{"id":"https://openalex.org/W4409422866","doi":"https://doi.org/10.1016/j.colsurfa.2025.136938","title":"Unveiling the potential of nano-structured lipid carriers for oral administration of cefepime: Bioavailability and safety investigations","display_name":"Unveiling the potential of nano-structured lipid carriers for oral administration of cefepime: Bioavailability and safety investigations","publication_year":2025,"publication_date":"2025-04-14","ids":{"openalex":"https://openalex.org/W4409422866","doi":"https://doi.org/10.1016/j.colsurfa.2025.136938"},"language":"en","primary_location":{"id":"doi:10.1016/j.colsurfa.2025.136938","doi":"https://doi.org/10.1016/j.colsurfa.2025.136938","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.colsurfa.2025.136938","pdf_url":null,"source":{"id":"https://openalex.org/S94313546","display_name":"Colloids and Surfaces A Physicochemical and Engineering Aspects","issn_l":"0927-7757","issn":["0927-7757","1873-4359"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Colloids and Surfaces A: Physicochemical and Engineering Aspects","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5114136428","display_name":"Shah Faisal Ghani","orcid":"https://orcid.org/0009-0004-2844-4911","observed_orcids":["https://orcid.org/0009-0004-2844-4911"]},"institutions":[{"id":"https://openalex.org/I12469534","display_name":"Quaid-i-Azam University","ror":"https://ror.org/04s9hft57","country_code":"PK","type":"education","lineage":["https://openalex.org/I12469534"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Shah Faisal Ghani","raw_affiliation_strings":["Department of Pharmacy, Quaid-I-Azam University, Islamabad 45320, Pakistan","Nanomedicine Research Group, Department of Pharmacy, Quaid-i-Azam University, Pakistan"],"raw_orcid":"https://orcid.org/0009-0004-2844-4911","affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Quaid-I-Azam University, Islamabad 45320, Pakistan","institution_ids":["https://openalex.org/I12469534"]},{"raw_affiliation_string":"Nanomedicine Research Group, Department of Pharmacy, Quaid-i-Azam University, Pakistan","institution_ids":["https://openalex.org/I12469534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004121375","display_name":"Zakir Ali","orcid":"https://orcid.org/0000-0002-7262-909X","observed_orcids":["https://orcid.org/0000-0002-7262-909X"]},"institutions":[{"id":"https://openalex.org/I12469534","display_name":"Quaid-i-Azam University","ror":"https://ror.org/04s9hft57","country_code":"PK","type":"education","lineage":["https://openalex.org/I12469534"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Zakir Ali","raw_affiliation_strings":["Department of Pharmacy, Quaid-I-Azam University, Islamabad 45320, Pakistan","Nanomedicine Research Group, Department of Pharmacy, Quaid-i-Azam University, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Quaid-I-Azam University, Islamabad 45320, Pakistan","institution_ids":["https://openalex.org/I12469534"]},{"raw_affiliation_string":"Nanomedicine Research Group, Department of Pharmacy, Quaid-i-Azam University, Pakistan","institution_ids":["https://openalex.org/I12469534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070709818","display_name":"Kifayat Ullah Shah","orcid":"https://orcid.org/0000-0003-4061-8174","observed_orcids":["https://orcid.org/0000-0003-4061-8174"]},"institutions":[{"id":"https://openalex.org/I12469534","display_name":"Quaid-i-Azam University","ror":"https://ror.org/04s9hft57","country_code":"PK","type":"education","lineage":["https://openalex.org/I12469534"]}],"countries":["PK"],"is_corresponding":true,"raw_author_name":"Kifayat Ullah Shah","raw_affiliation_strings":["Nanomedicine Research Group, Department of Pharmacy, Quaid-i-Azam University, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nanomedicine Research Group, Department of Pharmacy, Quaid-i-Azam University, Pakistan","institution_ids":["https://openalex.org/I12469534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110549938","display_name":"Rashna Mirza","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12469534","display_name":"Quaid-i-Azam University","ror":"https://ror.org/04s9hft57","country_code":"PK","type":"education","lineage":["https://openalex.org/I12469534"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Rashna Mirza","raw_affiliation_strings":["Nanomedicine Research Group, Department of Pharmacy, Quaid-i-Azam University, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nanomedicine Research Group, Department of Pharmacy, Quaid-i-Azam University, Pakistan","institution_ids":["https://openalex.org/I12469534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054375548","display_name":"Ali H. Alamri","orcid":"https://orcid.org/0000-0001-6790-2226","observed_orcids":["https://orcid.org/0000-0001-6790-2226"]},"institutions":[{"id":"https://openalex.org/I82952536","display_name":"King Khalid University","ror":"https://ror.org/052kwzs30","country_code":"SA","type":"education","lineage":["https://openalex.org/I82952536"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Ali H. Alamri","raw_affiliation_strings":["Department of Pharmaceutics, College of Pharmacy, King Khalid University, Abha 62529, Saudi Arabia"],"raw_orcid":"https://orcid.org/0000-0001-6790-2226","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, College of Pharmacy, King Khalid University, Abha 62529, Saudi Arabia","institution_ids":["https://openalex.org/I82952536"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072326258","display_name":"Adel M. Al Fatease","orcid":"https://orcid.org/0000-0002-4608-5949","observed_orcids":["https://orcid.org/0000-0002-4608-5949"]},"institutions":[{"id":"https://openalex.org/I82952536","display_name":"King Khalid University","ror":"https://ror.org/052kwzs30","country_code":"SA","type":"education","lineage":["https://openalex.org/I82952536"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Adel Al Fatease","raw_affiliation_strings":["Department of Pharmaceutics, College of Pharmacy, King Khalid University, Abha 62529, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, College of Pharmacy, King Khalid University, Abha 62529, Saudi Arabia","institution_ids":["https://openalex.org/I82952536"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026552478","display_name":"Ahmed A. Lahiq","orcid":"https://orcid.org/0000-0002-2781-6515","observed_orcids":["https://orcid.org/0000-0002-2781-6515"]},"institutions":[{"id":"https://openalex.org/I47164929","display_name":"Najran University","ror":"https://ror.org/05edw4a90","country_code":"SA","type":"education","lineage":["https://openalex.org/I47164929"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Ahmed A. Lahiq","raw_affiliation_strings":["Department of Pharmaceutics, College of Pharmacy, Najran University, Najran 66262, Saudi Arabia"],"raw_orcid":"https://orcid.org/0000-0002-2781-6515","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, College of Pharmacy, Najran University, Najran 66262, Saudi Arabia","institution_ids":["https://openalex.org/I47164929"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064484330","display_name":"Nabil K. Alruwaili","orcid":"https://orcid.org/0000-0003-2358-4259","observed_orcids":["https://orcid.org/0000-0003-2358-4259"]},"institutions":[{"id":"https://openalex.org/I199702508","display_name":"Jouf University","ror":"https://ror.org/02zsyt821","country_code":"SA","type":"education","lineage":["https://openalex.org/I199702508"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Nabil K. Alruwaili","raw_affiliation_strings":["Pharmaceutics Department, College of pharmacy, Jouf University, Sakaka, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmaceutics Department, College of pharmacy, Jouf University, Sakaka, Saudi Arabia","institution_ids":["https://openalex.org/I199702508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040128343","display_name":"Sung Giu Jin","orcid":"https://orcid.org/0000-0003-1558-5155","observed_orcids":["https://orcid.org/0000-0003-1558-5155"]},"institutions":[{"id":"https://openalex.org/I89015989","display_name":"Dankook University","ror":"https://ror.org/058pdbn81","country_code":"KR","type":"education","lineage":["https://openalex.org/I89015989"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sung Giu Jin","raw_affiliation_strings":["Department of Pharmaceutical Engineering, Dankook University, 119 Dandae-ro, Dongnam-gu, Cheonan 31116, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Engineering, Dankook University, 119 Dandae-ro, Dongnam-gu, Cheonan 31116, South Korea","institution_ids":["https://openalex.org/I89015989"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082933658","display_name":"Fakhar ud Din","orcid":"https://orcid.org/0000-0001-9537-4897","observed_orcids":["https://orcid.org/0000-0001-9537-4897"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Fakhar ud Din","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5070709818","https://openalex.org/A5082933658"],"corresponding_institution_ids":["https://openalex.org/I12469534"],"apc_list":{"value":3200,"currency":"USD","value_usd":3200},"apc_paid":null,"fwci":2.936,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.89924296,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":98},"biblio":{"volume":"718","issue":null,"first_page":"136938","last_page":"136938"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.899399995803833,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.899399995803833,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.08540000021457672,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.008500000461935997,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cefepime","display_name":"cefepime","score":0.9929999709129333},{"id":"https://openalex.org/keywords/nanostructured-lipid-carriers","display_name":"nanostructured lipid carriers","score":1.0},{"id":"https://openalex.org/keywords/oral-bioavailability","display_name":"oral bioavailability","score":0.9850000143051147},{"id":"https://openalex.org/keywords/oral-drug-delivery","display_name":"oral drug delivery","score":0.6740000247955322},{"id":"https://openalex.org/keywords/cephalosporins","display_name":"cephalosporins","score":0.7990000247955322},{"id":"https://openalex.org/keywords/intestinal-permeability","display_name":"intestinal permeability","score":0.9409999847412109},{"id":"https://openalex.org/keywords/sustained-release","display_name":"sustained drug release","score":0.8320000171661377},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.9470000267028809},{"id":"https://openalex.org/keywords/acute-oral-toxicity","display_name":"acute oral toxicity","score":0.8899999856948853},{"id":"https://openalex.org/keywords/microemulsion-formulation","display_name":"microemulsion formulation","score":0.6100000143051147},{"id":"https://openalex.org/keywords/formulation-optimization","display_name":"formulation optimization","score":0.5759999752044678},{"id":"https://openalex.org/keywords/antimicrobial-activity","display_name":"antimicrobial activity","score":0.75},{"id":"https://openalex.org/keywords/formulation-stability","display_name":"formulation stability","score":0.41499999165534973}],"concepts":[{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.8564109802246094},{"id":"https://openalex.org/C2777050379","wikidata":"https://www.wikidata.org/wiki/Q2552927","display_name":"Cefepime","level":5,"score":0.7907112240791321},{"id":"https://openalex.org/C2780357685","wikidata":"https://www.wikidata.org/wiki/Q154357","display_name":"Nano-","level":2,"score":0.4225984215736389},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3998187482357025},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3970857858657837},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2414328157901764},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.13480040431022644},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.12619063258171082},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09935459494590759},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.08565923571586609},{"id":"https://openalex.org/C94665300","wikidata":"https://www.wikidata.org/wiki/Q63391344","display_name":"Antibiotic resistance","level":3,"score":0.0},{"id":"https://openalex.org/C2779631663","wikidata":"https://www.wikidata.org/wiki/Q425152","display_name":"Imipenem","level":4,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.colsurfa.2025.136938","doi":"https://doi.org/10.1016/j.colsurfa.2025.136938","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.colsurfa.2025.136938","pdf_url":null,"source":{"id":"https://openalex.org/S94313546","display_name":"Colloids and Surfaces A Physicochemical and Engineering Aspects","issn_l":"0927-7757","issn":["0927-7757","1873-4359"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Colloids and Surfaces A: Physicochemical and Engineering Aspects","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4239385037","display_name":null,"funder_award_id":"20-14604/ NRPU/R&D/HEC/2021","funder_id":"https://openalex.org/F4320326275","funder_display_name":"Higher Education Commision, Pakistan"},{"id":"https://openalex.org/G493831566","display_name":null,"funder_award_id":"RGP2/441/45","funder_id":"https://openalex.org/F33954902","funder_display_name":"Deanship of Scientific Research, King Khalid University"}],"funders":[{"id":"https://openalex.org/F33954902","display_name":"Deanship of Scientific Research, King Khalid University","ror":null},{"id":"https://openalex.org/F4320322799","display_name":"Higher Education Commission, Pakistan","ror":"https://ror.org/038y3sz68"},{"id":"https://openalex.org/F4320326275","display_name":"Higher Education Commision, Pakistan","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":66,"referenced_works":["https://openalex.org/W1975602129","https://openalex.org/W1993788795","https://openalex.org/W2004328494","https://openalex.org/W2010254711","https://openalex.org/W2010815001","https://openalex.org/W2012100899","https://openalex.org/W2014660114","https://openalex.org/W2025722135","https://openalex.org/W2032943033","https://openalex.org/W2044339866","https://openalex.org/W2077978240","https://openalex.org/W2090797092","https://openalex.org/W2138361094","https://openalex.org/W2153169646","https://openalex.org/W2263666717","https://openalex.org/W2319555222","https://openalex.org/W2346739591","https://openalex.org/W2468932732","https://openalex.org/W2510302043","https://openalex.org/W2529131687","https://openalex.org/W2561865027","https://openalex.org/W2587424776","https://openalex.org/W2619526664","https://openalex.org/W2626406601","https://openalex.org/W2729600751","https://openalex.org/W2733552611","https://openalex.org/W2883531566","https://openalex.org/W2908880800","https://openalex.org/W2916175089","https://openalex.org/W2922428194","https://openalex.org/W2922779642","https://openalex.org/W2927771003","https://openalex.org/W2984384571","https://openalex.org/W2999829767","https://openalex.org/W3007601922","https://openalex.org/W3063038978","https://openalex.org/W3072334995","https://openalex.org/W3088839394","https://openalex.org/W3092689949","https://openalex.org/W3109450700","https://openalex.org/W3122181071","https://openalex.org/W3124195603","https://openalex.org/W3130362014","https://openalex.org/W3155650066","https://openalex.org/W3158742378","https://openalex.org/W4220838565","https://openalex.org/W4224989569","https://openalex.org/W4282963968","https://openalex.org/W4285004972","https://openalex.org/W4289930104","https://openalex.org/W4291718519","https://openalex.org/W4301186636","https://openalex.org/W4306967789","https://openalex.org/W4309462613","https://openalex.org/W4309478024","https://openalex.org/W4381250557","https://openalex.org/W4382182463","https://openalex.org/W4386629757","https://openalex.org/W4387336506","https://openalex.org/W4396669334","https://openalex.org/W4396748143","https://openalex.org/W4397008493","https://openalex.org/W4400774618","https://openalex.org/W4403923157","https://openalex.org/W4404645972","https://openalex.org/W4406078847"],"related_works":["https://openalex.org/W4404645972","https://openalex.org/W3063038978","https://openalex.org/W2924002328","https://openalex.org/W4286320540","https://openalex.org/W2914632087","https://openalex.org/W2991174590","https://openalex.org/W2976103913","https://openalex.org/W3133950897","https://openalex.org/W7223453510","https://openalex.org/W4406908542"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2025-04-15T00:00:00"}