{"id":"https://openalex.org/W4409411682","doi":"https://doi.org/10.1128/aac.00884-24","title":"Novel Plasmodium falciparum Kelch13 polymorphisms in Cameroon with structural and physicochemical impact","display_name":"Novel Plasmodium falciparum Kelch13 polymorphisms in Cameroon with structural and physicochemical impact","publication_year":2025,"publication_date":"2025-04-14","ids":{"openalex":"https://openalex.org/W4409411682","doi":"https://doi.org/10.1128/aac.00884-24","pmid":"https://pubmed.ncbi.nlm.nih.gov/40227034","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12057353"},"language":"en","primary_location":{"id":"doi:10.1128/aac.00884-24","doi":"https://doi.org/10.1128/aac.00884-24","is_oa":true,"landing_page_url":"https://doi.org/10.1128/aac.00884-24","pdf_url":null,"source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.1128/aac.00884-24","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008166522","display_name":"Loick Pradel Kojom Foko","orcid":"https://orcid.org/0000-0002-4286-147X","observed_orcids":["https://orcid.org/0000-0002-4286-147X"]},"institutions":[{"id":"https://openalex.org/I76782289","display_name":"National Institute of Malaria Research","ror":"https://ror.org/031vxrj29","country_code":"IN","type":"facility","lineage":["https://openalex.org/I37048141","https://openalex.org/I76782289"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Loick P. Kojom Foko","raw_affiliation_strings":["Parasite & Host Biology, ICMR-National Institute of Malaria Research"],"raw_orcid":"https://orcid.org/0000-0002-4286-147X","affiliations":[{"raw_affiliation_string":"Parasite & Host Biology, ICMR-National Institute of Malaria Research","institution_ids":["https://openalex.org/I76782289"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026654267","display_name":"Jahnvi Jakhan","orcid":"https://orcid.org/0000-0001-9443-558X","observed_orcids":["https://orcid.org/0000-0001-9443-558X"]},"institutions":[{"id":"https://openalex.org/I76782289","display_name":"National Institute of Malaria Research","ror":"https://ror.org/031vxrj29","country_code":"IN","type":"facility","lineage":["https://openalex.org/I37048141","https://openalex.org/I76782289"]},{"id":"https://openalex.org/I99364266","display_name":"Academy of Scientific and Innovative Research","ror":"https://ror.org/053rcsq61","country_code":"IN","type":"education","lineage":["https://openalex.org/I99364266"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Jahnvi Jakhan","raw_affiliation_strings":["Academy of Scientific and Innovative Research (AcSIR)","Parasite & Host Biology, ICMR-National Institute of Malaria Research"],"raw_orcid":"https://orcid.org/0000-0001-9443-558X","affiliations":[{"raw_affiliation_string":"Academy of Scientific and Innovative Research (AcSIR)","institution_ids":["https://openalex.org/I99364266"]},{"raw_affiliation_string":"Parasite & Host Biology, ICMR-National Institute of Malaria Research","institution_ids":["https://openalex.org/I76782289"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067202587","display_name":"Geetika Narang","orcid":"https://orcid.org/0000-0002-9905-1857","observed_orcids":["https://orcid.org/0000-0002-9905-1857"]},"institutions":[{"id":"https://openalex.org/I76782289","display_name":"National Institute of Malaria Research","ror":"https://ror.org/031vxrj29","country_code":"IN","type":"facility","lineage":["https://openalex.org/I37048141","https://openalex.org/I76782289"]},{"id":"https://openalex.org/I99364266","display_name":"Academy of Scientific and Innovative Research","ror":"https://ror.org/053rcsq61","country_code":"IN","type":"education","lineage":["https://openalex.org/I99364266"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Geetika Narang","raw_affiliation_strings":["Academy of Scientific and Innovative Research (AcSIR)","Parasite & Host Biology, ICMR-National Institute of Malaria Research"],"raw_orcid":"https://orcid.org/0000-0002-9905-1857","affiliations":[{"raw_affiliation_string":"Academy of Scientific and Innovative Research (AcSIR)","institution_ids":["https://openalex.org/I99364266"]},{"raw_affiliation_string":"Parasite & Host Biology, ICMR-National Institute of Malaria Research","institution_ids":["https://openalex.org/I76782289"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079785805","display_name":"Joseph Hawadak","orcid":"https://orcid.org/0000-0003-4145-9953","observed_orcids":["https://orcid.org/0000-0003-4145-9953"]},"institutions":[{"id":"https://openalex.org/I76782289","display_name":"National Institute of Malaria Research","ror":"https://ror.org/031vxrj29","country_code":"IN","type":"facility","lineage":["https://openalex.org/I37048141","https://openalex.org/I76782289"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Joseph Hawadak","raw_affiliation_strings":["Parasite & Host Biology, ICMR-National Institute of Malaria Research"],"raw_orcid":"https://orcid.org/0000-0003-4145-9953","affiliations":[{"raw_affiliation_string":"Parasite & Host Biology, ICMR-National Institute of Malaria Research","institution_ids":["https://openalex.org/I76782289"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059057536","display_name":"Carole Else Eboumbou Moukoko","orcid":"https://orcid.org/0000-0003-3252-6552","observed_orcids":["https://orcid.org/0000-0003-3252-6552"]},"institutions":[{"id":"https://openalex.org/I163423212","display_name":"University of Douala","ror":"https://ror.org/02zr5jr81","country_code":"CM","type":"education","lineage":["https://openalex.org/I163423212"]},{"id":"https://openalex.org/I4210114134","display_name":"Centre Pasteur du Cameroun","ror":"https://ror.org/0259hk390","country_code":"CM","type":"facility","lineage":["https://openalex.org/I4210114134"]}],"countries":["CM"],"is_corresponding":false,"raw_author_name":"Carole E. Eboumbou Moukoko","raw_affiliation_strings":["Department of Biological Sciences, Faculty of Medicine and Pharmaceutical Sciences, The University of Douala","Laboratory of Parasitology, Mycology and Virology, Postgraduate Training Unit for Health Sciences, Postgraduate School for Pure and Applied Sciences, The University of Douala","Malaria Research Unit, Centre Pasteur Cameroon"],"raw_orcid":"https://orcid.org/0000-0003-3252-6552","affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Faculty of Medicine and Pharmaceutical Sciences, The University of Douala","institution_ids":["https://openalex.org/I163423212"]},{"raw_affiliation_string":"Laboratory of Parasitology, Mycology and Virology, Postgraduate Training Unit for Health Sciences, Postgraduate School for Pure and Applied Sciences, The University of Douala","institution_ids":["https://openalex.org/I163423212"]},{"raw_affiliation_string":"Malaria Research Unit, Centre Pasteur Cameroon","institution_ids":["https://openalex.org/I4210114134"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079871736","display_name":"Vineeta Singh","orcid":"https://orcid.org/0000-0003-0113-7394","observed_orcids":["https://orcid.org/0000-0003-0113-7394"]},"institutions":[{"id":"https://openalex.org/I76782289","display_name":"National Institute of Malaria Research","ror":"https://ror.org/031vxrj29","country_code":"IN","type":"facility","lineage":["https://openalex.org/I37048141","https://openalex.org/I76782289"]},{"id":"https://openalex.org/I99364266","display_name":"Academy of Scientific and Innovative Research","ror":"https://ror.org/053rcsq61","country_code":"IN","type":"education","lineage":["https://openalex.org/I99364266"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Vineeta Singh","raw_affiliation_strings":["Academy of Scientific and Innovative Research (AcSIR)","Parasite & Host Biology, ICMR-National Institute of Malaria Research"],"raw_orcid":"https://orcid.org/0000-0003-0113-7394","affiliations":[{"raw_affiliation_string":"Academy of Scientific and Innovative Research (AcSIR)","institution_ids":["https://openalex.org/I99364266"]},{"raw_affiliation_string":"Parasite & Host Biology, ICMR-National Institute of Malaria Research","institution_ids":["https://openalex.org/I76782289"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5079871736"],"corresponding_institution_ids":["https://openalex.org/I76782289","https://openalex.org/I99364266"],"apc_list":null,"apc_paid":null,"fwci":2.7866,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.88441413,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":98},"biblio":{"volume":"69","issue":"5","first_page":"e0088424","last_page":"e0088424"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12685","display_name":"Phytochemical compounds biological activities","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plasmodium-falciparum","display_name":"Plasmodium falciparum","score":1.0},{"id":"https://openalex.org/keywords/pfk13","display_name":"pfk13","score":0.7459999918937683},{"id":"https://openalex.org/keywords/artemisinin-based-combination-therapy","display_name":"artemisinin-based combination therapy","score":0.8080000281333923},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.9779999852180481},{"id":"https://openalex.org/keywords/nonsynonymous-snps","display_name":"non-synonymous SNPs","score":0.8399999737739563},{"id":"https://openalex.org/keywords/protein-structure-prediction","display_name":"protein structure prediction","score":0.5099999904632568},{"id":"https://openalex.org/keywords/molecular-surveillance","display_name":"molecular surveillance","score":0.628000020980835},{"id":"https://openalex.org/keywords/genetic-diversity","display_name":"genetic diversity","score":0.6759999990463257},{"id":"https://openalex.org/keywords/cameroon","display_name":"Cameroon","score":0.6019999980926514},{"id":"https://openalex.org/keywords/asymptomatic-malaria","display_name":"asymptomatic malaria","score":0.5860000252723694},{"id":"https://openalex.org/keywords/solvent-accessible-surface-area","display_name":"solvent accessible surface area","score":0.8050000071525574},{"id":"https://openalex.org/keywords/hydrophobicity","display_name":"hydrophobicity","score":0.8309999704360962}],"concepts":[{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.6645211577415466},{"id":"https://openalex.org/C8185291","wikidata":"https://www.wikidata.org/wiki/Q2844457","display_name":"Amplicon","level":4,"score":0.5679848194122314},{"id":"https://openalex.org/C2776120307","wikidata":"https://www.wikidata.org/wiki/Q426921","display_name":"Artemisinin","level":4,"score":0.5542536973953247},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5398586988449097},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5385732054710388},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5115874409675598},{"id":"https://openalex.org/C2778371730","wikidata":"https://www.wikidata.org/wiki/Q311383","display_name":"Plasmodium falciparum","level":3,"score":0.5010297298431396},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.34211763739585876},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.2111685574054718},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.18321830034255981},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.10679039359092712}],"mesh":[{"descriptor_ui":"D000962","descriptor_name":"Antimalarials","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002163","descriptor_name":"Cameroon","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004351","descriptor_name":"Drug Resistance","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010963","descriptor_name":"Plasmodium falciparum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D010963","descriptor_name":"Plasmodium falciparum","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015800","descriptor_name":"Protozoan Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015800","descriptor_name":"Protozoan Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D016778","descriptor_name":"Malaria, Falciparum","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D016778","descriptor_name":"Malaria, Falciparum","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D037621","descriptor_name":"Artemisinins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D037621","descriptor_name":"Artemisinins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1128/aac.00884-24","doi":"https://doi.org/10.1128/aac.00884-24","is_oa":true,"landing_page_url":"https://doi.org/10.1128/aac.00884-24","pdf_url":null,"source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12057353","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12057353/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12057353/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrob Agents Chemother","raw_type":"Text"},{"id":"pmid:40227034","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40227034","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial agents and chemotherapy","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1128/aac.00884-24","doi":"https://doi.org/10.1128/aac.00884-24","is_oa":true,"landing_page_url":"https://doi.org/10.1128/aac.00884-24","pdf_url":null,"source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320320717","display_name":"Department of Biotechnology, Ministry of Science and Technology, India","ror":"https://ror.org/03tjsyq23"},{"id":"https://openalex.org/F4320320720","display_name":"Indian Council of Medical Research","ror":"https://ror.org/0492wrx28"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4409411682.pdf","grobid_xml":"https://content.openalex.org/works/W4409411682.grobid-xml"},"referenced_works_count":81,"referenced_works":["https://openalex.org/W1508404210","https://openalex.org/W1842557358","https://openalex.org/W1993347313","https://openalex.org/W2001500896","https://openalex.org/W2018913979","https://openalex.org/W2043762150","https://openalex.org/W2059145105","https://openalex.org/W2114213072","https://openalex.org/W2124634096","https://openalex.org/W2132393729","https://openalex.org/W2132926880","https://openalex.org/W2137886330","https://openalex.org/W2140784970","https://openalex.org/W2146272590","https://openalex.org/W2161311583","https://openalex.org/W2169991380","https://openalex.org/W2467259677","https://openalex.org/W2515644495","https://openalex.org/W2553359142","https://openalex.org/W2581264398","https://openalex.org/W2602013043","https://openalex.org/W2605045843","https://openalex.org/W2608549546","https://openalex.org/W2626161490","https://openalex.org/W2742731343","https://openalex.org/W2749244569","https://openalex.org/W2755331695","https://openalex.org/W2792700637","https://openalex.org/W2799524357","https://openalex.org/W2884909983","https://openalex.org/W2885958698","https://openalex.org/W2890391722","https://openalex.org/W2895693270","https://openalex.org/W2909546920","https://openalex.org/W2953906682","https://openalex.org/W2963985006","https://openalex.org/W2972289672","https://openalex.org/W2981340699","https://openalex.org/W2994777803","https://openalex.org/W3006913511","https://openalex.org/W3037549998","https://openalex.org/W3046809066","https://openalex.org/W3092583192","https://openalex.org/W3094990210","https://openalex.org/W3100866488","https://openalex.org/W3104285666","https://openalex.org/W3112801398","https://openalex.org/W3134711737","https://openalex.org/W3135563966","https://openalex.org/W3154986366","https://openalex.org/W3157709634","https://openalex.org/W3178183856","https://openalex.org/W3193685371","https://openalex.org/W3200040377","https://openalex.org/W4214687308","https://openalex.org/W4225073124","https://openalex.org/W4226025175","https://openalex.org/W4280496773","https://openalex.org/W4281780147","https://openalex.org/W4283832134","https://openalex.org/W4293577596","https://openalex.org/W4301398476","https://openalex.org/W4308119866","https://openalex.org/W4309662872","https://openalex.org/W4310471116","https://openalex.org/W4311125934","https://openalex.org/W4311282568","https://openalex.org/W4312203321","https://openalex.org/W4318911934","https://openalex.org/W4323663186","https://openalex.org/W4362672518","https://openalex.org/W4381251909","https://openalex.org/W4385415784","https://openalex.org/W4385840397","https://openalex.org/W4386225325","https://openalex.org/W4387013612","https://openalex.org/W4388725111","https://openalex.org/W4389010057","https://openalex.org/W4391304211","https://openalex.org/W4394874943","https://openalex.org/W4401630446"],"related_works":["https://openalex.org/W4214687308","https://openalex.org/W4280496773","https://openalex.org/W3150073017","https://openalex.org/W4409380660","https://openalex.org/W4210801110","https://openalex.org/W2571397745","https://openalex.org/W6958261766","https://openalex.org/W4404069466","https://openalex.org/W3114507332","https://openalex.org/W3159783306"],"abstract_inverted_index":{"ABSTRACT":[0],"The":[1,69,89,151,208],"recent":[2],"emergence":[3],"of":[4,27,57,67,95,104,117,125,154,181,186,190,214,223,238],"Plasmodium":[5],"falciparum":[6],"(":[7,40],"Pf":[8,49],")":[9,42],"parasites":[10],"resistant":[11],"to":[12,83,175],"artemisinin-based":[13],"combination":[14],"therapies":[15],"(ACT)":[16],"in":[17,35,63,112,122,199,216],"Africa":[18],"has":[19],"outlined":[20],"the":[21,32,36,93,96,105,160,165,177,182,187,191,200,211,217,221,243],"need":[22],"for":[23],"continuous":[24],"molecular":[25],"surveillance":[26],"artemisinin":[28,228],"partial":[29,229],"resistance.":[30,230],"Here,":[31],"genetic":[33,152],"polymorphism":[34],"Kelch":[37],"13":[38],"gene":[39,71,162],"pfk13":[41,70,155,161],"and":[43,59,79,92,102,147,159,179,206],"its":[44],"structural":[45],"impact":[46,94],"were":[47,81,108,120],"analyzed.":[48],"DNA":[50],"was":[51,72,157],"extracted":[52],"from":[53],"dried":[54],"blood":[55],"spots":[56],"symptomatic":[58],"asymptomatic":[60],"individuals":[61],"living":[62],"different":[64],"epidemiological":[65],"facets":[66],"Cameroon.":[68],"amplified":[73],"by":[74],"nested":[75],"polymerase":[76],"chain":[77],"reaction,":[78],"amplicons":[80],"sequenced":[82],"detect":[84],"single":[85],"nucleotide":[86],"polymorphisms":[87,97],"(SNPs).":[88],"evolutionary":[90],"history":[91],"on":[98,242],"physicochemical":[99,188],"properties,":[100],"structure,":[101],"function":[103,178],"pfK13":[106,183,193,244],"protein":[107,194],"appraised":[109],"using":[110],"various":[111],"silico":[113],"models.":[114],"A":[115],"total":[116],"ten":[118],"SNPs":[119,129,225,241],"identified":[121],"this":[123],"study,":[124],"which":[126],"five":[127],"non-synonymous":[128],"have":[130],"not":[131],"been":[132],"previously":[133],"reported":[134],"(L647":[135],"F":[136],",":[137,140,143,146,173],"D648":[138],"V":[139],"N657":[141],"S":[142],"K658":[144],"R":[145],"L663":[148,171],"P":[149,172],").":[150],"diversity":[153],"sequences":[156,195],"low,":[158],"evolved":[163],"under":[164],"neutral":[166],"model.":[167],"Some":[168],"mutations,":[169],"especially":[170],"appeared":[174],"affect":[176],"structure":[180,245],"protein.":[184],"Analysis":[185],"properties":[189],"Cameroonian":[192],"revealed":[196],"slight":[197],"changes":[198],"solvent-accessible":[201],"surface":[202],"area,":[203],"isoelectric":[204],"point,":[205],"hydrophobicity.":[207],"results":[209],"support":[210],"ongoing":[212],"use":[213],"ACTs":[215],"study":[218],"areas,":[219],"given":[220],"absence":[222],"validated":[224],"associated":[226],"with":[227],"Computational":[231],"findings":[232],"suggest":[233],"a":[234],"possible":[235],"deleterious":[236],"effect":[237],"some":[239],"novel":[240],"and/or":[246],"function.":[247]},"counts_by_year":[{"year":2026,"cited_by_count":4}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2025-04-14T00:00:00"}