{"id":"https://openalex.org/W4409412848","doi":"https://doi.org/10.1038/s41467-025-58676-8","title":"Specific labeling of outer membrane vesicles with antibiotic-conjugated probe reveals early bacterial infections in blood","display_name":"Specific labeling of outer membrane vesicles with antibiotic-conjugated probe reveals early bacterial infections in blood","publication_year":2025,"publication_date":"2025-04-14","ids":{"openalex":"https://openalex.org/W4409412848","doi":"https://doi.org/10.1038/s41467-025-58676-8","pmid":"https://pubmed.ncbi.nlm.nih.gov/40229269","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11997070"},"language":"en","primary_location":{"id":"doi:10.1038/s41467-025-58676-8","doi":"https://doi.org/10.1038/s41467-025-58676-8","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-025-58676-8","pdf_url":"https://www.nature.com/articles/s41467-025-58676-8.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41467-025-58676-8.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012529630","display_name":"Qianbei Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210103346","display_name":"Nanfang Hospital","ror":"https://ror.org/01eq10738","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103346"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qianbei Li","raw_affiliation_strings":["Department of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China","institution_ids":["https://openalex.org/I4210103346","https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046881833","display_name":"Zihao Ou","orcid":"https://orcid.org/0000-0001-8722-7205","observed_orcids":["https://orcid.org/0000-0001-8722-7205"]},"institutions":[{"id":"https://openalex.org/I4210103346","display_name":"Nanfang Hospital","ror":"https://ror.org/01eq10738","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103346"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zihao Ou","raw_affiliation_strings":["Department of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. ozh_xnp@smu.edu.cn"],"raw_orcid":"https://orcid.org/0000-0001-8722-7205","affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. ozh_xnp@smu.edu.cn","institution_ids":["https://openalex.org/I4210103346","https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007437872","display_name":"Jinduan Lin","orcid":"https://orcid.org/0000-0003-0052-8836","observed_orcids":["https://orcid.org/0000-0003-0052-8836"]},"institutions":[{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinduan Lin","raw_affiliation_strings":["Department of Laboratory Medicine, Affiliated Qingyuan Hospital, Guangzhou Medical University (Qingyuan People's Hospital), Qingyuan, 511500, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Affiliated Qingyuan Hospital, Guangzhou Medical University (Qingyuan People's Hospital), Qingyuan, 511500, China","institution_ids":["https://openalex.org/I92039509"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Die Tang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180726961","display_name":"Shenzhen University","ror":"https://ror.org/01vy4gh70","country_code":"CN","type":"education","lineage":["https://openalex.org/I180726961"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Die Tang","raw_affiliation_strings":["Medical Laboratory of the Third Affiliated Hospital of Shenzhen University, Shenzhen, 518003, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Laboratory of the Third Affiliated Hospital of Shenzhen University, Shenzhen, 518003, China","institution_ids":["https://openalex.org/I180726961"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100608490","display_name":"Bairong He","orcid":"https://orcid.org/0000-0002-2995-1964","observed_orcids":["https://orcid.org/0000-0002-2995-1964"]},"institutions":[{"id":"https://openalex.org/I4210103346","display_name":"Nanfang Hospital","ror":"https://ror.org/01eq10738","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103346"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bairong He","raw_affiliation_strings":["Department of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China","institution_ids":["https://openalex.org/I4210103346","https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101424018","display_name":"Yuanyuan Wu","orcid":"https://orcid.org/0000-0003-4783-5366","observed_orcids":["https://orcid.org/0000-0003-4783-5366"]},"institutions":[{"id":"https://openalex.org/I4210103346","display_name":"Nanfang Hospital","ror":"https://ror.org/01eq10738","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103346"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuanyuan Wu","raw_affiliation_strings":["Department of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China","institution_ids":["https://openalex.org/I4210103346","https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100584677","display_name":"Xinyue Huang","orcid":"https://orcid.org/0009-0002-0707-7361","observed_orcids":["https://orcid.org/0009-0002-0707-7361","https://orcid.org/0009-0005-0046-9524"]},"institutions":[{"id":"https://openalex.org/I150229711","display_name":"University of Electronic Science and Technology of China","ror":"https://ror.org/04qr3zq92","country_code":"CN","type":"education","lineage":["https://openalex.org/I150229711"]},{"id":"https://openalex.org/I4210090173","display_name":"Chengdu Women's and Children's Central Hospital","ror":"https://ror.org/008x2am79","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210090173"]},{"id":"https://openalex.org/I4210103346","display_name":"Nanfang Hospital","ror":"https://ror.org/01eq10738","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103346"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinyue Huang","raw_affiliation_strings":["Department of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China","Prenatal Diagnosis Center, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 611731, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China","institution_ids":["https://openalex.org/I4210103346","https://openalex.org/I58200834"]},{"raw_affiliation_string":"Prenatal Diagnosis Center, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 611731, China","institution_ids":["https://openalex.org/I150229711","https://openalex.org/I4210090173"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084576788","display_name":"Xixin Huang","orcid":"https://orcid.org/0000-0002-7846-4425","observed_orcids":["https://orcid.org/0000-0002-7846-4425"]},"institutions":[{"id":"https://openalex.org/I150229711","display_name":"University of Electronic Science and Technology of China","ror":"https://ror.org/04qr3zq92","country_code":"CN","type":"education","lineage":["https://openalex.org/I150229711"]},{"id":"https://openalex.org/I4210090173","display_name":"Chengdu Women's and Children's Central Hospital","ror":"https://ror.org/008x2am79","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210090173"]},{"id":"https://openalex.org/I4210103346","display_name":"Nanfang Hospital","ror":"https://ror.org/01eq10738","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103346"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xixin Huang","raw_affiliation_strings":["Department of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China","Prenatal Diagnosis Center, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 611731, China"],"raw_orcid":"https://orcid.org/0000-0002-7846-4425","affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China","institution_ids":["https://openalex.org/I4210103346","https://openalex.org/I58200834"]},{"raw_affiliation_string":"Prenatal Diagnosis Center, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 611731, China","institution_ids":["https://openalex.org/I150229711","https://openalex.org/I4210090173"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Bingbing Ru","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210103346","display_name":"Nanfang Hospital","ror":"https://ror.org/01eq10738","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103346"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bingbing Ru","raw_affiliation_strings":["Department of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China","institution_ids":["https://openalex.org/I4210103346","https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Qianwen Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210120929","display_name":"Zhujiang Hospital","ror":"https://ror.org/02mhxa927","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210120929"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qianwen Wang","raw_affiliation_strings":["Department of Critical Care Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, 510260, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Critical Care Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, 510260, China","institution_ids":["https://openalex.org/I4210120929","https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068975342","display_name":"Weirong Yao","orcid":"https://orcid.org/0000-0003-4730-3976","observed_orcids":["https://orcid.org/0000-0003-4730-3976","https://orcid.org/0009-0002-3038-3359","https://orcid.org/0000-0002-8800-7201","https://orcid.org/0000-0001-5124-1160"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Weirong Yao","raw_affiliation_strings":["The Second Hospital of Zhangzhou, Zhangzhou, 363000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Second Hospital of Zhangzhou, Zhangzhou, 363000, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068980726","display_name":"Bo Situ","orcid":"https://orcid.org/0000-0002-4623-9530","observed_orcids":["https://orcid.org/0000-0002-4623-9530","https://orcid.org/0009-0000-1966-6767"]},"institutions":[{"id":"https://openalex.org/I4210103346","display_name":"Nanfang Hospital","ror":"https://ror.org/01eq10738","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103346"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Bo Situ","raw_affiliation_strings":["Department of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. bositu@smu.edu.cn","State Key Laboratory of Multi-organ Injury Prevention and Treatment, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. bositu@smu.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. bositu@smu.edu.cn","institution_ids":["https://openalex.org/I4210103346","https://openalex.org/I58200834"]},{"raw_affiliation_string":"State Key Laboratory of Multi-organ Injury Prevention and Treatment, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. bositu@smu.edu.cn","institution_ids":["https://openalex.org/I4210103346","https://openalex.org/I58200834"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087284408","display_name":"Lei Zheng","orcid":"https://orcid.org/0000-0003-2576-8780","observed_orcids":["https://orcid.org/0000-0003-2576-8780","https://orcid.org/0000-0001-7835-3963"]},"institutions":[{"id":"https://openalex.org/I4210103346","display_name":"Nanfang Hospital","ror":"https://ror.org/01eq10738","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103346"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lei Zheng","raw_affiliation_strings":["Department of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. nfyyzhenglei@smu.edu.cn","State Key Laboratory of Multi-organ Injury Prevention and Treatment, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. nfyyzhenglei@smu.edu.cn"],"raw_orcid":"https://orcid.org/0000-0003-2576-8780","affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. nfyyzhenglei@smu.edu.cn","institution_ids":["https://openalex.org/I4210103346","https://openalex.org/I58200834"]},{"raw_affiliation_string":"State Key Laboratory of Multi-organ Injury Prevention and Treatment, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. nfyyzhenglei@smu.edu.cn","institution_ids":["https://openalex.org/I4210103346","https://openalex.org/I58200834"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5046881833","https://openalex.org/A5068980726","https://openalex.org/A5087284408"],"corresponding_institution_ids":["https://openalex.org/I4210103346","https://openalex.org/I58200834"],"apc_list":{"value":6990,"currency":"USD","value_usd":6990},"apc_paid":{"value":6990,"currency":"USD","value_usd":6990},"fwci":13.3314,"has_fulltext":true,"cited_by_count":61,"citation_normalized_percentile":{"value":0.99524725,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"16","issue":"1","first_page":"3535","last_page":"3535"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.8413000106811523,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.8413000106811523,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10873","display_name":"Bacterial Infections and Vaccines","score":0.1145000010728836,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.009700000286102295,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bacterial-outer-membrane-vesicles","display_name":"bacterial outer membrane vesicles","score":0.9240000247955322},{"id":"https://openalex.org/keywords/extracellular-vesicles","display_name":"extracellular vesicles","score":0.7260000109672546},{"id":"https://openalex.org/keywords/pneumonia","display_name":"pneumonia","score":0.5270000100135803},{"id":"https://openalex.org/keywords/blood-biomarkers","display_name":"blood biomarkers","score":0.6909999847412109},{"id":"https://openalex.org/keywords/nano-flow-cytometry","display_name":"nano-flow cytometry","score":0.8299999833106995},{"id":"https://openalex.org/keywords/gram-negative-bacteria","display_name":"Gram-negative bacteria","score":0.9110000133514404},{"id":"https://openalex.org/keywords/host-pathogen-interaction","display_name":"host-pathogen interaction","score":0.7910000085830688},{"id":"https://openalex.org/keywords/differential-diagnosis-of-infection","display_name":"differential diagnosis of infection","score":0.4099999964237213}],"concepts":[{"id":"https://openalex.org/C146587185","wikidata":"https://www.wikidata.org/wiki/Q258248","display_name":"Bacterial outer membrane","level":4,"score":0.7150988578796387},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.6420606374740601},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5557488799095154},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.5408310294151306},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.5154141187667847},{"id":"https://openalex.org/C2776460866","wikidata":"https://www.wikidata.org/wiki/Q170065","display_name":"Pathogen","level":2,"score":0.4933845102787018},{"id":"https://openalex.org/C2780675486","wikidata":"https://www.wikidata.org/wiki/Q423765","display_name":"Polymyxin","level":3,"score":0.49336233735084534},{"id":"https://openalex.org/C130316041","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Vesicle","level":3,"score":0.4492902159690857},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.1781316101551056},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10056206583976746},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.09731778502464294},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000067128","descriptor_name":"Extracellular Vesicles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000080943","descriptor_name":"Bacterial Outer Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000080943","descriptor_name":"Bacterial Outer Membrane","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D001424","descriptor_name":"Bacterial Infections","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D001424","descriptor_name":"Bacterial Infections","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D001424","descriptor_name":"Bacterial Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005456","descriptor_name":"Fluorescent Dyes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011112","descriptor_name":"Polymyxin B","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1038/s41467-025-58676-8","doi":"https://doi.org/10.1038/s41467-025-58676-8","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-025-58676-8","pdf_url":"https://www.nature.com/articles/s41467-025-58676-8.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:10809069","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11997070","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:40229269","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40229269","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature communications","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11997070","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11997070/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nat Commun","raw_type":"Text"},{"id":"pmh:oai:RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-58676-8","doi":null,"is_oa":false,"landing_page_url":"https://www.nature.com/articles/s41467-025-58676-8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:d95633b0a44e4414b31d9a3c23ca1242","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/d95633b0a44e4414b31d9a3c23ca1242","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, Vol 16, Iss 1, Pp 1-14 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41467-025-58676-8","doi":"https://doi.org/10.1038/s41467-025-58676-8","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-025-58676-8","pdf_url":"https://www.nature.com/articles/s41467-025-58676-8.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1120618306","display_name":null,"funder_award_id":"82025024","funder_id":"https://openalex.org/F4320334953","funder_display_name":"China National Funds for Distinguished Young Scientists"},{"id":"https://openalex.org/G1647297549","display_name":null,"funder_award_id":"2022J001","funder_id":"https://openalex.org/F4320326228","funder_display_name":"Southern Medical University"},{"id":"https://openalex.org/G1785851351","display_name":null,"funder_award_id":"202301-202","funder_id":"https://openalex.org/F4320311429","funder_display_name":"Guangzhou Medical University"},{"id":"https://openalex.org/G2778505653","display_name":null,"funder_award_id":"82025024","funder_id":"https://openalex.org/F4320336125","funder_display_name":"National Science Fund for Distinguished Young Scholars"},{"id":"https://openalex.org/G3094682114","display_name":null,"funder_award_id":"82230080","funder_id":"https://openalex.org/F4320335575","funder_display_name":"Key Programme"},{"id":"https://openalex.org/G3385547954","display_name":null,"funder_award_id":"82272438","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4511196743","display_name":null,"funder_award_id":"20232BBG70019","funder_id":"https://openalex.org/F4320322665","funder_display_name":"Natural Science Foundation of Jiangxi Province"},{"id":"https://openalex.org/G6226226059","display_name":null,"funder_award_id":"82302593","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6655762250","display_name":null,"funder_award_id":"82230080","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7106545543","display_name":null,"funder_award_id":"82272438","funder_id":"https://openalex.org/F4320321921","funder_display_name":"Natural Science Foundation of Guangdong Province"},{"id":"https://openalex.org/G7997517078","display_name":null,"funder_award_id":"2023A1515012512","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8144513847","display_name":null,"funder_award_id":"2023A1515012512","funder_id":"https://openalex.org/F4320321921","funder_display_name":"Natural Science Foundation of Guangdong Province"},{"id":"https://openalex.org/G8549013717","display_name":null,"funder_award_id":"82025024","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G857098172","display_name":null,"funder_award_id":"2022J001","funder_id":"https://openalex.org/F4320326242","funder_display_name":"Nanfang Hospital"},{"id":"https://openalex.org/G8672501308","display_name":null,"funder_award_id":"2023B1515020058","funder_id":"https://openalex.org/F4320321921","funder_display_name":"Natural Science Foundation of Guangdong Province"}],"funders":[{"id":"https://openalex.org/F4320311429","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321921","display_name":"Natural Science Foundation of Guangdong Province","ror":null},{"id":"https://openalex.org/F4320322665","display_name":"Natural Science Foundation of Jiangxi Province","ror":null},{"id":"https://openalex.org/F4320326228","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39"},{"id":"https://openalex.org/F4320326242","display_name":"Nanfang Hospital","ror":"https://ror.org/01eq10738"},{"id":"https://openalex.org/F4320334953","display_name":"China National Funds for Distinguished Young Scientists","ror":"https://ror.org/01pab2602"},{"id":"https://openalex.org/F4320335575","display_name":"Key Programme","ror":null},{"id":"https://openalex.org/F4320336125","display_name":"National Science Fund for Distinguished Young Scholars","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4409412848.pdf","grobid_xml":"https://content.openalex.org/works/W4409412848.grobid-xml"},"referenced_works_count":67,"referenced_works":["https://openalex.org/W799775483","https://openalex.org/W1860874235","https://openalex.org/W1997969528","https://openalex.org/W2004918900","https://openalex.org/W2020863352","https://openalex.org/W2044638539","https://openalex.org/W2051349444","https://openalex.org/W2063421071","https://openalex.org/W2074485750","https://openalex.org/W2079177004","https://openalex.org/W2104714277","https://openalex.org/W2105018820","https://openalex.org/W2118337827","https://openalex.org/W2125499085","https://openalex.org/W2141852713","https://openalex.org/W2146558097","https://openalex.org/W2335807995","https://openalex.org/W2345407464","https://openalex.org/W2509403318","https://openalex.org/W2512831030","https://openalex.org/W2532347900","https://openalex.org/W2738537980","https://openalex.org/W2781817102","https://openalex.org/W2788752071","https://openalex.org/W2895797788","https://openalex.org/W2899663373","https://openalex.org/W2900555106","https://openalex.org/W2903104615","https://openalex.org/W2914973875","https://openalex.org/W2929426756","https://openalex.org/W2953017819","https://openalex.org/W2972523593","https://openalex.org/W2998853022","https://openalex.org/W3005700774","https://openalex.org/W3012868903","https://openalex.org/W3027962356","https://openalex.org/W3096406237","https://openalex.org/W3135700409","https://openalex.org/W3155580838","https://openalex.org/W3174715883","https://openalex.org/W3186241151","https://openalex.org/W3190826868","https://openalex.org/W3192077473","https://openalex.org/W3209652043","https://openalex.org/W4205836573","https://openalex.org/W4229370911","https://openalex.org/W4280563139","https://openalex.org/W4308368583","https://openalex.org/W4309503005","https://openalex.org/W4327745747","https://openalex.org/W4380880199","https://openalex.org/W4385197136","https://openalex.org/W4389339115","https://openalex.org/W4389703338","https://openalex.org/W4390913522","https://openalex.org/W4396789576","https://openalex.org/W4399211618","https://openalex.org/W4399919097","https://openalex.org/W4399983587","https://openalex.org/W4400199313","https://openalex.org/W4400235812","https://openalex.org/W4400410325","https://openalex.org/W4400654775","https://openalex.org/W4400874054","https://openalex.org/W4400884064","https://openalex.org/W4403953188","https://openalex.org/W4409430637"],"related_works":["https://openalex.org/W4319838906","https://openalex.org/W4414000170","https://openalex.org/W4393167567","https://openalex.org/W4404616320","https://openalex.org/W2478952582","https://openalex.org/W2054431685","https://openalex.org/W6910282286","https://openalex.org/W4414923980","https://openalex.org/W2112236099","https://openalex.org/W3043319924"],"abstract_inverted_index":{"Bacterial":[0,139],"outer":[1,11,140],"membrane":[2,12,141],"vesicles":[3,78,142,179],"(OMVs)":[4,143],"are":[5,144],"nano-sized":[6,145],"structures":[7],"derived":[8],"from":[9,75,122,147,177],"the":[10,35,159],"of":[13,37,89,136],"Gram-negative":[14,148],"bacteria,":[15,149],"which":[16,62],"have":[17],"emerged":[18],"as":[19,28,97,99,133],"key":[20],"players":[21],"in":[22,39,54,155],"host-pathogen":[23],"interactions,":[24],"yet":[25,151],"their":[26,73],"potential":[27],"biomarkers":[29,135],"remains":[30],"largely":[31],"unexplored":[32],"due":[33],"to":[34,153,169],"difficulty":[36],"identification":[38],"complex":[40],"biological":[41,156],"samples.":[42,157],"Here":[43],"we":[44,91],"show":[45,112,161],"an":[46],"approach":[47],"for":[48,115,180],"detecting":[49],"and":[50,79,119,172],"quantifying":[51],"bacterial":[52,64,117,137,182],"OMVs":[53],"blood":[55,105],"using":[56,82,164],"a":[57,162,165],"Polymyxin":[58,166],"B-fluorescein":[59,167],"probe":[60,68,168],"(PmBF),":[61],"targets":[63],"lipopolysaccharides":[65],"(LPS).":[66],"The":[67],"selectively":[69,170],"labels":[70],"OMVs,":[71,174],"enabling":[72],"differentiation":[74],"host":[76],"extracellular":[77],"quantitative":[80],"analysis":[81],"nano-flow":[83],"cytometry.":[84],"In":[85,107],"male":[86],"mouse":[87],"models":[88],"pneumonia,":[90],"observe":[92],"elevated":[93],"serum":[94],"PmBF+":[95,110,131],"EVs":[96,111,132],"early":[98],"6":[100],"h":[101],"post-infection,":[102],"preceding":[103],"positive":[104],"cultures.":[106],"clinical":[108],"samples,":[109],"superior":[113],"performance":[114],"diagnosing":[116],"infections":[118],"differentiate":[120],"them":[121,176],"virus":[123],"or":[124],"mycoplasma":[125],"infections.":[126,138],"Our":[127],"findings":[128],"highlight":[129],"circulating":[130],"promising":[134],"particles":[146],"critical":[150],"hard":[152],"identify":[154],"Here,":[158],"authors":[160],"method":[163],"label":[171],"quantify":[173],"distinguishing":[175],"other":[178],"precise":[181],"infection":[183],"diagnosis.":[184]},"counts_by_year":[{"year":2026,"cited_by_count":45},{"year":2025,"cited_by_count":16}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2025-04-14T00:00:00"}
