{"id":"https://openalex.org/W4409424911","doi":"https://doi.org/10.1016/j.molmed.2025.03.008","title":"Phosphoglycerate kinase 1 as a therapeutic target in neurological disease","display_name":"Phosphoglycerate kinase 1 as a therapeutic target in neurological disease","publication_year":2025,"publication_date":"2025-04-14","ids":{"openalex":"https://openalex.org/W4409424911","doi":"https://doi.org/10.1016/j.molmed.2025.03.008","pmid":"https://pubmed.ncbi.nlm.nih.gov/40234116"},"language":"en","primary_location":{"id":"doi:10.1016/j.molmed.2025.03.008","doi":"https://doi.org/10.1016/j.molmed.2025.03.008","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.molmed.2025.03.008","pdf_url":null,"source":{"id":"https://openalex.org/S64855341","display_name":"Trends in Molecular Medicine","issn_l":"1471-4914","issn":["1471-4914","1471-499X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in Molecular Medicine","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.molmed.2025.03.008","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5114623176","display_name":"Harriet McHale-Owen","orcid":"https://orcid.org/0000-0003-3438-2249","observed_orcids":["https://orcid.org/0000-0003-3438-2249"]},"institutions":[{"id":"https://openalex.org/I4405270431","display_name":"Euan MacDonald Centre for Motor Neuron Disease Research","ror":"https://ror.org/00pb3n413","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I4405270431"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Harriet McHale-Owen","raw_affiliation_strings":["Biomedical Sciences, Edinburgh Medical School, University of Edinburgh, Edinburgh, UK; Euan MacDonald Centre for Motor Neuron Disease Research, University of Edinburgh, Edinburgh, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Sciences, Edinburgh Medical School, University of Edinburgh, Edinburgh, UK; Euan MacDonald Centre for Motor Neuron Disease Research, University of Edinburgh, Edinburgh, UK","institution_ids":["https://openalex.org/I4405270431","https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087947862","display_name":"Kiterie M. E. Faller","orcid":"https://orcid.org/0000-0002-4525-7059","observed_orcids":["https://orcid.org/0000-0002-4525-7059"]},"institutions":[{"id":"https://openalex.org/I4405270431","display_name":"Euan MacDonald Centre for Motor Neuron Disease Research","ror":"https://ror.org/00pb3n413","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I4405270431"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Kiterie M.E. Faller","raw_affiliation_strings":["Biomedical Sciences, Edinburgh Medical School, University of Edinburgh, Edinburgh, UK; Euan MacDonald Centre for Motor Neuron Disease Research, University of Edinburgh, Edinburgh, UK; Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Sciences, Edinburgh Medical School, University of Edinburgh, Edinburgh, UK; Euan MacDonald Centre for Motor Neuron Disease Research, University of Edinburgh, Edinburgh, UK; Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, UK","institution_ids":["https://openalex.org/I4405270431","https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085898310","display_name":"Helena Chaytow","orcid":"https://orcid.org/0000-0003-2257-7620","observed_orcids":["https://orcid.org/0000-0003-2257-7620"]},"institutions":[{"id":"https://openalex.org/I4405270431","display_name":"Euan MacDonald Centre for Motor Neuron Disease Research","ror":"https://ror.org/00pb3n413","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I4405270431"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Helena Chaytow","raw_affiliation_strings":["Biomedical Sciences, Edinburgh Medical School, University of Edinburgh, Edinburgh, UK; Euan MacDonald Centre for Motor Neuron Disease Research, University of Edinburgh, Edinburgh, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Sciences, Edinburgh Medical School, University of Edinburgh, Edinburgh, UK; Euan MacDonald Centre for Motor Neuron Disease Research, University of Edinburgh, Edinburgh, UK","institution_ids":["https://openalex.org/I4405270431","https://openalex.org/I98677209"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042253588","display_name":"Thomas Henry Gillingwater","orcid":"https://orcid.org/0000-0002-0306-5577","observed_orcids":["https://orcid.org/0000-0002-0306-5577"]},"institutions":[{"id":"https://openalex.org/I4405270431","display_name":"Euan MacDonald Centre for Motor Neuron Disease Research","ror":"https://ror.org/00pb3n413","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I4405270431"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Thomas H. Gillingwater","raw_affiliation_strings":["Biomedical Sciences, Edinburgh Medical School, University of Edinburgh, Edinburgh, UK; Euan MacDonald Centre for Motor Neuron Disease Research, University of Edinburgh, Edinburgh, UK. Electronic address: t.gillingwater@ed.ac.uk"],"raw_orcid":"https://orcid.org/0000-0002-0306-5577","affiliations":[{"raw_affiliation_string":"Biomedical Sciences, Edinburgh Medical School, University of Edinburgh, Edinburgh, UK; Euan MacDonald Centre for Motor Neuron Disease Research, University of Edinburgh, Edinburgh, UK. Electronic address: t.gillingwater@ed.ac.uk","institution_ids":["https://openalex.org/I4405270431","https://openalex.org/I98677209"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5042253588"],"corresponding_institution_ids":["https://openalex.org/I4405270431","https://openalex.org/I98677209"],"apc_list":{"value":7030,"currency":"USD","value_usd":7030},"apc_paid":{"value":7030,"currency":"USD","value_usd":7030},"fwci":1.0069,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.70965328,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"31","issue":"12","first_page":"1077","last_page":"1088"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.2632000148296356,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.2632000148296356,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.149399995803833,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13796","display_name":"Neuroprotection in Cerebral Ischemia","score":0.0908999964594841,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pgk1","display_name":"PGK1","score":1.0},{"id":"https://openalex.org/keywords/glycolysis","display_name":"glycolysis","score":0.9110000133514404},{"id":"https://openalex.org/keywords/cellular-energy-metabolism","display_name":"cellular energy metabolism","score":0.8420000076293945},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9110000133514404},{"id":"https://openalex.org/keywords/motor-neuron-disease","display_name":"motor neuron disease","score":1.0},{"id":"https://openalex.org/keywords/neurological-disorders","display_name":"neurological disorders","score":0.7160000205039978},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.5490000247955322},{"id":"https://openalex.org/keywords/drug-development","display_name":"drug development","score":0.5820000171661377}],"concepts":[{"id":"https://openalex.org/C155911427","wikidata":"https://www.wikidata.org/wiki/Q24772193","display_name":"Phosphoglycerate kinase","level":3,"score":0.7003514766693115},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5763307809829712},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4980502128601074},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.44745346903800964},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25081759691238403},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.23260828852653503},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18314889073371887},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10877114534378052}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009422","descriptor_name":"Nervous System Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009422","descriptor_name":"Nervous System Diseases","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D009422","descriptor_name":"Nervous System Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010735","descriptor_name":"Phosphoglycerate Kinase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D010735","descriptor_name":"Phosphoglycerate Kinase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010735","descriptor_name":"Phosphoglycerate Kinase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.molmed.2025.03.008","doi":"https://doi.org/10.1016/j.molmed.2025.03.008","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.molmed.2025.03.008","pdf_url":null,"source":{"id":"https://openalex.org/S64855341","display_name":"Trends in Molecular Medicine","issn_l":"1471-4914","issn":["1471-4914","1471-499X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in Molecular Medicine","raw_type":"journal-article"},{"id":"pmid:40234116","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40234116","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in molecular medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pure.ed.ac.uk:openaire/288a2563-dedf-46a9-8658-a237e87ae9c3","doi":null,"is_oa":true,"landing_page_url":"https://www.research.ed.ac.uk/files/516705460/Phosphoglycerate_kinase_1_as_a_therapeutic_target_in_neurological_disease.pdf","pdf_url":"https://www.research.ed.ac.uk/files/516705460/Phosphoglycerate_kinase_1_as_a_therapeutic_target_in_neurological_disease.pdf","source":{"id":"https://openalex.org/S4306400321","display_name":"Edinburgh Research Explorer (University of Edinburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I98677209","host_organization_name":"University of Edinburgh","host_organization_lineage":["https://openalex.org/I98677209"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"McHale-Owen, H, Faller, K M E, Chaytow, H & Gillingwater, T H 2025, 'Phosphoglycerate kinase 1 as a therapeutic target in neurological disease', Trends in Molecular Medicine. https://doi.org/10.1016/j.molmed.2025.03.008","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1016/j.molmed.2025.03.008","doi":"https://doi.org/10.1016/j.molmed.2025.03.008","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.molmed.2025.03.008","pdf_url":null,"source":{"id":"https://openalex.org/S64855341","display_name":"Trends in Molecular Medicine","issn_l":"1471-4914","issn":["1471-4914","1471-499X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in Molecular Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8999999761581421,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320312999","display_name":"MND Scotland","ror":"https://ror.org/04fzs4293"},{"id":"https://openalex.org/F4320313480","display_name":"LifeArc","ror":"https://ror.org/01dqb0q37"},{"id":"https://openalex.org/F4320314982","display_name":"Motor Neurone Disease Australia","ror":"https://ror.org/04es2gg88"},{"id":"https://openalex.org/F4320320108","display_name":"Motor Neurone Disease Association","ror":"https://ror.org/02gq0fg61"},{"id":"https://openalex.org/F4320320241","display_name":"Academy of Medical Sciences","ror":"https://ror.org/00c489v88"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4409424911.pdf","grobid_xml":"https://content.openalex.org/works/W4409424911.grobid-xml"},"referenced_works_count":77,"referenced_works":["https://openalex.org/W275847627","https://openalex.org/W1539227406","https://openalex.org/W1549063714","https://openalex.org/W1639658090","https://openalex.org/W1698967089","https://openalex.org/W1967646152","https://openalex.org/W1998908140","https://openalex.org/W1999223970","https://openalex.org/W2000699462","https://openalex.org/W2032162800","https://openalex.org/W2050560379","https://openalex.org/W2061090993","https://openalex.org/W2083250990","https://openalex.org/W2107257806","https://openalex.org/W2120992176","https://openalex.org/W2121397622","https://openalex.org/W2143464189","https://openalex.org/W2153187922","https://openalex.org/W2292259030","https://openalex.org/W2602703797","https://openalex.org/W2606220143","https://openalex.org/W2792402131","https://openalex.org/W2897079052","https://openalex.org/W2898767623","https://openalex.org/W2953962192","https://openalex.org/W2973064436","https://openalex.org/W3014564914","https://openalex.org/W3015136087","https://openalex.org/W3042019625","https://openalex.org/W3047530368","https://openalex.org/W3120728427","https://openalex.org/W3124481945","https://openalex.org/W3128588498","https://openalex.org/W3149186196","https://openalex.org/W3164190411","https://openalex.org/W3181492021","https://openalex.org/W3181748935","https://openalex.org/W3214783764","https://openalex.org/W4200109237","https://openalex.org/W4211041983","https://openalex.org/W4221021342","https://openalex.org/W4225546362","https://openalex.org/W4285792299","https://openalex.org/W4287922039","https://openalex.org/W4290987993","https://openalex.org/W4292848022","https://openalex.org/W4306746936","https://openalex.org/W4312085139","https://openalex.org/W4319334047","https://openalex.org/W4321780080","https://openalex.org/W4322764069","https://openalex.org/W4378745468","https://openalex.org/W4378908076","https://openalex.org/W4379619581","https://openalex.org/W4384925673","https://openalex.org/W4385839693","https://openalex.org/W4386834441","https://openalex.org/W4387234777","https://openalex.org/W4389849230","https://openalex.org/W4390461435","https://openalex.org/W4390964116","https://openalex.org/W4391514626","https://openalex.org/W4391609425","https://openalex.org/W4391734760","https://openalex.org/W4391952770","https://openalex.org/W4392595441","https://openalex.org/W4399327208","https://openalex.org/W4399510818","https://openalex.org/W4399832050","https://openalex.org/W4400381515","https://openalex.org/W4400814576","https://openalex.org/W4401093424","https://openalex.org/W4401484253","https://openalex.org/W4401504125","https://openalex.org/W4401724314","https://openalex.org/W6841369469","https://openalex.org/W6871528500"],"related_works":["https://openalex.org/W7162656929","https://openalex.org/W4401724314","https://openalex.org/W2981433474","https://openalex.org/W4389165697","https://openalex.org/W4400406134","https://openalex.org/W2973064436","https://openalex.org/W2981306086","https://openalex.org/W3200956509","https://openalex.org/W3145926469","https://openalex.org/W4391952770"],"abstract_inverted_index":{"Phosphoglycerate":[0],"kinase":[1],"1":[2],"(PGK1)":[3],"is":[4,35],"a":[5],"highly":[6],"conserved":[7],"enzyme":[8],"that":[9,51],"catalyzes":[10],"the":[11,65,69,87],"initial":[12],"ATP-producing":[13],"step":[14],"in":[15,28,59],"glycolysis.":[16],"Improving":[17],"cellular":[18],"energy":[19],"production":[20],"by":[21],"increasing":[22,53],"PGK1":[23,54,74,81],"activity":[24,55],"may":[25,56],"be":[26,57],"beneficial":[27,58],"multiple":[29,60],"neurological":[30,61],"conditions":[31,62],"where":[32],"cell":[33],"metabolism":[34],"dysregulated,":[36],"including":[37],"Parkinson's":[38],"disease":[39,44],"(PD)":[40],"and":[41,63],"motor":[42],"neuron":[43],"(MND).":[45],"This":[46],"review":[47],"examines":[48],"recent":[49],"evidence":[50],"suggests":[52],"discusses":[64],"current":[66],"challenges":[67],"surrounding":[68],"development":[70],"of":[71],"PGK1-focused":[72],"therapies.":[73],"has":[75],"considerable":[76],"therapeutic":[77],"potential,":[78],"but":[79],"novel":[80],"activators":[82],"are":[83],"needed":[84],"to":[85],"maximize":[86],"benefit":[88],"for":[89],"patients.":[90]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":3}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2025-04-15T00:00:00"}