{"id":"https://openalex.org/W4409418992","doi":"https://doi.org/10.36922/cp.5992","title":"Construction of prognostic risk models and identification and verify cation of biomarkers related to lactic acid metabolism and carbohydrate metabolism in lung adenocarcinoma","display_name":"Construction of prognostic risk models and identification and verify cation of biomarkers related to lactic acid metabolism and carbohydrate metabolism in lung adenocarcinoma","publication_year":2025,"publication_date":"2025-04-07","ids":{"openalex":"https://openalex.org/W4409418992","doi":"https://doi.org/10.36922/cp.5992"},"language":"en","primary_location":{"id":"doi:10.36922/cp.5992","doi":"https://doi.org/10.36922/cp.5992","is_oa":true,"landing_page_url":"https://doi.org/10.36922/cp.5992","pdf_url":null,"source":{"id":"https://openalex.org/S4387280152","display_name":"Cancer Plus","issn_l":"2661-3832","issn":["2661-3832","2661-3840"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Plus","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.36922/cp.5992","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101737845","display_name":"Zhiping Zhao","orcid":"https://orcid.org/0000-0002-0460-777X","observed_orcids":["https://orcid.org/0000-0002-0460-777X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhiping Zhao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067287185","display_name":"Jiande Cheng","orcid":"https://orcid.org/0000-0001-7714-3147","observed_orcids":["https://orcid.org/0000-0001-7714-3147"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jiande Cheng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5101081542","display_name":"Yanyan Hao","orcid":"https://orcid.org/0009-0008-6264-8538","observed_orcids":["https://orcid.org/0009-0008-6264-8538"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Yanyan Hao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5101081542"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.05890949,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"7","issue":"1","first_page":"43","last_page":"43"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.6151999831199646,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.6151999831199646,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.2460000067949295,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.06599999964237213,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lung-adenocarcinoma","display_name":"lung adenocarcinoma","score":1.0},{"id":"https://openalex.org/keywords/prognostic-risk-model","display_name":"prognostic risk model","score":0.9700000286102295},{"id":"https://openalex.org/keywords/lactate-metabolism","display_name":"lactate metabolism","score":0.847000002861023},{"id":"https://openalex.org/keywords/carbohydrate-metabolism","display_name":"carbohydrate metabolism","score":0.9990000128746033},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9010000228881836},{"id":"https://openalex.org/keywords/adh1a","display_name":"ADH1A","score":0.9330000281333923},{"id":"https://openalex.org/keywords/adh1b","display_name":"ADH1B","score":0.9990000128746033},{"id":"https://openalex.org/keywords/aldolase-a","display_name":"aldolase A","score":0.9990000128746033},{"id":"https://openalex.org/keywords/enolase-1","display_name":"alpha-enolase","score":1.0},{"id":"https://openalex.org/keywords/tumor-immune-microenvironment","display_name":"tumor immune microenvironment","score":0.847000002861023},{"id":"https://openalex.org/keywords/hub-genes","display_name":"hub genes","score":0.7390000224113464},{"id":"https://openalex.org/keywords/tumor-metabolism","display_name":"cancer metabolism","score":0.7670000195503235}],"concepts":[{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.6728451251983643},{"id":"https://openalex.org/C17093226","wikidata":"https://www.wikidata.org/wiki/Q2734081","display_name":"Carbohydrate metabolism","level":2,"score":0.5687735080718994},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.5503697395324707},{"id":"https://openalex.org/C2775920511","wikidata":"https://www.wikidata.org/wiki/Q161249","display_name":"Lactic acid","level":3,"score":0.538677990436554},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.5009105205535889},{"id":"https://openalex.org/C2779563347","wikidata":"https://www.wikidata.org/wiki/Q843799","display_name":"Adenocarcinoma of the lung","level":4,"score":0.45804494619369507},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.4421299993991852},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3833869695663452},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36708390712738037},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.358378529548645},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3242005407810211},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31808745861053467},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3160801827907562},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.18603816628456116},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12175211310386658},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.07267498970031738},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.06956446170806885}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.36922/cp.5992","doi":"https://doi.org/10.36922/cp.5992","is_oa":true,"landing_page_url":"https://doi.org/10.36922/cp.5992","pdf_url":null,"source":{"id":"https://openalex.org/S4387280152","display_name":"Cancer Plus","issn_l":"2661-3832","issn":["2661-3832","2661-3840"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Plus","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.36922/cp.5992","doi":"https://doi.org/10.36922/cp.5992","is_oa":true,"landing_page_url":"https://doi.org/10.36922/cp.5992","pdf_url":null,"source":{"id":"https://openalex.org/S4387280152","display_name":"Cancer Plus","issn_l":"2661-3832","issn":["2661-3832","2661-3840"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Plus","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1980130043","https://openalex.org/W2388915439","https://openalex.org/W4389519690","https://openalex.org/W2468743120","https://openalex.org/W2417572233","https://openalex.org/W2040370458","https://openalex.org/W1978952945","https://openalex.org/W3014767152","https://openalex.org/W2469790125","https://openalex.org/W2337761277"],"abstract_inverted_index":{"Lung":[0],"adenocarcinoma":[1],"(LUAD)":[2],"has":[3],"a":[4,100,256],"high":[5],"incidence":[6],"and":[7,11,31,50,55,73,92,96,122,142,165,181,190,196,209,230,238,254],"poor":[8],"prognosis.":[9],"Carbohydrate":[10],"lactic":[12,51,231],"acid":[13,52,232],"metabolism":[14,53,233],"drive":[15],"tumor":[16,261],"growth,":[17],"highlighting":[18],"the":[19,39,112,220],"need":[20],"to":[21,47,154,228],"identify":[22],"prognostic":[23,87,113,156,225],"genes":[24,54,59,69,76,80,88,152,226],"in":[25,38,125,213],"these":[26],"pathways":[27],"for":[28,259],"LUAD":[29,242],"diagnosis":[30],"treatment.":[32],"We":[33],"conducted":[34],"differentially":[35],"expressed":[36],"analysis":[37,46],"Cancer":[40],"Genome":[41],"Atlas":[42],"(TCGA)-LUAD,":[43],"applied":[44],"Spearman":[45],"correlate":[48],"carbohydrate":[49,229],"identified":[56],"key":[57,74,144],"model":[58,75,145,247],"using":[60],"weighted":[61],"gene":[62],"co-expression":[63],"network":[64],"analysis.":[65],"Overlapping":[66],"differential":[67],"expression":[68,124,211],"(DEGs),":[70],"correlated":[71,140],"genes,":[72,141,146],"yielded":[77],"candidates.":[78],"Hub":[79],"were":[81,105,192,200,216],"screened":[82],"by":[83,89,107,202],"molecular":[84],"complex":[85],"detection,":[86],"univariate":[90],"Cox,":[91],"least":[93],"absolute":[94],"shrinkage":[95],"selection":[97],"operator,":[98],"constructing":[99],"risk":[101,109,175],"model.":[102],"TCGA-LUAD":[103],"samples":[104,127,215],"stratified":[106],"median":[108],"score.":[110],"Finally,":[111],"genes\u2019":[114],"impact":[115],"on":[116],"LUAD\u2019s":[117],"immune":[118,170],"microenvironment":[119],"was":[120,128],"analyzed,":[121],"their":[123],"clinical":[126,214],"validated":[129],"through":[130],"real-time":[131],"quantitative":[132],"polymerase":[133],"chain":[134],"reaction.":[135],"From":[136],"7,252":[137],"DEGs,":[138],"189":[139],"3,900":[143],"20":[147],"candidates":[148],"emerged.":[149],"Nine":[150],"hub":[151],"led":[153],"five":[155,224],"genes:":[157],"ADH1A,":[158,188,206],"Alcohol":[159],"dehydrogenase":[160],"1B":[161],"(ADH1B),":[162],"ALDOA,":[163,208,236],"ENO1,":[164,237],"ACSS3.":[166],"In":[167,222],"addition,":[168],"nine":[169],"cells":[171,183],"differed":[172],"significantly":[173],"between":[174],"groups,":[176],"with":[177,186,219,241],"CD4":[178],"T,":[179],"monocytes,":[180],"mast":[182],"positively":[184],"correlating":[185],"ADH1B.":[187],"ADH1B,":[189,207,235],"ACSS3":[191],"downregulated,":[193],"contrasting":[194],"ALDOA":[195],"ENO1.":[197],"Consistent":[198],"results":[199],"obtained":[201],"protein":[203],"mapping.":[204],"Eventually,":[205],"ENO1":[210],"trends":[212],"similarly":[217],"consistent":[218],"dataset.":[221],"summary,":[223],"related":[227],"(ADH1A,":[234],"ACSS3)":[239],"associated":[240],"have":[243],"been":[244],"identified.":[245],"This":[246],"serves":[248],"as":[249],"an":[250],"effective":[251],"predictive":[252],"tool":[253],"offers":[255],"new":[257],"perspective":[258],"studying":[260],"metabolism.":[262]},"counts_by_year":[],"updated_date":"2026-09-21T07:43:02.447757","created_date":"2025-10-10T00:00:00"}
