{"id":"https://openalex.org/W4409412944","doi":"https://doi.org/10.1158/1078-0432.ccr-24-3435","title":"Global Transcriptional Complexity of Estrogen Receptor\u2013Low Positive Breast Cancers in the Prospective Swedish Population\u2013Based SCAN-B Cohort","display_name":"Global Transcriptional Complexity of Estrogen Receptor\u2013Low Positive Breast Cancers in the Prospective Swedish Population\u2013Based SCAN-B Cohort","publication_year":2025,"publication_date":"2025-04-14","ids":{"openalex":"https://openalex.org/W4409412944","doi":"https://doi.org/10.1158/1078-0432.ccr-24-3435","pmid":"https://pubmed.ncbi.nlm.nih.gov/40227228"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.ccr-24-3435","doi":"https://doi.org/10.1158/1078-0432.ccr-24-3435","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-24-3435","pdf_url":"https://aacrjournals.org/clincancerres/article-pdf/doi/10.1158/1078-0432.CCR-24-3435/3577919/ccr-24-3435.pdf","source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://aacrjournals.org/clincancerres/article-pdf/doi/10.1158/1078-0432.CCR-24-3435/3577919/ccr-24-3435.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022400466","display_name":"Siker Kimbung","orcid":"https://orcid.org/0000-0002-7001-8367","observed_orcids":["https://orcid.org/0000-0002-7001-8367"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Siker Kimbung","raw_affiliation_strings":["1Division of Oncology, Department of Clinical Sciences, Lund University, Lund, Sweden","2Lund University Cancer Center, Lund, Sweden","Lund University, Lund, Sverige, Sweden"],"raw_orcid":"https://orcid.org/0000-0002-7001-8367","affiliations":[{"raw_affiliation_string":"1Division of Oncology, Department of Clinical Sciences, Lund University, Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]},{"raw_affiliation_string":"2Lund University Cancer Center, Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]},{"raw_affiliation_string":"Lund University, Lund, Sverige, Sweden","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065213537","display_name":"Srinivas Veerla","orcid":"https://orcid.org/0000-0001-7328-6239","observed_orcids":["https://orcid.org/0000-0001-7328-6239"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Srinivas Veerla","raw_affiliation_strings":["1Division of Oncology, Department of Clinical Sciences, Lund University, Lund, Sweden","2Lund University Cancer Center, Lund, Sweden","Lund University, Lund, Sweden"],"raw_orcid":"https://orcid.org/0000-0001-7328-6239","affiliations":[{"raw_affiliation_string":"1Division of Oncology, Department of Clinical Sciences, Lund University, Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]},{"raw_affiliation_string":"2Lund University Cancer Center, Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]},{"raw_affiliation_string":"Lund University, Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kadum Muhammad","orcid":"https://orcid.org/0009-0009-0440-9587","observed_orcids":["https://orcid.org/0009-0009-0440-9587"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]},{"id":"https://openalex.org/I4210137844","display_name":"Sk\u00e5ne University Hospital","ror":"https://ror.org/02z31g829","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I4210137844"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Kadum Muhammad","raw_affiliation_strings":["2Lund University Cancer Center, Lund, Sweden","3Department of Hematology, Oncology and Radiation Physics, Lund University Hospital, Malm\u00f6/Lund, Sweden","Lund University, Lund, Sweden"],"raw_orcid":"https://orcid.org/0009-0009-0440-9587","affiliations":[{"raw_affiliation_string":"2Lund University Cancer Center, Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]},{"raw_affiliation_string":"3Department of Hematology, Oncology and Radiation Physics, Lund University Hospital, Malm\u00f6/Lund, Sweden","institution_ids":["https://openalex.org/I187531555","https://openalex.org/I4210137844"]},{"raw_affiliation_string":"Lund University, Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045322799","display_name":"Anna Ehinger","orcid":"https://orcid.org/0000-0001-9225-7396","observed_orcids":["https://orcid.org/0000-0001-9225-7396"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]},{"id":"https://openalex.org/I4210137844","display_name":"Sk\u00e5ne University Hospital","ror":"https://ror.org/02z31g829","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I4210137844"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Anna Ehinger","raw_affiliation_strings":["1Division of Oncology, Department of Clinical Sciences, Lund University, Lund, Sweden","2Lund University Cancer Center, Lund, Sweden","4Department of Clinical Genetics, Pathology and Molecular Diagnostics, Lund University Hospital, Lund, Sweden","Lund University, Lund, Sweden"],"raw_orcid":"https://orcid.org/0000-0001-9225-7396","affiliations":[{"raw_affiliation_string":"1Division of Oncology, Department of Clinical Sciences, Lund University, Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]},{"raw_affiliation_string":"2Lund University Cancer Center, Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]},{"raw_affiliation_string":"4Department of Clinical Genetics, Pathology and Molecular Diagnostics, Lund University Hospital, Lund, Sweden","institution_ids":["https://openalex.org/I187531555","https://openalex.org/I4210137844"]},{"raw_affiliation_string":"Lund University, Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040610749","display_name":"Johan Vallon\u2010Christersson","orcid":"https://orcid.org/0000-0002-2195-0385","observed_orcids":["https://orcid.org/0000-0002-2195-0385"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Johan Vallon-Christersson","raw_affiliation_strings":["1Division of Oncology, Department of Clinical Sciences, Lund University, Lund, Sweden","2Lund University Cancer Center, Lund, Sweden","Lund University, Lund, Sweden"],"raw_orcid":"https://orcid.org/0000-0002-2195-0385","affiliations":[{"raw_affiliation_string":"1Division of Oncology, Department of Clinical Sciences, Lund University, Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]},{"raw_affiliation_string":"2Lund University Cancer Center, Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]},{"raw_affiliation_string":"Lund University, Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070951926","display_name":"Martin Malmberg","orcid":"https://orcid.org/0000-0002-9500-8982","observed_orcids":["https://orcid.org/0000-0002-9500-8982"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]},{"id":"https://openalex.org/I4210137844","display_name":"Sk\u00e5ne University Hospital","ror":"https://ror.org/02z31g829","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I4210137844"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Martin Malmberg","raw_affiliation_strings":["2Lund University Cancer Center, Lund, Sweden","3Department of Hematology, Oncology and Radiation Physics, Lund University Hospital, Malm\u00f6/Lund, Sweden","Sk\u00e5ne University Hospital, Lund, Sweden"],"raw_orcid":"https://orcid.org/0000-0002-9500-8982","affiliations":[{"raw_affiliation_string":"2Lund University Cancer Center, Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]},{"raw_affiliation_string":"3Department of Hematology, Oncology and Radiation Physics, Lund University Hospital, Malm\u00f6/Lund, Sweden","institution_ids":["https://openalex.org/I187531555","https://openalex.org/I4210137844"]},{"raw_affiliation_string":"Sk\u00e5ne University Hospital, Lund, Sweden","institution_ids":["https://openalex.org/I4210137844"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103139296","display_name":"Niklas Loman","orcid":"https://orcid.org/0000-0003-1425-5189","observed_orcids":["https://orcid.org/0000-0003-1425-5189"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]},{"id":"https://openalex.org/I4210137844","display_name":"Sk\u00e5ne University Hospital","ror":"https://ror.org/02z31g829","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I4210137844"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Niklas Loman","raw_affiliation_strings":["1Division of Oncology, Department of Clinical Sciences, Lund University, Lund, Sweden","2Lund University Cancer Center, Lund, Sweden","3Department of Hematology, Oncology and Radiation Physics, Lund University Hospital, Malm\u00f6/Lund, Sweden","Lund University, Lund, Sweden"],"raw_orcid":"https://orcid.org/0000-0003-1425-5189","affiliations":[{"raw_affiliation_string":"1Division of Oncology, Department of Clinical Sciences, Lund University, Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]},{"raw_affiliation_string":"2Lund University Cancer Center, Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]},{"raw_affiliation_string":"3Department of Hematology, Oncology and Radiation Physics, Lund University Hospital, Malm\u00f6/Lund, Sweden","institution_ids":["https://openalex.org/I187531555","https://openalex.org/I4210137844"]},{"raw_affiliation_string":"Lund University, Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5103139296"],"corresponding_institution_ids":["https://openalex.org/I187531555","https://openalex.org/I4210137844"],"apc_list":null,"apc_paid":null,"fwci":2.2813,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.89012553,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"31","issue":"13","first_page":"2695","last_page":"2709"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11134","display_name":"Breast Lesions and Carcinomas","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.7770000100135803},{"id":"https://openalex.org/keywords/her2-negative-breast-cancer","display_name":"HER2-negative breast cancer","score":0.9490000009536743},{"id":"https://openalex.org/keywords/pam50-subtypes","display_name":"PAM50 molecular subtypes","score":0.8080000281333923},{"id":"https://openalex.org/keywords/tumor-transcriptome","display_name":"tumor transcriptome","score":0.7390000224113464},{"id":"https://openalex.org/keywords/tumor-infiltrating-lymphocytes","display_name":"tumor-infiltrating lymphocytes","score":0.8220000267028809},{"id":"https://openalex.org/keywords/endocrine-therapy-response","display_name":"endocrine therapy response","score":0.6790000200271606},{"id":"https://openalex.org/keywords/risk-of-recurrence","display_name":"recurrence risk","score":0.8529999852180481},{"id":"https://openalex.org/keywords/prognostic-signature","display_name":"prognostic signature","score":0.5879999995231628},{"id":"https://openalex.org/keywords/breast-cancer-molecular-subtypes","display_name":"breast cancer molecular subtypes","score":0.6589999794960022}],"concepts":[{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.708224356174469},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.6120001077651978},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5343688130378723},{"id":"https://openalex.org/C172313692","wikidata":"https://www.wikidata.org/wiki/Q14902310","display_name":"Estrogen receptor alpha","level":5,"score":0.5028132796287537},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.49843502044677734},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.4977476894855499},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4817100167274475},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4381549656391144},{"id":"https://openalex.org/C98717036","wikidata":"https://www.wikidata.org/wiki/Q14872994","display_name":"Progesterone receptor","level":5,"score":0.42497190833091736},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4155166745185852},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4062625765800476},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3974224030971527},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.32322925329208374},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013548","descriptor_name":"Sweden","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D013548","descriptor_name":"Sweden","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D013548","descriptor_name":"Sweden","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D013548","descriptor_name":"Sweden","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018719","descriptor_name":"Receptor, ErbB-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018719","descriptor_name":"Receptor, ErbB-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018719","descriptor_name":"Receptor, ErbB-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018719","descriptor_name":"Receptor, ErbB-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018719","descriptor_name":"Receptor, ErbB-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018719","descriptor_name":"Receptor, ErbB-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D064726","descriptor_name":"Triple Negative Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D064726","descriptor_name":"Triple Negative Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D064726","descriptor_name":"Triple Negative Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D064726","descriptor_name":"Triple Negative Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D064726","descriptor_name":"Triple Negative Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D064726","descriptor_name":"Triple Negative Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D064726","descriptor_name":"Triple Negative Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D064726","descriptor_name":"Triple Negative Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1158/1078-0432.ccr-24-3435","doi":"https://doi.org/10.1158/1078-0432.ccr-24-3435","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-24-3435","pdf_url":"https://aacrjournals.org/clincancerres/article-pdf/doi/10.1158/1078-0432.CCR-24-3435/3577919/ccr-24-3435.pdf","source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},{"id":"pmid:40227228","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40227228","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12209827","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12209827","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Clin Cancer Res","raw_type":"Text"},{"id":"pmh:oai:lup.lub.lu.se:4fc60b87-2561-49de-86b8-2bcefadda90c","doi":null,"is_oa":false,"landing_page_url":"https://lup.lub.lu.se/record/4fc60b87-2561-49de-86b8-2bcefadda90c","pdf_url":null,"source":{"id":"https://openalex.org/S4306400536","display_name":"Lund University Publications (Lund University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187531555","host_organization_name":"Lund University","host_organization_lineage":["https://openalex.org/I187531555"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 1078-0432","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.ccr-24-3435","doi":"https://doi.org/10.1158/1078-0432.ccr-24-3435","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-24-3435","pdf_url":"https://aacrjournals.org/clincancerres/article-pdf/doi/10.1158/1078-0432.CCR-24-3435/3577919/ccr-24-3435.pdf","source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.46000000834465027,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G531070471","display_name":null,"funder_award_id":"FBKS 2022-35 and FBKS-2020-9","funder_id":"https://openalex.org/F4320322790","funder_display_name":"Fru Berta Kamprads Stiftelse"},{"id":"https://openalex.org/G712881263","display_name":null,"funder_award_id":"2018-","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"},{"id":"https://openalex.org/G8456944708","display_name":null,"funder_award_id":"GN-2022-7-283","funder_id":"https://openalex.org/F4320321929","funder_display_name":"Gunnar Nilssons Cancerstiftelse"},{"id":"https://openalex.org/G976160396","display_name":"NORDIC TRIP \u2013 A TRANSLATIONAL RANDOMIZED PHASE III STUDY EXPLORING THE EFFECT OF THE ADDITION OF CAPECITABINE TO CARBOPLATIN BASED PREOPERATIVE CHEMOTHERAPY IN EARLY TRIPLE NEGATIVE BREAST CANECR","funder_award_id":"2018-00522","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"}],"funders":[{"id":"https://openalex.org/F4320321929","display_name":"Gunnar Nilssons Cancerstiftelse","ror":"https://ror.org/00292rj97"},{"id":"https://openalex.org/F4320322581","display_name":"Vetenskapsr\u00e5det","ror":"https://ror.org/03zttf063"},{"id":"https://openalex.org/F4320322790","display_name":"Fru Berta Kamprads Stiftelse","ror":"https://ror.org/04wv8j283"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4409412944.pdf","grobid_xml":"https://content.openalex.org/works/W4409412944.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2228116816","https://openalex.org/W2364285896","https://openalex.org/W3209895153","https://openalex.org/W2414141389","https://openalex.org/W2087504465","https://openalex.org/W2117019370","https://openalex.org/W2514299822","https://openalex.org/W2499263060","https://openalex.org/W200925908","https://openalex.org/W2134192859"],"abstract_inverted_index":{"PURPOSE:":[0],"There":[1],"is":[2,219],"uncertainty":[3],"whether":[4],"estrogen":[5],"receptor":[6,192],"(ER)-low":[7],"tumors":[8,52,101,154,262],"with":[9,164,213,242],"1%":[10],"to":[11,41,130,185,250,264],"10%":[12,157],"IHC":[13],"staining":[14],"of":[15,23,36,68,97,198,232,267,272],"nuclei":[16],"represent":[17],"a":[18,145,214,221,238],"distinct":[19,222],"molecular":[20,118,225],"biological":[21,226],"entity":[22,227],"breast":[24,51,115,124,223,277],"cancer,":[25],"posing":[26],"significant":[27,141],"challenges":[28],"for":[29],"their":[30],"clinical":[31],"management":[32],"and":[33,79,89,99,109,136,178,194,206,256],"the":[34,55,149,265],"development":[35],"novel":[37],"therapies.":[38,252],"We":[39,48],"aimed":[40],"elucidate":[42],"ER-low":[43,84,98,153,177,276],"tumor":[44,76],"biology.":[45],"EXPERIMENTAL":[46],"DESIGN:":[47],"analyzed":[49],"primary":[50],"included":[53],"in":[54,275],"Swedish":[56],"population-based":[57],"Sweden":[58],"Cancerome":[59],"Analysis":[60],"Network-Breast":[61],"(SCAN-B)":[62],"cohort,":[63],"2%":[64],"(n":[65],"=":[66],"174)":[67],"which":[69],"were":[70,81,120,159,210],"classified":[71],"as":[72],"ER-low.":[73],"Transcriptional":[74],"patterns,":[75],"inflammatory":[77],"infiltration,":[78],"prognosis":[80],"compared":[82],"between":[83,148,176],"versus":[85],"ER-negative":[86],"(ER-neg;":[87],"0%)":[88],"ER-positive":[90],"(ER-pos;":[91],">10%)":[92],"tumors.":[93,187],"RESULTS:":[94],"The":[95,269],"transcriptomes":[96],"ER-neg":[100,179],"remarkably":[102],"overlapped,":[103],"displaying":[104],"predominantly":[105],"nonluminal":[106],"PAM50":[107,196],"subtypes":[108,119],"downregulated":[110],"ER":[111,245],"signaling.":[112],"All":[113],"triple-negative":[114],"cancer":[116,224,278],"(TNBC)":[117],"represented":[121],"within":[122],"ER-low/HER2-negative":[123,132,189,218,261],"cancer.":[125],"Unsupervised":[126],"clustering":[127],"algorithms":[128],"failed":[129],"segregate":[131],"from":[133,202],"TNBC":[134],"tumors,":[135],"only":[137],"two":[138],"genes":[139],"showed":[140],"differential":[142],"expression":[143],"above":[144],"1.5-fold":[146],"difference":[147],"groups.":[150],"However,":[151],"borderline":[152,240],"(with":[155],"exactly":[156],"ER)":[158],"mostly":[160],"assigned":[161],"labels":[162],"associated":[163,212],"luminal":[165],"disease":[166],"biology,":[167],"suggesting":[168],"possible":[169],"endocrine":[170,251,273],"responsiveness.":[171],"Lymphocyte":[172],"infiltration":[173],"was":[174,181],"comparable":[175],"but":[180,228],"significantly":[182],"higher":[183],"relative":[184],"ER-pos":[186],"Within":[188],"disease,":[190],"hormone":[191],"positivity":[193],"low/intermediate":[195],"risk":[197,266],"recurrence":[199],"score":[200],"inferred":[201],"RNA":[203],"sequencing":[204],"data":[205],"lymphocyte":[207],"fraction":[208],"\u226530%":[209],"respectively":[211],"better":[215],"prognosis.":[216],"CONCLUSIONS:":[217],"not":[220],"an":[229],"integral":[230],"part":[231],"TNBC,":[233],"deserving":[234],"similar":[235],"treatments.":[236],"Nonetheless,":[237],"few":[239],"cases":[241],"moderately":[243],"active":[244],"signaling":[246],"can":[247],"potentially":[248],"respond":[249],"Hormone":[253],"receptor-related":[254],"signatures":[255],"tumor-infiltrating":[257],"lymphocytes":[258],"may":[259],"stratify":[260],"according":[263],"recurrence.":[268],"true":[270],"benefit":[271],"therapies":[274],"requires":[279],"prospective":[280],"investigation.":[281]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":2}],"updated_date":"2026-10-17T09:40:24.721904","created_date":"2025-10-10T00:00:00"}
