL","type":"facility","lineage":["https://openalex.org/I4210108594"]},{"id":"https://openalex.org/I4210112801","display_name":"Orygen","ror":"https://ror.org/02apyk545","country_code":"AU","type":"other","lineage":["https://openalex.org/I4210112801"]},{"id":"https://openalex.org/I4210151833","display_name":"Amsterdam University Medical Centers","ror":"https://ror.org/05grdyy37","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I865915315","display_name":"Vrije Universiteit Amsterdam","ror":"https://ror.org/008xxew50","country_code":"NL","type":"education","lineage":["https://openalex.org/I865915315"]}],"countries":["AU","NL"],"is_corresponding":true,"raw_author_name":"Laura K.M. Han","raw_affiliation_strings":["Department of Psychiatry, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands; Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia; Orygen, Parkville, VIC, Australia. Electronic address: l.han@amsterdamumc.nl"],"raw_orcid":"https://orcid.org/0000-0001-9647-3723","affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands; Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia; Orygen, Parkville, VIC, Australia. Electronic address: l.han@amsterdamumc.nl","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I4210108594","https://openalex.org/I4210112801","https://openalex.org/I4210151833","https://openalex.org/I865915315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029872329","display_name":"Niousha Dehestani","orcid":"https://orcid.org/0000-0002-3970-8239","observed_orcids":["https://orcid.org/0000-0002-3970-8239"]},"institutions":[{"id":"https://openalex.org/I149704539","display_name":"Deakin University","ror":"https://ror.org/02czsnj07","country_code":"AU","type":"education","lineage":["https://openalex.org/I149704539"]},{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I4210158168","display_name":"Melbourne Health","ror":"https://ror.org/04z4kmw33","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210158168"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Niousha Dehestani","raw_affiliation_strings":["Deakin University, Centre for Social and Early Emotional Development, School of Psychology, Faculty of Health, Geelong, Victoria, Australia; Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Victoria, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Deakin University, Centre for Social and Early Emotional Development, School of Psychology, Faculty of Health, Geelong, Victoria, Australia; Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Victoria, Australia","institution_ids":["https://openalex.org/I149704539","https://openalex.org/I165779595","https://openalex.org/I4210158168"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018485068","display_name":"Chao Suo","orcid":"https://orcid.org/0000-0002-9358-6690","observed_orcids":["https://orcid.org/0000-0002-9358-6690"]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Chao Suo","raw_affiliation_strings":["Turner Institute for Brain and Mental Health, School of Psychological Science and Monash Biomedical Imaging, Monash University, Victoria, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Turner Institute for Brain and Mental Health, School of Psychological Science and Monash Biomedical Imaging, Monash University, Victoria, Australia","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058807414","display_name":"Rothanthi Daglas\u2010Georgiou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I4210112801","display_name":"Orygen","ror":"https://ror.org/02apyk545","country_code":"AU","type":"other","lineage":["https://openalex.org/I4210112801"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Rothanthi Daglas-Georgiou","raw_affiliation_strings":["Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia; Orygen, Parkville, VIC, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia; Orygen, Parkville, VIC, Australia","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I4210112801"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088704274","display_name":"Melissa K Hasty","orcid":"https://orcid.org/0009-0000-9040-7602","observed_orcids":["https://orcid.org/0009-0000-9040-7602"]},"institutions":[{"id":"https://openalex.org/I4210112801","display_name":"Orygen","ror":"https://ror.org/02apyk545","country_code":"AU","type":"other","lineage":["https://openalex.org/I4210112801"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Melissa Hasty","raw_affiliation_strings":["Orygen, Parkville, VIC, Australia"],"raw_orcid":"https://orcid.org/0009-0000-9040-7602","affiliations":[{"raw_affiliation_string":"Orygen, Parkville, VIC, Australia","institution_ids":["https://openalex.org/I4210112801"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042386513","display_name":"Linda F. Kader","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I4210112801","display_name":"Orygen","ror":"https://ror.org/02apyk545","country_code":"AU","type":"other","lineage":["https://openalex.org/I4210112801"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Linda Kader","raw_affiliation_strings":["Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia; Orygen, Parkville, VIC, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia; Orygen, Parkville, VIC, Australia","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I4210112801"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084020146","display_name":"Brend\u00e1n Murphy","orcid":"https://orcid.org/0000-0001-5259-4849","observed_orcids":["https://orcid.org/0000-0001-5259-4849"]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Brendan P. Murphy","raw_affiliation_strings":["Department of Psychiatry, Monash University, Clayton, VIC, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Monash University, Clayton, VIC, Australia","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011264157","display_name":"Christos Pantelis","orcid":"https://orcid.org/0000-0002-9565-0238","observed_orcids":["https://orcid.org/0000-0002-9565-0238"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I4210158168","display_name":"Melbourne Health","ror":"https://ror.org/04z4kmw33","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210158168"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Christos Pantelis","raw_affiliation_strings":["Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Victoria, Australia"],"raw_orcid":"https://orcid.org/0000-0002-9565-0238","affiliations":[{"raw_affiliation_string":"Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Victoria, Australia","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I4210158168"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055959065","display_name":"Murat Y\u00fccel","orcid":"https://orcid.org/0000-0002-4705-452X","observed_orcids":["https://orcid.org/0000-0002-4705-452X"]},"institutions":[{"id":"https://openalex.org/I217937681","display_name":"QIMR Berghofer Medical Research Institute","ror":"https://ror.org/004y8wk30","country_code":"AU","type":"facility","lineage":["https://openalex.org/I217937681"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Murat Y\u00fccel","raw_affiliation_strings":["QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia"],"raw_orcid":"https://orcid.org/0000-0002-4705-452X","affiliations":[{"raw_affiliation_string":"QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia","institution_ids":["https://openalex.org/I217937681"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Michael Berk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I132157203","display_name":"Barwon Health","ror":"https://ror.org/00my0hg66","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I132157203"]},{"id":"https://openalex.org/I149704539","display_name":"Deakin University","ror":"https://ror.org/02czsnj07","country_code":"AU","type":"education","lineage":["https://openalex.org/I149704539"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Michael Berk","raw_affiliation_strings":["Deakin University, IMPACT, The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Barwon Health, P.O. Box 281, Geelong, 3220, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Deakin University, IMPACT, The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Barwon Health, P.O. Box 281, Geelong, 3220, Australia","institution_ids":["https://openalex.org/I132157203","https://openalex.org/I149704539"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006025400","display_name":"Lianne Schmaal","orcid":"https://orcid.org/0000-0001-9822-048X","observed_orcids":["https://orcid.org/0000-0001-9822-048X"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I4210112801","display_name":"Orygen","ror":"https://ror.org/02apyk545","country_code":"AU","type":"other","lineage":["https://openalex.org/I4210112801"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Lianne Schmaal","raw_affiliation_strings":["Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia; Orygen, Parkville, VIC, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia; Orygen, Parkville, VIC, Australia","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I4210112801"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5005159847"],"corresponding_institution_ids":["https://openalex.org/I165779595","https://openalex.org/I4210108594","https://openalex.org/I4210112801","https://openalex.org/I4210151833","https://openalex.org/I865915315"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":{"value":3000,"currency":"USD","value_usd":3000},"fwci":4.3035,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.94464862,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"95","issue":null,"first_page":"40","last_page":"48"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10854","display_name":"Bipolar Disorder and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10854","display_name":"Bipolar Disorder and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/first-episode-mania","display_name":"first-episode mania","score":0.878000020980835},{"id":"https://openalex.org/keywords/lithium","display_name":"lithium","score":0.6639999747276306},{"id":"https://openalex.org/keywords/quetiapine","display_name":"quetiapine","score":1.0},{"id":"https://openalex.org/keywords/brain-age","display_name":"brain age","score":0.6470000147819519},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.890999972820282},{"id":"https://openalex.org/keywords/bipolar-disorder","display_name":"bipolar disorder","score":0.8999999761581421},{"id":"https://openalex.org/keywords/schizoaffective-disorder","display_name":"schizoaffective disorder","score":0.9990000128746033},{"id":"https://openalex.org/keywords/youth","display_name":"youth","score":0.45500001311302185},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.5260000228881836},{"id":"https://openalex.org/keywords/functional-outcome","display_name":"functional outcome","score":0.5440000295639038}],"concepts":[{"id":"https://openalex.org/C2780634440","wikidata":"https://www.wikidata.org/wiki/Q408535","display_name":"Quetiapine","level":3,"score":0.913061261177063},{"id":"https://openalex.org/C2776809841","wikidata":"https://www.wikidata.org/wiki/Q185935","display_name":"Mania","level":4,"score":0.7156270146369934},{"id":"https://openalex.org/C2778541603","wikidata":"https://www.wikidata.org/wiki/Q152763","display_name":"Lithium (medication)","level":2,"score":0.5131719708442688},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.501209020614624},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.40837353467941284},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.40798813104629517},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.34591421484947205},{"id":"https://openalex.org/C2776174506","wikidata":"https://www.wikidata.org/wiki/Q131755","display_name":"Bipolar disorder","level":3,"score":0.280027836561203},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.072003573179245}],"mesh":[{"descriptor_ui":"D000069348","descriptor_name":"Quetiapine Fumarate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000069348","descriptor_name":"Quetiapine Fumarate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000069348","descriptor_name":"Quetiapine Fumarate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000069348","descriptor_name":"Quetiapine Fumarate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000069348","descriptor_name":"Quetiapine Fumarate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000069348","descriptor_name":"Quetiapine Fumarate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000069348","descriptor_name":"Quetiapine Fumarate","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000069348","descriptor_name":"Quetiapine Fumarate","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000069348","descriptor_name":"Quetiapine Fumarate","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000069348","descriptor_name":"Quetiapine Fumarate","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000069348","descriptor_name":"Quetiapine Fumarate","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000069348","descriptor_name":"Quetiapine Fumarate","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000087122","descriptor_name":"Mania","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D000087122","descriptor_name":"Mania","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D000087122","descriptor_name":"Mania","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D000087122","descriptor_name":"Mania","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D000087122","descriptor_name":"Mania","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D000087122","descriptor_name":"Mania","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D000087122","descriptor_name":"Mania","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000087122","descriptor_name":"Mania","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000087122","descriptor_name":"Mania","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000087122","descriptor_name":"Mania","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000087122","descriptor_name":"Mania","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000087122","descriptor_name":"Mania","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001714","descriptor_name":"Bipolar Disorder","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001714","descriptor_name":"Bipolar Disorder","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001714","descriptor_name":"Bipolar Disorder","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001714","descriptor_name":"Bipolar Disorder","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001714","descriptor_name":"Bipolar Disorder","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001714","descriptor_name":"Bipolar Disorder","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001714","descriptor_name":"Bipolar Disorder","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001714","descriptor_name":"Bipolar Disorder","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001714","descriptor_name":"Bipolar Disorder","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001714","descriptor_name":"Bipolar Disorder","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001714","descriptor_name":"Bipolar Disorder","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001714","descriptor_name":"Bipolar Disorder","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008137","descriptor_name":"Longitudinal Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008137","descriptor_name":"Longitudinal Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008137","descriptor_name":"Longitudinal Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008137","descriptor_name":"Longitudinal Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008137","descriptor_name":"Longitudinal Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008137","descriptor_name":"Longitudinal Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011618","descriptor_name":"Psychotic Disorders","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D011618","descriptor_name":"Psychotic Disorders","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D011618","descriptor_name":"Psychotic Disorders","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D011618","descriptor_name":"Psychotic Disorders","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D011618","descriptor_name":"Psychotic Disorders","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D011618","descriptor_name":"Psychotic Disorders","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D011618","descriptor_name":"Psychotic Disorders","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D011618","descriptor_name":"Psychotic Disorders","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D011618","descriptor_name":"Psychotic Disorders","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D011618","descriptor_name":"Psychotic Disorders","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D011618","descriptor_name":"Psychotic Disorders","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D011618","descriptor_name":"Psychotic Disorders","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D014150","descriptor_name":"Antipsychotic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D014150","descriptor_name":"Antipsychotic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D014150","descriptor_name":"Antipsychotic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D014150","descriptor_name":"Antipsychotic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D014150","descriptor_name":"Antipsychotic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D014150","descriptor_name":"Antipsychotic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018692","descriptor_name":"Antimanic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D018692","descriptor_name":"Antimanic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D018692","descriptor_name":"Antimanic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D018692","descriptor_name":"Antimanic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D018692","descriptor_name":"Antimanic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D018692","descriptor_name":"Antimanic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1016/j.euroneuro.2025.03.013","doi":"https://doi.org/10.1016/j.euroneuro.2025.03.013","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.euroneuro.2025.03.013","pdf_url":null,"source":{"id":"https://openalex.org/S168041952","display_name":"European Neuropsychopharmacology","issn_l":"0924-977X","issn":["0924-977X","1873-7862"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Neuropsychopharmacology","raw_type":"journal-article"},{"id":"pmid:40222151","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40222151","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:pure.amsterdamumc.nl:openaire/eec5da91-f52e-4001-8c71-098b79cd8f0a","doi":null,"is_oa":true,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/eec5da91-f52e-4001-8c71-098b79cd8f0a","pdf_url":null,"source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Han, L K M, Dehestani, N, Suo, C, Daglas-Georgiou, R, Hasty, M, Kader, L, Murphy, B P, Pantelis, C, Y\u00fccel, M, Berk, M & Schmaal, L 2025, 'Longitudinal brain age in first-episode mania youth treated with lithium or quetiapine', European neuropsychopharmacology, vol. 95, pp. 40-48. https://doi.org/10.1016/j.euroneuro.2025.03.013","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:figshare.com:article/28878929","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Longitudinal_brain_age_in_first-episode_mania_youth_treated_with_lithium_or_quetiapine/28878929","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:jupiter.its.unimelb.edu.au:11343/365038","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11343/365038","pdf_url":null,"source":{"id":"https://openalex.org/S4377196259","display_name":"Minerva Access (University of Melbourne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I165779595","host_organization_name":"The University of Melbourne","host_organization_lineage":["https://openalex.org/I165779595"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.euroneuro.2025.03.013","doi":"https://doi.org/10.1016/j.euroneuro.2025.03.013","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.euroneuro.2025.03.013","pdf_url":null,"source":{"id":"https://openalex.org/S168041952","display_name":"European Neuropsychopharmacology","issn_l":"0924-977X","issn":["0924-977X","1873-7862"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Neuropsychopharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.4000000059604645,"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[{"id":"https://openalex.org/G1853530184","display_name":"Development of a bench to bedside platform for novel therapy development for psychiatric disorders","funder_award_id":"2017131","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"},{"id":"https://openalex.org/G4464222258","display_name":"Developing Novel Preclinical Models for Neurodevelopmental Disorders - From Bedside to Bench","funder_award_id":"1196508","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"},{"id":"https://openalex.org/G5096710632","display_name":"Novel therapies for psychiatric disorders","funder_award_id":"1156072","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"},{"id":"https://openalex.org/G6486099322","display_name":"Identifying clinically relevant neurobiological markers of depression and suicidal behaviours","funder_award_id":"2017962","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"},{"id":"https://openalex.org/G8240382675","display_name":null,"funder_award_id":"452020227","funder_id":"https://openalex.org/F4320321800","funder_display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek"},{"id":"https://openalex.org/G8357078610","display_name":"Neurobiological \u2018risk\u2019 and \u2018resilience\u2019 biomarkers of severe mental illness","funder_award_id":"1105825","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"},{"id":"https://openalex.org/G9000043531","display_name":null,"funder_award_id":"RO1 MH129832","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000879626","display_name":"Neurobiologically-Based Subtyping of Multi-Cohort Samples with MDD and PTSD Symptoms","funder_award_id":"5r01mh129832-04","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320321800","display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","ror":"https://ror.org/04jsz6e67"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334705","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W296941733","https://openalex.org/W1946685806","https://openalex.org/W1980721081","https://openalex.org/W1984333078","https://openalex.org/W1997145589","https://openalex.org/W2020844317","https://openalex.org/W2030034545","https://openalex.org/W2071794120","https://openalex.org/W2131823335","https://openalex.org/W2135169462","https://openalex.org/W2149639459","https://openalex.org/W2157270343","https://openalex.org/W2167659819","https://openalex.org/W2266871031","https://openalex.org/W2272407280","https://openalex.org/W2581241207","https://openalex.org/W2584711339","https://openalex.org/W2592770720","https://openalex.org/W2605704940","https://openalex.org/W2752760030","https://openalex.org/W2783148479","https://openalex.org/W2811095131","https://openalex.org/W2883029237","https://openalex.org/W2954982788","https://openalex.org/W2961560364","https://openalex.org/W2976981404","https://openalex.org/W2977883299","https://openalex.org/W2982580298","https://openalex.org/W2990366895","https://openalex.org/W3004707186","https://openalex.org/W3009640614","https://openalex.org/W3024838586","https://openalex.org/W3046299245","https://openalex.org/W3046661931","https://openalex.org/W3087516486","https://openalex.org/W3087552014","https://openalex.org/W3092783643","https://openalex.org/W3121028338","https://openalex.org/W3151738440","https://openalex.org/W3160947785","https://openalex.org/W3184779465","https://openalex.org/W3199670916","https://openalex.org/W3203395588","https://openalex.org/W4225331400","https://openalex.org/W4226026390","https://openalex.org/W4244847179","https://openalex.org/W4309020793","https://openalex.org/W4311172419","https://openalex.org/W4317103725","https://openalex.org/W4323669613","https://openalex.org/W4387661692","https://openalex.org/W4389360706"],"related_works":["https://openalex.org/W2048461343","https://openalex.org/W2107475180","https://openalex.org/W2539509955","https://openalex.org/W2363771269","https://openalex.org/W2068370991","https://openalex.org/W1972331182","https://openalex.org/W2066868011","https://openalex.org/W2411632080","https://openalex.org/W2151384000","https://openalex.org/W2943961467"],"abstract_inverted_index":{"It":[0],"is":[1,218],"unclear":[2],"if":[3,222],"lithium":[4,48],"and":[5,16,30,64,73,202,229,235],"quetiapine":[6,51],"have":[7],"neuroprotective":[8],"effects,":[9],"especially":[10],"in":[11,32,118,167,227],"early":[12],"stages":[13],"of":[14,93,141,157,170],"bipolar":[15,77,228],"schizoaffective":[17,79,230],"disorders.":[18,231],"Here,":[19],"an":[20,111,147],"age-related":[21],"multivariate":[22],"brain":[23,106],"structural":[24],"measure":[25],"(i.e.,":[26],"brain-PAD)":[27],"at":[28,58],"baseline":[29,184,204],"changes":[31],"response":[33],"to":[34,47,98,124,135,220],"treatment":[35,144,200,207,223],"after":[36],"a":[37,86,101,215],"first-episode":[38],"mania":[39],"(FEM)":[40],"were":[41,45,56,83,152],"examined.":[42],"FEM":[43,122],"participants":[44,62],"randomized":[46],"(n=21)":[49],"or":[50,78,143,172],"(n=18)":[52],"monotherapy.":[53],"T1-weighted":[54],"scans":[55],"acquired":[57],"baseline,":[59],"3-months":[60],"(FEM":[61],"only)":[63],"12-months.":[65],"Brain":[66],"age":[67,107],"predictions":[68],"for":[69],"healthy":[70],"controls":[71,125],"(n=29)":[72],"young":[74,119,180],"people":[75,120],"with":[76,121,182,214],"disorder":[80],"(15-25":[81],"years)":[82],"derived":[84],"using":[85],"deep":[87],"learning":[88],"model":[89],"trained":[90],"on":[91],"one":[92],"the":[94,150,155,158],"largest":[95],"datasets":[96],"(N=53,542)":[97],"date.":[99],"Notably,":[100],"higher":[102,117],"brain-PAD":[103,115,161,194],"value":[104],"(predicted":[105],"-":[108,241],"age)":[109],"signifies":[110],"older-appearing":[112],"brain.":[113],"Baseline":[114,160],"was":[116],"compared":[123],"(+1.70":[126],"year,":[127],"p=0.04;":[128],"Cohen's":[129],"d=0.53":[130],"[SE=0.25],":[131],"CI":[132],"95%":[133],"[0.04":[134],"1.01]).":[136],"However,":[137,193],"no":[138],"significant":[139],"effects":[140,224],"time":[142,198],"group,":[145],"nor":[146,206],"interaction":[148],"between":[149],"two,":[151],"observed":[153],"throughout":[154],"course":[156],"study.":[159],"did":[162],"not":[163],"predict":[164],"any":[165],"change":[166],"symptomatic,":[168],"quality":[169],"life":[171],"functional":[173],"outcome":[174],"scores":[175],"over":[176,197],"12":[177],"months.":[178],"In":[179],"individuals":[181],"FEM,":[183],"findings":[185],"show":[186],"their":[187],"brains":[188],"appeared":[189],"older":[190],"than":[191],"controls.":[192],"remained":[195],"stable":[196],"across":[199],"groups":[201],"neither":[203],"values":[205],"predicted":[208],"12-month":[209],"outcomes.":[210],"A":[211],"longer":[212],"follow-up":[213],"larger":[216],"sample":[217],"warranted":[219],"determine":[221],"emerge":[225],"later":[226],"TRIAL":[232],"REGISTRATION:":[233],"Australian":[234],"New":[236],"Zealand":[237],"Clinical":[238],"Trials":[239],"Registry":[240],"ACTRN12607000639426.":[242]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-17T09:40:24.721904","created_date":"2025-10-10T00:00:00"}